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| 1 | Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy显示文摘AIM To compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor(PPI)-based therapies to treat Helicobacter pylori(H. pylori).METHODS We retrospectively analysed data from first-line(vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d)(n = 1353) and second-line(vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d)(n = 261) eradication treatments for H. pylori- positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related factors.RESULTS After the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9%(95%CI: 84.9%-90.5%), 71.6%(95%CI: 67.5%-75.5%), 62.9%(95%CI: 52.0%-72.9%), and 57.3%(95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs(P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group(P = 0.34), whereas it decreased the rates in the PPI groups(P = 0.013). The incidence of adverse events in the vonop-razan group was not different from the PPI group(P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based therapy.CONCLUSION Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. | Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 2 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 3 | Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients显示文摘 | Kenichi Takayasu Shigeki Arii Iwao Ikai Masao Omata Kiwamu Okita Takafumi Ichida Yutaka Matsuyama Yasuni Nakanuma Masamichi Kojiro Masatoshi Makuuchi Yoshio Yamaoka | 2006 | Gastroenterology2006，，2： | 5 |
| 4 | Report of the 15th follow-up survey of primary liver cancer显示文摘 | Iwao Ikai Yuji Itai Kiwamu Okita Masao Omata Masamichi Kojiro Kenichi Kobayashi Yasuni Nakanuma Shunji Futagawa Masatoshi Makuuchi Yoshio Yamaoka | 2003 | Hepatology Research2003，，1： | 2 |
| 5 | Hepatocellular carcinoma with nonalcoholic steatohepatitis显示文摘 | Sayaka Mori Takahiro Yamasaki Isao Sakaida Taro Takami Eiki Sakaguchi Teruaki Kimura Fumie Kurokawa Shiro Maeyama Kiwamu Okita | 2004 | Journal of Gastroenterology2004，，4： | 2 |
| 6 | Microfactory-concept,history and developments显示文摘 | Yuichi Okazaki Nozomu Mishima Kiwamu Ashida | 2004 | Manufacturing Science and Engineering2004，126，4： | 1 |
| 7 | Physiological Roles of Brassinosteroids in Early Growth of Arabidopsis: Brassinosteroids Have a Synergistic Relationship with Gibberellin as well as Auxin in Light-Grown Hypocotyl Elongation显示文摘 | Kiwamu Tanaka Yasushi Nakamura Tadao Asami Shigeo Yoshida Tomoaki Matsuo Shigehisa Okamoto | 2003 | Journal of Plant Growth Regulation2003，，3： | 1 |
| 8 | In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats显示文摘 | Goshi Shiota Takahiro Kunisada Kenji Oyama Akihide Udagawa Takahiro Nomi Kiwamu Tanaka Atsushi Tsutsumi Masato Isono Takafumi Nakamura Hirofumi Hamada Takashi Sakatani Stewart Sell Kenzo Sato Hisao Ito Hironaka Kawasaki | 2000 | FEBS Letters2000，，： | 1 |
| 9 | Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial显示文摘 | Isao Sakaida Seiji Kawazoe Kozo Kajimura Takafumi Saito Chiaki Okuse Koichi Takaguchi Mitsuru Okada Kiwamu Okita | 2014 | Hepatol Res2014，，1： | 1 |
| 10 | Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression显示文摘 | Kaoru Omori Shuji Terai Tsuyoshi Ishikawa Kouji Aoyama Isao Sakaida Hiroshi Nishina Koh Shinoda Shunji Uchimura Yoshihiko Hamamoto Kiwamu Okita | 2004 | FEBS Letters2004，，1： | 1 |
| 11 | Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients显示文摘 | Kenichi Takayasu Shigeki Arii Iwao Ikai Masao Omata Kiwamu Okita Takafumi Ichida Yutaka Matsuyama Yasuni Nakanuma Masamichi Kojiro Masatoshi Makuuchi Yoshio Yamaoka | 2006 | Gastroenterology2006，，2： | 1 |
| 12 | Propagation properties of train-induced vibration from tunnels 显示文摘 | Kojiro FUJII Yasushi TAKEI Kiwamu TSUNO | 2005 | QR of RTRI2005，46，3： | 1 |
| 13 | Anaerobic nitrogenfixing con- sortia consisting of clratridia isolated from gramineous plants显示文摘 | Kiwamu M Kiyo N Taro M | 2004 | Appl Envir Microbiol2004，70，5： | 1 |
| 14 | Epstein-Barr virus infection of the colon with inflammatory bowel disease显示文摘 | Hideo Yanai Norio Shimizu Susumu Nagasaki Nobuyuki Mitani Kiwamu Okita | 1999 | The American Journal of Gastroenterology1999，，6： | 1 |
| 15 | Lesson from the GFP/CCl4 model — Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis显示文摘 | Shuji Terai Isao Sakaida Hiroshi Nishina Kiwamu Okita | 2005 | Journal of Hepato-Biliary-Pancreatic Surgery2005，，3： | 1 |
| 16 | Microfactory concept,history and developments显示文摘 | Okazaki Yuichi Mishima Nozomu Ashida Kiwamu | 2004 | Journal of Manufacturing Science and Engineering2004，126，4： | 1 |
| 17 | Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway显示文摘 | Eiji Sakai Masaki Fukuyo Ken Ohata Keisuke Matsusaka Noriteru Doi Yasunobu Mano Kiyoko Takane Hiroyuki Abe Koichi Yagi Nobuyuki Matsuhashi Junichi Fukushima Masashi Fukayama Kiwamu Akagi Hiroyuki Aburatani Atsushi Nakajima Atsushi Kaneda | 2016 | Int. J. Cancer2016，，： | 1 |
| 18 | Continuous production of phosphor YAG:Tb nanoparticles hy hydrothermal synthesis in supercritical water显示文摘 | YUKIYA H TSUKASA H KIWAMU S | 2003 | Materials Research Bulletin2003，38，7： | 1 |
| 19 | Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients显示文摘 | Akihiro Matsumoto Eiji Tanaka Akinori Rokuhara Kendo Kiyosawa Hiromitsu Kumada Masao Omata Kiwamu Okita Norio Hayashi Takeshi Okanoue Shiro Iino Kyuichi Tanikawa | 2005 | Hepatology Research2005，，3： | 1 |
| 20 | Adsorption of deoxyribonucleic acid and poly (cytidylic acid)·poly (inosinic acid) onto the poly (styrene) latex显示文摘 | Kiwamu Y Kiyohiro F | 1990 | Journal of Colloid and Interface Science1990，136，： | 1 |
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