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| 1 | DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach显示文摘Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative staining.If the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is possible.However,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often challenging.Recently,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of GIST.DOG1,a membrane channel protein,is known to be overexpressed in GIST.Because the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative GISTs.KITnegative GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features histologically.We describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe anemia.Our findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs. | Takuya Wada Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 2 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 6 |
| 3 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 4 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 5 | Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients显示文摘AIM: To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients. METHODS: We studied 17 patients (15 men and 2 women, 21 lesions) with SESC in whom endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and open surgery were contraindicated from March 1999 through February 2009. None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g., liver cirrhosis, cerebral infarction, or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy. After conventional endoscopy, an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins. The lesion was then ablated by APC. We retrospectively studied the treatment time, number of APC sessions per site, complications, presence or absence of recurrence, and time to recurrence.RESULTS: The median duration of follow-up was 36 mo (range: 6-120 mo). All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱc). The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2. The median treatment time was 15 min (range: 10-36 min). The median number of treatment sessions per site was 2 (range: 1-4). The median hospital stay was 14 d (range: 5-68 d). Among the 17 patients (21 lesions), 2 (9.5%) had recurrence and underwent additional APC with no subsequent evidence of recurrence. There were no treatment-related complications, such as bleeding or perforation. CONCLUSION: APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease, as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy. | Kumiko Tahara Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Kento Nakatani Akira Naruke Myungchul Kim Wasaburo Koizumi | 2012 | World Journal of Gastroenterology2012，18，38： | 4 |
| 6 | Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Kenji Ishido Akira Naruke Tetuo Mikami Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，2： | 3 |
| 7 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 3 |
| 8 | Nanoparticles in Emissions and Atmospheric Environment: Now and Future显示文摘 | Seishiro Hirano Hiroshi Nitta Yuichi Moriguchi Shinji Kobayashi Yoshinori Kondo Kiyoshi Tanabe Takahiro Kobayashi Shinji Wakamatsu Masatoshi Morita Satoshi Yamazaki | 2003 | Journal of Nanoparticle Research (-)2003，，3： | 1 |
| 9 | Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis显示文摘AIM To clarify the histological changes associated with liver atrophy after percutaneous transhepatic portalembolization(PTPE) in pigs and humans. METHODS As a preliminary study, we performed pathological examinations of liver specimens from five pigs that had undergone PTPE in a time-dependent model of liver atrophy. In specimens from embolized lobes(EMB) and nonembolized lobes(controls), we measured the portal vein to central vein distance(PV-CV), the area and number of hepatocytes per lobule, and apoptotic activity using the terminal deoxynucleotidyl transferase dU TP nickend labeling assay. Immunohistochemical reactivities were evaluated for light chain 3(LC3) and lysosomal-associated membrane protein 2(LAMP2) as autophagy markers and for glutamine synthetase and cytochrome P450 2 E1(CYP2 E1) as metabolic zonation markers. Samples from ten human livers taken 20-36 d after PTPE were similarly examined. RESULTS PV-CVs and lobule areas did not differ between EMB and controls at day 0, but were lower in EMB than in controls at weeks 2, 4, and 6(P ≤ 0.001). Hepatocyte numbers were not significantly reduced in EMB at day 0 and week 2 but were reduced at weeks 4 and 6(P ≤ 0.05). Apoptotic activity was higher in EMB than in controls at day 0 and week 4. LC3 and LAMP2 staining peaked in EMB at week 2, with no significant difference between EMB and controls at weeks 4 and 6. Glutamine synthetase and CYP2 E1 zonation in EMB at weeks 2, 4, and 6 were narrower than those in controls. Human results were consistent with those of porcine specimens. CONCLUSION The mechanism of liver atrophy after PTPE has two histological phases: Hepatocellular atrophy is likely caused by autophagy in the first 2 wk and apoptosis thereafter. | Yasuhito Iwao Hidenori Ojima Tatsushi Kobayashi Yoji Kishi Satoshi Nara Minoru Esaki Kazuaki Shimada Nobuyoshi Hiraoka Minoru Tanabe Yae Kanai | 2017 | World Journal of Hepatology2017，9，32： | 1 |
| 10 | Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Kenji Ishido Akira Naruke Tetuo Mikami Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 11 | Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a retrospective comparison with conventional endoscopic resection in a single center显示文摘 | Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myungchul Kim Wasaburo Koizumi | 2014 | Gastric Cancer2014，，1： | 1 |
| 12 | Definitive Chemoradiation Therapy With Docetaxel, Cisplatin, and 5-Fluorouracil (DCF-R) in Advanced Esophageal Cancer: A Phase 2 Trial (KDOG 0501-P2)显示文摘 | Katsuhiko Higuchi Shouko Komori Satoshi Tanabe Chikatoshi Katada Mizutomo Azuma Hiromichi Ishiyama Tohru Sasaki Kenji Ishido Natsuya Katada Kazushige Hayakawa Wasaburo Koizumi | 2014 | International Journal of Radiation Oncology Biology Physics2014，，： | 1 |
| 13 | Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery显示文摘 | Manabu Shimomura Takao Hinoi Satoshi Ikeda Tomohiro Adachi Yasuo Kawaguchi Masakazu Tokunaga Tatsunari Sasada Hiroyuki Egi Kazuaki Tanabe Masazumi Okajima Hideki Ohdan | 2012 | Surgery2012，，： | 1 |
| 14 | Clinicopathological evaluation of duodenal well-differentiated endocrine tumors显示文摘AIM:To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors.METHODS:We examined clinicopathological characteristics in 11 consecutive patients with duodenal well-differentiated endocrine tumors treated by endoscopic therapy or surgery in our hospital from 1992 through 2007.Patients with well-differentiated endocrine tu-mors of the papilla of Vater or with gastrinoma were excluded.RESULTS:Three patients received endoscopic treatment,and 8 underwent surgery.In patients who received endoscopic treatment,the tumor diameter was less than 1.0 cm,with no histopathological evidence of lymphovascular invasion or invasion of the muscularis.There were no complications such as late bleedingor perforation after treatment.Among 8 patients with tumors less than 1.0 cm in diameter,3 underwent partial resection,and 2 underwent radical surgery.Three patients had lymphovascular invasion,1 had invasion of the muscularis,and 1 had proximal lymph node metastasis.Among 3 patients with tumors 1.0 cm or more in diameter,1 underwent partial resection,and 2 under-went radical surgery.One patient had lymphovascular invasion,with no lymph node metastasis.After treatment,all patients are alive and have remained free of metastasis and recurrence.CONCLUSION:Duodenal well-differentiated endocrine tumors less than 1.0 cm in diameter have a risk of lym-phovascular invasion,invasion of the muscularis,and lymph node metastasis,irrespective of procedural prob-lems. | Kenji Ishido Satoshi Tanabe Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Wasaburo Koizumi Tetsuo Mikami | 2010 | World Journal of Gastroenterology2010，16，36： | 1 |
| 15 | A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms (KDOG 0901)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Chikatoshi Katada Tohru Sasaki Kenji Ishido Akira Naruke Natsuya Katada Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 16 | Advances in reduced port laparoscopic liver resection显示文摘 | Daisuke Ban Atsushi Kudo Takumi Irie Takanori Ochiai Arihiro Aihara Satoshi Matsumura Shinji Tanaka Minoru Tanabe | 2015 | Asian J Endosc Surg2015，，1： | 1 |
| 17 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 1 |
| 18 | Recommended sedation and intraprocedural monitoring for gastric endoscopic submucosal dissection显示文摘 | Tohru Sasaki Satoshi Tanabe Kenji Ishido Mizutomo Azuma Chikatoshi Katada Katsuhiko Higuchi Wasaburo Koizumi | 2013 | Digestive Endoscopy2013，，： | 1 |
| 19 | A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Chikatoshi Katada Tohru Sasaki Kenji Ishido Akira Naruke Natsuya Katada Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 20 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 1 |
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