|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review显示文摘A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver tumor.As diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the liver.The lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively rare.Moreover,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of PEComa.In addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to enlarge.Therefore,a PEComa is difficult to diagnose.We conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors. | Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani | 2015 | World Journal of Gastroenterology2015，21，17： | 20 |
| 3 | Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors显示文摘AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon therapy.The patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 groups.Then,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing HCC.RESULTS:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 group.The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis. | Hiroshi Matsumura Kazushige Nirei Hitomi Nakamura Teruhisa Higuchi Yasuo Arakawa Masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 4 | Cardiac memory in patients with intermittent Wolff-Parkinson-White syndrome 显示文摘 | Nirei T Kasanuki H Ohnishi S | 1997 | J Electrocardiol1997，30，4： | 1 |
| 5 | Iron loss analysis of moving-coil- type linear DC motor显示文摘 | Nirei M Tang Y Mizuno T | 2000 | Sensors and Actuators2000，81，： | 1 |
| 6 | Cardiac memory in patients with intermittent Wolff-Parkinson-White syndrome显示文摘 | Nirei T Kasanuki H Ohnishi S | 1997 | J Electrocardiol1997，30，4： | 1 |
| 7 | Effect of an adzuki bean extract on hepatic anti-oxidant enzyme mRNAs in D-galactosamine-treated rats 显示文摘 | Ohba K Nirei M Watanabe S | 2005 | Biosci Biotechnol Biochem2005，69，10： | 1 |
| 8 | Idiopathic Ventricular Fibrillation Induced With Vagal Activity in Patients Without Obvious Heart Disease显示文摘 | Hiroshi Kasanuki Satoshi Ohnishi Masato Ohtuka Naoki Matsuda Takashi Nirei Reiko Isogai Morio Shoda Yukari Toyoshima Saichi Hosoda | 1997 | Circulation1997，，9： | 1 |
| 9 | Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer显示文摘 | Yasuda K Nirei T Tsuno NH | 2011 | Cancer Sci2011，102，7： | 1 |
| 10 | Angular error analysis of an 8X-VR resolver with an eccentric rotor 显示文摘 | NIREI M YANANOTO Y KITAZAWA K | 2002 | Journal of Magnetism and Magnetic Materials2002，24，25： | 1 |
| 11 | Density of CD4( + ) and CD8 ( + ) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer显示文摘 | Yasuda K Nirei T Sunami E | 2011 | Radiat Oncol2011，6，： | 1 |
| 12 | Angular error analysis of an 8X - VR resolver with an eccentric rotor显示文摘 | NIREI M YANANOTO Y KITAZAWA K | 2002 | Journal of Magnetism and Magnelic Materials2002，24，25： | 1 |
| 13 | Intratumoral in-jection of interleukin-2 augments the local and abscopaleffects of radiotherapy in murine rectal cancer 显示文摘 | Yasuda K Nirei T Tsuno NH | 2011 | Cancer Sci2011，102，7： | 1 |
| 14 | Influence of Occult Hepatitis B Virus Coinfection on the Incidence of Fibrosis and Hepatocellular Carcinoma in Chronic Hepatitis C显示文摘 | Matsuoka Shunichi Nirei Kazushige Tamura Akinori Nakamura Hitomi Matsumura Hiroshi Oshiro Shuu Arakawa Yasuo Yamagami Hiroaki Tanaka Naohide Moriyama Mitsuhiko | 2009 | Intervirology2009，，5： | 1 |
| 15 | Density of CD4+and CD8+T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy(CRT)for rectal cancer显示文摘 | Yasuda K Nirei T Sunami E | 2011 | Radiat Oncol2011，6，： | 1 |
| 16 | Influence of Occult Hepatitis B Virus Coinfection on the Incidence of Fibrosis and Hepatocellular Carcinoma in Chronic Hepatitis C显示文摘 | Matsuoka Shunichi Nirei Kazushige Tamura Akinori Nakamura Hitomi Matsumura Hiroshi Oshiro Shuu Arakawa Yasuo Yamagami Hiroaki Tanaka Naohide Moriyama Mitsuhiko | 2009 | Intervirology2009，，5： | 1 |
| 17 | Effect of an adzuki bean extract on hepatic anti-oxidantenzyme mRNAs in D galactosamine-treated rats显示文摘 | Ohba K Nirei M Watanabe S | 2005 | Bioscience Biotechnology Biochemistry2005，69，10： | 1 |
| 18 | Intratumoral injection of in-terleukin-2 augments the local and abscopal effects of radiothera-py in murine rectal cancer显示文摘 | Yasuda K Nirei T Tsuno NH | 2011 | Cancer Sci2011，102，7： | 1 |
| 19 | Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition显示文摘 | Kumiko Hongo Nelson H. Tsuno Kazushige Kawai Kazuhito Sasaki Manabu Kaneko Masaya Hiyoshi Koji Murono Noriko Tada Takako Nirei Eiji Sunami Koki Takahashi Hirokazu Nagawa Joji Kitayama Toshiaki Watanabe | 2012 | Journal of Surgical Research2012，，： | 1 |
| 20 | Pharmacological profile of FR 139317,a novel, potent endothelin ETA receptor antagonist显示文摘 | Nirei H Shoubo M | 1993 | J Pharmacol Exp Ther1993，264，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员