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| 1 | DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach显示文摘Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative staining.If the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is possible.However,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often challenging.Recently,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of GIST.DOG1,a membrane channel protein,is known to be overexpressed in GIST.Because the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative GISTs.KITnegative GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features histologically.We describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe anemia.Our findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs. | Takuya Wada Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 2 | Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment显示文摘Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required. | Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，8： | 4 |
| 3 | Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients显示文摘AIM: To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients. METHODS: We studied 17 patients (15 men and 2 women, 21 lesions) with SESC in whom endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and open surgery were contraindicated from March 1999 through February 2009. None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g., liver cirrhosis, cerebral infarction, or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy. After conventional endoscopy, an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins. The lesion was then ablated by APC. We retrospectively studied the treatment time, number of APC sessions per site, complications, presence or absence of recurrence, and time to recurrence.RESULTS: The median duration of follow-up was 36 mo (range: 6-120 mo). All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱc). The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2. The median treatment time was 15 min (range: 10-36 min). The median number of treatment sessions per site was 2 (range: 1-4). The median hospital stay was 14 d (range: 5-68 d). Among the 17 patients (21 lesions), 2 (9.5%) had recurrence and underwent additional APC with no subsequent evidence of recurrence. There were no treatment-related complications, such as bleeding or perforation. CONCLUSION: APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease, as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy. | Kumiko Tahara Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Kento Nakatani Akira Naruke Myungchul Kim Wasaburo Koizumi | 2012 | World Journal of Gastroenterology2012，18，38： | 4 |
| 4 | Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Kenji Ishido Akira Naruke Tetuo Mikami Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，2： | 3 |
| 5 | Narrow Band Imaging: A New Diagnostic Approach to Visualize Angiogenesis in Superficial Neoplasia显示文摘 | Manabu Muto Chikatoshi Katada Yasushi Sano Shiegaki Yoshida | 2005 | Clinical Gastroenterology and Hepatology2005，，7： | 2 |
| 6 | Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Kenji Ishido Akira Naruke Tetuo Mikami Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，2： | 1 |
| 7 | Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a retrospective comparison with conventional endoscopic resection in a single center显示文摘 | Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myungchul Kim Wasaburo Koizumi | 2014 | Gastric Cancer2014，，1： | 1 |
| 8 | Definitive Chemoradiation Therapy With Docetaxel, Cisplatin, and 5-Fluorouracil (DCF-R) in Advanced Esophageal Cancer: A Phase 2 Trial (KDOG 0501-P2)显示文摘 | Katsuhiko Higuchi Shouko Komori Satoshi Tanabe Chikatoshi Katada Mizutomo Azuma Hiromichi Ishiyama Tohru Sasaki Kenji Ishido Natsuya Katada Kazushige Hayakawa Wasaburo Koizumi | 2014 | International Journal of Radiation Oncology Biology Physics2014，，： | 1 |
| 9 | Clinicopathological evaluation of duodenal well-differentiated endocrine tumors显示文摘AIM:To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors.METHODS:We examined clinicopathological characteristics in 11 consecutive patients with duodenal well-differentiated endocrine tumors treated by endoscopic therapy or surgery in our hospital from 1992 through 2007.Patients with well-differentiated endocrine tu-mors of the papilla of Vater or with gastrinoma were excluded.RESULTS:Three patients received endoscopic treatment,and 8 underwent surgery.In patients who received endoscopic treatment,the tumor diameter was less than 1.0 cm,with no histopathological evidence of lymphovascular invasion or invasion of the muscularis.There were no complications such as late bleedingor perforation after treatment.Among 8 patients with tumors less than 1.0 cm in diameter,3 underwent partial resection,and 2 underwent radical surgery.Three patients had lymphovascular invasion,1 had invasion of the muscularis,and 1 had proximal lymph node metastasis.Among 3 patients with tumors 1.0 cm or more in diameter,1 underwent partial resection,and 2 under-went radical surgery.One patient had lymphovascular invasion,with no lymph node metastasis.After treatment,all patients are alive and have remained free of metastasis and recurrence.CONCLUSION:Duodenal well-differentiated endocrine tumors less than 1.0 cm in diameter have a risk of lym-phovascular invasion,invasion of the muscularis,and lymph node metastasis,irrespective of procedural prob-lems. | Kenji Ishido Satoshi Tanabe Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Wasaburo Koizumi Tetsuo Mikami | 2010 | World Journal of Gastroenterology2010，16，36： | 1 |
| 10 | A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms (KDOG 0901)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Chikatoshi Katada Tohru Sasaki Kenji Ishido Akira Naruke Natsuya Katada Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 11 | Lunar cratering chro nology:Statistical fluctuation of crater production frequency and its effect on age determination显示文摘 | Morota T Haruyama J Chikatoshi H | | 0，，04： | 1 |
| 12 | High sensitivity TSS prediction: estimates of locations where TSS cannot occur显示文摘 | Ulf Schaefer Rimantas Kodzius Chikatoshi Kai Jun Kawai Piero Carninci Yoshihide Hayashizaki Vladimir B BaSic | 2010 | PLoSONE2010，5，13： | 1 |
| 13 | Narrow Band Imaging: A New Diagnostic Approach to Visualize Angiogenesis in Superficial Neoplasia显示文摘 | Manabu Muto Chikatoshi Katada Yasushi Sano Shiegaki Yoshida | 2005 | Clinical Gastroenterology and Hepatology2005，，7： | 1 |
| 14 | Recommended sedation and intraprocedural monitoring for gastric endoscopic submucosal dissection显示文摘 | Tohru Sasaki Satoshi Tanabe Kenji Ishido Mizutomo Azuma Chikatoshi Katada Katsuhiko Higuchi Wasaburo Koizumi | 2013 | Digestive Endoscopy2013，，： | 1 |
| 15 | A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Chikatoshi Katada Tohru Sasaki Kenji Ishido Akira Naruke Natsuya Katada Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 16 | The quantitative determination of cyanide in blood using ECD/ GC 显示文摘 | kazuo Matsubara Hiroshi Shiono | 1988 | JpnJ LegalMed1988，，： | 1 |
| 17 | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells显示文摘 | Tomohiro Omura Masaru Asari Joe Yamamoto Kumiko Oka Chisato Hoshina Chikatoshi Maseda Toshio Awaya Yoshikazu Tasaki Hiroshi Shiono Atsushi Yonezawa Satohiro Masuda Kazuo Matsubara Keiko Shimizu | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 18 | A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms (KDOG 0901)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Chikatoshi Katada Tohru Sasaki Kenji Ishido Akira Naruke Natsuya Katada Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 19 | CYFRA 21-1 asa disease severity marker for autoimmune pulmonary alve-olar proteinosis显示文摘 | Torn A Yoshikazu I Chikatoshi S | 2013 | Respirology2013，85，11： | 1 |
| 20 | Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a retrospective comparison with conventional endoscopic resection in a single center显示文摘 | Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myungchul Kim Wasaburo Koizumi | 2014 | Gastric Cancer2014，，： | 1 |
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