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| 1 | A Novel Integrated Method for Large-Scale Detection, Identification, and Quantification of Widely Targeted Metabolites: Application in the Study of Rice Metabolomics显示文摘液体 chromatographymass spectrometry (最小公倍数) 基于 metabolomics 被 MS 2 的构造便于光谱从全部的扫描 ESI MS/MS 数据的标签(MS2T ) 图书馆,和广泛地指向的 metabolomics methodusing MS/MS 数据的发展从真标准聚在一起。在这份报告,称为逐步的多重离子 monitoring-enhancedproduct 离子(逐步的 MIMEPI ) 的新奇策略被开发构造 MS2T 图书馆,逐步的 MIM 在被用作调查 scansto 触发 EPI 的获得。698 的一个全部的数字(几乎) 有 MS 2 系列的非冗余的代谢物被获得,哪个 135 代谢物被识别 / 注解。集成数据从我们的 MS2T libraryand 收集了监视的另外的可得到的多重反应(MRM ) 信息,一个广泛地指向的 metabolomics 方法被开发 toquantify 277 代谢物,包括一些植物激素。在米饭叶的脱水回答和自然变化 ofthese 代谢物的评估不仅与代谢物 suchas 血清素衍生物建议了 abscisic 酸(骆驼毛的织物)的协调规定, polyamine 在干旱应力下面结合,而且为 indica 和装饰用的梨树米饭亚种的辨别作为潜在的标记揭示了一些 C-glycosylated 黄酮。新 MS2T 图书馆构造和广泛地指向的 metabolomics 策略能被用作工具 forrice 功能的 genomics.Key 词: | Wei Chen Liang Gong Zilong GUO Wensheng Wang Hongyan Zhang Xianqing Liu SibinYu Lizhong Xiong Jie Luo | 2013 | Molecular Plant2013，6，6： | 162 |
| 2 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | High matrix metalloproteinase-9 expression induces angiogenesis and basement membrane degradation in stroke-prone spontaneously hypertensive rats after cerebral infarction显示文摘Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal and brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced cerebral infarction in strokeprone spontaneously hypertensive rats by intragastric administration of high-sodium water(1.3% NaCl) for 7 consecutive weeks. Immunohistochemical and immunofluorescence assays demonstrated that, compared with the non-infarcted contralateral hemisphere, stroke-prone spontaneously hypertensive rats on normal sodium intake and Wistar-Kyoto rats, matrix metalloproteinase-9 expression, the number of blood vessels with discontinuous collagen IV expression and microvessel density were significantly higher, and the number of continuous collagen IV-positive blood vessels was lower in the infarct border zones of stroke-prone spontaneously hypertensive rats given high-sodium water. Linear correlation analysis showed matrix metalloproteinase-9 expression was positively correlated with the number of discontinuously collagen IV-labeled blood vessels and microvessel density in cerebral infarcts of stroke-prone spontaneously hypertensive rats. These results suggest that matrix metalloproteinase-9 upregulation is associated with increased regional angiogenesis and degradation of collagen IV, the major component of the basal lamina, in stroke-prone spontaneously hypertensive rats with high-sodium water-induced focal cerebral infarction. | Huilian Hou Guanjun Zhang Hongyan Wang Huilin Gong Chunbao Wang Xuebin Zhang | 2014 | Neural Regeneration Research2014，9，11： | 30 |
| 5 | Neoproterozoic Mafic Dykes and Basalts in the Southern Margin of Tarim,Northwest China:Age,Geochemistry and Geodynamic Implications显示文摘Neoproterozoic 裂缝相关的 mafic 火的岩石广泛地在塔里姆·布洛克,的北、南部的边缘两个都被散布 NW 中国。这里,我们沿着 Tarim 的南部的边缘报导地球年代学和 Neoproterozoic mafic 女同性恋和暗岩的系统的整个岩石的地球化学。在有在他们的炮兵阵地年龄的 stratigraphic 限制的联合,我们的锆石 U-Pb 年龄显示 mafic 女同性恋在 ca 被使结晶。802 妈,和暗岩,与 ca 可能同时代。在在 Tarim 的北边缘的 Quruqtagh 的 740 妈暴烈的岩石。元素并且女同性恋和暗岩建议的 mafic 的 Nd 同位素地球化学他们的原始岩浆分别地从 asthenospheric 披风(象 OIB 一样) 和 lithospheric 披风被导出,与外壳的材料的可变吸收。集成在现在的学习和那供应的数据在 Tarim 的北边缘以前报导了,我们认出 Neoproterozoic mafic 的披风来源的二种类型在 Tarim 的火的岩石,也就是在北边缘的 matasomatized subcontinental lithospheric 披风( SCLM )和在南部的边缘的 asthenospheric 披风。在整个塔里姆·布洛克的 Neoproterozoic 火的岩石的全面合成在 ca 导致了 Neoproterozoic 火的活动的二个主要事件的识别。820800 妈和 ca。780740 妈分别地。火的活动的这二个事件与在许多另外的 Rodinian 大陆的那些是并发的并且在 Rodinia 的分散期间与披风羽毛活动有关是最可能的。 | ZHANG Chuanhn YANG Dongsheng WANG Hongyan DONG Yongguan YE Haimin | 2010 | Acta Geologica Sinica(English Edition)2010，84，3： | 26 |
| 6 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 7 | Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia: meta-analysis of currently available randomized controlled trials显示文摘 | Meiling MENG Wei LI Shaowei ZHANG Hongyan WANG Jianhua SHENG Jijun WANG Chunbo LI | 2015 | 上海精神医学2015，27，1： | 22 |
| 8 | Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis显示文摘Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency. | Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 22 |
| 9 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 10 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 11 | Effects of dietary supplementation of Artemisia argyi aqueous extract on antioxidant indexes of small intestine in broilers显示文摘The present study was conducted to investigate the effect of Artemisia argyi aqueous extract(AAE) on antioxidant indexes in the small intestine. A total of 192 Arbor Acre broiler chickens(one-day-old) were randomly divided into 4 treatments with 6 replicates of 8 chickens. These 4 diets were formulated by adding 0, 500,1,000 and 2,000 mg/kg AAE to the basal diet. The results showed as follows: 1) compared with the control, the total antioxidant capacity(T-AOC) in ileum for the 2,000 mg/kg treatment group was significantly increased at 21 days of age(P < 0.05); the T-AOC levels in jejunum and ileum were significantly increased in broilers supplemented with 500 mg/kg AAE at 42 days of age(P < 0.05), and the T-AOC levels in jejunum and ileum were significantly improved in 1,000 mg/kg treatment group(P < 0.01), 2) At 21 days of age, supplementation of 500 mg/kg AAE significantly increased the catalase(CAT) activity of small intestine, and the glutathione peroxidase(GSH-Px) activity of jejunum was improved(P < 0.01), meanwhile, the GSH-Px activity of duodenum and the total superoxide dismutase(T-SOD) activity of duodenum and jejunum were significantly higher than those of the control group(P < 0.05); supplementation of 1,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum and the GSH-Px activity of duodenum and jejunum(P < 0.05), and the ileum GSH-Px activity was significantly increased(P < 0.01); supplementation of 2,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum(P < 0.05). At 42 days of age, supplementation of 500 mg/kg AAE significantly increased the GSH-Px activity of ileum and the T-SOD activity of duodenum(P < 0.05),meanwhile, the T-SOD activity of jejunum was significantly increased(P < 0.01); supplementation of1,000 mg/kg AAE significantly increased the CAT activity of jejunum and the T-SOD activity of ileum(P < 0.01), and the GSH-Px activity of jejunum was significantly increased(P < 0.05); supplementation of2,000 mg/kg AAE significantly increased the T-SOD activity of ileum(P < 0.05), but significantly decreased the CAT activity of ileum and the GSH-Px activity of jejunum(P < 0.05). 3) The malondialdehyde(MDA) levels of 3 AAE supplementation groups were significantly decreased at 21 and 42 days of age(P < 0.05). The results suggested that dietary supplementation with AAE could improve the antioxidative capacity of small intestine in broilers. | Fei Zhao Binlin Shi Dengsheng Sun Hongyan Chen Manman Tong Pengfei Zhang Xiaoyu Guo Sumei Yan | 2016 | Animal Nutrition2016，，3： | 18 |
| 12 | Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion显示文摘 | Xin Fu Jun Xiao Yuning Wei Sheng Li Yan Liu Jie Yin Kun Sun Hao Sun Huating Wang Zongkang Zhang Bao-Ting Zhang Chun Sheng Hongyan Wang Ping Hu | 2015 | Cell Research2015，25，6： | 16 |
| 13 | Frequency modulated weak signal detection based on stochastic resonance and genetic algorithm显示文摘Stochastic resonance system is subject to the restriction of small frequency parameter in weak signal detection,in order to solve this problem,a frequency modulated weak signal detection method based on stochastic resonance and genetic algorithm is presented in this paper. The frequency limit of stochastic resonance is eliminated by introducing carrier signal,which is multiplied with the measured signal to be injected in the stochastic resonance system,meanwhile,using genetic algorithm to optimize the carrier signal frequency,which determine the generated difference-frequency signal in the lowfrequency range,so as to achieve the stochastic resonance weak signal detection. Results showthat the proposed method is feasible and effective,which can significantly improve the output SNR of stochastic resonance,in addition,the system has the better self-adaptability,according to the operation result and output phenomenon,the unknown frequency of the signal to be measured can be obtained,so as to realize the weak signal detection of arbitrary frequency. | XING Hongyan LU Chunxia ZHANG Qiang | 2016 | Instrumentation2016，3，1： | 16 |
| 14 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 15 | CRISPR technology is revolutionizing the improvement of tomato and other fruit crops显示文摘Fruits are major sources of essential nutrients and serve as staple foods in some areas of the world.The increasing human population and changes in climate experienced worldwide make it urgent to the production of fruit crops with high yield and enhanced adaptation to the environment,for which conventional breeding is unlikely to meet the demand.Fortunately,clustered regularly interspaced short palindromic repeat(CRISPR)technology paves the way toward a new horizon for fruit crop improvement and consequently revolutionizes plant breeding.In this review,the mechanism and optimization of the CRISPR system and its application to fruit crops,including resistance to biotic and abiotic stresses,fruit quality improvement,and domestication are highlighted.Controversies and future perspectives are discussed as well. | Tian Wang Hongyan Zhang Hongliang Zhu | 2019 | Horticulture Research2019，6，1： | 13 |
| 16 | Rice Expression Database(RED):An integrated RNA-Seq-derived gene expression database for rice显示文摘Rice is one of the most important stable food as well as a monocotyledonous model organism for the plant research community.Here,we present RED(Rice Expression Database;http://gffzzd1bc3ab4bbbc4005hkf55vcfwfbok6cpp.ffgz.tsg.suse.edu.cn),an integrated database of rice gene expression profiles derived entirely from RNA-Seq data.RED features a comprehensive collection of 284 high-quality RNA-Seq experiments,integrates a large number of gene expression profiles and covers a wide range of rice growth stages as well as various treatments.Based on massive expression profiles,RED provides a list of housekeeping and tissue-specific genes and dynamically constructs co-expression networks for gene(s) of interest.Besides,it provides user-friendly web interfaces for querying,browsing and visualizing expression profiles of concerned genes.Together,as a core resource in BIG Data Center,RED bears great utility for characterizing the function of rice genes and better understanding important biological processes and mechanisms underlying complex agronomic traits in rice. | Lin Xia Dong Zou Jian Sang Xingjian Xu Hongyan Yin Mengwei Li Shuangyang Wu Songnian Hu Lili Hao Zhang Zhang | 2017 | Journal of Genetics and Genomics2017，44，5： | 12 |
| 17 | Earth surface processes and their effects on human behavior in monsoonal China during the Pleistocene-Holocene epochs显示文摘There is a wide diversity of landforms in China.The topography of three major terraces,decreasing in height stepwise from west to east,was formed by the early Miocene.With the commencement of the Great Northern Hemisphere Glaciations(GHGs)and the glacial-interglacial cycles in the Pleistocene,thick loess deposits accumulated in north China,and fluvial terraces were formed and lakes expanded and contracted in eastern and central China.The earliest evidence of hominins in China is dated to ~1.7 Ma;they occupied the monsoon-dominated region for a long interval,until the late Pleistocene,~50 ka.In this study,we investigated a large area rich in the relics and artifacts of early man.The results indicate that the early humans occupied riverine areas,especially medium-sized fluvial basins,and lake shores.Even in the relatively recent geological past,the occupation and abandonment of settlements were directly forced by the shifting of sand dune fields in the desert-loess transitional zone,which in turn was closely associated with variations in the monsoon climate and vegetation patterns.Our observations indicate that landforms were one of the main determinants of early human behavior,in that loess tableland,large alluvial plains,desert-Gobi areas,and the Tibetan Plateau,were not suitable environments for early human settlement.We infer that the early humans in China adapted their behavior to specific landforms and landform processes.The monsoon climate,which shapes the large-scale step-like pattern of fluvial landforms,promotes vegetation coverage and dominates soil formation,provides a crucial context for early human adaptation.The adaptation of early humans to earth surface processes in East Asia is investigated for the first time in this study.Future investigations will provide further information that will increase our understanding of the linkage between early human behavior and landform processes in East Asia. | LU Huayu ZHUO Haixin ZHANG Wenchao WANG Shejiang ZHANG Hongyan SUN Xuefeng JIA Xin XU Zhiwei WANG Xianyan | 2017 | Journal of Geographical Sciences2017，27，11： | 12 |
| 18 | Effect of Jinhua Qinggan granules on novel coronavirus pneumonia in patients显示文摘OBJECTIVE: To evaluate the effectiveness and safety of Jinhua Qinggan granules in the treatment of patients with novel coronavirus pneumonia(COVID-19).METHODS: Eighty cases of COVID-19 diagnosed from January 24 to February 17, 2020 in Beijing YouAn Hospital Affiliated to Capital Medical University were retrospectively analyzed. All 80 patients received symptomatic and supportive treatment.Among them, 44 patients took Jinhua Qinggan granules(treatment group) within 24 h of admission, and the remaining 36 patients either did not take Jinhua Qinggan granules or took the granules for less than 2 d(control group). In this study, we compared the duration of viral nucleic acid detection and of pneumonia absorption improvement between the two groups.RESULTS: Among the 80 cases, 37 were male(46%)and 43 were female(54%) with age ranging from15 to 86 years, with an average age of 51.19 years.The average duration of viral nucleic acid detection was(7 ± 4) d in the Jinhua Qinggan administration group and(10 ± 4) d for the control group(P =0.010), following which, nucleic acid tests were negative. Of the two groups, 56.82% in the Jinhua Qinggan treatment group and 27.78% in the control group demonstrated negative nucleic acid tests within 7 d or less. The 7-day viral clearance rate was significantly higher in the Jinhua Qinggan group compared with the control group(P = 0.009). Furthermore, the pneumonia recovery time indicated by chest CT was(8 ± 4) d in the Jinhua Qinggan group, which was significantly shorter than the control group, at(10 ± 5) d(P = 0.021). No adverse reactions were found in the treatment group after taking this medicine.CONCLUSION: In patients with COVID-19, Jinhua Qinggan granules can effectively shorten the duration of nucleic acid detection and promote the absorption of pneumonia inflammatory exudate without obvious adverse reactions. | Liu Zengli Li Xiuhui Gou Chunyan Li Li Luo Xiaolan Zhang Chun Zhang Yin Zhang Jiaying Jin Aihua Li Hongyan Zeng Yuan Li Tongzeng Wang Xiaojun | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 11 |
| 19 | Clinicopathological features and survival analysis of gastroenteropancreatic neuroendocrine neoplasms: a retrospective study in a single center of China显示文摘Objective: To investigate the clinicopathological features, survival and prognostic factors for gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) in a Chinese population.Methods: We investigated 154 consecutive patients(88 males, 66 females; median age 56 years, age range 9-86 years) diagnosed with GEP-NENs between 2001 and 2013 at The Affiliated Hospital of Qingdao University. Demographic, clinical and pathological variables and survival data were retrieved.Results: The pancreas was the most common site of involvement(63/154, 40.9%). Tumor size varied from 0.3 to 16.0 cm(median, 1.2 cm). The patients were followed up for a median period of 22 months(range, 1-157 months). The estimated 3- and 5-year overall survival(OS) rates for all patients were 84.0% and 81.9%, respectively. Multivariate analysis showed that larger tumor size, lymphatic metastases and distant metastases were significant predictors for poor survival outcome.Conclusions: Our data provide further information on the clinicopathological features of GEP-NENs in China. Additionally, we identified tumor size, lymphatic metastases and distant metastases as independent prognostic factors for long-term survival. | Xuelong Jiao Yujun Li Hongyan Wang Shanglong Liu Dongfeng Zhang Yanbing Zhou | 2015 | Chinese Journal of Cancer Research2015，27，3： | 10 |
| 20 | Grain-size Characteristics of Sediments Formed Since 8600 yr B.P. in Middle Reaches of Yarlung Zangbo River in Tibet and Their Paleoenvironmental Significance显示文摘Widespread aeolian sediments have been found in the middle reaches of the Yarlung Zangbo River, China. The grain-size characteristics of sediments from Cha’er Section in the area were analyzed. The results show that the section include one stratum of paleo-mobile dunes, four strata of paleo-semi-fixed dunes, two strata of paleo-fixed dunes, one stratum of sandy immature soils. The paleo-mobile and paleo-semi-fixed dune sand in this section are simi- lar to modern aeolian sand in either grain-size composition or Mz and σ distribution. Compared the above types of dunes each other, the content of sand substance decreases, while the content of silt and clay increases for paleo-fixed dunes and sandy immature soils. Combined with age data for each stratum, the analysis shows that these strata are the products of climate changes and the evolution of aeolian landforms. The evolutionary sequence of the paleoclimate and of aeolian activities in the valley since 8600 yr B.P. reveals four stages: 8600–5700 yr B.P., when the paleoclimate was cold and dry, with strong winds, thereby activating dunes; 5700–3600 yr B.P., when it was warm and wet, with weak winds, causing dunes to undergo soil-forming processes; 3600–1900 yr B.P., when climate shifted from cold-dry with strong winds to warm-wet with weak winds, and activated dunes were fixed again; and 1900 yr B.P. –present, when the climate became fine, with weak winds, fixing dunes again. | ZHENG Yinghua WU Yongqiu LI Sen TAN Lihua GOU Shiwei ZHANG Hongyan | 2009 | Chinese Geographical Science2009，19，2： | 10 |
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