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| 1 | Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases显示文摘Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic disorders.Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte apoptosis.In addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate conditions.Although remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in detail.Furthermore,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials.This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases. | Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang | 2011 | Cellular & Molecular Immunology2011，8，1： | 26 |
| 2 | The role of neutrophils in the development of liver diseases显示文摘肝疾病包含许多肝条件,包括肝失败,肝肝硬化和尖锐、长期的肝炎的一个系列,例如酒鬼,丰满,药,病毒、长期的肝炎。肝损害是在肝疾病的一个主要原因的因素;通常,这些因素包括直接的肝损坏和调停免疫者的肝损害。Neutrophils (也作为 neutrophilic granulocytes 或 polymorphonuclear 白血球(PMN ) 知道) 是在人的最丰富的传播的白血房间类型,并且 PMN 是一个主要天生的有免疫力的房间子集。到微脉管系统的 neutrophils 的不恰当的激活和 homing 贡献肝疾病的许多类型的病理学的表明。这评论总结基于临床的电流和动物模型研究的嗜中性调停肝损害的新奇概念。 | Ruonan Xu Huihuang Huang Zheng Zhang Fu-Sheng Wang | 2014 | Cellular & Molecular Immunology2014，11，3： | 19 |
| 3 | Liver fibrosis: mechanisms of immune-mediated liver injury显示文摘肝纤维变性和它的结束阶段后果,肝硬化,代表最后的普通小径几乎所有长期的肝疾病。对肝的星形的房间激活的研究,细胞外的矩阵合成和降级和 cytokines 和 chemokines 的贡献的不平衡进一步阐明了机制内在的纤维变性。而且,在适应的主人和天生的免疫系统的变化的澄清加速了我们在肝发炎和纤维变性之间的协会的理解。肝的纤维变性的机制的继续的说明提供了纤维变性前进和回归的一个全面模型。这评论总结在纤维变性的领域里被做了的改进的当前的概念。 | Ruonan Xu Zheng Zhang Fu-Sheng Wang | 2012 | Cellular & Molecular Immunology2012，9，4： | 16 |
| 4 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 5 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 6 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 7 | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis显示文摘补充 5a (C5a ) 被导致 neutrophils 的功能的缺陷在败血的致病含有;然而, C5a 受体的用途(C5aRs;C5aR 和 C5L2 ) 因为为败血的管理的 biomarkers 是不明确的。这研究在嗜中性的功能上在 neutrophils 和他们的效果上调查了 C5aR 和 C5L2 的动态表示。我们发现败血病人与健康、全身的煽动性的反应相比在 neutrophils 上显示了 C5aR 和 C5L2 的低表示层次症候群(先生) 题目,和这个表示模式与疾病严厉被相关。另外, C5aR 和 C5L2 的表示层次与败血病人的幸存被联系。在 vitro, C5a 的增加显著地从败血病人在 neutrophils 减少了 C5aR 和 C5L2 表示层次和 IL-8 生产。那些调查结果建议 C5aRs 的减少的表示为败血病人与 neutrophils 和差的预后的功能的缺陷被联系。总的来说,这些调查结果可以帮助作为早标记建立 C5aRs 表示层次预言败血的严厉。 | Ruonan Xu Fang Lin Chunmei Bao Huihuang Huang Chengcheng Ji Siyu Wang Lei Jin Lijian Sun Ke Li Zheng Zhang Fu-Sheng Wang | 2016 | Cellular & Molecular Immunology2016，13，1： | 10 |
| 8 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 9 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 10 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 11 | Sm-doped g-C_(3)N_(4)/Ti_(3)C_(2) MXene heterojunction for visible-light photocatalytic degradation of ciprofloxacin显示文摘A heterojunction of Sm-doped g-C_(3)N_(4)/Ti_(3)C_(2) MXene(SCN/MX)was constructed via prepolymerization and solid mixture-calcination method.The modified g-C_(3)N_(4) presented a hollow porous seaweed-like shape which can increase its specific area and active sites.In SCN/MX composite,the optical properties,no matter optical absorption ability or separation performance of photo-induced electrons and holes,were enhanced.Among them,Sm-doping may play an important role on transferring the photogenerated electrons to suppress their recombination,and Ti_(3)C_(2) MXene would broaden light absorption and further improve the carrier migration efficiency.The SCN/MX presented higher photocatalytic degradation efficiency(>99%)of cipro floxacin under visible light irradiation.The quenching experiments and electron spin-resonance spectroscopy confirmed that the dominated active materials were superoxide radical and holes.The degradation mechanisms of ciprofloxacin(CIP)over the SCN/MX were attacking of the active materials on the piperazine ring and quinolone ring,and the final products were CO_(2),H_(2)O and F^(-). | Mingchuan Yu Huanjing Liang Ruonan Zhan Lei Xu Junfeng Niu | 2021 | Chinese Chemical Letters2021，32，7： | 3 |
| 12 | Neutrophils in liver diseases:pathogenesis and therapeutic targets显示文摘Previously,it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions.However,recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation.The phenotypic and functional plasticity of neutrophils has been identified in patients with cancer,inflammatory disorders,infections,and other diseases.Currently,neutrophils,with their autocrine,paracrine,and immune modulation functions,have been shown to be involved in liver diseases,including viral hepatitis,nonalcoholic steatohepatitis,alcoholic liver disease,liver fibrosis,cirrhosis,liver failure,and liver cancer.Accordingly,this review summarizes the role of neutrophils in liver diseases. | Kai Liu Fu-Sheng Wang Ruonan Xu | 2021 | Cellular & Molecular Immunology2021，18，1： | 3 |
| 13 | Review on water leakage control in distribution networks and the associated environmental benefits显示文摘Water supply is the primary element of an urban system. Due to rapid urbanization and water scarcity, maintaining a stable and safe water supply has become a challenge to many cities, whereas a large amount of water is lost from the pipes of distribution systems. Water leakage is not only a waste of water resources, but also incurs great socio-economic costs. This article presents a comprehensive review on the potential water leakage control approaches and specifically discusses the benefits of each to environmental conservation. It is concluded that water leakage could be further reduced by improving leakage detection capability through a combination of predictive modeling and monitoring instruments, optimizing pipe maintenance strategy, and developing an instant pressure regulation system. The environment could benefit from these actions because of water savings and the reduction of energy consumption as well as greenhouse gas emissions. | Qiang Xu Ruiping Liu Qiuwen Chen Ruonan Li | 2014 | Journal of Environmental Sciences2014，26，5： | 2 |
| 14 | The Effect of CD3-Specific Monoclonal Antibody on Treating Experimental Autoimmune Myasthenia Gravis显示文摘CD3-specific monoclonal antibody was the first one used for clinical practice in field of transplantation. Recently,renewed interests have elicited in its capacity to prevent autoimmune diabetes by inducing immune tolerance. In this study, we tested whether this antibody can also be used to treat another kind of autoimmune disease myasthenia gravis (MG) and explored the possible mechanisms. MG is caused by an autoimmune damage mediated by antibody- and complement-mediated destruction of AChR at the neuromuscular junction. We found that administration of CD3-specific antibody (Fab)2 to an animal model with experimental autoimmune myasthenia gravis (EAMG) (B6 mice received 3 times of AChR/CFA immunization) could not significantly improve the clinical signs and clinical score. When the possible mechanisms were tested, we found that CD3 antibody treatment slightly down-regulated the T-cell response to AChR, modestly up-regulation the muscle strength. And no significant difference in the titers of IgG2b was found between CD3 antibody treated and control groups. These data indicated that CD3-specific antibody was not suitable for treating MG, an antibody- and complementmediated autoimmune disease, after this disease has been established. The role of CD3-specific antibody in treating this kind of disease remains to be determined. | Ruonan Xu~1 Jianan Wang~1 Guojiang Chen~1 Gencheng Han~1 Renxi Wang~1 Beifen Shen~1 Yan Li~(1,2) ~1Institute of Basic Medical Science,Academy of military Medical Science,Beijing 100850,China ~2Department of Molecular Immunology,Institute of Basic Medical Science,27 Taiping Road,Beijing 100850,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 2 |
| 15 | Ultrafast and real-time physical random bit extraction with all-optical quantization显示文摘Optical chaos generated by perturbing semiconductor lasers has been viewed,over recent decades,as an excellent entropy source for fast physical random bit generation(RBG)owing to its high bandwidth and large random fluctuations.However,most optical-chaos-based random bit generators perform their quantization process in the electrical domain using electrical analog-to-digital converters,so their real-time rates in a single channel are severely limited at the level of Gb/s due to the electronic bottleneck.Here,we propose and experimentally demonstrate an all-optical method for RBG where chaotic pulses are quantized into a physical random bit stream in the all-optical domain by means of a length of highly nonlinear fiber.In our proof-of-concept experiment,a 10-Gb/s random bit stream is successfully generated on-line using our method.Note that the single-channel real-time rate is limited only by the chaos bandwidth.Considering that the Kerr nonlinearity of silica fiber with an ultrafast response of few femtoseconds is exploited for composing the key part of quantizing laser chaos,this scheme thus may operate potentially at much higher real-time rates than 100 Gb/s provided that a chaotic entropy source of sufficient bandwidth is available. | Ya Guo Qiang Cai Pu Li Ruonan Zhang Bingjie Xu K.Alan Shore Yuncai Wang | 2022 | Advanced Photonics2022，4，3： | 2 |
| 16 | Granulocyte-macrophage colony-stimulating factor:an immunotarget for sepsis and COVID-19显示文摘Granulocyte-macrophage colony-stimulating factor(GM-CSF),which belongs to the colony-stimulating factor(CSF)superfamily and was originally identified as a hemopoietic growth factor,is mainly produced by lymphocytes and innate lymphoid cells.Nonhematopoietic cell populations such as fibroblasts,endothelial cells,and epithelial cells may also secrete GM-CSF in response to an activating stimulus. | Xiuying Mu Kai Liu Huajie Li Fu-Sheng Wang Ruonan Xu | 2021 | Cellular & Molecular Immunology2021，18，8： | 1 |
| 17 | Mesenchymal stem cell therapy for severe COVID-19显示文摘The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has placed a global public burden on health authorities.Although the virological characteristics and pathogenesis of COVID-19 has been largely clarified,there is currently no specific therapeutic measure.In severe cases,acute SARS-CoV-2 infection leads to immune disorders and damage to both the adaptive and innate immune responses.Having roles in immune regulation and regeneration,mesenchymal stem cells(MSCs)serving as a therapeutic option may regulate the over-activated inflammatory response and promote recovery of lung damage.Since the outbreak of the COVID-19 pandemic,a series of MSC-therapy clinical trials has been conducted.The findings indicate that MSC treatment not only significantly reduces lung damage,but also improves patient recovery with safety and good immune tolerance.Herein,we summarize the recent progress in MSC therapy for COVID-19 and highlight the challenges in the field. | Lei Shi Lifeng Wang Ruonan Xu Chao Zhang Yunbo Xie Kai Liu Tiantian Li Wei Hu Cheng Zhen Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 1 |
| 18 | Mechanism of C5a-induced immunologic derangement in sepsis显示文摘Sepsis is a life-threatening medical condition that triggers an uncontrolled inflammatory reaction and is caused by the entry of various microorganisms into the human bloodstream.Sepsis is mainly encountered in intensive care units(ICUs)due to the reduced immunological defenses of ICU patients.Approximately 1.5 million patients develop sepsis annually in industrialized countries. | Ruonan Xu Fang Lin Chunmei Bao Fu-Sheng Wang | 2017 | Cellular & Molecular Immunology2017，14，9： | 1 |
| 19 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 20 | BmMD-2A responds to 20-hydroxyecdysone and regulates Bombyx mori silkworm innate immunity in larva-to-pupa metamorphosis显示文摘20E-hydroxyecdysone(20E)plays important roles in larval molting and metamorphosis in insects and is also involved in the insect innate immune response.Insect metamorphosis is a highly successful strategy for environmental adaptation and is the most vulnerable stage during which the insect is susceptible to various pathogens.20E regulates a series of antimicrobial peptides(AMPs)through the immunodeficiency(IMD)pathway activation in Drosophila;nevertheless,whether other immune pathways are involved in 20E-regulated insect immunity is unknown.Our previous studies showed that BmMD-2A is a member of the MD-2-related lipid recognition(ML)family of proteins that are involved in the Bombyx mori innate immunity Toll signaling pathway.In this study,we further demonstrate that BmMD-2A is also positively regulated by 20E,and the BmMD-2A neutralization experiment suggested that 20E activates some downstream immune effect factors,the AMP genes against Escherichia coli and Staphylococcus aureus,through the regulation of BmMD-2A in larval metamorphosis,implying that B.mori may use the Toll-ML signaling pathway to maintain innate immune balance in the larval-pupal metamorphosis stage,which is a different innate immunity pathway regulated by 20E compared to the IMD pathway in Drosophila. | Ruonan Zhang Xue Chen Yuan Wang Xu Bai Qiong Yang Yangjin Zhong Xiao-Qiang Yu Fengliang Jin Wanying Yang | 2023 | Insect Science2023，30，2： | 0 |
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