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| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 5 |
| 3 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 1 |
| 4 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 5 | Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori显示文摘 | Tatsuro Watanabe Hideaki Tsuge Takahito Imagawa Daisuke Kise Kazuya Hirano Masatoshi Beppu Atsushi Takahashi Kensei Yamaguchi Hirota Fujiki Masami Suganuma | 2010 | Journal of Cancer Research and Clinical Oncology2010，，6： | 1 |
| 6 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 7 | Clinicopathological characteristics and prognostic impact of colorectalcancers with NRAS mutations显示文摘 | Toshiro Ogura Miho Kakuta Toshimasa Yatsuoka Yoji Nishimura Hirohiko Sakamoto Kensei Yamaguchi Minoru Tanabe Yoichi Tanaka Kiwamu Akagi | 2014 | Oncology Reports2014，，1： | 1 |
| 8 | Phase Ⅱ study of paclitaxel with 3-h infusion in patients with advanced gastric cancer显示文摘 | Kensei Yamaguchi Masahiro Tada Noboru Horikoshi | | 0，，： | 1 |
| 9 | Characterization of a novel oncogenic K-ras mutation in colon cancer显示文摘 | Kiwamu Akagi Ryosuke Uchibori Kensei Yamaguchi Keiko Kurosawa Yoichiro Tanaka Tomoko Kozu | 2006 | Biochemical and Biophysical Research Communications2006，，3： | 1 |
| 10 | The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males显示文摘 | Tsutomu Ishikubo Yoji Nishimura Kensei Yamaguchi Udompun Khansuwan Yoshiko Arai Terutada Kobayashi Yasuo Ohkura Yojiro Hashiguchi Yoichi Tanaka Kiwamu Akagi | 2004 | Cancer Letters2004，，1： | 1 |
| 11 | A psychological evaluation method for fluctuating random noise based on fuzzy set theory 显示文摘 | Shizuma Yamaguchi Yuichi Kato Kensei Oimatsu | 1995 | Applied Acoustics1995，45，2： | 1 |
| 12 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 13 | A Psychological Evaluation Method for Fluctuating Random Noise Based on Fuzzy Set Theory 显示文摘 | Shizuma Yamaguchi Yuichi Kato Kensei Oimatsu Tetsuro Saeki | 1995 | Applied Acoustics (S0003-682X)1995，45，2： | 1 |
| 14 | The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males显示文摘 | Tsutomu Ishikubo Yoji Nishimura Kensei Yamaguchi | 2004 | Cancer Letters2004，216，1： | 1 |
| 15 | Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori显示文摘 | Tatsuro Watanabe Hideaki Tsuge Takahito Imagawa Daisuke Kise Kazuya Hirano Masatoshi Beppu Atsushi Takahashi Kensei Yamaguchi Hirota Fujiki Masami Suganuma | 2010 | Journal of Cancer Research and Clinical Oncology2010，，6： | 1 |
| 16 | Randomized Phase III Study of 5-Fluorouracil Continuous Infusion vs. Sequential Methotrexate and 5-Fluorouracil Therapy in Far Advanced Gastric Cancer with Peritoneal Metastasis (JCOG0106)显示文摘 | Kuniaki Shirao Narikazu Boku Yasuhide Yamada Kensei Yamaguchi Toshihiko Doi Masahiro Goto Junichiro Nasu Tadamichi Denda Yasuo Hamamoto Atsuo Takashima Haruhiko Fukuda Atsushi Ohtsu Akira Sawaki Hogara Nishisaki Kenji Amagai Yasuyuki Suzuki | 2013 | Japanese Journal of Clinical Oncology2013，，10： | 1 |
| 17 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 18 | Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study)显示文摘 | Kei Muro Narikazu Boku Yasuhiro Shimada Akihito Tsuji Shinichi Sameshima Hideo Baba Taroh Satoh Tadamichi Denda Kenji Ina Tomohiro Nishina Kensei Yamaguchi Hiroya Takiuchi Taito Esaki Shinya Tokunaga Hiroyuki Kuwano Yoshito Komatsu Masahiko Watanabe Ichin | 2010 | Lancet Oncology2010，，9： | 1 |
| 19 | A Psychological Evaluation Method for Fluctuating Random Noise Based on Fuzzy Set Theory 显示文摘 | Shizuma Yamaguchi Yuichi Kato Kensei Oimatsu Tetsuro Saeki | 1995 | Applied Acoustics (S0003-682X)1995，45，2： | 1 |
| 20 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 1 |
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