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| 1 | The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage显示文摘在应力之上,肿瘤 suppressor p53 的水平显著地被提高,是众所周知的。然而尽管有广泛的研究,包含的内在的机制重要为导致压力的 p53 规定内部播放器仍然不充分被理解。我们人的 lincRNA-RoR (RoR ) 是 p53 的一个强壮的否定管理者的现在的证据。不同于通过 ubiquitin-proteasome 小径引起 p53 降级的 MDM2, RoR 通过和异构的原子 ribonucleoprotein 的直接相互作用压制 p53 翻译我(hnRNP 我) 。重要地,带 hnRNP 的一个 28 底 RoR 序列我有约束力的主题为 p53 压抑必要、足够。我们进一步证明 RoR 禁止调停 p53 的房间周期拘捕和 apoptosis。最后,我们表明 p53 transcriptionally 导致 RoR 表示的一个 RoR-p53 自动调整的反馈环。一起,这些结果建议 RoR-hnRNP I-p53 轴可以组成一个另外的监视网络让房间更好对各种各样的压力作出回应。 | Ali Zhang Nanjiang Zhou Jianguo Huang Qian Liu Koji Fukuda Ding Ma Zhaohui Lu Cunxue Bai Kounosuke Watabe Yin-Yuan Mo | 2013 | Cell Research2013，23，3： | 47 |
| 2 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 3 | High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis显示文摘AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis.METHODS: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome. | Kazuhiro Shimazu Koji Fukuda Taichi Yoshida Masahiro Inoue Hiroyuki Shibata | 2016 | World Journal of Gastroenterology2016，22，26： | 9 |
| 4 | Reactive astrocytes promote the metastatic growth of breast cancer stem‐like cells by activating Notch signalling in brain显示文摘 | Fei Xing Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Andrew Wilber Yin‐Yuan Mo Brian E. Moore Wen Liu Koji Fukuda Megumi Iiizumi Sambad Sharma Yin Liu Kerui Wu Elizabeth Peralta Kounosuke Watabe | 2013 | EMBO Mol Med2013，，3： | 1 |
| 5 | Bifidobac- teria can protect from enteropathogenic infection through production of acetate 显示文摘 | Fukuda S Hidehiro Toh Koji Hase | 2011 | Nature2011，469，7： | 1 |
| 6 | Loss of the Major Duodenal Papilla Results in Brown Pigment Biliary Stone Formation in Pdx1 Null Mice显示文摘 | Akihisa Fukuda Yoshiya Kawaguchi Kenichiro Furuyama Sota Kodama Takeshi Kuhara Masashi Horiguchi Masayuki Koizumi Koji Fujimoto Ryuichiro Doi Christopher V.E. Wright Tsutomu Chiba | 2006 | Gastroenterology2006，，3： | 1 |
| 7 | Adsorptive granulocyte and monocyte apheresis for refractory Crohn’s disease: an open multicenter prospective study显示文摘 | Yoshihiro Fukuda Toshiyuki Matsui Yasuo Suzuki Kazunari Kanke Takayuki Matsumoto Masakazu Takazoe Takayuki Matsumoto Satoshi Motoya Terasu Honma Koji Sawada Tsuneyoshi Yao Takashi Shimoyama Toshifumi Hibi | 2004 | Journal of Gastroenterology2004，，12： | 1 |
| 8 | Pressureless sintering and mechanical properties of titanium aluminum carbide显示文摘 | Shinobu Hashimoto Masaru Takeuchi Koji Inoue Sawao Honda Hideo Awaji Koichiro Fukuda Shaowei Zhang | 2007 | Materials Letters2007，，10： | 1 |
| 9 | Endovascular obliteration of bleeding duodenal varices in patients with liver cirrhosis显示文摘 | Carlos Armando Zamora Koji Sugimoto Masakatsu Tsurusaki Kenta Izaki Tetsuya Fukuda Shinichi Matsumoto Yoichiro Kuwata Ryota Kawasaki Takanori Taniguchi Shozo Hirota Kazuro Sugimura | 2006 | European Radiology2006，，1： | 1 |
| 10 | Bifidobacteria can protect from enteropathogenic infection throughproduction of acetate显示文摘 | Shinji Fukuda Hidehiro Toh Koji Hase | 2011 | Nature2011，469，： | 1 |
| 11 | Decoy receptor 3 regulates the expression of various genes in rheumatoidarthritis synovial fibroblasts显示文摘 | Koji Fukuda Yasushi Miura Toshihisa Maeda Masayasu Takahashi Shinya Hayashi Masahiro Kurosaka | 2013 | International Journal of Molecular Medicine2013，，4： | 1 |
| 12 | Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy显示文摘 | Tameyoshi Yamamoto Hiroaki Nagano Yasuharu Imai Kazuto Fukuda Hitoshi Matsumoto Motoi Kondo Hideo Ota Masato Nakamura Hiroshi Wada Takehiro Noda Bazarragchaa Damdinsuren Keizo Dono Koji Umeshita Shoji Nakamori Masato Sakon Kenichi Wakasa Morito Monden | 2007 | International Journal of Clinical Oncology2007，，2： | 1 |
| 13 | DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoidsynovial fibroblasts显示文摘 | Masayasu Takahashi Yasushi Miura Shinya Hayashi Koji Tateishi Koji Fukuda Masahiro Kurosaka | 2011 | International Journal of Molecular Medicine2011，，3： | 1 |
| 14 | Synchronous or Metachronous Double Cancers of the Pancreas and Other Organs: Report on 12 Cases显示文摘 | Naofumi Eriguchi Shigeaki Aoyagi Masao Hara Koji Okuda Tsuyoshi Tamae Shuichi Fukuda Kotaro Hashino Shinji Sato Kei Fujiki Satoshi Furukawa Atsuo Jimi | 2000 | Surgery Today2000，，8： | 1 |
| 15 | Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy显示文摘 | Yukiko Tsuda Yasushi Yoshimatsu Hiroshi Aoki Kentaro Nakamura Masaki Irie Katsuyuki Fukuda Nobuo Hosoe Nobuo Takada Koji Shirai Yasuo Suzuki | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 16 | Efficacy and Long-Term Outcome of Treatment for Pure Red Cell Aplasia after Allogeneic Stem Cell Transplantation from Major ABO-Incompatible Donors显示文摘 | Makoto Hirokawa Takahiro Fukuda Kazuteru Ohashi Michihiro Hidaka Tatsuo Ichinohe Koji Iwato Heiwa Kanamori Makoto Murata Toru Sakura Masahiro Imamura Soichi Adachi Ritsuro Suzuki Yasuo Morishima Hisashi Sakamaki | 2013 | Biology of Blood and Marrow Transplantation2013，，7： | 1 |
| 17 | Cetuximab-mediated ADCC activity is correlated with the cell surfaceexpression level of EGFR but not with the KRAS/BRAF mutational status in colorectalcancer显示文摘 | Yuki Seo Yoshiyuki Ishii Hiroki Ochiai Kazumasa Fukuda Shingo Akimoto Tetsu Hayashida Koji Okabayashi Masashi Tsuruta Hirotoshi Hasegawa Yuko Kitagawa | 2014 | Oncology Reports2014，，5： | 1 |
| 18 | Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn’s disease, respectively显示文摘 | Hiroko Sashio Kazuo Tamura Reiko Ito Yoshihiro Yamamoto Hiroko Bamba Tadashi Kosaka Shin Fukui Koji Sawada Yoshihiro Fukuda Kazutami Tamura Masamichi Satomi Takashi Shimoyama Jun-ichi Furuyama | 2002 | Immunogenetics2002，，12： | 1 |
| 19 | Surgical resection combined with chemotherapy for advanced hepatocellular carcinoma with tumor thrombus: Report of 19 cases显示文摘 | Shuichi Fukuda Koji Okuda Mahiro Imamura Ichiro Imamura Naofumi Eriguchi Shigeaki Aoyagi | 2002 | Surgery2002，，3： | 1 |
| 20 | Radiologic Variations in Gastrorenal Shunts and Collateral Veins from Gastric Varices in Images Obtained Before Balloon-Occluded Retrograde Transvenous Obliteration显示文摘 | Hiroaki Maeda Shozo Hirota Satoshi Yamamoto Kaoru Kobayashi Keisuke Arai Yoshiya Miyamoto Tetsuya Fukuda Koji Sugimoto Norio Nakao | 2007 | CardioVascular and Interventional Radiology2007，，3： | 1 |
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