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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 3 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 4 | Numerical Simulation of a Class of Nonlinear Wave Equations by Lattice Boltzmann Method显示文摘In this paper,we develop a lattice Boltzmann model for a class ofone-dimensional nonlinear wave equations,including the second-order hyperbolictelegraph equation,the nonlinear Klein-Gordon equation,the damped and undampedsine-Gordon equation and double sine-Gordon equation.By choosing properly theconservation condition between the macroscopic quantity u,and the distributionfunctions and applying the Chapman-Enskog expansion,the governing equation isrecovered correctly from the lattice Boltzmann equation.Moreover,the local equilib-rium distribution function is obtained.The results of numerical examples have beencompared with the analytical solutions to confirm the good accuracy and the applica-bility of our scheme. | Yali Duan Linghua Kong Min Guo | 2017 | Communications in Mathematics and Statistics2017，5，1： | 4 |
| 5 | Template-free hydrothermal synthesis of single-crystalline SnO_2 nanocauliflowers and their optical properties显示文摘Large-scale single-crystalline SnO2 nanocauliflowers were successfully synthesized using a hydrothermal growth method without any template. The samples were characterized by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), en- ergy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). FE-SEM images show that the as-grown SnO2 nanocauliflowers are constructed of tetragonal prisms with a width of 500-600 nm. XRD, EDS, and SAED results indicate that the as-grown SnO2 nanocauliflowers are single crystalline with the tetragonal rutile crystalline structure. The growth mechanism of SnO2 nanocauliflowers is also preliminarily discussed on the basis of different Sn(OH) 62- concentrations, and it is found that Sn(OH) 62- concentration plays an important role in determining the shape of the prepared SnO2. Room temperature photoluminescence was further carried out on SnO_2 nanocauliflowers to investigate their optical properties. An intense blue luminescence centered at a wavelength of 424 nm is observed in the as-grown SnO2 nanocauliflowers. | WANG Yali GUO Min ZHANG Mei WANG Xidong | 2009 | Rare Metals2009，28，5： | 2 |
| 6 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 7 | Simvastatin Regulates Myocardial Cytokine Expression and Improves Ventricular Remodeling in Rats after Acute Myocardial Infarction显示文摘 | Jinying Zhang Xiang Cheng Yu-Hua Liao MD Baojun Lu Yali Yang Bin Li Hongxia Ge Min Wang Ying Liu Zhangqiang Guo Ling Zhang | 2005 | Cardiovascular Drugs and Therapy2005，，1： | 1 |
| 8 | Isolation and identification of endophytic fungus SX01, a red pigment producer from Ginkgo biloba L显示文摘 | Min Qiu Ruisheng Xie Yu Shi Haimin Chen Yali Wen Yongsheng Gao Xiufang Hu | 2010 | World Journal of Microbiology and Biotechnology2010，，6： | 1 |
| 9 | DDIT4通过p53和MAPK通路促进胃癌增殖和肿瘤发生显示文摘背景与目的胃癌(gastric cancer,GC)是世界上最常见的恶性肿瘤之一,在我国尤为常见。DNA损伤诱导转录因子4(DNAdamage-inducibletranscript4,DDIT4)是哺乳动物雷帕霉素靶蛋白抑制因子,由多种细胞应激诱导产生;然而,它在胃癌中的关键作用仍然未知。本研究旨在探讨DDIT4与胃癌发展的关系及其作用机制。方法我们采用蛋白免疫印迹法、实时聚合酶链反应、免疫组化或免疫荧光法检测DDIT4在胃癌细胞和组织中的表达情况。采用高通量筛选、细胞计数试剂盒-8、克隆形成和体内成瘤实验检测细胞增殖情况。采用流式细胞术检测细胞凋亡和细胞周期分布情况。结果 DDIT4在胃癌细胞和组织中表达上调。在胃癌细胞中下调DDIT4表达可抑制体外和体内的细胞增殖并增强了5-氟尿嘧啶诱导的细胞凋亡和细胞周期阻滞。与之相反,在正常胃上皮细胞中DDIT4的异位表达促进了细胞增殖、降低了化疗敏感性。进一步研究表明,丝裂原活化蛋白激酶和p53信号通路参与抑制细胞增殖并在DDIT4下调后增强化疗敏感性。结论 DDIT4促进了胃癌细胞增殖和肿瘤发生,为研究DDIT4在人类胃癌发生、发展中的作用提供了新思路。 | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2019 | 癌症2019，38，3： | 1 |
| 10 | An ensemble model based on weighted support vector regression and its application in annealing heating process显示文摘Dear editor, In the steel industry, the annealing heating production directly impacts the economic benefits of enterprises;hence, accurately predicting the required gas flow is very important. On account of high equipment complexity, it costs lots of time for maintaining a traditional mechanism model at a good working condition;data-driven model, such as support vector regression (SVR), has been used in industry processes . | Yongyue ZHANG Weihua CAO Yali JIN Min WU | 2019 | Science China(Information Sciences)2019，62，4： | 1 |
| 11 | Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway显示文摘Ginkgol C17:1 has been shown to inhibit apoptosis and migration of cancer cells,but the underlying mechanisms are not fully elucidated.In this study,we explored whether the inhibitory effects of Ginkgol C17:1 were associated with epidermal growth factor receptor(EGFR) and PI3K/Akt signaling.The results showed that EGF treatment increased the phosphorylation of EGFR,PI3 K,Akt,mTOR and NF-κB,and also enhanced the proliferation,migration and invasion of HepG2 cells.Ginkgol C17:1 dose-dependently inhibited EGF-induced phosphorylation/activation of all the key components including EGFR,PI3 K,Akt,mTOR and NF-kB,leading to a significant reduction either of proliferation or migration and invasion of HepG2 cells.Notably,treatment with Ginkgol C17:1 in mice suppressed the growth of tumor mass in vivo,and expression of EGFR in the tumor tissue.The results suggest that Ginkgol C17:1 is a potent tumor inhibiting compound that acts on EGF-induced signal transduction of the PI3K/Akt signaling pathways,and may represent a clinically interesting candidate for cancer therapy. | Yueying Li Jun Liu Xiaoming Yang Yan Dong Yali Liu Min Chen | 2017 | The Journal of Biomedical Research2017，31，3： | 1 |
| 12 | Routine Os analysis by isotope dilution-inductively coupled plasma source mass spectrometry:OsO4 in water solution gives high sensitivity 显示文摘 | Sun Yali Zhou Mei-Fu Sun Min | 2001 | J Anal At Speetrom2001，16，4： | 1 |
| 13 | Superconductivity in Ba_(1-x)Sm_xFFeAs and Eu_(1-x)Sm_xFFeAs systems显示文摘We synthesized the samples Ba1-xSmxFFeAs and Eu1-xSmxFFeAs with ZrCuSiAs-type structure. These samples were characterized by resistivity and susceptibility. It is found that the substitution of rare earth metal for alkaline earth metal in the two systems suppresses the anomaly in resistivity and in-duces superconductivity. Superconductivity at 54 K in nominal composition Ba0.5Sm0.5FFeAs and at 51 K for Eu0.5Sm0.5FFeAs is realized, indicating that the superconducting transition temperatures in the iron arsenide fluorides is the same as that in oxypnictides with the same structure. | WU Gang XIE YaLi CHEN Hong ZHONG Min LIU RongHua SHI BingCai LI QiuJu WANG XiangFeng WU Tao YAN YaJun YING JianJun CHEN XianHui | 2009 | Chinese Science Bulletin2009，54，11： | 1 |
| 14 | Characteristics of Pre-summer Daytime Cloud Regimes over Coastal South China from the Himawari-8 Satellite显示文摘Using the high spatiotemporal resolution(2 km-and-10 min)data from the Advanced Himawari Imager onboard the Himawari-8 satellite,this study documents the fine-scale characteristics of daytime cloud regimes(CRs)over coastal South China during the pre-summer rainy season(April–June).Six CRs(CR1–CR6)are identified based on the joint frequency distribution of cloud top brightness temperature and cloud optical thickness,namely,the optically thin-to-moderate cloud mixture,optically thin warm clouds with cirrus,optically thick warm clouds,weak convective cloud mixture,strong convective clouds,and extreme,deep convective clouds.The optically thick warm clouds are the major CR during April and May,with higher frequencies over land,especially along the urban agglomeration,rather than the offshore which may be an indicator of the higher aerosol concentrations being a contributing factor over the cities.The CRs with weak convective cloud mixtures and strong convective clouds appear more frequently over the land,while the two CRs with optically thinner clouds occur mainly offshore.Synoptic flow patterns(SPs)are objectively identified and examined focusing on those favoring the two major rainproducing CRs(CR5 and CR6)and the highly reflective CR with optically thick warm clouds(CR3).The two SPs favoring CR5 and CR6 are characterized by abundant moisture with low-level jets after monsoon onset,and a northwest highsoutheast low pattern with strong dynamic convergence along the coastline,respectively.The non-convective CR3 with high reflectance is related to a SP that features the western North Pacific subtropical high extending more westward,leading to a moderate moisture supply and a wide range of convective available potential energy,but also,large convective inhibition. | Mingxin LI Yali LUO Min MIN | 2022 | Advances in Atmospheric Sciences2022，39，12： | 0 |
| 15 | Multilayer Porous Vanadium Nitride Microsheets Anodes for Highly Stable Na-ion Batteries显示文摘Sodiumion batteries(SIBs)have attracted intensive attention as promising alternative to lithium-ionbatteries(LIBs)for large scale energy storage systems because of low cost of sodium,similar energy storage mechanism and the reasonable performance.However,it is still a great challenge to search and design a robust structure of anode materials with excellent cycling stability and high rate capability for SIBs.Herein,multilayer porous vanadium nitride(VN)microsheets are synthesized through a facile and scalable hydrothermal synthesis-nitrogenization strategy as an effective anode material for SIBs.The multilayer porous VN microsheets not only offer more active sites for fast Na+insertion/extraction process and short diffusion pathway,but also effectively buffer the volume change of anode due to more space in the multilayer porous structure.The large proportions of capacitive behavior imply that the Na+charge storage depends on the intercalation pseudocapacitive mechanism.The multilayer porous VN microsheets electrodes manifest excellent cycling stability and rate capability,delivering a discharge capacity of 156.1 mA·h/g at 200 mA/g after 100 cycles,and a discharge capacity of 111.9 mA·h/g at 1.0 A/g even after 2300 cycles with the Coulombic efficiency of nearly 100%. | HU Tao YANG Weiwei WANG Cheng BU Yali JIN Feng ZHANG Dongwen GU Min LIU Wenhui LIANG Qinghua LIU Ruiqing FENG Xiaomiao MA Yanwen | 2021 | Chemical Research in Chinese Universities2021，37，2： | 0 |
| 16 | Plasma treated carbon paper electrode greatly improves the performance of iron-hydrogen battery for low-cost energy storage显示文摘A novel iron-hydrogen battery system, whose Fe^(3+)/Fe^(2+)cathode circumvents slowly dynamic oxygen reduction reaction and anode is fed with clean and cordial hydrogen, is systematically investigated. The maximum discharge power density of the iron-hydrogen battery reaches to 96.0 m W/cm^(2) under the room temperature. The capacity reaches to 17.2 Ah/L and the coulombic and energy efficiency are achieved to99% and 86%, respectively, during the galvanostatic charge-discharge test. Moreover, stable cycling test is observed for more than 240 h and 100 cycles with the iron sulfate in the sulfuric acid solutions. It is found that air plasma treatment onto the cathode carbon paper can generate the oxygen-containing groups and increase the hydrophilic pores proportion to ca. 40%, enlarging nearly 6-fold effective diffusion coefficient and improving the mass transfer in the battery performance. The simple iron-hydrogen energy storage battery design offers us a new strategy for the large-scale energy storage and hydrogen involved economy. | Chuang Bai Fandi Ning Saifei Pan Huihui Wang Yali Li Min Shen Xiaochun Zhou | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 17 | Advanced unconventional techniques for sub-100 nm nanopatterning显示文摘Patterned nanostructures with ultrasmall features endow functional devices with unique nanoconfinement and performance enhancements.The increasing demand for miniaturization has stimulated the development of sub-100 nm nanopatterning techniques.Beyond conventional lithography—which is limited by unavoidable factors—advanced patterning techniques have been reported to produce nanoscale features down to molecular or even atomic scale.In this review,unconventional techniques for sub-100 nm nanopatterning are discussed,in particular the principles by which to achieve the desired patterns(among other important issues).Such techniques can be classified into three categories:template-replica,template-induced,and template-free techniques.Moreover,multi-dimensional nanostructures consist of various building materials,the unique properties of which are summarized.Finally,the remaining challenges and opportunities for large-scale patterning,the improvement of device perfor-mance,the multi-dimensional nanostructures of biocompatible materials,molecular-scale patterning,and the carbon footprint requirements for future nanofabrication processes are discussed. | Mengmeng Guo Zhiyuan Qu Fanyi Min Zheng Li Yali Qiao Yanlin Song | 2022 | InfoMat2022，4，8： | 0 |
| 18 | Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy显示文摘Despite recent advances in tumor treatment, reactive oxygen species(ROS)-mediated therapy, such as photodynamic therapy(PDT) and chemical dynamic therapy(CDT), remains challenging mainly due to hypoxia in tumor microenviroment. Relieving the hypoxia of tumor tissue has been considered as an attractive strategy for enhancing efficacy of ROS-based cancer treatment.Herein, one cascaded platform was developed to overcome tumor hypoxia and synergistically enhance the effect of ROSmediated therapy. This platform is based on cleavable bimetallic metal organic polymers(DOX@Fe/Mn-THPPTK-PEG). As an efficient Fenton-like material, it could not only produce cytotoxic ·OH by catalyzing the decomposition of intracellular H2O2, but also generate O2 to alleviate tumor hypoxia. In addition, the DOX-loaded metal organic polymers(MOPs could be disrupted after being exposed to laser irradiation or/and treated with H2O2, and then release the DOX for chemotherapy. Overall, 3 therapies(hypoxia-relieved PDT, photo-enhanced CDT, and ROS-mediated chemotherapy) could be achieved simultaneously by such a smart platform. Furthermore, T1-weighted MRI imaging ability of the MOPs could be greatly improved under H2O2 treatment.Therefore, total four robust functions were realized in a simple platform. These findings demonstrate great clinical potentials of the MOPs for cancer theranostics. | Haozhe He Lihua Du Min Tan Yali Chen Liejing Lu Yongcheng An Yong Wang Xiaoxia Li Bo Li Jun Shen Jun Wu Xintao Shuai | 2020 | Science China Chemistry2020，63，7： | 0 |
| 19 | Slc43a2^(+)T cell metastasis from spleen to brain in RGNNV infected teleost显示文摘The origin of T cells in the teleost's brain is unclear.While viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral organs.Here,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing analysis.After viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2^(+)T cells synchronously increased in the spleen and brain.During the infection tests in asplenic zebrafish(tlx1^▲zebrafish model),no increase in the number of slc43a2^(+)T cells was observed in the brain.Single-cell transcriptomic analysis indicated that slc43a2^(+)T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune response.This study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish. | Qing Wang Yali Liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao Han Jiang Qiang Lin Qiwei Qin | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 20 | Simplified outlier detection for improving therobustness of a fuzzy model显示文摘Dear editor,Fuzzy models have been widely employed in various fields,such as complex industrial process modeling,classification,function approximation,and time series prediction.Extracting fuzzy rules is very important as they determine the capabilities of the fuzzy model.In recent years,data-based methods such as fuzzy clustering,genetic algorithm,and neural networks[1–3],have been proposed for extracting fuzzy rules.However,these methods require continual learning or possess complicated mechanisms that make them impractical for engineering applications. | Yali JIN Weihua CAO Min WU Yan YUAN | 2020 | Science China(Information Sciences)2020，63，4： | 0 |
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