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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients显示文摘 | Kenichi Takayasu Shigeki Arii Iwao Ikai Masao Omata Kiwamu Okita Takafumi Ichida Yutaka Matsuyama Yasuni Nakanuma Masamichi Kojiro Masatoshi Makuuchi Yoshio Yamaoka | 2006 | Gastroenterology2006，，2： | 5 |
| 3 | A Trial Study of Propranolol and Zhigancao Decoction on the Central Depressant and Anti-osteoporosic Action in Ovariectomized Rats显示文摘Objective: This study was originally designed to observe the effects of propranolol (a β-blocker) and Zhigancao Decoction (炙甘草汤 ZGCD) on bone mass in ovariectomized rats. Methods: Thirty-eight female Sprague-Dawley rats were divided into four groups initially, a sham-operated group (Sham, n=7), a model ovariectomized (OVX) group (Model, n=7), a propranolol group (Pro, n=12) and a ZGCD group (ZGCD, n=12). After 15 weeks of treatment, the expected effects were not found. In order to verify the situations of the experiment, we modified the study by administering calcitonin to a subgroup of the tested Pro and ZGCD rats. Results: The Pro and ZGCD treatments showed decreased heart rate and plasma norepinephrine level, but neither an increased bone mass nor any bone metabolism differences from the model rats were found. However, the OVX-induced bone loss was prevented by the sequent treatment of calcitonin. Conclusions: The results provide no evidence that the β-blocker propranolol may stimulate bone formation, and do not justify its use for clinical treatment of osteoporosis. | Zhang Wenping Masayuki Kanehara Zhang Yanjun Guo Yi Shigeru Urata Hiroyuki Nakazawa Takayasu Murakami Atushi Takeda Torao Ishida | 2008 | Journal of Traditional Chinese Medicine2008，28，1： | 3 |
| 4 | Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats显示文摘 | Masahito Hara Masakazu Takayasu Kazuhiko Watanabe | 2000 | J Neurosurg (Spine 1)2000，93，： | 2 |
| 5 | High dose intravenous methylprednisolone resolves esophageal stricture resistant to balloon dilatation with intralesional injection of dexamethasone显示文摘 | Nobuyuki Morikawa Toshiro Honna Tatsuo Kuroda Koji Watanabe Hideaki Tanaka Hajime Takayasu Akihiro Fujino Hiroko Tanemura Makoto Matsukubo | 2008 | Pediatric Surgery International2008，，10： | 2 |
| 6 | Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines显示文摘 | Kenichi Takayasu Shigeki Arii Masatoshi Kudo Takafumi Ichida Osamu Matsui Namiki Izumi Yutaka Matsuyama Michiie Sakamoto Osamu Nakashima Yonson Ku Norihiro Kokudo Masatoshi Makuuchi | 2011 | Journal of Hepatology2011，，4： | 2 |
| 7 | Generalized periodontitis treated with periodontal,orthodontic,and prosthodontic therapy:A case report显示文摘BACKGROUND Generalized periodontitis is a severe periodontal disease characterized by rapid periodontal destruction in healthy persons.This case report describes the treatment of a severe crowding,large overjet,and occlusal collapse due to the loss of anterior guidance with generalized periodontitis.CASE SUMMARY A 35-year-old female patient with a chief complaint of crowding and maxillary protrusion was diagnosed with generalized periodontitis by clinical and radiographic examinations.To improve crowding and overjet,orthodontic treatment was performed after basic periodontal therapy.Severely damaged upper right lateral incisor and left canine were extracted,and lower right first premolar and left second premolar were also removed to treat severe crowding.After orthodontic treatment,periodontal flap surgery for upper left molars and guided tissue regeneration for the lower left second molar was performed.Then,a dental implant was inserted in the upper left canine legion.The esthetics of the maxillary anterior tooth was improved by prosthetic restorations.The treatment result showed a well-improved occlusion with proper anterior guidance and healthy periodontal tissue after a retention period of 10 years.CONCLUSION Periodontal,orthodontic,and prosthodontic treatments are extremely useful to improve function and stable periodontal tissue for generalized periodontitis. | Masato Kaku Shinji Matsuda Takayasu Kubo Saiji Shimoe Kazuhiro Tsuga Hidemi Kurihara Kotaro Tanimoto | 2021 | World Journal of Clinical Cases2021，9，21： | 2 |
| 8 | Gene expression of cytokines and growth factors in the lungs after paraquat dismutase显示文摘 | Ishida Y Takayasu T Kimura A | 2006 | Am J Respair Crit Care Med2006，8，2： | 1 |
| 9 | Zipf's Law in Income Distribution of Companies 显示文摘 | OKUYAMA K TAKAYASU M TAKAYASU H | 1999 | Physica A1999，，269： | 1 |
| 10 | Early advanced hepatocellular carcinoma: evaluation of CT and MR appearance with pathologic correlation显示文摘 | Winter TC 3rd Takayasu K Muramatsu Y | 1994 | Radiology1994，192，4： | 1 |
| 11 | Imaging diagnosis of bile duct cystadenocarcinoma显示文摘 | Takayasu K Muramatusu Y Moriyama N | 1988 | Cancer1988，61，： | 1 |
| 12 | 1/f noise in a traffic model显示文摘 | Takayasu M Takayasu H | 1993 | Fractals1993，1，04： | 1 |
| 13 | Protein kinase inhibition by fasudil hydrochlofidepromotes neurological recovery after spinal cord injury, in rats 显示文摘 | Hara M Takayasu M Watanabe K | 2000 | J Neurosurg2000，93，1： | 1 |
| 14 | Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients显示文摘 | Takayasu K Arii S Ikai I | 2006 | Gastroenterology2006，131，： | 1 |
| 15 | Preoperative portal embolization to increase safety of major hepateetomy for hilar bile duet carcinomar a preliminary report 显示文摘 | Makuuchi M Thai BL Takayasu K | 1990 | Surgery1990，107，5： | 1 |
| 16 | Electrochemical corrosion studies of thixomolded AZ91D alloy in sodium chloride solution显示文摘 | Nakatsugawa I Takayasu H Araki K | 2003 | Materials Science Forum2003，，： | 1 |
| 17 | Electrochemical corrosion studies of thixomolded AZ91D alloy in sodium chloride solution显示文摘 | Nakatugawa I Takayasu H ArakiK | 2003 | Materials Science Forum2003，，： | 1 |
| 18 | Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats显示文摘 | Niwa M Inao S Takayasu M | 2001 | Neurol Med Chir2001，41，2： | 1 |
| 19 | Effects of opening pe- fitumoralsy rinxesonm ot orevo kedpotenfial sduring resection of anintramedulIaryspinalcordtumor asereport显示文摘 | Maesawa S Takayasu M Kajita Y | 2004 | NeurolMed- Chir(Tokyo)2004，44，5： | 1 |
| 20 | Gene expression of cytokines and growth factors in the lung after paraquat administration in mice显示文摘 | Ishida Y Takayasu T Kimura A | 2006 | Leg Med2006，8，2： | 1 |
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