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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 3 | Modifying the Autism Spectrum Rating Scale(6–18 years)to a Chinese Context:An Exploratory Factor Analysis显示文摘The purpose of this study was to explore the psychometric properties of the Chinese version of the autism spectrum rating scale(ASRS). We recruited 1,625community-based children and 211 autism spectrum disorder(ASD) cases from 4 sites, and the parents of all participants completed the Chinese version of the ASRS. A robust weighted least squares means and variance adjusted estimator was used for exploratory factor analysis. The3-factor structure included 59 items suitable for the current sample. The item reliability for the modi?ed Chinese version of the ASRS(MC-ASRS) was excellent. Moreover,with 60 as the cut-off point, receiver operating characteristic analysis showed that the MC-ASRS had excellent discriminate validity, comparable to that of the unmodi?ed Chinese version(UC-ASRS), with area under the curve values of 0.952(95% CI: 0.936–0.967) and 0.948(95% CI:0.930–0.965), respectively. Meanwhile, the con?rm factor analysis revealed that MC-ASRS had a better construct validity than UC-ASRS based on the above factor solution in another children sample. In conclusion, the MC-ASRS shows better ef?cacy in epidemiological screening for ASD in Chinese children. | Hao Zhou Lili Zhang Xuerong Luo Lijie Wu Xiaobing Zou Kun Xia Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 8 |
| 4 | DNA N^6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs显示文摘ALKBH1 was recently discovered as a demethylase for DNA N^6-methyladenine(N6-m A), a new epigenetic modification, and interacts with the core transcriptional pluripotency network of embryonic stem cells.However, the role of ALKBH1 and DNA N6-m A in regulating osteogenic differentiation is largely unknown.In this study, we demonstrated that the expression of ALKBH1 in human mesenchymal stem cells(MSCs)was upregulated during osteogenic induction. Knockdown of ALKBH1 increased the genomic DNA N6-m A levels and significantly reduced the expression of osteogenic-related genes, alkaline phosphatase activity, and mineralization. ALKBH1-depleted MSCs also exhibited a restricted capacity for bone formation in vivo.By contrast, the ectopic overexpression of ALKBH1 enhanced osteoblastic differentiation. Mechanically,we found that the depletion of ALKBH1 resulted in the accumulation of N6-m A on the promoter region of ATF4, which subsequently silenced ATF4 transcription. In addition, restoring the expression of ATP by adenovirus-mediated transduction successfully rescued osteogenic differentiation. Taken together, our results demonstrate that ALKBH1 is indispensable for the osteogenic differentiation of MSCs and indicate that DNA N6-m A modifications area new mechanism for the epigenetic regulation of stem cell differentiation. | Chenchen Zhou Yuting Liu Xiaobing Li Jing Zou Shujuan Zou | 2016 | Bone Research2016，4，3： | 6 |
| 5 | Chinese Norms for the Autism Spectrum Rating Scale显示文摘This study aimed to establish norms for the modi?ed Chinese version of the Autism Spectrum Rating Scale(ASRS). Participants were recruited from Shanghai,Harbin, Guangzhou, and Changsha, China, and their parents and teachers were invited to complete the Chinese Parent version and the Teacher version of the ASRS. In both versions, boys had signi?cantly higher sub-scale scores and total score(T-score) by 1–3 and 4–5 points respectively, than girls(both P \ 0.001). Age had weak correlations with some sub-scores and the T-score(r ranged from-0.1859 to 0.0738), and some reached signi?cance(P \ 0.03). The correlations appeared stronger and were more common in females. The T-score based on Chinese norms ideally correlated with the score based on the United States norms in boys and girls for both versions.Norms for the Chinese version of the ASRS for children aged 6–12 years are proposed and may be helpful for screening individuals with autism spectrum disorders from the general population of children. | Hao Zhou Lili Zhang Xiaobing Zou Xuerong Luo Kun Xia Lijie Wu Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 6 | Assessing the Accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for Screening Autism Spectrum Disorder in Chinese Children显示文摘The reported prevalence of autism spectrum disorder(ASD) has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modi?ed Chinese version of a newly-developed ASD screening tool, the Modi?ed Chinese Autism Spectrum Rating Scales(MC-ASRS) in screening for ASD in Chi nese children aged 6–12 years, through comparison with the Social Responsiveness Scale(SRS) that has been widely used for ASD screening. We recruited the par ents/caregivers of 1588 typically-developing children and190 children with ASD aged 6–12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRSperformed as well as SRS in sensitivity, speci?city, and area-under-the-curve(both [0.95) in receiver operating characteristic analysis, with a fair false-negative rate.These results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population. | Bingrui Zhou Hao Zhou Lijie Wu Xiaobing Zou Xuerong Luo Eric Fombonne Yi Wang Weili Yan Xiu Xu | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 7 | Runxl protects against the pathological progression of osteoarthritis显示文摘Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runxl in joint diseases is not well known.In the current study,we aimed to explore the role of Runxl in osteoarthritis induced by anterior cruciate ligament transaction(ACLT)surgery.We showed that chondrocyte-specific Runxl knockout(Runx1f/fCol2a1-Cre)aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis.Moreover,we observed thinning and ossification of the growth plate,a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis.We overexpressed Runxl by adeno-associated virus(AAV)in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis.ChIP-seq analysis identified new targets that interacted with Runxl in cartilage pathology,and we confirmed the direct interactions of these factors with Runxl by ChIP-qPCR.This study helps us to understand the function of Runxl in osteoarthritis and provides new clues for targeted osteoarthritis therapy. | Chenchen Zhou Yujia Cui Yueyi Yang Daimo Guo Demao Zhang Yi Fan Xiaobing Li Jing Zou Jing Xie | 2021 | Bone Research2021，9，4： | 4 |
| 8 | Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder显示文摘The aim of this study was to explore the differences between boys and girls in the diagnosis and clinical phenotypes of autism spectrum disorder(ASD) in China's mainland. Children diagnosed with ASD(n = 1064, 228 females) were retrospectively included in the analysis. All children were assessed using the Autism Diagnostic Interview-Revised(ADI-R) and Autism Diagnostic Observation Schedule(ADOS). The results showed that girls scored significantly higher in ADI-R socioemotional reciprocity than boys, and also scored lower in ADI-R and ADOS restricted and repetitive behaviors(RRBs). Meanwhile, the proportions of girls who satisfied the diagnostic cut-off scores in the ADI-R RRBs domain were lower than in boys(P \ 0.05). Our results indicated that girls with ASD show greater socio-emotional reciprocity than boys. Girls also tended to show fewer RRBs than boys, and the type of RRBs in girls differ from those in boys. The ADI-R was found to be less sensitive in girls, particularly for assessment in the RRBs domain. | Shihuan Wang Hongzhu Deng Cong You Kaiyun Chen Jianying Li Chun Tang Chaoqun Ceng Yuanyuan Zou Xiaobing Zou | 2017 | Neuroscience Bulletin2017，33，2： | 3 |
| 9 | Effect of photoionisation on initial discharge in air under nanosecond pulse voltage显示文摘Effects of photoionisation on the development and electron runaway of the initial discharge in atmospheric air under nanosecond pulse voltage were studied via twodimensional particle-in-cell/Monte Carlo collision simulations.It was found that photoionisation has little effect at the beginning of the initial discharge.However,as the discharge channel gradually develops towards the anode,photoionisation shows greater impacts on the morphology of discharge but has little influence on the velocity of discharge development.Photoionisation does not appear to have a decisive effect on the growth trend of the highest energy of runaway electrons,but it does affect the change rate of the highest energy and overall distribution of electron energy,resulting in a higher proportion of energetic electrons.The difference in the distributions of the electron energy between the two cases,with and without considering photoionisation,can be attributed to the impact of photoionisation on the discharge morphology,which in turn distorted the electric field.The spatial density distributions of the electrons produced by photoionisation further explained the differences.The authors’results explicitly demonstrate the influence of photoionisation on the development and the electron runaway of the initial discharge under nanosecond pulse voltage,which provides more comprehensive knowledge for the atmospheric air gap nanosecond pulse discharge physics. | Yutai Li Yangyang Fu Zhigang Liu Handong Li Peng Wang Haiyun Luo Xiaobing Zou Xinxin Wang | 2023 | High Voltage2023，8，2： | 2 |
| 10 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 2 |
| 11 | A pulsed power generator for x-pinch experiments显示文摘 | ZOU Xiaobing LIU Rui ZENG Naigong | 2006 | High Power Laser and Particle Beams2006，24，4： | 1 |
| 12 | A three-frame Mach-Zehnder interferometer for measuring dense magnetized plasmas显示文摘 | Wang Xinxin Zou Xiaobing Liu Zhen | 2003 | Rev Sci Instrum2003，74，3： | 1 |
| 13 | A pulsed power generator for x-pinch experiments 显示文摘 | Xiaobing Zou Rui Liu Naigong Zeng | 2006 | Laser and Particle Beams2006，24，4： | 1 |
| 14 | Evolution of the electrically exploding wire observed with a Mach-Zehnder interferometer 显示文摘 | Ma Zhiguo Zou Xiaobing Wang Xinxin | 2009 | Appl Phys Lett2009，94，18： | 1 |
| 15 | X-ray backlighting of developments of X-pinches and wire-array Z-pinches using an X-pinch显示文摘 | Zhao Tong Zou Xiaobing Wang Xinxin | | 0，，04： | 1 |
| 16 | A pulsed power generator for X-pinch experiments显示文摘 | Zou Xiaobing Liu Rui Zeng Naigong | | 0，，04： | 1 |
| 17 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 1 |
| 18 | A pulsed power generator for X-pinch experiments显示文摘 | Zou Xiaobing Liu Rui Zeng Naigong | | 0，，： | 1 |
| 19 | Experimental study of gas-puff z-pinch plasma显示文摘 | ZOU Xiaobing WANG Xinxin LUO Chengmu | 2005 | Plasma Sources Science and Technology2005，14，2： | 1 |
| 20 | Load section design of a pulsed power generator for X-pinch显示文摘 | Liu Riu Wang Xinxin Zou Xiaobing | 2007 | IEEE Trans on Dielectrics and Electrical Insulation2007，14，4： | 1 |
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