|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Micro RNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6显示文摘AIM: To investigate the microR NA(miR NA) expression during histological progression from colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using microarray, the sequential changes in miR NA expression profiles were compared in colonic lesions from matched samples; histologically, nonneoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. Cell proliferation assay was performed to observe the effect of miR NA, and its target genes were predicted using bioinformatics approaches and the expression profile of SW480 transfected with the miR NA mimics. mR NA and protein levels of the target gene in colon cancer cell lines with a mimic control or miR NA mimics were measured using qR TPCR and Western blotting. The expression levels of miR NA and target gene in colorectal tissue samples were also measured.RESULTS: Microarray analysis identified that the miR-320 family, including miR-320 a, miR-320 b, miR-320 c, miR-320 d and miR-320 e, were differentially expressed in adenomaand submucosal invasive carcinoma. The mi R-320 family, which inhibits cell proliferation, is frequently downregulated in colorectal adenoma and submucosal invasive carcinoma tissues. Seven genes including CDK6 were identified to be common in the results of gene expression array and bioinformatics analyses performed to find the target gene of the miR-320 family. We confirmed that mR NA and protein levels of CDK6 were significantly suppressed in colon cancer cell lines with miR-320 family mimics. CDK6 expression was found to increase from non-neoplastic mucosa through adenoma to submucosal invasive carcinoma tissues and showed an inverse correlation with miR-320 family expression.CONCLUSION: MiR-320 family affects colorectal tumor proliferation by targeting CDK6, plays important role in its growth, and is considered to be a biomarker for its early detection. | Toshihiro Tadano Yoichi Kakuta Shin Hamada Yosuke Shimodaira Masatake Kuroha Yoko Kawakami Tomoya Kimura Hisashi Shiga Katsuya Endo Atsushi Masamune Seiichi Takahashi Yoshitaka Kinouchi Tooru Shimosegawa | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 9 |
| 3 | Temperature Programmed Reduction Studies on CeO_2-Containing Catalysts显示文摘Temperature programmed reduction (TPR) study was carried out for CeO 2/Al 2O 3 and CeO 2/ZrO 2 catalysts to evaluate oxygen storage property induced by a facile redox cycling of Ce ion. The CeO 2/ZrO 2 catalyst possesses excellent oxygen storage activity at 373 K after reduction above 1173 K although the oxygen storage of CeO 2/Al 2O 3 catalyst after reduction above 1173 K is poor because of the formation of CeAlO 3. Consequently, the oxygen storage on the CeO 2/ZrO 2 catalyst smoothly occurs from low temperatures when the catalyst is reduced even at high temperatures. | Noriyoshi Kakuta Harunobu Ohkita Takanori Mizushima | 2004 | Journal of Rare Earths2004，22，1： | 5 |
| 4 | Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures显示文摘AIM:To investigate the short and long-term outcomes of endoscopic balloon dilatation(EBD) for Crohn's disease(CD) strictures.METHODS:Between January 1995 and December 2011,47 EBD procedures were performed in 30 patients(8 females and 22 males) with CD.All patients had strictures through which an endoscope could not pass,and symptoms of these strictures included abdominal pain,abdominal fullness,nausea,and/or vomiting.The 47 strictures included 17 anastomotic and 30 de novo strictures.Endoscopy and dilatation were performed under conscious sedation with intravenous diazepam or flunitrazepam.The dilatations were all performed using through-the-scope balloons with diameters from 8 mm to 20 mm on inflation and lengths of 30-80 mm.Each dilatation session consisted of two to four,3-min multistep inflations of the balloon,repeated at intervals of 1 wk until adequate dilatation(up to 15-20 mm in diameter) was achieved.The follow-up data were collected from medical records and analyzed retrospectively.Primary success was defined as passage of the scope through the stricture after EBD.Longterm outcomes were analyzed focusing on interventionfree survival and surgery-free survival demonstrated by the Kaplan-Meier method.(Intervention-free meant cases in which neither endoscopic balloon re-dilatation nor surgery was needed after the first dilatation during the observation period).The log rank test was used to evaluate the difference in long-term outcomes between anastomotic and de novo stricture cases.RESULTS:Primary success was achieved in 44 of the 47 strictures(93.6%).Balloon dilatations failed in 3 cases(6.4%).In 1 case,EBD was a technical failure because the guide-wire could not be passed through the stricture which showed severe adhesion and was a flexural lesion of the intestine.In 2 cases,unexpected perforations occurred immediately after balloon dilatation.Of the 47 treatments,complications occurred in 5(10.6%).All 5 patients had de novo strictures.One suffered bleeding,two high fever and there were colorectal perforations.One of the patients with a colorectal perforation was treated surgically,the other was managed conservatively.These 2 cases correspond to the two aforementioned EBD failures.Long-term outcomes were evaluated for the 44 successfully-treated strictures after a median follow-up of 26 mo(range,2-172 mo).During the observation period,re-strictures after EBDs occurred in 26 cases(60.5%).Fourteen of these 26 re-stricture cases underwent EBD again,but in two EBD failed and surgery was ultimately performed in both cases.Twelve of the 26 re-stricture cases were initially treated surgically when the re-strictures occurred.Finally,30 of the 47 strictures(63.8%) were successfully managed with EBD,allowing surgery to be avoided.Intervention-free survival evaluated by the Kaplan-Meier method was 75% at 12 mo,58% at 24 mo,and 43% at 36 mo.There was no significant difference between the anastomotic strictures(n = 16) and de novo strictures(n = 28) in the intervention-free survival as evaluated by the log-rank test.Surgery-free survival evaluated by the Kaplan-Meier method was 90% at 12 mo,75% at 24 mo,and 53% at 36 mo.The 16 anastomotic strictures were associated with significantly better surgery-free survivals than the 28 de novo strictures(log-rank test:P < 0.05).CONCLUSION:Anastomotic strictures were associated with better long-term outcomes than de novo strictures,indicating that stricture type might be useful for predicting the long-term outcomes of EBD. | Katsuya Endo Seiichi Takahashi Hisashi Shiga Yoichi Kakuta Yoshitaka Kinouchi Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，1： | 3 |
| 5 | Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia–Reperfusion Injury显示文摘 | Toyofumi Abe Xiao-Kang Li Koji Yazawa Naoyuki Hatayama Lin Xie Bunpei Sato Yoichi Kakuta Koichi Tsutahara Masayoshi Okumi Hidetoshi Tsuda Jun-ya Kaimori Yoshitaka Isaka Michiya Natori Shiro Takahara Norio Nonomura | 2012 | Transplantation Journal2012，，1： | 2 |
| 6 | Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study显示文摘 | Kensuke Kubota Yukio Kakuta Shunji Kawamura Yasunobu Abe Masahiko Inamori Harunobu Kawamura Hiroyuki Kirikoshi Noritoshi Kobayashi Satoru Saito Atushi Nakajima | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，5： | 2 |
| 7 | Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients显示文摘 | Takatoshi Kakuta Reika Tanaka Toru Hyodo Hajime Suzuki Genta Kanai Mikako Nagaoka Hiroo Takahashi Nobuhito Hirawa Yoichi Oogushi Toshio Miyata Hiroyuki Kobayashi Masafumi Fukagawa Akira Saito | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 8 | Studies on interrelation of structure and antitumor effects of polysaccharides: antitumor action of periodate-modificd, branched (1→3)-β-D-glucan of Auricularia auricula-judae, and other polysaccharides containing (1→3)-glycosidic linkages显示文摘 | Misaki A Kakuta M | 1981 | Carbohytdr Res1981，92，： | 1 |
| 9 | Prognosis of parathyroid function after succesful PETT guided by color Doppler flow mapping in chronic dialysis patients 显示文摘 | Kakuta T Fukagawa M Tominaga Y | 1999 | Am J Kidney Dis1999，33，6： | 1 |
| 10 | A 10-year retrospective cohort study on the risk factors for peritoneal dialysis-related peritonitis:a single-center study at Tokai University Hospital显示文摘 | Nishina M Yanagi H Kakuta T | 2013 | Clin & Experi Nephrol2013，，： | 1 |
| 11 | Steam reforming of tar derived from the steam pyrolysis of biomass over metal catalyst supported on zeolite显示文摘 | Malinee Kaewpanha Guoqing Guan Xiaogang Hao Zhongde Wang Yutaka Kasai Seiji Kakuta Kastuki Kusakabe Abuliti Abudula | 2013 | Journal of the Taiwan Institute of Chemical Engin2013，，6： | 1 |
| 12 | Telmisartan has the stronge binding affinity to angiotensin ]I type 1 receptor: comparison with other angiotensin lI type receptor blockers显示文摘 | Kakuta H Sodoh K Sasamata M | 2012 | Int J Clin Pharmacol Res2012，25，1： | 1 |
| 13 | Hydrogen photoproduction by Nation/cadmium sulfide/platinum films in water/sulfide ion solutions 显示文摘 | Mau AWH Huang CB Kakuta N Bard AJ Campion A Fox MA | 1984 | J Am Chem Soc1984，106，22： | 1 |
| 14 | Photocatalytic activity of Cu2 O nanoparticles prepared through novel synthesis method of precursor reduction in the presence of thiosulfate 显示文摘 | Kakuta S Abe T | 2009 | Solid State Sci2009，11，8： | 1 |
| 15 | Lan- inamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration显示文摘 | KUBO S TOMOZAWA T KAKUTA M | 2010 | Antimicrob Agents Chemother2010，54，3： | 1 |
| 16 | Synthesis of NbC and NbB 2 by MA-SHS in air process显示文摘 | Takeshi Tsuchida Tsuyoshi Kakuta | 2005 | Journal of Alloys and Compounds2005，，： | 1 |
| 17 | Isolation and characterization of polysaccharides of kikurgae fruit body of Auricularia auricula-judae显示文摘 | Sone Y Kakuta M Misaki A | 1978 | Agricultural Biology and Chemistry1978，42，2： | 1 |
| 18 | Establishment of a cell line with phenotypes of chondrocyte from a human osteogenic sarcoma of the mandible显示文摘 | Kakuta S Tachibana H | 2000 | J Oral Pathol Med2000，29，7： | 1 |
| 19 | Dynamic study of the oxidation state of copper in the course of carbon monoxide oxidation over powdered CuO and Cu20显示文摘 | Nagase K Zheng Y Kakuta J | 1999 | Catal1999，187，1： | 1 |
| 20 | Purification and properties of neutral protease from an aspergillus ochraceus A70 isolated Chinese ham (Jinhua huotoui)显示文摘 | Kakuta T Wagu Y Okada T | 1998 | Journal of Agricultural Science Tokyo1998，42，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员