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| 1 | Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer显示文摘AIM: To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. METHODS: By immunohistochemical staining using specifi c antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas) and analyzed their relationship with clinicopathological features. RESULTS: Both normal gastric epithelium and carci- noma cells expressed a significant level of leptin. In cases with OB-R staining, carcinoma cells showed OB-R- positive expression, but the intensity was weaker than that in normal mucosa. The expression of OB-R showed a signifi cant correlation with the level of leptin expres- sion. The expression levels of both leptin and OB-R tend- ed to increase as the depth of tumor invasion or TMN stage increased (P < 0.01). Lymph node metastasis was detected in 49.5% (47/95) of leptin-strong cases and in 50.5% (48/95) of OB-R-positive cases, and the rate was 33% (37/112) in leptin-weak cases and 17% (19/112) in OB-R-negative cases. Both venous and lymphatic inva- sion also tended to be observed frequently in positive tumors as compared with negative tumors. Interestingly, in the 96 leptin- or OB-R-positive tumors, hematogenous metastasis was detected preoperatively in 3 (3.1%) pa- tients. In contrast, none of the carcinomas that lacked expression of leptin and OB-R showed hematogenous metastasis. CONCLUSION: Overexpression of leptin and expres- sion of OB-R may play a positive role in the process of progression in gastric cancer. Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer. | Makoto Ishikawa Joji Kitayama Hirokazu Nagawa | 2006 | World Journal of Gastroenterology2006，12，34： | 20 |
| 2 | Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men显示文摘瞄准:决定在浆液类脂化合物层次和结肠的息肉形成之间的真实协会。方法:我们执行了大规模分析在表面的腺瘤或癌和禁食浆液在为为结肠癌屏蔽经历了全部的结肠镜检查的病人全部的胆固醇(TC ) 和 triglycerides (TG ) 铺平的肤色的发生之间的关联的回顾的学习。结果:没有任何肿瘤的损害,两水平显著地作为与病人相比与腺瘤在病人被提高(TC 207.6+/-29.5 对 199.5+/-34.3, n=4883, P<0.001;TG 135.0+/-82.2 对 108.7+/-71.5, n=4874, P<0.001 ) 。差别在有管状腺瘤然而并非在那些与的病人是重要的覆有一层绒毛或 serrated 腺瘤。包括年龄和性别的多重逻辑回归分析表明 TG 是在男性(P<0.01 ) ,然而并非在女病人的一个独立关联因素。在有侵略的癌的病人的 TG 的水平没与腺瘤在病人从那显示出重要举起。这些调查结果建议 hypertriglyceridemia 是为在人的结肠的腺瘤的一个独立风险因素。结论:尽管浆液甘油三酸酯的高水平不看起来机械地涉及癌的发展,有全部的结肠镜检查的浆液 TG 和集中的监视的减小可以与 hypertriglyceridemia 在人有利益。 | Masafumi Tabuchi Joji Kitayama Hirokazu Nagawa | 2006 | World Journal of Gastroenterology2006，12，8： | 11 |
| 3 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 4 | Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells显示文摘AIM: To examine whether lysophosphatidic acid (LPA)induces phosphorylation of c-Met and epidermal growth factor receptor (EGFR), both of which have been proposed as prognostic markers of colorectal cancer, and whether LPA induces cyclooxygenase-2 (COX-2) expression in human colon cancer cells.METHODS: Using a human colon cancer cell line, LoVo cells, we performed immunoprecipitation analysis,followed by Western blot analysis. We also examined whether LPA induced COX-2 expression, by Western blot analysis.RESULTS: Immunoprecipitation analysis revealed that 10 μmol/L LPA induced tyrosine phosphorylation of c-Met and EGFR in LoVo cells within a few minutes. We found that c-Met tyrosine phosphorylation induced by LPA was not attenuated by pertussis toxin or a matrix metalloproteinase inhibitor, in marked contrast to the results for EGFR. In addition, 0.2-40 μmol/L LPA induced COX-2 expression in a dose-dependent manner.CONCLUSION: Our results suggest that LPA acts upstream of various receptor tyrosine kinases (RTKs) and COX-2,and thus may act as a potent stimulator of colorectal cancer. | Joji Kitayama Hironori Yamaguchi Hiroharu Yamashita Ken Mori Toshiaki Watanabe Hirokazu Nagawa | 2005 | World Journal of Gastroenterology2005，11，36： | 5 |
| 5 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 6 | Salvage Gastrectomy After Intravenous and Intraperitoneal Paclitaxel (PTX) Administration with Oral S-1 for Peritoneal Dissemination of Advanced Gastric Cancer with Malignant Ascites显示文摘 | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Hiroharu Yamashita Shigenobu Emoto Shoich Kaisaki Toshiaki Watanabe | 2014 | Annals of Surgical Oncology2014，，2： | 2 |
| 7 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 8 | Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response显示文摘 | Hiroharu Yamashita Joji Kitayama Masataka Taguri Hirokazu Nagawa | 2009 | World Journal of Surgery2009，，6： | 2 |
| 9 | Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination显示文摘 | Shigenobu Emoto Hironori Ishigami Hiroharu Yamashita Hironori Yamaguchi Shoichi Kaisaki Joji Kitayama | 2012 | Gastric Cancer2012，，2： | 2 |
| 10 | Intraperitoneal administration of cisplatin via an in situ cross-linkable hyaluronic acid-based hydrogel for peritoneal dissemination of gastric cancer显示文摘 | Shigenobu Emoto Hironori Yamaguchi Takao Kamei Hironori Ishigami Takashi Suhara Yukimitsu Suzuki Taichi Ito Joji Kitayama Toshiaki Watanabe | 2014 | Surgery Today2014，，5： | 1 |
| 11 | Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: Report of a case显示文摘 | Jun Suzuki Shinsuke Kazama Joji Kitayama Hiroshi Uozaki Tetsuro Miyata Hirokazu Nagawa | 2009 | Surgery Today2009，，3： | 1 |
| 12 | Endoscopic and histopathologic findings after formalin application for hemorrhage caused by chronic radiation-induced proctitis显示文摘 | Tsuyoshi Konishi Toshiaki Watanabe Joji Kitayama Junji Shibahara Hirokazu Nagawa | 2005 | Gastrointestinal Endoscopy2005，，1： | 1 |
| 13 | Different Tissue Distribution of Paclitaxel With Intravenous and Intraperitoneal Administration显示文摘 | Daisuke Soma Joji Kitayama Hironori Ishigami Shoichi Kaisaki Hirokazu Nagawa | 2009 | Journal of Surgical Research2009，，1： | 1 |
| 14 | Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients With Colorectal Cancer显示文摘 | Kazushige Kawai Soichiro Ishihara Hironori Yamaguchi Eiji Sunami Joji Kitayama Hiroaki Miyata Toshiaki Watanabe | 2015 | Annals of Surgery2015，，5： | 1 |
| 15 | Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer显示文摘 | Akihiro Sako Joji Kitayama Makoto Ishikawa Hiroharu Yamashita Hirokazu Nagawa | 2006 | Gastric Cancer2006，，4： | 1 |
| 16 | Correlation of the therapeutic effect of activated tumor-draining lymph node cells with specific interferon-γ production in vitro显示文摘 | Shinichi Sameshima Keisuke Sakai Hirokazu Nagawa Nelson Tsuno Joji Kitayama Tetsuichiro Muto | 1999 | Surgery Today1999，，1： | 1 |
| 17 | Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer显示文摘 | Akihiro Sako Joji Kitayama Makoto Ishikawa Hiroharu Yamashita Hirokazu Nagawa | 2006 | Gastric Cancer2006，，4： | 1 |
| 18 | CD133(?) Cells, Derived From a Single Human Colon Cancer Cell Line, Are More Resistant to 5-Fluorouracil (FU) Than CD133(+) Cells, Dependent on the β1-Integrin Signaling显示文摘 | Kumiko Hongo Junichiro Tanaka Nelson H. Tsuno Kazushige Kawai Takeshi Nishikawa Yasutaka Shuno Kazuhito Sasaki Manabu Kaneko Masaya Hiyoshi Eiji Sunami Joji Kitayama Koki Takahashi Hirokazu Nagawa | 2012 | Journal of Surgical Research2012，，2： | 1 |
| 19 | Prognostic Value of Peritoneal Cytology and the Combination of Peritoneal Cytology and Peritoneal Dissemination in Colorectal Cancer显示文摘 | Takeshi Nishikawa Toshiaki Watanabe Eiji Sunami Nelson H. Tsuno Joji Kitayama Hirokazu Nagawa | 2009 | Diseases of the Colon & Rectum2009，，12： | 1 |
| 20 | Primary malignant melanoma of the esophagus treated by esophagectomy and adjuvant dendritic-cell therapy显示文摘 | Masahiro Asakage Joji Kitayama Nelson H. Tsuno Yasuhiro Komuro Shoichi Kaisaki Nobukazu Hori Hirokazu Nagawa Nelson H. Tsuno Nobukazu Hori Koki Takahashi | 2005 | Journal of Gastroenterology2005，，5： | 1 |
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