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| 1 | 前瞻性和回顾性心电门控64层CT冠状动脉成像影像质量,血管狭窄和放射剂量评估的对照性研究显示文摘目的证实前瞻性心电图(ECG)触发冠状动脉CT血管成像(下称前瞻性cT血管成像)和回顾性ECG门控冠状动脉CT血管成像(下称回顾性CT血管成像)同样有效。方法研究得到机构审查委员会的批准并获得知情同意书。60例心率低于75次/min且需行冠状动脉CT血管成像的病人入组。使用64层CT进行了前瞻性和回顾性CT血管成像。记录数据采集时间。2位独立心脏影像诊断医师使用美国心脏协会17段分段法,对影像质量进行主观评估(1为优秀,4为差),并评估血管的狭窄程度(0%狭窄,1%~49%狭窄,50%-75%狭窄,〉75%狭窄)。 | N. Hirai J. Horiguchi C. Fujioka M. Kiguchi H. Yamamoto N.Matsuura 邱建星(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 80 |
| 2 | Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation显示文摘AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction(PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops.METHODS:The anatomy of the union of the pancreatic and bile ducts was assessed by using endoscopic retrograde cholangiopancreatography(ERCP).Patients with a long common channel in which communication between the pancreatic and bile ducts was maintained even during sphincter contraction were diagnosed as having PBM.Of these,patients in which the maximal diameter of the bile duct was less than 10 mm were diagnosed with PBM without biliary dilatation.The process of diagnosing 54 patients with PBM without biliary dilatation was retrospectively investigated.Histopathological analysis of resected gallbladder specimens from 8 patients with PBM without biliary dilatation or cancer was conducted.RESULTS:Thirty-six PBM patients without biliary dilatation were diagnosed with gallbladder cancer after showing clinical symptoms such as abdominal or back pain(n = 16) or jaundice(n = 12).Radical surgery for gallbladder cancer was only possible in 11 patients(31%) and only 4 patients(11%) survived for 5 years.Eight patients were suspected as having PBM without biliary dilatation from the finding of gallbladder wall thickening on ultrasound and the diagnosis was confirmed by ERCP and/or magnetic resonance cholangiopancreatography(MRCP).The median age of these 8 patients was younger by a decade than PBM patients with gallbladder cancer.All 8 patients underwent prophylactic cholecystectomy and bile duct cancer has not occurred.Wall thickness and mucosal height of the 8 resected gallbladders were significantly greater than controls,and hyperplastic changes,hypertrophic muscular layer,subserosal fibrosis,and adenomyomatosis were detected in 7(88%),5(63%),7(88%) and 5(63%) patients,respectively.Ki-67 labeling index was high and K-ras mutation was detected in 3 of 6 patients.CONCLUSION:To detect PBM without biliary dilatation before onset of gallbladder cancer,we should perform MRCP for individuals showing increased gallbladder wall thickness on ultrasound. | Kensuke Takuma Terumi Kamisawa Taku Tabata Seiichi Hara Sawako Kuruma Yoshihiko Inaba Masanao Kurata Goro Honda Koji Tsuruta Shin-ichiro Horiguchi Yoshinori Igarashi | 2012 | World Journal of Gastroenterology2012，18，26： | 13 |
| 3 | Energy saving in wireless sensor networks显示文摘 | Hnin Yu Shwe JIANG Xiao-hong Susumu Horiguchi | 2009 | 通讯和计算机(中英文版)2009，6，5： | 4 |
| 4 | 对超声凝胶中丙二醇发生过敏接触性皮炎1例(发生在肝细胞癌动脉导管栓塞治疗皮肤损伤泄露处) | Horiguchi Y. Honda T. Fujii S. 冯义国 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，11： | 4 |
| 5 | MK-0626,a selective DPP-4 inhibitor,attenuates hepatic steatosis in ob/ob mice显示文摘AIM:To investigate the mechanism and in vivo effects of MK-0626,a dipeptidyl peptidase-4 inhibitor,on hepatic steatosis using ob/ob mice.METHODS:We analyzed obese(ob/ob)8-wk-old male mice that had been randomly divided into two groups of ob/ob mice(n=16 each)and were treated with1.5 or 3 mg/kg MK-0626 and two control groups of untreated ob/ob mice and lean littermates(n=16 each).All mice were fed a normal chow diet with or without MK-0626 for either four or eight weeks.Blood samples were collected,and total hepatectomy was performed.RESULTS:The administration of dietary MK-0626 ameliorated the hepatic lipid accumulation in ob/ob micetreated with 3 mg/kg MK-0626(3 MK),P<0.05,vs untreated ob/ob mice(ob/ob).The MK-0626 treatment reduced the serum alanine aminotransferase levels(both treatment groups,P<0.05 vs ob/ob)and glucoses/insulin levels/calculated HOMA scores(1.5 MK,P<0.05vs ob/ob;3 MK,P<0.01 vs ob/ob)and increased the serum adiponectin levels(3 MK,P<0.05 vs ob/ob)in a dose-dependent manner.The MK-0626 treatment increased the m RNA expression of peroxisome proliferator-activated receptorα/microsomal triglyceride transfer protein(1.5 MK,P<0.05 vs ob/ob;3 MK,P<0.01vs ob/ob)but reduced the sterol regulatory element binding transcription factor-1c/fatty acid synthase/stearoyl-Co A desaturase-1(both treatment groups,P<0.01 vs ob/ob).The MK-0626 treatment increased the activity of AMP-activated protein kinase(AMPK)(both treatment groups,P<0.01 vs ob/ob).CONCLUSION:MK-0626 could attenuate hepatic steatosis through enhancing AMPK activity,inhibiting hepatic lipogenic gene expression,enhancing triglyceride secretion from liver and increasing serum adiponectin levels. | Tatsuya Ohyama Ken Sato Yuichi Yamazaki Hiroaki Hashizume Norio Horiguchi Satoru Kakizaki Masatomo Mori Motoyasu Kusano Masanobu Yamada | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 6 | 角蛋白5的尾部区域1649碱基缺失突变的临床异质性:1个单纯型大疱性表皮松解症伴斑状色素沉着的日本家系 | Horiguchi Y. Sawamura D. Mori R. 李政霄 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，11： | 3 |
| 7 | Successful biliary drainage using a metal stent through the gastric stoma显示文摘We report a case of biliary drainage for malignant stricture using a metal stent with an ultrathin endoscope through the gastric stoma. A 78-year-old female was referred to our hospital for jaundice and fever. She had undergone percutaneous endoscopic gastrostomy(PEG) for esophageal obstruction after radiation therapy for cancer of the pharynx. Abdominal contrast-enhanced computed tomography showed a 3-cm enhanced mass in the middle bile duct and dilatation of the intrahepatic bile duct. We initially performed endoscopic retrograde cholangiopancreatography(ERCP) with a trans-oral approach. However, neither the side-viewing endoscope nor the ultrathin endoscope passed through the esophageal orifice. Thus, we eventually performed ERCP via the PEG stoma using an ultrathin endoscope. We performed biliary drainage with a 6F introducer selfexpanding metal stent. The cytology findings obtained by brush cytology showed malignancy. Her laboratory results were restored to normal levels after drainage and no complication occurred. | Kazuyuki Matsumoto Hironari Kato Koichiro Tsutsumi Yutaka Akimoto Daisuke Uchida Takeshi Tomoda Naoki Yamamoto Yasuhiro Noma Shigeru Horiguchi Hiroyuki Okada Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 8 | 日本工程试验卫星ETS—Ⅶ无人自动交会对接系统的在轨演示显示文摘空间交会对接(RVD)技术是进行航天器在轨修复、空间站补给和设备更换等未来空间活动的必要技术。日本从事空间交会对接技术的研究,尤其受到在21世纪初期通过发射无人有翼往返运输系统(HOPE)实现为α国际空间站(SS)的日本实验舱(JEM)提供后勤支持服务的任务驱动。HOPE-SS交会对接任务的特点是由无人航天器向载人航天器实现RVD。NASDA筑波空间中心从70年代初期就开始从事RVD系统的研究工作,研究重点集中在开发高度自动和安全的RVD系统。目前,由工程试验卫星-Ⅶ(ETS-Ⅶ)在轨演示无人自动RVD系统的工程正在进展之中,ETS-Ⅶ将在1997年由H-Ⅶ运载火箭发射入轨,此次在轨飞行演示试验是NASDA开发RVD技术的第一步,其主要目的在于在不久将来即21世纪初发展自动RVD技术及空间遥操作机器人技术。本文将介绍ETS-ⅦRVD系统的初步研究成果,包括RVD试验计划、试验系统和运行方案。为实现自动和安全RVD系统,需建立星载飞行管理系统(FMS)。本文将描述制导、导航和控制系统(GNC)设计以及FMS策略。工程样机(EM)的设计工作开始于1994年冬天,并拟于1995年初在RVD系统测试中使用。本文也将报告RVD系统的验证确认计划及其地面测试设备。 | Isao Kawano Masaaki Mokuno Hiroshi Horiguchi Koichi Kibe | 1997 | 控制工程(北京)1997，，2： | 2 |
| 9 | Efficacy of Endoscopic Over 3-branched Partial Stent-in-Stent Drainage Using Self-expandable Metallic Stents in Patients With Unresectable Hilar Biliary Carcinoma显示文摘 | Daisuke Uchida Hironari Kato Shinichiro Muro Yasuhiro Noma Naoki Yamamoto Shigeru Horiguchi Ryo Harada Koichiro Tsutsumi Hirofumi Kawamoto Hiroyuki Okada Kazuhide Yamamoto | 2015 | Journal of Clinical Gastroenterology2015，，6： | 2 |
| 10 | Pneumatosis intestinalis with obstructing intussusception:A case report and literature review显示文摘Pneumatosis intestinalis(PI) often represents a benign condition that should not be considered as an argument for surgery. We report a patient with PI and obstructing intussusception who underwent urgent colectomy and review the literatures regarding PI with intussusception. A 20-year-old man presented at our hospital with a 3-d intermittent lower abdominal pain history. He underwent steroid therapy for membranoproliferative glomerulonephritis for 4 years. Computed tomography revealed ascending colon intussusception with air within the wall. Intraoperative colonoscopy revealed numerous soft polypoid masses with normal overlying mucosa and right hemicolectomy was performed. Histological examination of colonic wall sections revealed large cysts in the submucosal layer. The pathological diagnosis was PI. Nine cases of intussusception associated with primary PI have been reported. Although primary PI often represents a benign condition that should not be considered as an argument for surgery,if the case involves intussusception and obstruction,emergent laparotomy should be considered. | Yujiro Itazaki Hironori Tsujimoto Nozomi Ito Hiroyuki Horiguchi Shinsuke Nomura Kyohei Kanematsu Shuichi Hiraki Suefumi Aosasa Junji Yamamoto Kazuo Hase | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 2 |
| 11 | Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice显示文摘AIM: To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy (PH). METHODS: Survival after PH was observed with 21 NK2 transgenic mice and 23 wild-type (WT) mice over 10 d. Liver regeneration was analyzed using histology and immunohistochemistry. Expressions of genes were analyzed using Northern blot analysis, immunoprecipitation and immunoblotting, and reverse transcriptase polymerase chain reaction assay. KaplanMeier method and the log-rank test were used for ahalyzing the survival after PH. Differences in the resultsof immunohistochemistry and percentage of liver regeneration was determined by the Student's t-test. RESULTS: More than half of NK2 transgenic mice died within 48 h after PH. After PH, increased deposition of small lipid droplets in hepatocytes was evident and hepatic proliferation was inhibited in NK2 transgenic mice. The hepatic expression and kinase activity of HGF receptor, c-Met, were unchanged among WT mice and NK2 transgenic mice after PH. The expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver tissues were prolonged in NK2 transgenic mice that died after PH.CONCLUSION: Our findings indicate that overexpression of NK2 inhibits liver regeneration after PH. | Toshiyuki Otsuka Norio Horiguchi Daisuke Kanda Takashi Kosone Yuichi Yamazaki Kazuhisa Yuasa Naondo Sohara Satoru Kakizaki Ken Sato Hitoshi Takagi Glenn Merlino Masatomo Mori | 2005 | World Journal of Gastroenterology2005，11，47： | 2 |
| 12 | Clinical characteristics of null responders to Peg-IFNα2b/ ribavirin therapy for chronic hepatitis C显示文摘AIM: To predict which chronic hepatitis C patients are likely to be late-responders, we herein investigated the clinical characteristics of null-responders at 36 wk with hepatitis C virus (HCV) genotype Ib and a high viral load during the course of pegylated interferon (Peg-IFN)/ ribavirin ther apy. METHODS: One hundred forty-two patients with genotype Ib HCV and a high viral load were included in this study. Peg-IFNα2b (1.5 μg/kg once a week) and ribavirin (600-1000 mg per day according to body weight) were administered for 48 wk. We def ined nullresponders as the cases that never cleared serum HCV RNA as determined using RT-PCR until 36 wk. Other patients were def ined as responders. We compared the clinical characteristics (age, gender, body mass index, previous treatment) and HCV RNA titer during the therapy between null-responders and responders.RESULTS: The HCV RNA clearance rate was 17.9% (24/134), 46.3% (62/134), 60.6% (86/142), 86.6% (123/142), and 88.0% (125/142) at 4, 8, 12, 24, and 36 wk, respectively. There were 17 patients (12.0%) who were still null-responders at 36 wk. There were no differences in the clinical characteristics between the responders and null-responders except for the titer and decline rates of HCV RNA at 1 wk and 4 wk. The HCV RNA titers at 1 wk and after 4 wk of treatment were significantly higher in the null-responders in comp arison to the responders (P <0.01). The serum HCV RNA titers of the responders decreased by 1.3 log after 1 wk of treatment, and 1.6 log after 4 wk of treatm ent, respectively. On the other hand, the titers of the null responders decreased by only 0.5 log after 1 wk, and 0.7 log after 4 wk of treatment, respectively. The decrease rates of HCV RNA after 1 and 4 wk of treatm ent were signif icantly worse for null responders than for the responders (P <0.01). CONCLUSION: The HCV RNA titer at 1 wk and 4 wk after initiating treatment may be useful for predicting null-responders to Peg-IFNα2b/ribavirin therapy. However, further investigation is needed to determine the optimal time at which the decision to discontinue the Peg-IFNα2b/ribavirin therapy for null-responders can be made. | Hideyuki Suzuki Satoru Kakizaki Norio Horiguchi Takeshi Ichikawa Ken Sato Hitoshi Takagi Masatomo Mori | 2010 | World Journal of Hepatology2010，2，11： | 2 |
| 13 | Sclerosing cholecystitis associated with autoimmune pancreatitis显示文摘瞄准:与自体免疫的胰腺炎(AIP ) 在病人评估胆囊的组织病理学说、放射学的调查结果。方法:19 个 AIP 病人的胆囊的放射学的调查结果回顾地被考察。8 个 AIP 病人的 Resected 胆囊组织学地被检验,免疫与 anti-IgG4 抗体被染色。控制为征兆的胆石由胆囊 resected 组成了(n = 10 ) 并且那些为胰腺的癌在胰头十二指肠切除术期间搬迁了(n = 10 ) ,以及额外的肝的胆汁管和胰为胰腺的癌由胰头十二指肠切除术搬迁了(n = 10 ) 。结果:胆囊墙变厚被超声检测或与 AIP 在 10 个病人计算了断层摄影术(3 严重并且 7 中等) ;在这些病人,额外的肝的胆汁管的严重狭窄也被注意。组织学地,胆囊变厚在 8 中的 6 个被检测(75%) 有 AIP 的病人;4 个盒子与纤维变性有透壁 lymphoplasmacytic 渗入,并且 2 个盒子有基于 mucosal 的 lymphoplasmacytic 渗入。与稠密的纤维变性和弥漫的 lymphoplasmacytic 渗入的额外的肝的胆汁管墙的可观的透壁的变厚在 7 个病人被检测。Immunohistochemically, IgG4 积极的浆细胞的严重或中等的渗入在所有 8 个病人的胆囊,胆汁管,和胰被检测,但是没在控制被检测。结论:胆囊墙与纤维变性和 IgG4 积极的血浆房间的丰富的渗入变厚经常与 AIP 在病人被检测。我们建议一个新术语的使用,致硬化的胆汁,为这些盒子,那被象致硬化的胰腺炎或致硬化的胆管炎的一样的机制在 AIP 导致。 | Terumi Kamisawa Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto Shinichirou Horiguchi | 2006 | World Journal of Gastroenterology2006，12，23： | 2 |
| 14 | Combination therapy with daclatasvir and asunaprevir for dialysis patients infected with hepatitis C virus显示文摘The standard antiviral therapy for dialysis patients infected with hepatitis C virus(HCV) is(pegylated) interferon monotherapy, but its efficacy is insufficient. Oral direct-acting antiviral agents(DAAs) have recently been developed for chronic hepatitis C patients. However, some DAAs have contraindications for chronic renal failure(CRF). Daclatasvir and asunaprevir are metabolized largely in the liver and are not contraindicated in CRF. Combination therapy with daclatasvir and asunaprevir was used for 4 dialysis patients infected with genotype 1b HCV. One patient had viral breakthrough, and the 3 others had sustained virological response 12. One patient was admitted for heart failure and percutaneous coronary intervention due to concomitant ischemic disease. Heart failure was unlikely to be caused by the combination therapy, as it was probably due to water overload. The patient continued to receive the combination therapy after the remission of the heart failure. The combination therapy was well tolerated in the other patients. | Ken Sato Yuichi Yamazaki Tatsuya Ohyama Takeshi Kobayashi Norio Horiguchi Satoru Kakizaki Motoyasu Kusano Masanobu Yamada | 2016 | World Journal of Clinical Cases2016，4，3： | 2 |
| 15 | Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology显示文摘AIM To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis(NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction technology.METHODS Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. One hundred and two patients, including 79 NASH and 23 non-NASH patients were analyzed in order to create the predictionmodel, another cohort with 77 patients including 65 NASH and 12 non-NASH patients were analyzed to validate the algorithm.RESULTS Alanine aminotransferase, C-reactive protein, homeostasis model assessment insulin resistance, albumin were extracted as predictors of NASH using a recursive-rule extraction algorithm. When we adopted the extracted rules for the validation cohort using a highly accurate rule extraction algorithm, the predictive accuracy was 79.2%. The positive predictive value, negative predictive value,sensitivity and specificity were 88.9%, 35.7%, 86.2% and 41.7%, respectively.CONCLUSION We successfully generated a useful model for predicting NASH in Japanese morbidly obese patients based on their biochemical profile using a rule extraction algorithm. | Daisuke Uehara Yoichi Hayashi Yosuke Seki Satoru Kakizaki Norio Horiguchi Hiroki Tojima Yuichi Yamazaki Ken Sato Kazuki Yasuda Masanobu Yamada Toshio Uraoka Kazunori Kasama | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 16 | 经颅磁刺激运动诱发电位在腰椎管狭窄症临床评价中的应用价值显示文摘目的分析经颅磁刺激运动诱发电位(motor evoked potentials,MEP)在腰椎管狭窄症临床评价中的应用价值。方法23例腰椎管狭窄患者,男12例,女lI例;年龄52-83岁,平均67.9岁。单纯腰椎管狭窄症11例,合并腰椎退变性滑脱12例。就诊时平均病程31.5个月(3个月-10年)。出现单侧下肢症状者(疼痛或麻木、无力)9例,双下肢均出现者14例。所有患者均合并间歇性跛行,出现跛行前平均行走距离为302.1m(3-1000m)。MRI中最狭窄节段的硬膜囊面积值(minimum cross-sectional area,MCSA)平均0.4cm。(0.1-4).9em。)。于患者双侧跨内收肌处记录经颅磁刺激MEP潜伏期(MEP latency,MEPLT),同时收集患者治疗前JOA评分、视觉模拟评分(VAS,包括腰痛,下肢、臀部痛及麻木程度)。采用SPSS12.0软件进行统计学分析。结果MEPLT为(42.1+2.8)ms,JOA评分为(15.9+4.8)分。腰痛、下肢及臀部痛、下肢及臀部麻木感VAS分别为(6.0+2.9)分、(7.7+1.9)分、(7.3+3.0)分。MEPLT与步行距离、下肢症状类型及麻木VAS存在相关。步行距离〈500m者MEPLT明显延长(t=3.529,P〈0.05)。结论MEPLT延长在腰椎管狭窄患者出现临床体征之前即可出现,MEP可有效反映患者的主观症状。 | 刘新宇 Shunsuke Konno Masabumi Miyamoto Yoshikazu Gembun Gen Horiguchi Hiromoto Ito 郑燕平 李建民 宫良泰 | 2009 | 中华骨科杂志2009，29，1： | 2 |
| 17 | Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes 显示文摘 | Kuriyama K Shimizu T Horiguchi T | 2002 | Inflamm Res2002，51，10： | 1 |
| 18 | RuHCl( CO ) ( PPh3 ) 3 -catalyzed chemoselective transfer-hydrogenation of enones leading to saturated ketones 显示文摘 | Takahide D Fukuyama T Horiguchi J | 2006 | Synlett2006，，5： | 1 |
| 19 | Prediction of extraprostatic cancer by prostate specific antigen density,endorectal MRI,and biopsy Gieason score in clinically localized prostate cancer 显示文摘 | Horiguchi A Nakashima J Horiguchi Y | 2003 | Prostate2003，56，1： | 1 |
| 20 | The transcription factor AtGRF5 and the ranscription coactivator AN3 regulate cell proliferation in leaf primordia of Arabidopsis thaliana显示文摘 | Horiguchi G Kim G-T Tsukaya H | 2005 | Plant J2005，43，： | 1 |
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