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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 3 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 2 |
| 4 | Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis显示文摘 | Haruya Ishiguro Shoichi Saito Hiroo Imazu Hiroyuki Aihara Tomohiro Kato Hisao Tajiri Cristiano Spada | 2011 | Gastroenterology Research and Practice2011，，： | 2 |
| 5 | Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse显示文摘 | Hitoshi Yoshiji Shigeki Kuriyama Junichi Yoshii Yasuhide Ikenaka Ryuichi Noguchi Toshiya Nakatani Hirohisa Tsujinoue Koji Yanase Tadashi Namisaki Hiroo Imazu Hiroshi Fukui | 2002 | Hepatology2002，，4： | 1 |
| 6 | Diagnostic approach using endosonography guided fine needle aspiration for lymphadenopathy in primary sclerosing cholangitis显示文摘We report a case of primary sclerosing cholangitis (PSC) with benign lyphadenopathy which was diagnosed with endosonography guided fine needle aspiration (EUS-FNA). A 65-year-old woman was admitted to Jikei University Hospital with severe jaundice. Although endoscopic retrograde cholangiography and liver biopsy revealed the findings consistent with PSC, abdominal computed tomography revealed numerous large perihepatic lymph nodes with a maximum diameter of more than 3 cm. Therefore, EUS-FNA was done in order to exclude malignant lymphadenopathy, and adequate specimens obtained by EUS-FNA showed reactive hyperplasia of lymphnode. The patients were scheduled to undergo liver transplantation. | Shintaro Tsukinaga Hiroo Imazu Yujiro Uchiyama Hiroshi Kakutani Akira Kuramoti Masayuki Kato Keisuke Kanazawa Tsuyoshi Kobayashi Yasuyuki Searashi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 7 | Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma显示文摘 | Hitoshi Yoshiji Shigeki Kuriyama Junichi Yoshii Yasuhide Ikenaka Ryuichi Noguchi Daniel J. Hicklin James Huber Toshiya Nakatani Hirohisa Tsujinoue Koji Yanase Hiroo Imazu Hiroshi Fukui | 2002 | Hepatology2002，，4： | 1 |
| 8 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 1 |
| 9 | Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatment显示文摘 | Akira Kuramochi Hiroo Imazu Hiroshi Kakutani Yujiro Uchiyama Shoryoku Hino Mitsuyoshi Urashima | 2007 | Journal of Gastroenterology2007，，3： | 1 |
| 10 | Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differentiation of autoimmune pancreatitis from pancreatic carcinoma显示文摘 | Hiroo Imazu Keisuke Kanazawa Naoki Mori Keiichi Ikeda Hiroshi Kakutani Kazuki Sumiyama Shoryoku Hino Tiing Leong Ang Salem Omar Hisao Tajiri | 2012 | Scandinavian Journal of Gastroenterology2012，，7： | 1 |
| 11 | Contrast-enhanced harmonic EUS with novel ultrasonographic contrast (Sonazoid) in the preoperative T-staging for pancreaticobiliary malignancies显示文摘 | Hiroo Imazu Yujiro Uchiyama Kazuhiro Matsunaga Kei-ichi Ikeda Hiroshi Kakutani Yoshihiro Sasaki Kazuki Sumiyama Tiing Leong Ang Salem Omar Hisao Tajiri | 2010 | Scandinavian Journal of Gastroenterology2010，，6： | 1 |
| 12 | Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatment显示文摘 | Akira Kuramochi Hiroo Imazu Hiroshi Kakutani Yujiro Uchiyama Shoryoku Hino Mitsuyoshi Urashima | 2007 | Journal of Gastroenterology2007，，3： | 1 |
| 13 | Is it safe to perform endoscopic band ligation for the duodenum? A pilot study in ex vivo porcine models显示文摘 | Hiroshi Kakutani Shigemasa Sasaki Kaoru Ueda Kazuki Takakura Kazuki Sumiyama Hiroo Imazu Syoryoku Hino Muneo Kawamura Hisao Tajiri | 2012 | Minimally Invasive Therapy & Allied Technologies2012，，2： | 1 |
| 14 | Is it safe to perform endoscopic band ligation for the duodenum? A pilot study in ex vivo porcine models显示文摘 | Hiroshi Kakutani Shigemasa Sasaki Kaoru Ueda Kazuki Takakura Kazuki Sumiyama Hiroo Imazu Syoryoku Hino Muneo Kawamura Hisao Tajiri | 2012 | Minimally Invasive Therapy & Allied Technologies2012，，2： | 1 |
| 15 | Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differentiation of autoimmune pancreatitis from pancreatic carcinoma显示文摘 | Hiroo Imazu Keisuke Kanazawa Naoki Mori Keiichi Ikeda Hiroshi Kakutani Kazuki Sumiyama Shoryoku Hino Tiing Leong Ang Salem Omar Hisao Tajiri | 2012 | Scandinavian Journal of Gastroenterology2012，，7： | 1 |
| 16 | Interferon treatment of chronic hepatitis C in patients with hemophilia or von Willebrand’s disease in Japan显示文摘 | Masahide Yoshikawa Hiroshi Fukui Hideyuki Kojima Hitoshi Yoshiji Takemi Sakamoto Hiroo Imazu Toshiya Nakanani Yoshinobu Matsumura Shigeki Kuriyama Junichi Yamao Masato Uemura Akira Takaya Tadasu Tsujii Midori Shima Akira Yoshioka | 1995 | Journal of Gastroenterology1995，，3： | 1 |
| 17 | Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions显示文摘 | shigeo koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Yuko Kamata Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，9： | 1 |
| 18 | Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe:In vivo mouse pancreatic ductal adenocarcinoma model显示文摘Background:Ultrasound-targeted microbubble destruction(UTMD)induces cellular inflow of drugs at low intensity,while high intensity eradicates tumor vessels.Since vascular endothelial growth factor receptor 2(VEGFR2)is highly expressed in pancreatic ductal adenocarcinoma(PDAC),VEGFR2-targeted microbubble(MB)might additionally increase the tissue specificity of drugs and thus improve antitumor effects.In addition,fixing the dual pulse intensity could maximize MB properties.This study evaluated the one-off(experiment 1)and cumulative(experiment 2)treatment effect of UTMD by regulating the dual pulse output applied to PDAC using VEGFR2-targeted MB.Methods:C57BL/6 mice inoculated with Pan-02 cells were allocated to five groups:VEGFR2-targeted MB+gemcitabine(GEM),VEGFR2-targeted MB,non-targeted MB+GEM,GEM,and control groups.After injection of GEM or GEM and either VEGFR2-targeted or non-targeted MB,UTMD was applied for several minutes at low intensity followed by high intensity application.In experiment 1,mice were treated by the protocol described above and then euthanized immediately or at the tumor diameter doubling time(TDT).In experiment 2,the same protocol was repeated weekly and mice were euthanized at TDT regardless of protocol completion.Histological analysis by CD31 and VEGFR2 staining provided microvascular density(MVD)and VEGFR2 expression along vessels(VEGFR2v)or intra/peripheral cells(VEGFR2c).Results:In experiment 1,TDT was significantly longer in the VEGFR2-targeted MB+GEM group compared to the non-targeted MB+GEM,GEM,and control groups,while the VEGFR2-targeted MB group showed no statistical significance.MVD and VEGFR2v in the immediate euthanasia was significantly lower in the VEGFR2-targeted MB+GEM and VEGFR2-targeted MB groups than other conditions.In experiment 2,the VEGFR2-targeted MB+GEM group produced significantly longer TDT than the GEM or control groups,whereas the VEGFR2-targeted MB group showed no significant difference.Histology revealed significantly reduced VEGFR2v and VEGFR2c in the VEGFR2-targeted and non-targeted MB+GEM groups,while only VEGFR2v was significantly less in the VEGFR2-targeted MB group.Conclusions:UTMD-mediated GEM therapy with the dual pulse application using VEGFR2-targeted MB substantially suppresses PDCA growth. | Nana Shimamoto Masaki Ito Masafumi Chiba Sadamu Honma Hiroo Imazu Kazuki Sumiyama | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 1 |
| 19 | Comparison of two sodium phosphate tablet-based regimens and a polyethylene glycol regimen for colon cleansing prior to colonoscopy: a randomized prospective pilot study显示文摘 | Hiroyuki Aihara Shoichi Saito Hiroshi Arakawa Hiroo Imazu Salem Omar Mitsuru Kaise Hisao Tajiri | 2009 | International Journal of Colorectal Disease2009，，9： | 1 |
| 20 | Is there an alternative therapy to cyanoacrylate injection for safe and effective obliteration of bleeding gastric varices?显示文摘 | Hiroo Imazu Kuniyuki Kojima Masahiko Katsumura Salem Omar | 2006 | World Journal of Gastroenterology2006，12，34： | 0 |
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