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| 1 | One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent显示文摘瞄准:为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法,在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法:由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后,一他们被放在胆总管,在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们,另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后,导管被移开 2 或 3 d 过程以后。结果:EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人, 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论:他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida Yasuo Arima Manabu Watanabe Eiichi Uchida Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，15： | 28 |
| 2 | Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer显示文摘AIM:To investigate human epidermal growth factor receptor 2(HER2)-phosphatidylinositol 3-kinase(PI3K)-vAkt murine thymoma viral oncogene homolog signaling pathway.METHODS:We analyzed 231 formalin-fixed,paraffinembedded gastric cancer tissue specimens from Japanese patients who had undergone surgical treatment.The patients' age,sex,tumor location,depth of invasion,pathological type,lymph node metastasis,and pathological stage were determined by a review of the medical records.Expression of HER2 was analyzed by immunohistochemistry(IHC) using the HercepTest TM kit.Standard criteria for HER2 positivity(0,1+,2+,and 3+) were used.Tumors that scored 3+ were considered HER2-positive.Expression of phospho Akt(pAkt) was also analyzed by IHC.Tumors were considered pAkt-positive when the percentage of positive tumor cells was 10% or more.PI3K,catalytic,alpha polypeptide(PIK3CA) mutations in exons 1,9 and 20 were analyzed by pyrosequencing.Epstein-Barr virus(EBV) infection was analyzed by in situ hybridization targeting EBV-encoded small RNA(EBER) with an EBER-RNA probe.Microsatellite instability(MSI) was analyzed by polymerase chain reaction using the mononucleotide markers BAT25 and BAT26.RESULTS:HER2 expression levels of 0,1+,2+ and 3+ were found in 167(72%),32(14%),12(5%) and 20(8.7%) samples,respectively.HER2 overexpression(IHC 3+) significantly correlated with intestinal histological type(15/20 vs 98 /205,P = 0.05).PIK3CA mutations were present in 20 cases(8.7%) and significantly correlated with MSI(10/20 vs 9/211,P < 0.01).The mutation frequency was high(21%) in T4 cancers and very low(6%) in T2 cancers.Mutations in exons 1,9 and 20 were detected in 5(2%),9(4%) and 7(3%) cases,respectively.Two new types of PIK3CA mutation,R88Q and R108H,were found in exon1.All PIK3CA mutations were heterozygous missense singlebase substitutions,the most common being H1047R(6/20,30%) in exon20.Eighteen cancers(8%) were EBV-positive and this positivity significantly correlated with a diffuse histological type(13/18 vs 93/198,P = 0.04).There were 7 cases of lymphoepithelioma-like carcinomas(LELC) and 6 of those cases were EBV-positive(percent/EBV:6/18,33%;percent/all LELC:6/7,86%).pAkt expression was positive in 119(53%) cases but showed no correlation with clinicopathological characteristics.pAkt expression was significantly correlated with HER2 overexpression(16/20 vs 103/211,P < 0.01) but not with PIK3CA mutations(12/20 vs 107/211,P = 0.37) or EBV infection(8/18 vs 103/211,P = 0.69).The frequency of pAkt expression was higher in cancers with exon20 mutations(100%) than in those with exon1(40%) or exon9(56%) mutations.One case showed both HER2 overexpression and EBV infection and 3 cases showed both PIK3CA mutations and EBV infection.However,no cases showed both PIK3CA mutations and HER2 overexpression.One EBVpositive cancer with PIK3CA mutation(H1047R) was MSI-positive.Three of these 4 cases were positive for pAkt expression.In survival analysis,pAkt expression significantly correlated with a poor prognosis(hazard ratio 1.75;95%CI:1.12-2.80,P = 0.02).CONCLUSION:HER2 expression,PIK3CA mutations and EBV infection in gastric cancer were characterized.pAkt expression significantly correlates with HER2 expression and with a poor prognosis. | Yasutaka Sukawa Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Kunimoto Hiromu Suzuki Yasushi Adachi Mayumi Nakazawa Takayuki Nobuoka Mariko Kawayama Masashi Mikami Takashi Matsuno Tadashi Hasegawa Koichi Hirata Kohzoh Imai Yasuhisa Shinomura | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 3 | Factors affecting recurrence after surgery for Crohn's disease显示文摘Although in Crohn's disease post-operative recurrence is common, the determinants of disease recurrence remain speculative. The aim of this study was to examine factors affecting post-operative recurrence of Crohn's disease. A Medline-based literature review was carried out. The following factors were investigated: age at onset of disease, sex, family history of Crohn's disease,smoking, duration of Crohn's disease before surgery,prophylactic medical treatment (corticosteroids, 5-amino salicylic acid [5-ASA] and immunosuppressants),anatomical site of involvement, indication for surgery (perforating or non-perforating disease), length of resected bowel, anast-omotic technique, presence of granuloma in the specimen, involvement of disease at the resection margin, blood transfusions and postoperative complications. Smoking significantly increases the risk of recurrence (risk is approximately twice as high), especially in women and heavy smokers. Quitting smoking reduces the post-operative recurrence rate. A number of studies have shown a higher risk when the duration of the disease before surgery was short. There were, however, different definitions of 'short' among the studies. Prophylactic cortic-osteroids therapy is not effective in reducing the post-operative recurrence. A number of randomized controlled trials offered evidence of the efficacy of 5-ASA (mesalazine) in reducing post-operative recurrence. Recently, the thera-peutic efficacy of immunosuppressive drugs (azathioprine and 6-mercaptopurine) in the prevention of post-operative recurrence has been investigated and several studies have reported that these drugs might help prevent the recurrence. Further clinical trials would be necessary to evaluate the prophylactic efficacy of immunosuppressants.Several studies showed a higher recurrence rate in patients with perforating disease than in those with non-perforating disease. However, evidence for differing recurrence rates in perforating and non-perforating diseases is inconclusive.A number of retrospective studies reported that a stapled functional end-to-end anastomosis was associated with a lower recurrence rate compared with other types of anastomosis. However, prospective randomized studies would be necessary to draw a definite conclusion. Many studies found no difference in the recurrence rates between patients with radical resection and non-radical resection. Therefore, minimal surgery including strictureplasty has been justified in the management of Crohn's disease. In this review, the following factors do not seem to be predictive of post-operative recurrence:age at onset of disease, sex, family history of Crohn's disease, anatomical site of disease, length of resected bowel, presence of granuloma in the specimen, blood transfusions and post-operative complications. The most significant factor affecting post-operative recurrence of Crohn's disease is smoking. Smoking significantly increases the risk of recurrence. A short disease duration before surgery seems, albeit to a very minor degree, to be associated with a higher recurrence rate. 5-ASA has been shown with some degree of confidence to lead to a lower recurrence rate. The prophylactic efficacy of immunosuppressive drugs should be assessed in future.A wider anastomotic technique after resection may reduce the post-operative recurrence rate, though this should be investigated with prospective randomized controlled trials. | Takayuki Yamamoto | 2005 | World Journal of Gastroenterology2005，11，26： | 17 |
| 4 | A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B显示文摘Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal outcome.In this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid.In both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became undetectable.Entecavir treatment was continued.Generally,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few weeks.During this time lag,liver cell injury continued and the disease progressed.Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B. | Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，13： | 16 |
| 5 | Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy显示文摘AIM To compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor(PPI)-based therapies to treat Helicobacter pylori(H. pylori).METHODS We retrospectively analysed data from first-line(vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d)(n = 1353) and second-line(vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d)(n = 261) eradication treatments for H. pylori- positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related factors.RESULTS After the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9%(95%CI: 84.9%-90.5%), 71.6%(95%CI: 67.5%-75.5%), 62.9%(95%CI: 52.0%-72.9%), and 57.3%(95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs(P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group(P = 0.34), whereas it decreased the rates in the PPI groups(P = 0.013). The incidence of adverse events in the vonop-razan group was not different from the PPI group(P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based therapy.CONCLUSION Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. | Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 6 | Reactive lymphoid hyperplasia of the liver:A case report and review of literature显示文摘有反应淋巴的增生(RLH ) 的一个 53 岁的女病人的一个盒子,肝的临床上指明的同样假的淋巴瘤在这篇文章被描述。病人为顺便说一下在另一所医院发现的肝的肿瘤的进一步的评估进入我们的医院。各种各样的诊断方法,包括的 ultrasonography (美国) ,计算机化的断层摄影术(CT ) ,磁性的回声成像(MRI ) 和肝的血管造影术与与肝细胞癌(HCC ) 一致的突出的调查结果在肝显示了三小损害。外科的切除术被执行,三损害是作为肝的 RLH 诊断的用显微镜。损害与滤泡和 hyalinized 包括了淋巴样细胞的巨大的渗入内部小囊的空格。Immunohistochemical 检查表明渗透的淋巴细胞没有突出的原子非典型和 polyclonality。肝的 RLH 是一个很稀罕的条件,仅仅 12 个案例在英语文学被报导了。报导案例的多数是中年的女人并且关于他们的一半有象自体免疫的甲状腺炎那样的一些免疫逻辑畸形, Sjogren 的症候群,主要免疫不全,主要胆汁性肝硬变。因为他们临床上经常作为 HCC 被误诊,外科是为这些病人的治疗的选择。尽管他们的病理类似于恶性淋巴瘤,临床的功课是完全良性的。作者建议肝的 RLH 能被它的临床的特征从 HCC 区别。 | Takuro Machida Toshiyuki Takahashi Tomoo Itoh Michiaki Hirayama Takayuki Morita Shoichi Horita | 2007 | World Journal of Gastroenterology2007，13，40： | 13 |
| 7 | Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers显示文摘瞄准:为了是估计在纤维变性区域(FA ) 之间的关联,并且把 FibroScan 的诊断精确性比作用操作的接收装置的标记弄弯的另外的存在的肝纤维变性(LF ) ,由数字图象分析(DIA ) 计算了分析。方法:我们招募了包括正常的肝,肝炎 B,和丙肝为三不同病原学经历了肝切除术的 30 个病人。肝僵硬被使用 FibroScan 测量。FA 然后被 DIA 计算评估 LF 以便避免任何采样偏爱。结果:FA 否定地与凝血素相关时间(磅) ,血小板计数,卵磷脂胆固醇 acyltransferase (LCAT ) ,和白朊前(白长袍的) 。在另一方面, FibroScan 的调查结果与类似的标记相关。FA 断然与 FibroScan,浆液 hyaluronate 水平,和类型 IV 骨胶原相关水平,和 aspartate 转氨酶到血小板比率索引(APRI ) 。在操作的接收装置下面的区域弯因为 FibroScan 为另外的标记比那高,尽管统计意义是最小的。结论:我们的调查结果建议 FibroScan 能开始被用来作为肝活体检视(磅) 和血清诊断的一种选择估计 LF,因为它是有可比较的诊断精确性考虑的一个安全方法存在 LF 标记。 | Masaki Kawamoto Toru Mizuguchi Tadashi Katsuramaki Minoru Nagayama Hideki Oshima Hiroyuki Kawasaki Takayuki Nobuoka Yasutoshi Kimura Koichi Hirata | 2006 | World Journal of Gastroenterology2006，12，27： | 12 |
| 8 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012，18，1： | 11 |
| 9 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 10 | Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma:Recent progress in pathogenesis and management显示文摘Recent progress in the research regarding the molecular pathogenesis and management of gastric mucosaassociated lymphoid tissue(MALT)lymphoma is reviewed.In approximately 90%of cases,Helicobacter pylori(H.pylori)infection plays the causative role in the pathogenesis,and H.pylori eradication is nowadays the first-line treatment for this disease,which leads to complete disease remission in 50%-90%of cases.In H.pylori-dependent cases,microbe-generated immune responses,including interaction between B and T cells involving CD40 and CD40L co-stimulatory molecules,are considered to induce the development of MALT lymphoma.In H.pylori-independent cases,activation of the nuclear factor-κB pathway by oncogenic products of specific chromosomal translocations such as t(11;18)/API2-MALT1,or inactivation of tumor necrosis factor alpha-induced protein 3(A20)are considered to contribute to the lymphomagenesis.Recently,a largescale Japanese multicenter study confirmed that the long-term clinical outcome of gastric MALT lymphoma after H.pylori eradication is excellent.Treatment modalities for patients not responding to H.pylori eradication include a'watch and wait'strategy,radiotherapy,chemotherapy,rituximab immunotherapy,and a combination of these.Because of the indolent behavior of MALT lymphoma,second-line treatment should be tailored in consideration of the clinical stage and extent of the disease in each patient. | Shotaro Nakamura Takayuki Matsumoto | 2013 | World Journal of Gastroenterology2013，19，45： | 11 |
| 11 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 12 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 10 |
| 13 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 14 | The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice显示文摘Lipid and phenolic metabolism are important for pollen exine formation. In Arabidopsis, polyketide synthases(PKSs) are essential for both sporopollenin biosynthesis and exine formation. Here, we characterized the role of a polyketide synthase(OsPKS2) in male reproduction of rice(Oryza sativa). Recombinant OsPKS2 catalyzed the condensation of fatty acyl-CoA with malonyl-CoA to generate triketide and tetraketide α-pyrones, the main components of pollen exine. Indeed, the ospks2 mutant had defective exine patterning and was male sterile. However, the mutant showed no significant reduction in sporopollenin accumulation. Compared with the WT(wild type), ospks2 displayed unconfined and amorphous tectum and nexine layers in the exine, and less organized Ubisch bodies. Like the pksb/lap5 mutant of the Arabidopsis ortholog, ospks2 showed broad alterations in the profiles of anther-related phenolic compounds.However, unlike pksb/lap5, in which most detected phenolics were substantially decreased, ospks2 accumulated higher levels of phenolics. Based on these results and our observation that OsPKS2 is unable to fully restore the exine defects in the pksb/lap5, we propose that PKS proteins have functionally diversified during evolution.Collectively, our results suggest that PKSs represent a conserved and diversified biochemical pathway for anther and pollen development in higher plants. | Xiaolei Zhu Jing Yu Jianxin Shi Takayuki Tohge Alisdair R.Fernie Sagit Meir Asaph Aharoni Dawei Xu Dabing Zhang Wanqi Liang | 2017 | Journal of Integrative Plant Biology2017，59，9： | 9 |
| 15 | Cerebral lipiodol embolism related to a vascular lake during chemoembolization in hepatocellular carcinoma:A case report and review of the literature显示文摘A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma(HCC). Even after the injection of 7 m L of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts. | Hideki Ishimaru Minoru Morikawa Takayuki Sakugawa Ichiro Sakamoto Yasuhide Motoyoshi Yohei Ikebe Masataka Uetani | 2018 | World Journal of Gastroenterology2018，24，37： | 9 |
| 16 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 17 | 重型柴油机用新型废气再循环系统显示文摘重型废气涡轮增压柴油机用涡轮增压器的总效率比轿车用小型增压器的高。由于进气歧管压力比废气压力高,所以其废气再循环困难。IHI公司为重型柴油机中的废气再循环研制了一种新型涡轮增压器,其压气机侧有一个再循环通道与在增压器进口处的狭窄环形切槽连接,此处的静压力比进气歧管处的低。装用此涡轮增压器的JIS柴油机的13工况试验结果表明:无需明显牺牲燃油耗就能降低26%的NO_x排放量。 | Takayuki Yamada Nobuyuki Ikeya Nobuhiro Kondoh 段缨 | 2002 | 国外内燃机2002，34，2： | 8 |
| 18 | Identification of activity stop locations in GPS trajectories by density-based clustering method combined with support vector machines显示文摘The identification of activity locations in continuous GPS trajectories is an essential preliminary step in obtaining person trip data and for activity-based transportation demand forecasting.In this research,a two-step methodology for identifying activity stop locations is proposed.In the first step,an improved density-based spatial clustering of applications with noise(DBSCAN) algorithm identifies stop points and moving points;then in the second step,the support vector machines(SVMs) method distinguishes activity stops from non-activity stops among the identified stop points.A time sequence constraint and a direction change constraint are applied as improvements to DBSCAN(yielding an improved algorithm known as C-DBSCAN).Then three major features are extracted for use in the SVMs method:stop duration,mean distance to the centroid of a cluster of points at a stop location,and the shorter of distances from current location to home and to the workplace.The proposed methodology was tested using GPS data collected from mobile phones in the Nagoya area of Japan.The C-DBSCAN algorithm achieves an accuracy of 90%in identifying stop points in the first step,while the SVMs method is 96%accurate in distinguishing the locations of activity stops from non-activity stops in the second step.Compared to other variants of DBSCAN used to identify activity locations from GPS trajectories,this two-step method is generally superior. | Lei Gong Hitomi Sato Toshiyuki Yamamoto Tomio Miwa Takayuki Morikawa | 2015 | Journal of Modern Transportation2015，23，3： | 8 |
| 19 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 20 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
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