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| 1 | Review of the diagnosis and management of gastrointestinal bezoars显示文摘The formation of a bezoar is a relatively infrequentdisorder that affects the gastrointestinal system.Bezoars are mainly classified into four types dependingon the material constituting the indigestible mass of thebezoar phytobezoars, trichobezoars, pharmacobezoars,and lactobezoars. Gastric bezoars often cause ulcerativelesions in the stomach and subsequent bleeding,whereas small intestinal bezoars present with smallbowel obstruction and ileus. A number of articles haveemphasized the usefulness of Coca-Cola? administrationfor the dissolution of phytobezoars. However, persimmonphytobezoars may be resistant to such dissolutiontreatment because of their harder consistency comparedto other types of phytobezoars. Better understanding ofthe etiology and epidemiology of each type of bezoarwill facilitate prompt diagnosis and management.Here we provide an overview of the prevalence, classification,predisposing factors, and manifestations ofbezoars. Diagnosis and management strategies arealso discussed, reviewing mainly our own case series.Recent progress in basic research regarding persimmonphytobezoars is also briefly reviewed. | Masaya Iwamuro Hiroyuki Okada Kazuhiro Matsueda Tomoki Inaba Chiaki Kusumoto Atsushi Imagawa Kazuhide Yamamoto | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 22 |
| 2 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 3 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 4 | Endoscopic submucosal dissection for early gastric cancer: results and degrees of technical difficulty as well as success显示文摘 | A. Imagawa H. Okada Y. Kawahara R. Takenaka J. Kato H. Kawamoto S. Fujiki R. Takata T. Yoshino Y. Shiratori | 2006 | Endoscopy2006，，10： | 2 |
| 5 | Outcome of patients who have undergone total enteroscopy for obscure gastrointestinal bleeding显示文摘AIM:To assess the diagnostic success and outcome among patients with obscure gastrointestinal bleeding who underwent total enteroscopy with double-balloon endoscopy.METHODS:Total enteroscopy was attempted in 156 patients between August 2003 and June 2008 at Hiroshima University Hospital and achieved in 75 (48.1%).It is assessed whether sources of bleeding were identified,treatment methods,complications,and 1-year outcomes (including re-bleeding) after treatment,and we compared re-bleeding rates among patients.RESULTS:The source of small bowel bleeding was identified in 36 (48.0%) of the 75 total enteroscopy patients;the source was outside the small bowel in 11 patients (14.7%) and not identified in 28 patients (37.3%).Sixty-one of the 75 patients were followed up for more than 1 year (27.2 ± 13.3 mo).Four (6.6%) of these patients showed signs of re-bleeding during the first year,but bleeding did not recur after treatment.Although statistical significance was not reached,a marked difference was found in the re-bleeding rate between patients in whom total enteroscopy findings were positive (8.6%,3/35) and negative (3.8%,1/26) (3/35 vs 1/26,P=0.63).CONCLUSION:A good outcome can be expected for patients who undergo total enteroscopy and receive proper treatment for the source of bleeding in the small bowel. | Takayoshi Shishido Shiro Oka Shinji Tanaka Hiroki Imagawa Yoshito Takemura Shigeto Yoshida Kazuaki Chayama | 2012 | World Journal of Gastroenterology2012，18，7： | 2 |
| 6 | Hepatic Artery Pseudoaneurysm: A Report of Seven Cases and a Review of the Literature显示文摘 | David S. Finley Marcelo W. Hinojosa Mahbod Paya David K. Imagawa | 2005 | Surgery Today2005，，7： | 2 |
| 7 | Fulminant type 1 diabetes:a nationwide survey in Japan显示文摘 | Imagawa A Hanafusa T Uchigata Y | | 0，，8： | 2 |
| 8 | Advances in managing hepatocellular carcinoma显示文摘为 hepatocellular 癌的治疗的多重形式是可得到的,取决于肿瘤尺寸和数字。外科的切除术仍然是标准答案,只要剩余肝功能储备是足够的。在有先进肝硬化的病人,肝移植是比较喜欢的选择,当这些病人不能在切除术以后有足够的肝的保守。抢救肝移植也为精选很少成为了一种选择在外科的切除术以后复发的病人。夺格的技术被用于减轻以及完全破坏肿瘤到也,充当附属物到切除术,或向舞台前方满足米兰标准以便一个病人可以是肝移植的一个候选人的肿瘤。Radiofrequency 脱离,微波脱离, chemoembolization, radioembolization,和不可逆的 electroporation 都在这个能力被使用了。当前, sorafenib 是唯一的美国食物和药同意管理为 hepatocellular 化学疗法癌。sorafenib 的功效在有另外的代理人的联合, transarterial chemoembolization,和外科的切除术当前正在被调查。Sunitinib 和 brivanib,酷氨酸 kinase 禁止者,为化疗作为潜在的首要或第二线的选择失败了。在有 erlotinib 的联合的 Bevacizumab 当前也正在被学习。为 ramucirumab 和 axitinib 的最后的分析是未解决的。Tivantinib,一个选择间充质上皮的转变因素(相遇) 禁止者,也在遇见高度肿瘤为功效正在经历临床的试用。这评论服务强调出现在 hepatocellular 癌的治疗的当前、新的技术。 | Marielle Reataza David K. Imagawa | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 9 | Endoscopic submucosal dissection for cancers of the remnant stomach after distal gastrectomy显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Takao Tsuzuki Satoru Yagi Jun Kato Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Masahiro Nakagawa Motowo Mizuno Tomoki Inaba Tatsuya Toyokawa Kohsaku Sakaguchi | 2008 | Gastrointestinal Endoscopy2008，，2： | 2 |
| 10 | The role of tumor necrosis factor in alograft rejection 显示文摘 | MILLIS JM OLTHOFF KM | 1990 | Transplantation1990，50，： | 1 |
| 11 | Efficacy and li-mitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: report of an open label case series显示文摘 | MORI M IMAGAWA T HARA R | 2012 | J Rheumatol2012，39，4： | 1 |
| 12 | Fulminant type 1 diabetes: a nationwide survey in Japan显示文摘 | Imagawa A Hanafusa T Uchigata Y | 2003 | Diabetes Care2003，26，8： | 1 |
| 13 | Expression of lactate dehydrogenase-A and -B messenger ribonucleic acids in chick glycogen body 显示文摘 | Imagawa T Yamamoto E Sawada M | 2006 | Pouh Sci2006，85，： | 1 |
| 14 | Splat profile of impinging droplets on rough substrates:Influence of suface roughness显示文摘 | AMADA S IMAGAWA K AOKI S | 2002 | Surface and Coatings Technology2002，154，1： | 1 |
| 15 | ESR studies of radio-photoluminescent centers in silver-activated phosphate glass显示文摘 | YOKOTA R IMAGAWA H | 1965 | Journal of Physical Society of Japan1965，20，： | 1 |
| 16 | A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibod- ies显示文摘 | Imagawa A Hanafusa T Miyagawa J | 2000 | N Engl J Med2000，342，5： | 1 |
| 17 | Fulminant type 1 diabetes--an importanl subtype in East Asia显示文摘 | Imagawa A Hanafusa T | 2011 | Diabetes Me tab Res Rev2011，27，8： | 1 |
| 18 | Radio-photolumi- nescent centers in silver-activated phosphate glass 显示文摘 | YOKOTA R IMAGAWA H | 1967 | Journal of Physical Society of Japan1967，23，5： | 1 |
| 19 | Fulminant type 1 diabetes mellitus显示文摘 | Imagawa A Hanafusa T | 2006 | Endocr J2006，53，5： | 1 |
| 20 | Fulminant type 1 diabetes:A nationwide survey in Japan显示文摘 | Imagawa A Hanafusa T Uchigata Y | 2003 | Dia- betes Care2003，26，8： | 1 |
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