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| 1 | Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients显示文摘The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore,management of the various symptoms of liver cirrhosis is essential, and agingrelated parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging. | Kenya Kamimura Akira Sakamaki Hiroteru Kamimura Toru Setsu Takeshi Yokoo Masaaki Takamura Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，15： | 9 |
| 2 | Application of A* Algorithm for Real-time Path Re-planning of an Unmanned Surface Vehicle Avoiding Underwater Obstacles显示文摘This paper describes path re-planning techniques and underwater obstacle avoidance for unmanned surface vehicle(USV) based on multi-beam forward looking sonar(FLS). Near-optimal paths in static and dynamic environments with underwater obstacles are computed using a numerical solution procedure based on an A* algorithm. The USV is modeled with a circular shape in 2 degrees of freedom(surge and yaw). In this paper, two-dimensional(2-D) underwater obstacle avoidance and the robust real-time path re-planning technique for actual USV using multi-beam FLS are developed. Our real-time path re-planning algorithm has been tested to regenerate the optimal path for several updated frames in the field of view of the sonar with a proper update frequency of the FLS. The performance of the proposed method was verified through simulations, and sea experiments. For simulations, the USV model can avoid both a single stationary obstacle, multiple stationary obstacles and moving obstacles with the near-optimal trajectory that are performed both in the vehicle and the world reference frame. For sea experiments, the proposed method for an underwater obstacle avoidance system is implemented with a USV test platform. The actual USV is automatically controlled and succeeded in its real-time avoidance against the stationary undersea obstacle in the field of view of the FLS together with the Global Positioning System(GPS) of the USV. | Thanapong Phanthong Toshihiro Maki Tamaki Ura Takashi Sakamaki Pattara Aiyarak | 2014 | Journal of Marine Science and Application2014，13，1： | 8 |
| 3 | Spontaneous regression of hepatocellular carcinoma: A mini-review显示文摘Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions. | Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，21： | 4 |
| 4 | Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage. | Kohei Ogawa Kenya Kamimura Yukari Watanabe Yosuke Motai Daisuke Kumaki Ryoya Seki Akira Sakamaki Satoshi Abe Hirokazu Kawai Takeshi Suda Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Clinical Cases2017，5，6： | 4 |
| 5 | Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review显示文摘The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia(FMD) and segmental arterial mediolysis(SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain. | Masayoshi Ko Kenya Kamimura Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi Mizuno Shuji Terai | 2018 | World Journal of Gastroenterology2018，24，32： | 2 |
| 6 | Eight-year follow-up of patients with immune thrombocytopenic purpura related to H. pylori infection显示文摘 | Taku Kikuchi Takeshi Kobayashi Takuya Yamashita Kazuteru Ohashi Hisashi Sakamaki Hideki Akiyama | 2011 | Platelets2011，，1： | 2 |
| 7 | Granulocytapheresis for the Treatment of Severe Alcoholic Hepatitis: A Case Series and Literature Review显示文摘 | Kenya Kamimura Michitaka Imai Akira Sakamaki Shigeki Mori Masaaki Kobayashi Ken-ichi Mizuno Manabu Takeuchi Takeshi Suda Minoru Nomoto Yutaka Aoyagi | 2014 | Digestive Diseases and Sciences2014，，2： | 2 |
| 8 | Association of HLA-DR DQ genotype with different beta-cell functions at IDDM diagnosis in Japanese children 显示文摘 | Sugihara S Sakamaki T Konda S | 1997 | Diabetes1997，46，： | 1 |
| 9 | Characteristics of patients with chronic low back pain selected for surgery : a comparison with the general popula- tion reported from the Swedish lumbar spine study 显示文摘 | Fritzell P Sakamaki T | 2002 | Spine2002，11，： | 1 |
| 10 | Biofeedback rehabili- tation for prevention of synkinesis after facial palsy 显示文摘 | Nakamura K Toda N Sakamaki K | 2003 | Otolar-yngol Head Neck Surg2003，128，： | 1 |
| 11 | Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor显示文摘 | Kanda Y Sakamaki H Sao H | 2005 | Biol Blood Marrow Transplant2005，11，11： | 1 |
| 12 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | SHIVAKUMAR L MINNA J SAKAMAKI T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 13 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 14 | Formation of nitrous acid and nitric oxide in the heterogeneous dark reaction of nitrogen dioxide and water vapor in a smog champer显示文摘 | Sakamaki F Hatakeyama S Akimoto H | 1983 | Int J Chem Kinet1983，15，： | 1 |
| 15 | Arginine methylation of BCL-2 antagonist of cell death(BAD)counteracts its phosphorylation andinactivation by Akt显示文摘 | Sakamaki J Daitoku H Ueno K | 2011 | Proc Natl Acad Sci USA2011，108，15： | 1 |
| 16 | Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: is the pediatric spon- dylolisthesis a physis stress fracture of vertebral body 显示文摘 | Sairyo K Katoh S Sakamaki T | 2004 | Spine2004，5，： | 1 |
| 17 | The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion显示文摘 | Liu M Sakamaki T Casimiro MC | | 0，，24： | 1 |
| 18 | The rassfla tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
| 19 | Biotransformation of Cycloalkanediones by Caragana chamlagu 显示文摘 | CHAI W SAKAMAKI H KITANAKA S | 2003 | Japan: Bull Chem Sac Jpn2003，76，： | 1 |
| 20 | The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation显示文摘 | Shivakumar L Minna J Sakamaki T | 2002 | Mol Cell Biol2002，22，12： | 1 |
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