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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review显示文摘A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver tumor.As diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the liver.The lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively rare.Moreover,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of PEComa.In addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to enlarge.Therefore,a PEComa is difficult to diagnose.We conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors. | Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani | 2015 | World Journal of Gastroenterology2015，21，17： | 20 |
| 3 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 4 | 大鼠急性内囊出血后血液流变特性经时变化的研究显示文摘目的观察大鼠急性内囊出血后血液流变特性的经时变化,总结变化规律,分析其对微循环的影响。方法将大鼠随机分为假手术组及出血组,后者又分为出血后3、6、12、24h四个亚组,每组6只。尾尖剪断取自体血0.1ml定位注射至大鼠右侧内囊,假手术组除不注血外,其余操作同出血组。假手术组即刻取血,出血组分别于各时间点取血做血液流变学检测。结果各出血组与假手术组比较,血液流变学各指标总体水平呈上升趋势(P<0.05);出血各组间比较,全血低切黏度在出血后3~12h明显升高,全血高切黏度、血浆黏度在24h升高最明显,红细胞压积(HCT)、红细胞聚集指数(EAI)及纤维蛋白原(Fib)含量随时间推移逐渐升高,前者在24h达高峰,后两者高峰时间为出血后12~24h。结论大鼠急性内囊出血后不同时段的血液流变学参数发生了有统计学意义的改变,将影响中枢神经系统的微循环功能。 | 张丽敏 金学隆 王世忠 李之烨 Mizoguchi Kazushige | 2009 | 中国微循环2009，13，3： | 5 |
| 5 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 6 | Aberrant Eph B/ephrin-B expression in experimental gastric lesions and tumor cells显示文摘AIM: To determine whether the expression profiles of Eph B receptor and ephrin-B ligand can be used as markers for dysplastic/oncogenic transformation in gastric mucosa.METHODS: The protein expression and localization ofEph B and ephrin-B in normal, ulcerated regenerating, and dysplastic gastric mucosa were examined in a rat experimental model by immunolabeling, and m RNA expression was assessed in four human gastric carcinoma cell lines by reverse transcription-polymerase chain reaction.RESULTS: Ephrin-B- and Eph B-expressing regions were divided along the pit-gland axis in normal gastric units. Eph B2 was transiently upregulated in the experimental ulcer, and its expression domain extended to gastric pits and/or the luminal surface where ephrin-B-expressing pit cells reside. Eph B2, B3, and B4 and ephrin-B1 were coexpressed in the experimental gastric dysplasia, and more than one ligand-receptor pair was highly expressed in each of the gastric carcinoma cell lines.CONCLUSION: Robust and stable coexpression of Eph B and ephrin-B is a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines as compared to normal gastric and ulcerated regenerating epithelia. Thus, Eph B/ephrin-B may be a useful marker combination for dysplastic/oncogenic transformation in gastric cancer. | Shintaro Uchiyama Noritaka Saeki Kazushige Ogawa | 2015 | World Journal of Gastroenterology2015，21，2： | 3 |
| 7 | Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012显示文摘 | Hirotaka Ohara Kazuichi Okazaki Hirohito Tsubouchi Kazuo Inui Shigeyuki Kawa Terumi Kamisawa Susumu Tazuma Kazushige Uchida Kenji Hirano Hitoshi Yoshida Takayoshi Nishino Shigeru Ko Nobumasa Mizuno Hideaki Hamano Atsushi Kanno Kenji Notohara Osamu Hasebe | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，5： | 3 |
| 8 | Long-term outcomes of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP) has been considered a favorable-prognosis disease; however,currently,there is limited information on natural course of AIP during long-term follow-up. Recently published studies regarding the long-term outcomes of AIP has demonstrated the developments of pancreatic stone formation,exocrine insufficiency,and endocrine insufficiency are observed in 5%-41%,34%-82%,and 38%-57% of patients having the disease. Furthermore,the incidence rate of developing pancreatic cancer ranges from 0% to 4.8% during the long-term followup. The event of death from AIP-related complications other than accompanying cancer is likely to be rare. During follow-up of AIP patients,careful surveillance for not only relapse of the disease but also development of complications at regular intervals is needed. | Tsukasa Ikeura Hideaki Miyoshi Masaaki Shimatani Kazushige Uchida Makoto Takaoka Kazuichi Okazaki | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 9 | Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors显示文摘AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon therapy.The patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 groups.Then,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing HCC.RESULTS:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 group.The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis. | Hiroshi Matsumura Kazushige Nirei Hitomi Nakamura Teruhisa Higuchi Yasuo Arakawa Masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 10 | Establishment of a serum IgG 4 cut‐off value for the differential diagnosis of IgG 4‐related sclerosing cholangitis: A J apanese cohort显示文摘 | Hirotaka Ohara Takahiro Nakazawa Shigeyuki Kawa Terumi Kamisawa Tooru Shimosegawa Kazushige Uchida Kenji Hirano Takayoshi Nishino Hideaki Hamano Atsushi Kanno Kenji Notohara Osamu Hasebe Takashi Muraki Etsuji Ishida Itaru Naitoh Kazuichi Okazaki | 2013 | J Gastroenterol Hepatol2013，，7： | 2 |
| 11 | Epinephrine sprayed on the papilla for prevention of post-ERCP pancreatitis显示文摘 | Mitsunobu Matsushita Hiroshi Takakuwa Naoto Shimeno Kazushige Uchida Akiyoshi Nishio Kazuichi Okazaki | 2009 | Journal of Gastroenterology2009，，1： | 2 |
| 12 | Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?显示文摘 | Hiroshi Onishi Hiroki Shirato Yasushi Nagata Masahiro Hiraoka Masaharu Fujino Kotaro Gomi Katsuyuki Karasawa Kazushige Hayakawa Yuzuru Niibe Yoshihiro Takai Tomoki Kimura Atsuya Takeda Atsushi Ouchi Masato Hareyama Masaki Kokubo Takuyo Kozuka Takuro Arimo | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 2 |
| 13 | Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘 | Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka | 2007 | Cancer Chemotherapy and Pharmacology2007，，6： | 2 |
| 14 | “IgG4 Cholangiopathy - current concept, diagnosis and pathogenesis “显示文摘 | Kazuichi Okazaki Kazushige Uchida Masanori Koyabu Hideaki Miyoshi Tsukasa Ikeura Makoto Takaoka | 2014 | Journal of Hepatology2014，，： | 2 |
| 15 | Current concept and diagnosis of IgG4-related disease in the hepato-bilio-pancreatic system显示文摘 | Kazuichi Okazaki Kazushige Uchida Tsukasa Ikeura Makoto Takaoka | 2013 | Journal of Gastroenterology2013，，3： | 2 |
| 16 | Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘 | Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka | 2007 | Cancer Chemotherapy and Pharmacology2007，，6： | 1 |
| 17 | Design and Implementation of NAREGI SuperScheduler Based on the OGSA Architecture显示文摘NAREGI 在 2003-2007 期间是一个 5 年的日本国家格子工程,目的是其首领开发一套格子中间件用作未来电子科学的一个基础。NAREGIalso 试图在格子中间件的标准化带路,基于 OGSA 建筑学。Itssuper 调度程序基于建议 OGSA 他们建筑学,因为它成为在 OGSA-EMSarchitecture 文件 v.1.0 以内实现记录部件关系的首先工作的实现。通过在设计和实现的努力和经验,记录 OGSA 他们建筑学是相当可行的,这被证实了,但是将要求精炼和速度改进的重要数量使结束它的详细说明。Thesuper 调度程序也越过多重地点支持合作分配支持执行到对面的基于 ofgrid 的 MPI 用机器制造的自动化执行。如此的资源分配要求在没在当前的 OGSA 他们建筑学盖住的 OGSA 他们部件之间的复杂相互作用,其中一些是重要的。总的来说,工作与 OGSA 他们安排证明了不仅工作,而且那它的工作分配和执行时间在合理界限以内。 | Satoshi Matsuoka Masayuki Hatanaka Yasumasa Nakano Yuji Iguchi Toshio Ohno Kazushige Saga Hidemoto Nakada | 2006 | Journal of Computer Science & Technology2006，21，4： | 1 |
| 18 | Effective 'Coca-Cola' Therapy for Phytobezoars 显示文摘 | MITSUNOBU MATSUSHITA TOSHIRO FUKUI KAZUSHIGE UCHIDA | 2008 | Internal Medicine2008，，47： | 1 |
| 19 | Living cationic polymerization of isobutyl vinyl ether initiated by the trimethylsilyl iodide/zinc iodide system显示文摘 | Mitsuo Sawamoto Masami Kamigaito Kazushige Kojima Toshinobu Higashimura | 1988 | Polymer Bulletin1988，，4： | 1 |
| 20 | Ribbon-like variegation of Pinus radiata using the adsorption of dyes in the capillary penetration process显示文摘 | KAZUSHIGE A SHIGEKI Y | 2003 | Mokuzai Gakkaishi2003，49，1： | 1 |
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