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| 1 | Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?显示文摘In immunoglobulin G4(IgG4)-related disease(RD),organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs.Although infiltration of many IgG4-positive plasma cells is detected in the gastric and colonic mucosa and major duodenal papilla of patients with autoimmune pancreatitis,it cannot be diagnosed as a gastrointestinal lesion involved in IgG4-RD,because none of the following is observed in these lesions:a mass-like formation;dense fibrosis;or obliterative phlebitis.Based on our review of the literature,there appear to be two types of IgG4-related gastrointestinal disease.One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach,consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells,which usually show submucosal spreading.The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach,colon,and major duodenal papilla,showing polypoid or mass-like lesions.Most solitary IgG4-related gastrointestinal lesions that are not associated with other IgG4-RD appear to be difficult to diagnose.It is of utmost importance to rule out malignancy.However,these lesions may respond to steroid therapy.To avoid unnecessary resection,IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. | Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Yuka Endo Go Kuwata Koichi Koizumi Tooru Shimosegawa Kazuichi Okazaki Tsutomu Chiba | 2013 | World Journal of Gastroenterology2013，19，35： | 12 |
| 2 | HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer显示文摘BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression. | Akio Kaito Takeshi Kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita | 2019 | World Journal of Clinical Cases2019，7，15： | 5 |
| 3 | Phase transitions in the Pb(Zn1/3Nb2/3)O3-PbTiO3 system显示文摘 | KUWATA J UCHINO K NOMURA S | 1981 | Ferroelectrics1981，37，： | 3 |
| 4 | Fetal heart rate pattern reflecting the severity of placental abruption显示文摘 | Rie Usui Shigeki Matsubara Akihide Ohkuchi Tomoyuki Kuwata Takashi Watanabe Akio Izumi Mitsuaki Suzuki | 2008 | Archives of Gynecology and Obstetrics2008，，3： | 3 |
| 5 | Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population显示文摘 | Masaki Aizawa Akiko K. Nagatsuma Koji Kitada Takeshi Kuwata Satoshi Fujii Taira Kinoshita Atsushi Ochiai | 2014 | Gastric Cancer2014，，1： | 2 |
| 6 | Perforating veins in recurrent esophageal varices evaluated by endoscopic color Doppler ultrasonography with a galactose-based contrast agent显示文摘 | Takahiro Sato Katsu Yamazaki Jouji Toyota Yoshiyasu Karino Takumi Ohmura Jun Akaike Yasuaki Kuwata Toshihiro Suga | 2004 | Journal of Gastroenterology2004，，5： | 2 |
| 7 | Vitamin A deficiency in mice causes a sestemic expansion of myeloid cells显示文摘 | Kuwata T Wang IM Tamura T | 2000 | Blood2000，95，11： | 1 |
| 8 | HLA-DM genes polymorphisms in atopic dermatitis显示文摘 | KUWATA S YANAGISAWA M NAKAGAWA H | 1996 | J Allergy Clin Immunol1996，98，62： | 1 |
| 9 | Experimental study on Vascularized bone allografts for reconstruction of massive bone defects显示文摘 | Doi k kuwata N | 1994 | Microsurg1994，15，： | 1 |
| 10 | Protection against infections by oral lactoferrin: Evaluation in animal models显示文摘 | Susumu Teraguchi Hiroyuki Wakabayashi Hidefumi Kuwata | 2004 | BioMetals2004，17，： | 1 |
| 11 | Effect of dilution rate on competitive interactions between the cyanobacterium Microcystis novacekii and the green alga scenedesmus quadricauda in mixed chemostat cultures显示文摘 | KAORU TAKEYA AKIRA KUWATA MAKOTO YOSHIDA | 2004 | Journal of Plankton Research2004，26，1： | 1 |
| 12 | Maternal manifes- tation of Ballantyne^ syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma 显示文摘 | Takahashi H Matsubara S Kuwata T | 2014 | J Obstet Gynaecol Res2014，40，4： | 1 |
| 13 | Patients with Gravesdisease who developed insulin auto immune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1·0406显示文摘 | Uchigata Y Kuwata S Tsushims T | 1993 | J Clin Endocrinol Metab1993，77，： | 1 |
| 14 | Comparison of pharmacokineetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats 显示文摘 | Kuwata K Nagayama S Hirakawa Y | 2000 | Gan To Kagaku Ryoho2000，27，6： | 1 |
| 15 | Cloud condensation nuclei activity at Jeju Island,Korea in spring 2005显示文摘 | Kuwata M Kondo Y Miyazaki Y | 2008 | Atmospheric Chemistry and Physics2008，8，11： | 1 |
| 16 | Safe maritime navigation with COLREGS using velocity ob- stacles 显示文摘 | KUWATA Y WOLF M T ZARZHITSKY D | 2013 | IEEE Journal of Oceanic Engineering2013，39，1： | 1 |
| 17 | Association of DMA and DMB with RA in Japanese显示文摘 | Takeuchi F Nabeta H Kuwata S | 1997 | Clin Exp Rhanmatol1997，15，2： | 1 |
| 18 | Response of a Solid Sate Potentiometric Sensor Using LaF3 to a Small Amount of H2 or CO in Air at Room Temperature 显示文摘 | Miura N | 1984 | Chemistry Letters1984，3，： | 1 |
| 19 | Sensitive flame ionization detector for the determination of traces of atmospheric hydrocarbons by capillary column gas chromatography 显示文摘 | Tsujino Y Kuwata K | 1993 | Journal of Chromatography A1993，642，12： | 1 |
| 20 | HLAandanti-GQ1bIgGantibodyinMiller-FishersyndromeandGuillain-Barresyndrome显示文摘 | ChibaA KusunokiS KuwataS etal | 1995 | JNeuroimmunol1995，61，： | 1 |
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