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| 1 | Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions显示文摘AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(RASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVR) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major RASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVR at 12 wk after treatment completion(SVR12).RESULTS The overall SVR12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVR12. There were no significant differences in SVR12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVR12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of < 6.0 log IU/m L(P < 0.001). The SVR12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P < 0.001). The L31 substitution-positive group showed a lower SVR12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVR12 and had available pretreatment and post-treatment sera had additional RASs in NS3:D168, NS5:L31, and Y93 substitution at treatment failure.CONCLUSION Combination of DCV and ASV is associated with a high SVR rate. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure. | Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Toshihide Shima Yoshito Itoh | 2017 | World Journal of Hepatology2017，9，25： | 3 |
| 2 | Endoscopic management of Dieulafoy's lesion using Isoamyl-2-cyanoacrylate显示文摘Dieulafoy's lesion (DL) is a rare but important cause of obscure gastrointestinal bleeding that may be over-looked during diagnostic endoscopy. Mortality rates are similar to those of other causes for gastrointestinal bleeding. Diagnosis by upper endoscopy is the modal-ity of choice during acute bleeding. In the absence of active bleeding, the lesion resembles a raised nipple or visible vessel. There are no guidelines regarding effective selective therapy for DL, when diagnosed, en-doscopist experience is the major determinant of the treatment strategy. Following our strategy, an expert endoscopist with a skilled assistant should have a high rate of successful DL diagnosis when an obscured gas-trointestinal lesion is suspected. Cyanoacryltes com-pounds have been used successfully in management of Gastric varices and DLs. To our knowledge, there have been no previous reports regarding use of isoamyl-2-cyanoacrylate (AMCRYLATE ; Concord Drugs Ltd.,Hyderabad, India) as an effective therapy for gastric DL without serious complications. In our case study, Isoamyl-2-cyanoacrylate (AMCRYLATE) was effective and safe for treating DL. Surgical wedge resection of the lesion should be considered as a therapeutic option if endoscopic therapy fails. | Abd Elrazek M Aly Abd Elrazek Nakamura Yoko Moriguchi Hiroki Mohamed Afify Mohamed Asar Badr Ismael Magdy Salah | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 3 |
| 3 | Erythropoietin -induced proliferation of gastric mucosal cells显示文摘瞄准:在胃的标本上分析红细胞生成素受体的本地化并且用一个猪的胃的上皮的房间文化模型在正常胃的上皮的增长上描绘红细胞生成素的效果。方法:红细胞生成素受体被 RT-PCR,西方的弄污和 immunohistochermistry 检测。有教养的胃的粘膜房间上的红细胞生成素的生长刺激效果被 ELISA 用 bromodeoxyuridine (BrdU ) 决定。结果:红细胞生成素受体在有教养的猪的胃的粘膜上皮细胞上被检测。红细胞生成素受体也在胃的粘膜上皮的底组织化学地被检测。BrdU 试金由红细胞生成素的管理在有教养的猪的胃的粘膜上皮细胞的生长潜力表明了剂量依赖者增加,以及这些效果被反的管理禁止 -- 红细胞生成素抗体(P<0.01 ) 。结论:这些调查结果显示红细胞生成素有一个潜力增殖经由红细胞生成素的胃的粘膜上皮受体。 | Kazuro Itoh Yoshio Sawasaki Kyoko Takeuchi Shingo Kato Nobuhiro Imai Yoichiro Kato Noriyuki Shibata Makio Kobayashi Yoshiyuki Moriguchi Masato Higuchi Fumio Ishihata Yushi Sudoh Soichiro Miura | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 4 | Expression analysis of anthocyanin biosynthetic genes in apple skin: Effect of UV-B and temperature显示文摘 | Benjamin Ewa Ubi Chikako Honda Hideo Bessho Satoru Kondo Masato Wada Shozo Kobayashi Takaya Moriguchi | 2005 | Plant Science2005，，3： | 2 |
| 5 | Bud endodormancy in deciduous fruit trees:advances and prospects显示文摘Bud endodormancy is a complex physiological process that is indispensable for the survival,growth,and development of deciduous perennial plants.The timely release of endodormancy is essential for flowering and fruit production of deciduous fruit trees.A better understanding of the mechanism of endodormancy will be of great help in the artificial regulation of endodormancy to cope with climate change and in creating new cultivars with different chilling requirements.Studies in poplar have clarified the mechanism of vegetative bud endodormancy,but the endodormancy of floral buds in fruit trees needs further study.In this review,we focus on the molecular regulation of endodormancy induction,maintenance and release in floral buds of deciduous fruit trees.We also describe recent advances in quantitative trait loci analysis of chilling requirements in fruit trees.We discuss phytohormones,epigenetic regulation,and the detailed molecular network controlling endodormancy,centered on SHORT VEGETATIVE PHASE(SVP)and Dormancy-associated MADS-box(DAM)genes during endodormancy maintenance and release.Combining previous studies and our observations,we propose a regulatory model for bud endodormancy and offer some perspectives for the future. | Qinsong Yang Yuhao Gao Xinyue Wu Takaya Moriguchi Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 2 |
| 6 | Mode of action of the anti-influenza virus activity of plant flavonoid, 5,7,4'- trihydroxy - 8 - methoxyflavone, from the roots of Scutellaria baicalensis 显示文摘 | Nagai T Moriguchi R Suzuki Y | 1995 | AntiviRal Res1995，26，1： | 1 |
| 7 | Management strategies using pharmacogenomics in patients with severe HCV-1b infection:a decision analysis显示文摘 | Uemura T Kobayashi M | 2002 | Hepatology2002，36，： | 1 |
| 8 | Do the cardiac glands exist in the cow显示文摘 | Imai M Shibata T Moriguchi K | 1990 | Okajimas Folia Anat Jpan1990，67，5： | 1 |
| 9 | Hepatocyte growth factor (HGF) as a potential index of severity of hypertension显示文摘 | Morishita R Moriguchi A Higaki J | 1999 | Hypertens Res1999，22，5： | 1 |
| 10 | Levels and role of sucrose synthase accumulation in fruit of Asian pear显示文摘 | MORIGUCHI T ABE K YAMAKI S | 1992 | J Amer Soc Hort Sci1992，117，2： | 1 |
| 11 | Opposing action of angiotensin-(1-7) and angiotensin in the brain of transgenic hypertensive rats显示文摘 | Moriguchi A Tallant EA Matsumura K | 1995 | Hypertension1995，25，6： | 1 |
| 12 | Purification and characterization of sucrose synthase from peach fruit显示文摘 | Moriguchi T Yamaki S | 1988 | Plant Cell Physiol1988，29，8： | 1 |
| 13 | Distinct domains of mouse dishevelled are responsible for the c-jun N-terminal kinase/ stress-activated protein kinase activation and the axis formation in vertebrates显示文摘 | Moriguchi T Kawachi K Kamakura S | 1999 | J Biol Chem1999，274，30： | 1 |
| 14 | Preparation and regeneration of proto plasts from mycelia of Morchella 显示文摘 | MORIGUCHI M KTEGAWA S | 1985 | Agric Biol Chem1985，49，9： | 1 |
| 15 | Body mass index (BMI) is a reliable index to estimate obesity as a risk factor for deteriorating health显示文摘 | Kato M Shimazu M Moriguchi S | 1996 | Tokushima J Exp Med1996，43，12： | 1 |
| 16 | N-acetyl-beta-Dglucosaminidase (NAG) as the most sensitive marker of tubular dysfunction for monitoring residents innon-polluted areas显示文摘 | Moriguchi J Inoue Y Kamiyama S | 2009 | Toxicol Lett2009，190，： | 1 |
| 17 | In vivo expression patterns of Survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma显示文摘 | Takashima H Nakajima T Moriguchi M | 2005 | Laver Int2005，25，1： | 1 |
| 18 | Methyl-D-mannopyranoside-responsive release of microcapsulated glucoamylase 显示文摘 | Shimada A Shinohara K Moriguchi K | 1999 | Journal of Bioscience and Bioengineering1999，87，4： | 1 |
| 19 | Levels and role of sucrose synthase, sucrose-phosphate synthase and acid invertase in sucrose accumulation in fruit of Asianpear显示文摘 | MORIGUCHI T ABE K SANADA T YAMAKI S | 1992 | J Am Soc Hortic Sci1992，117，： | 1 |
| 20 | An efficient method for developing SNP markers based on EST data combined with high resolution melting (HRM) analysis 显示文摘 | Ujino-Ihara T Taguchi Y Moriguchi Y | 2010 | BMC Res Notes2010，3，： | 1 |
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