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| 1 | A comprehensive classification method for VOC emission sources to tackle air pollution based on VOC species reactivity and emission amounts显示文摘In China, volatile organic compound(VOC) control directives have been continuously released and implemented for important sources and regions to tackle air pollution. The corresponding control requirements were based on VOC emission amounts(EA), but never considered the significant differentiation of VOC species in terms of atmospheric chemical reactivity. This will adversely influence the effect of VOC reduction on air quality improvement. Therefore,this study attempted to develop a comprehensive classification method for typical VOC sources in the Beijing–Tianjin–Hebei region(BTH), by combining the VOC emission amounts with the chemical reactivities of VOC species. Firstly, we obtained the VOC chemical profiles by measuring 5 key sources in the BTH region and referencing another 10 key sources, and estimated the ozone formation potential(OFP) per ton VOC emission for these sources by using the maximum incremental reactivity(MIR) index as the characteristic of source reactivity(SR). Then, we applied the data normalization method to respectively convert EA and SR to normalized EA(NEA) and normalized SR(NSR) for various sources in the BTH region.Finally, the control index(CI) was calculated, and these sources were further classified into four grades based on the normalized CI(NCI). The study results showed that in the BTH region,furniture coating, automobile coating, and road vehicles are characterized by high NCI and need to be given more attention; however, the petro-chemical industry, which was designated as an important control source by air quality managers, has a lower NCI. | Guohao Li Wei Wei Xia Shao Lei Nie Hailin Wang Xiao Yan Rui Zhang | 2018 | Journal of Environmental Sciences2018，30，5： | 32 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 4 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 5 | Wave dispersion and attenuation in viscoelastic isotropic media containing multiphase flow and its application显示文摘In this paper,we introduce the complex modulus to express the viscoelasticity of a medium.According to the correspondence principle,the Biot-Squirt(BISQ)equations in the steady-state case are presented for the space-frequency domain described by solid displacements and fluid pressure in a homogeneous viscoelastic medium.The effective bulk modulus of a multiphase flow is computed by the Voigt formula,and the characteristic squirt-flow length is revised for the gas-included case.We then build a viscoelastic BISQ model containing a multiphase flow.Through using this model,wave dispersion and attenuation are studied in a medium with low porosity and low permeability.Furthermore,this model is applied to observed interwell seismic data.Analysis of these data reveals that the viscoelastic parameter tanδ is not a constant.Thus,we present a linear frequency-dependent function in the interwell seismic frequency range to express tanδ.This improves the fit between the observed data and theoretical results. | YANG Lei YANG DingHui NIE JianXin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 13 |
| 6 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 7 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 8 | Comparison of the performance of the CRUSADE, ACUITY-HORIZONS, and ACTION bleeding scores in ACS patients undergoing PCI: insights from a cohort of 4939 patients in China显示文摘BackgroundThe 十字军,行动和尖酸地平线分数通常被使用预言与急性冠的症候群(交流) 在病人为事件放血的在里面医院专业,但是这些的同类的性质为人口限制建模 ? 简单推测到另外的本地人口。我们试图在中国 patients.MethodsWe 比较三个风险模型的表演评估了三的表演为预言主要流血事件在心肌的梗塞( TIMI )由 thrombolysis 定义的在里面医院预言分数严肃(专业和未成年者)事件,在有 non-ST-elevation 交流(NSTE交流)或圣举起的中国交流病人的一个队心肌的梗塞( STEMI )。三个风险模型的刻度和辨别被 Hosmer-Lemeshow 测试和 C 统计数值分别地评估。我们由严肃的流血率是的 Delong 非参量的 test.ResultsTIMI 比较了风险分数的预兆的精确性 1.1% 外套(1.9% 和 0.86% 为 STEMI 和 NSTE 交流,分别地) 。十字军,行动和 ACUTIY 地平线分数为主要流血显示出一个足够的差别对待的能力:在全面病人, C 统计数值分别地是 0.80, 0.77,和 0.70;在 NSTE 交流病人, C 统计数值分别地是 0.73, 0.72,和 0.64;在 STEMI 病人, C 统计数值分别地是 0.91, 0.92,和 0.75。为尖酸地平线模型的 C 统计数值是比为 TIMI 的预言的 CRUSADE 和行动分数的那些显著地低的在全面病人的严肃的流血(与十字军相比, z = 3.83, P = 0.02;与行动相比, z = 3.51, P = 0.03 ) ;在 NSTE 交流病人(与十字军相比, z = 2.37, P = 0.01;与行动相比, z = 2.11, P = 0.04 ) ,并且在 STEMI 病人(与十字军相比, z = 2.6.77, P = 0.02;与行动相比, z = 7.91, P = 0.002 ) 。当 CRUSADE 和行动模型与对方相比时,没有差别被观察,不管全面病人( z = 0.68 , P = 0.31 )并且两个都交流打字(NSTE交流, z = 0.52 , P = 0.60 ),并且 STEMI 病人( z = 0.36 , P = 0.74 )。然而,三个风险分数都在我们的学习在每风险层化过高估计绝对主要流血风险。例如,在高风险层化的十字军 20 的预言的率是 11.9% 对 5.3%.ConclusionsThe 十字军和行动分数的实际的率为在里面医院专业与尖酸地平线相比流血让更大的刻度和辨别与经历一种总线标准的交流在中国病人得分。然而,他们都为中国人口过高估计流血风险率。这些风险分数的刻度将为在中国人口的归纳是有用的。 | Ran LIU Shu-Zheng LYU Guan-Qi ZHAO Wen ZHENG Xiao WANG Xue-Dong ZHAO Sheng-Hui ZHOU Lei ZHEN Shao-Ping NIE | 2017 | Journal of Geriatric Cardiology2017，14，2： | 9 |
| 9 | Solving 3D Electromagnetic Scattering and Radiation by Local Multilevel Fast Multipole Algorithm显示文摘 | HU Jun NIE Zaiping LEI Lin RUI Xi WANG Jun | 2007 | Chinese Journal of Electronics2007，16，2： | 8 |
| 10 | Intermetallic PtBi core/ultrathin Pt shell nanoplates for efficient and I stable methanol and ethanol electro-oxidization显示文摘The development of Pt-based core/shell nanoparticles represents an emerging class of electrocatalysts for fuel cells, such as methanol oxidation reaction (MOR) and ethanol oxidation reaction (EOR). Here, we present a one-pot synthesis approach to prepare hexagonal PtBi/Pt core/shell nan ostructure composed of an in termetallic PtiBii core and an ultrathi n Pt shell with well-defined shape, size, and composition.The structure and the synergistic effect among different components enhanced their MOR and EOR performanee. The optimized Pt2Bi nanoplates exhibit excellent mass activities in both MOR (4,820 mA·mgpt^-1) and EOR (5,950 mA·mgpt^1) conducted in alkaline media, which are 6.15 times and 8.63 times higher than those of commercial Pt/C, respectively. Pt2Bi nan opiates also show superior operati on durability to commercial Pt/C. This work may inspire the rational design and synthesis of Pt-based nanoparticles with improved performance for fuel cells and other applications. | Xiaolei Yuan Xiaojing Jiang Muhan Cao Lei Chen Kaiqi Nie Yong Zhang Yong Xu Xuhui Sun Yanguang Li Qiao Zhang | 2019 | Nano Research2019，12，2： | 7 |
| 11 | The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses,cell differentiation and proliferation显示文摘p204 is a member of the interferon-inducible p200 family proteins in mice.The p200 family has been reported to be multifunctional regulators of cell proliferation,differentiation,apoptosis and senescence.Interferon-inducible protein 16(IFI16)is regarded as the human ortholog of p204 in several studies.This is possibly due to the similarity of their structures.However the consistency of their functions is still elusive.Currently,an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases.This review specially focuses on IFI16 and p204,the member of p200 family in human and murine respectively,and their pathophysiological roles in innate immune responses,cell differentiation and proliferation. | Hua Zhao Elena Gonzalezgugel Lei Cheng Brendon Richbourgh Lin Nie Chuanju Liu | 2015 | Genes & Diseases2015，2，1： | 7 |
| 12 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 13 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044skf55vcfwfbok6cpp.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 14 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 15 | Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice显示文摘Protostemonine (PSN ) 是从 Stemona sessilifolia 的根提取的主要的反煽动性的碱(在繁体中文药作为 Baibu 知道) 。这里,我们报导 lipopolysaccharide (LPS ) 上的 PSN 的禁止的效果在老鼠在 vitro 和导致 LPS 的尖锐的肺损害导致了巨噬细胞激活。巨噬细胞房间线 RAW264.7 房间和老鼠骨头导出髓的巨噬细胞(BMDM ) 为 0.5 h 与 PSN (1, 3, 10, 30 和 100 mol/L ) 被对待然后为 24 h 与 LPS (0.1 g/mL ) 质问了。有 PSN 的预告的处理显著地禁止了 MAPK 和 AKT 的导致 LPS 的 phosphorylation,在巨噬细胞的 iNOS 表示和没有生产。C57BL/6 老鼠 intratracheally 与 LPS (5 mg/kg ) 被注射导致尖锐的肺损害(ALI ) 。老鼠随后与 PSN 被对待(10 mg/kg, ip ) 在在 LPS 以后的 4 和 24 h 挑战。PSN 管理显著地稀释了导致 LPS 的煽动性的房间渗入,减少的支持 inflammatory cytokine (TNF- , IL-1 和 IL-6 ) 生产和消除的调停 LPS 的肺浮肿。而且, PSN 管理显著地禁止了导致 LPS 的肺的军邮局活动。同时,在肺的 p38 MAPK, iNOS 表示和没有生产的导致 LPS 的 phosphorylation 也被压制。结果证明 PSN 有效地在 vitro 并且在 vivo 稀释导致 LPS 的煽动性的回答;有益的效果与 MAPK 和 AKT 和支持 inflammatory 调停人的减少的表示的减少的 phosphorylation 被联系,例如 iNOS,没有并且 cytokines。这些数据建议 PSN 可以是在 ALI 的处理的一个潜在的治疗学的代理人。 | Ya-xian WU Hui-qiong HE Yun-juan NIE Yun-he DING Lei SUN Feng QIAN | 2018 | Acta Pharmacologica Sinica2018，39，1： | 7 |
| 16 | Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure显示文摘瞄准:CXCR3,经由绑定它的特定的 ligand CXCL10,在导致的香烟烟(CS ) 起一个重要作用肺的发炎。CXCR3 优先地在激活的 T 房间被表示(主要 CD8 + T 房间) 。这研究的目的是用 CXCR3 在导致 CS 的肺的损害调查 CXCR3 的角色基因缺乏的(CXCR3−/−) 老鼠。方法:在煽动性的房间和 CD8 + T 房间和在在 mRNA 和蛋白质层次的 bronchoalveolar 洗室年龄液体和肺的煽动性的调停人和 chemokines 的表示的渗入的差别在 CXCR3−/− 之间被比较老鼠并且野类型(WT ) 在在 CS 暴露的 3 d 以后的 2 h 的老鼠。结果:与他们的 WT 对应物相比, CXCR3−/−老鼠显示出减轻的发炎,由更少煽动性的房间证实了特别地细胞毒素的 CD8 + T 房间,在 bronchoalveolar 洗室年龄液体和肺纸巾。在 mRNA 和蛋白质层次,有显著地在 CXCR3−/− 的煽动性、趋化性的 cytokines,包括的 TNF-α , interleukin-8, interferon-γ ,转变生长 factor-β1,和 CXCL10 的底层老鼠。结论:我们 CXCR3 在招募是重要的数据表演煽动性的房间(特别地 CD8 + T 房间) 进航线和肺,以及开始煽动性并且在跟随短期的 CS 侮辱的 2 h 的 fibrotic cytokines 版本。CXCR3 能是为 CS 导致的肺的发炎的处理的一个新奇目标。 | Li NIE Ruo-lan XIANG Yong LIU Wei-xun ZHOU Lei JIANG Bao LU Bao-sen PANG De-yun CHENG Jin-ming GAO | 2008 | Acta Pharmacologica Sinica2008，29，12： | 6 |
| 17 | FRUCTOKINASE-LIKE PROTEIN 1 interacts with TRXz to regulate chloroplast development in rice显示文摘Chloroplast genes are transcribed by the plastidencoded RNA polymerase(PEP) or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS(FLNs) are phosphofructokinase-B(Pfk B)-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLN activity in rice remain elusive.Previously, we identified and characterized a heat-stress sensitive albino(hsa_1) mutant in rice. Map-based cloning revealed that HSA_1 encodes a putative OsFLN_2. Here, we further demonstrated that knockdown or knockout of the OsFLN_1, a close homolog of HSA_1/OsFLN_2, considerably inhibits chloroplast biogenesis and the fln_1 knockout mutants, created by clustered regularly interspaced short palindromic repeats(CRISPR) and CRISPR-associate protein_9, exhibit severe albino phenotype and seedling lethality. Moreover, OsFLN_1 localizes to the chloroplast.Yeast two-hybrid, pull-down and bimolecular fluorescencecomplementation experiments revealed that OsFLN_1 and HSA_1/OsFLN_2 interact with THIOREDOXINZ(OsTRXz) to regulate chloroplast development. In agreement with this,knockout of OsTRXz resulted in a similar albino and seedling lethality phenotype to that of the fln_1 mutants. Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln_1 and trxz mutants, indicating that loss of OsFLN_1, HSA_1/OsFLN_2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. These results show that OsFLN_1 and HSA_1/OsFLN_2 contribute to chloroplast biogenesis and plant growth. | Lei He Sen Zhang Zhennan Qiu Juan Zhao Wendan Nie Haiyan Lin Zhengge Zhu Dali Zeng Qian Qian Li Zhu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 6 |
| 18 | Development of a multiplex reverse transcription-PCR assay for simultaneous detection of garlic viruses显示文摘A preliminary screening for garlic viruses in garlic plants in Hunan,China,using existing monoplex(simplex) reverse transcription-polymerase chain reaction(RT-PCR) procedures detected four viruses/virus groups.These viruses/virus groups were Onion yellow dwarf virus(OYDV),Leek yellow stripe virus(LYSV),Shallot latent virus(SLV) and allexiviruses(e.g.,garlic viruses A,B,C,D,E,X).Sequence analysis of the projected allexivirus amplicons revealed the allexivirus in the infected garlic plants was Garlic virus D(GarV-D),which shared 92-97%sequence identities with various isolates from the world.A multiplex RT-PCR(mRT-PCR) was therefore developed to simultaneously detect and differentiate the four viruses/virus groups.To achieve this,four primer pairs targeting allexiviruses,OYDV,LYSV and SLV were designed.The anticipated amplicon sizes are 183 bp(allexiviruses),265 bp(OYDV),404 bp(LYSV) and 592 bp(SLV),respectively.All primer pairs produced virus-specific fragments in both simplex and multiplex formats,thus confirming the efficacy of the newly developed mRT-PCR for detection of these viruses.The mRT-PCR further was evaluated by applying it to garlic plant samples collected in two geographic locations in Hunan.Allexiviruses,OYDV,LYSV and SLV were detected in 50.9,40.3,28.3 and 58.5%of leaf samples,respectively;and mixed infections with two or more viruses accounted for 54%of the garlic samples.The results obtained by mRT-PCR were confirmed by simplex RT-PCR assays.In conclusion,this newly developed mRT-PCR provides a rapid,sensitive and reliable method for the detection and identification of major garlic viruses. | HU Xin-xi LEI Yan WANG Pei TANG Lin-fei HE Chang-zheng SONG Yong XIONG Xing-yao NIE Xian-zhou | 2015 | Journal of Integrative Agriculture2015，14，5： | 6 |
| 19 | Causes of rockfalls in Al-Huwayshah area,Yemen显示文摘According to topography of Yemen,most areas and villages are located at obligated crest,toe of mountain and under cliffs.Therefore Al-Huwayshah consisting of Tawilah sandstone group is characterized by steep slope reach to 90° in some areas.This area is affected by strong tectonic movements and faults that occurred during the geological epochs.This effect enhances to find out fractures and joints as well as the rocks become brittle and ready to slide depending on the position of area.And there are some fractures and joints on the surface of the areas due to tectonic movement associated with opening the Red Sea and Gulf of Aden.The rainfalls,fractures,joints,earthquakes,gravity,vegetations,temperatures and human activities play a big role in the processes of rockfalls and landslides in this area.All those factors are considered as the basic causes and catalyzed factors for occurrence of rockfall in the studide area.In addition,the authors carried out laboratory test for many rock samples to get the physical properties of the rocks. | Aref M. O. AL-JABALI NIE Lei Abdo S. AL-MAQTARY Hussein AL-AKHALI Mohammed HAZAEA Fadel AL-AGHBARI | 2009 | Global Geology2009，12，1： | 6 |
| 20 | Multi-dimension apportionment of clean air “parade blue”phenomenon in Beijing显示文摘The mass concentration and major chemical components of fine particulate matter were measured before,during and after Beijing's massive parade commemorating 70th anniversary of the Chinese Victory in World War II on September 3,2015.Regional emission inventory,positive matrix factorization(PMF),observations from space and backward air mass trajectories were jointly applied to identify the major pollution sources and their temporal and spatial variations.The contributions of emissions variations and the meteorological conditions related to the'parade blue'phenomenon in Beijing and its surrounding areas were investigated in detail.The main cause of the decreased PM_(2.5)mass concentration was attributed to the absolute reduction in emissions of primary air pollutants.The chemical composition of PM_(2.5)varied significantly before,during and after the parade.Fugitive dust particles were well controlled,the secondary formation of PM_(2.5)was reduced along with the controlled gaseous precursors'emissions from vehicles and industrial sources during the temporary intensified control period.During the parade period,the SO_2and NO_2column concentrations in Beijing and the surrounding areas decreased sharply,indicating that the coordinated reduction in primary emissions from the surrounding areas of Beijing played an important role in lowering the ambient concentration of SO_2and NO_2and accordingly lowered PM_(2.5)and improved the regional air quality.A comparison of the temperature,humidity,and wind speed and direction during the same periods in 2014 and 2015 showed that the meteorological conditions positively influenced the achievement of'parade blue'. | Yifeng Xue Yong Wang Xuefeng Li Hezhong Tian Lei Nie Xiaoqing Wu Junrui Zhou Zhen Zhou | 2018 | Journal of Environmental Sciences2018，30，3： | 5 |
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