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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 3 | Seafloor hydrothermal activity and polymetallic sulfide exploration on the southwest Indian ridge显示文摘Polymetallic sulfides have attracted more attentions,which are regarded as one of the potential seabed mineral resources for their high grade of precious metal elements such as Cu,Zn,Pb,Au,and Ag.Since2007,there are four China dayang cruises(CDCs)with eight legs totally,which have been carried out to investigate polymetallic sulfides on the southwest Indian ridge(SWIR),and eight hydrothermal vents have been found.In2011,the China Ocean Mineral Resources Research and Development Association(COMRA)and International Seabed Authority(ISA)signed a 15-year contract for exploration for polymetallic sulfides located on the SWIR between 46°S and 53°S.The area allocated to the COMRA is approximately 10,000 km2.In this paper,we review the recent research advances about hydrothermal activity of the SWIR by the CDCs.As for the sulfides exploration in the future,some aspects should be emphasized,such as the controlling factors of sulfide mineralization on the SWIR,prospecting methods of inactive and buried sulfide deposits,sulfides resources assessment method,and the nearbottom sulfides exploration technology systems. | Chunhui Tao Huaiming Li Xiaobing Jin Jianping Zhou Tao Wu Yonghua He Xianming Deng Chunhua Gu Guoyin Zhang Weiyong Liu | 2014 | Chinese Science Bulletin2014，59，19： | 25 |
| 4 | A novel method for purification of recombinant adeno-associated virus vectors on a large scale显示文摘A novel method for recombinant adeno-associ-ated virus (rAAV) purification on large scale is described. The method involves three steps, including chloroform treatment, PEG/NaCl precipitation and chloroform extraction. The whole procedure can be performed in four hours. Using this purification method, we can reproducibly obtain, from 4 × 109 of proviral cells cultured in roller bottles, purified rAAV-GFP stocks with titers of around 5×1013 particles/mL and purity greater than 95%. The infectious titers of the vector stocks were up to 2×1012 TU/mL, thus particle-to-infectivity rate was about 25. Under an electronic microscope, most rAAV particles appeared full and a few were in intermediate form. Empty particles were rarely seen. The purified rAAV-GFP stocks have been successfully used in in vitro and in vivo transfection experiments. Therefore, this new method offers a simple, rapid and cost-effective way for large-scale rAAV purification. | WU Xiaobing DONG Xiaoyan WU Zhijian CAO Hui NIU Dongbin QU Jianguo WANG Hong HOU Yunde | 2001 | Chinese Science Bulletin2001，46，6： | 21 |
| 5 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 6 | Leaf N and P stoichiometry of 57 plant species in the Karamori Mountain Ungulate Nature Reserve,Xinjiang,China显示文摘Nitrogen(N) and phosphorus(P) are the major nutrients that constrain plant growth and development,as well as the structure and function of ecosystems.Hence,leaf N and P patterns can contribute to a deep understanding of plant nutrient status,nutrient limitation type of ecosystems,plant life-history strategy and differentiation of functional groups.However,the status and pattern of leaf N and P stoichiometry in N-deficiency desert ecosystems remain unclear.Under this context,the leaf samples from 57 plant species in the Karamori Mountain Ungulate Nature Reserve,eastern Junggar Desert,China were investigated and the patterns and interrelations of leaf N and P were comparatively analyzed.The results showed that the average leaf N concentration,P concentration,and N:P ratio were 30.81 mg/g,1.77 mg/g and 17.72,respectively.This study found that the leaf N concentration and N:P ratio were significantly higher than those of studies conducted at global,national and regional scales;however,the leaf P concentration was at moderate level.Leaf N concentration was allometrically correlated with leaf P and N:P ratio across all species.Leaf N,P concentrations and N:P ratio differed to a certain extent among plant functional groups.C_4 plants and shrubs,particularly shrubs with assimilative branches,showed an obviously lower P concentration than those of C_3 plants,herbs and shrubs without assimilative branches.Shrubs with assimilative branches also had lower N concentration.Fabaceae plants had the highest leaf N,P concentrations(as well as Asteraceae) and N:P ratio;other families had a similar N,P-stoichiometry.The soil in this study was characterized by a lack of N(total N:P ratio was 0.605),but had high N availability compared with P(i.e.the available N:P ratio was 1.86).This might explain why plant leaves had high N concentration(leaf N:P ratio>16).In conclusion,the desert plants in the extreme environment in this study have formed their intrinsic and special stoichiometric characteristics in relation to their life-history strategy. | TAO Ye WU Ganlin ZHANG Yuanming ZHOU Xiaobing | 2016 | Journal of Arid Land2016，8，6： | 18 |
| 7 | Generation of a recombinant herpes simplex virus which can provide packaging function for recombinant adeno-associated virus显示文摘The generation of a recombinant HSV (rHSV) that can provide packaging function for rAAV production is described. A set of cosmids including cos48, cos28, cos6, cos14 and cos56, which represents the HSV-1 genome was used for generation of this rHSV. Rep and cap genes of AAV-2 were inserted into Xba Ⅰ site of UL2 gene on cos6, generating cos6-rcΔUL2. After being digested with Pac Ⅰ , cos6-rcΔUL2 and the other 4 cosmids were cotrans-fected into BHK-21 cells. The recombinant virus HSV1-rc/ΔUL2 carrying rep and cap genes was generated due to the homologous recombination of the 5 cosmids. The results showed that the existence of rep and cap genes on this rHSV was stable from passage to passage and the rHSV could support the packaging of rAAV either in cells transiently transfected with AAV vector or in stable cell line harboring AAV vector. Further modification of this rHSV and optimization of conditions involved in rAAV preparation may lead to a large-scale production of rAAV in the near future. | WU Zhijian, WU Xiaobing and HOU YundeState Key Laboratory for Molecular Virology and Genetic Engineering , Institute of Virology , Chinese Academy of Preventive Medicine , Beijing 100052, China Corresponding author | 1999 | Chinese Science Bulletin1999，44，8： | 15 |
| 8 | High-accuracy primary and transfer standards for radiometric calibration显示文摘The first research and experimental results obtained in China of high-accuracy radiometric calibration based on cryogenic radiometer are reported. Uncertainties of cryogenic radiometer and trap detectors at 7 wavelengths in the visible spectrum (488-786 nm) were less than 0.023% and 0.035% respectively, which proved the reasonability and possibility of establishing and transferring high-accuracy radiometric standards based on detectors. | Xiaobing Zheng Haoyu Wu Junping Zhang Yucheng Liu Wei Zhou Leyi Wang Yanli Qiao | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 9 | Distribution, features, and influence factors of the submarine topographic boundaries of the Okinawa Trough显示文摘Based on multiple types of data, the topographical features of the Okinawa Trough(OT) have been characterized and a computation method has been proposed to determine the break point of continental shelf(BOS), foot point of the continental slope(FOS), the central axial point, and the maximum depth point. A total of 48 topographical profiles that crosscut the continental slope have been used to determine the trends of the BOS and FOS(the BOS and FOS lines) in the East China Sea(ECS). The trend of central axial points in the OT has been similarly determined by analyzing 39 topographical profiles across the axis of the trough. The BOS line forms the boundary between the continental shelf and slope. In the ECS, the BOS line roughly follows the 200 m isobath, continuously in the northern and middle parts of the OT, but jumping about somewhat in the south. The FOS line is the boundary between the continental slope and the bottom of the trough. The depth of the FOS increases gradually from north to south in the OT. Intense incisions by canyons into the slope in the southern part of the trough have led to the complex distribution of FOS. Topographical profiles crosscutting the northern, middle, and southern parts of the OT exhibit features that include: a single W-shape, a composite W-shape, and a U-shape, respectively, which suggests that in the middle and northern parts of the trough the central axial points are always located on seamount peaks or ridges associated with linear seamounts, whereas in the south they are found in the center of en echelon depressions. The line formed by the central axial points is the east-west dividing line of the OT, which indicates that the trough is a natural gap that prevents the extension of ECS continental shelf to the east. The distributions of the BOS and FOS lines are influenced by fluctuation of sea levels and submarine canyons, whereas the distribution of axis lines is controlled by tectonics and deposition. | WU ZiYin LI JiaBiao JIN XiangLong SHANG JiHong LI ShouJun JIN XiaoBing | 2014 | Science China Earth Sciences2014，57，8： | 11 |
| 10 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
| 11 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 12 | Modifying the Autism Spectrum Rating Scale(6–18 years)to a Chinese Context:An Exploratory Factor Analysis显示文摘The purpose of this study was to explore the psychometric properties of the Chinese version of the autism spectrum rating scale(ASRS). We recruited 1,625community-based children and 211 autism spectrum disorder(ASD) cases from 4 sites, and the parents of all participants completed the Chinese version of the ASRS. A robust weighted least squares means and variance adjusted estimator was used for exploratory factor analysis. The3-factor structure included 59 items suitable for the current sample. The item reliability for the modi?ed Chinese version of the ASRS(MC-ASRS) was excellent. Moreover,with 60 as the cut-off point, receiver operating characteristic analysis showed that the MC-ASRS had excellent discriminate validity, comparable to that of the unmodi?ed Chinese version(UC-ASRS), with area under the curve values of 0.952(95% CI: 0.936–0.967) and 0.948(95% CI:0.930–0.965), respectively. Meanwhile, the con?rm factor analysis revealed that MC-ASRS had a better construct validity than UC-ASRS based on the above factor solution in another children sample. In conclusion, the MC-ASRS shows better ef?cacy in epidemiological screening for ASD in Chinese children. | Hao Zhou Lili Zhang Xuerong Luo Lijie Wu Xiaobing Zou Kun Xia Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 8 |
| 13 | Experimental Research on Gas-Liquid Two-Phase Spiral Flow in Horizontal Pipe显示文摘In view of the importance of gas-liquid two-phase spiral flow and the few research reports at home and abroad,the gas-liquid two-phase spiral flow patterns have been researched in a horizontal pipe with different parameters investigated by means of observation and a high-speed camera.Since the appearance of spiral flow makes the distribution of twophase flow more complicated,the flow patterns appearing in the experiments were divided into the Spiral Wavy Stratified Flow(SWS),the Spiral Bubble Flow(SB),the Spiral Slug Flow(SS),the Spiral Linear Flow(SL),the Spiral Axial Flow(SA),and the Spiral Dispersed Flow(SD) by the observations and with reference to the predecessors' research achievements.A flow pattern map has been drawn up.The influence of velocity,vane angle and vane area on flow pattern conversion boundary and pressure drop has been studied,with a solid foundation laid for the future research work. | Wang Shuli Rao Yongchao Wu Yuxian Wang Xiaobing | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，3： | 7 |
| 14 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 15 | Complete genome analysis of Ketogulonigenium sp. WB0104显示文摘Ketogulonigenium sp. may convert L-sorbose into 2-keto-L-gulonic acid, the vitamin C precursor. The genome of Ketogulonigenium sp. WB0104 consists of a circular 2765030 bp chromo- some with 61.69% G+C content and two circular plasmids of 267968 and 242707 bp. The genome contains 2727 open reading frames (ORFs). The systems of replication, transcription, translation, carbohydrate and energy metabolism are intact, but the repair system is incomplete. About 640 predicted ORFs have been found to encode transporter pro- teins, which account for about one fourth of total predicted ORFs, noticeably higher than other docu- mented bacteria. This may be due to the fact that WB0104 adapts to soil circumstance. | YANG Fan JIA Qian XIONG Zhaohui ZHANG Xiaobing WU Hongtao ZHAO Ying YANG Jian ZHU Junping DONG Jie XUE Ying SUN Lilian SHEN Yan JIN Qi | 2006 | Chinese Science Bulletin2006，51，8： | 6 |
| 16 | Long-term ex vivo monitoring of in vivo microRNA activity in liver using a secreted luciferase sensor显示文摘Technology for monitoring in vivo microRNA (miRNA) activity is extremely important for elucidating miRNA biology.However,in vivo studies of miRNA have been hampered by the lack of a convenient approach to reliably reflect real-time functional changes in miRNAs.Sensors for miRNA were developed by adding miRNA target sequences to the 3'-untranslated region of Gaussia princeps luciferase (Gluc) mRNA.These sensors were then evaluated in vitro and in vivo by measuring Gluc activity in cell supernatants and in peripheral blood.Sensors driven by the CMV promoter were effective for monitoring miR-122 in living cells,but not for the long-term monitoring of miR-122 or miR-142 in mouse liver because of CMV-promoter silencing.Replacing the CMV promoter with a CAG promoter rendered these sensors effective for the long-term monitoring of relevant liver miRNA activities.We subsequently used the CAG-promoter-based sensor for the long-term monitoring of endogenous liver miR-122,miR142 and miR-34a activities,as well as for exogenous miR-34a activity.Our study demonstrates that real-time in vivo activities of miRNAs can be continuously and conveniently detected in mouse liver using the sensors that we have developed. | WANG Gang DONG XiaoYan HU JianYang TIAN WenHong YUCHI Jie WANG Yue WU XiaoBing | 2011 | Science China(Life Sciences)2011，54，5： | 6 |
| 17 | Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells显示文摘Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始,渗入,和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里,我们发现那配对的相关 homeobox 1 (PRRX1 ) ,以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发,在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步, PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强,而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后, PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此,我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。 | Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong Kuan Tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 18 | Linear Strain-Gradient Effect on the Energy Bandgap in Bent CdS Nanowires显示文摘尽管在半导体的可能的非同类的紧张效果被调查了因为在一半上世纪和紧张坡度能每在灵活 nanostructures 的测微计是超过 1% ,我们仍然缺乏他们对精力乐队的影响的理解。这里,我们进行紧张坡度的系统的阴极射线发光光谱学研究在在低温度的有弹性地弄弯的 CdS nanowires 的导致的激子精力移动,并且发现在弄弯的 nanowires 的激子精力红移动与紧张坡度成正比,格子失真的一个索引。密度功能的计算在弄弯的 nanostructures 显示出乐队差距减小的一样的趋势并且揭示内在的机制。半导体的乐队差距上的重要线性紧张坡度效果应该在在 nanoelectronics 调节光电子的性质的方法上打开新灯。 | Qiang Fu Zi Yue Zhang Liangzhi KOU Peicai Wu Xiaobing Han Xinli Zhu Jingyun Gao Jun Xu Qing Zhao Wanlin Guo Dapeng Yu | 2011 | Nano Research2011，4，3： | 5 |
| 19 | Chinese Norms for the Autism Spectrum Rating Scale显示文摘This study aimed to establish norms for the modi?ed Chinese version of the Autism Spectrum Rating Scale(ASRS). Participants were recruited from Shanghai,Harbin, Guangzhou, and Changsha, China, and their parents and teachers were invited to complete the Chinese Parent version and the Teacher version of the ASRS. In both versions, boys had signi?cantly higher sub-scale scores and total score(T-score) by 1–3 and 4–5 points respectively, than girls(both P \ 0.001). Age had weak correlations with some sub-scores and the T-score(r ranged from-0.1859 to 0.0738), and some reached signi?cance(P \ 0.03). The correlations appeared stronger and were more common in females. The T-score based on Chinese norms ideally correlated with the score based on the United States norms in boys and girls for both versions.Norms for the Chinese version of the ASRS for children aged 6–12 years are proposed and may be helpful for screening individuals with autism spectrum disorders from the general population of children. | Hao Zhou Lili Zhang Xiaobing Zou Xuerong Luo Kun Xia Lijie Wu Yimin Wang Xiu Xu Xiaoling Ge Yong-Hui Jiang Eric Fombonne Weili Yan Yi Wang | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 20 | Assessing the Accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for Screening Autism Spectrum Disorder in Chinese Children显示文摘The reported prevalence of autism spectrum disorder(ASD) has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modi?ed Chinese version of a newly-developed ASD screening tool, the Modi?ed Chinese Autism Spectrum Rating Scales(MC-ASRS) in screening for ASD in Chi nese children aged 6–12 years, through comparison with the Social Responsiveness Scale(SRS) that has been widely used for ASD screening. We recruited the par ents/caregivers of 1588 typically-developing children and190 children with ASD aged 6–12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRSperformed as well as SRS in sensitivity, speci?city, and area-under-the-curve(both [0.95) in receiver operating characteristic analysis, with a fair false-negative rate.These results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population. | Bingrui Zhou Hao Zhou Lijie Wu Xiaobing Zou Xuerong Luo Eric Fombonne Yi Wang Weili Yan Xiu Xu | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
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