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| 1 | Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis显示文摘Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric cancer.The cagA gene product,CagA,is delivered into gastric epithelial cells via the bacterial type IV secretion system.Delivered CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala(EPIYA)motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and-independent manners.Analysis of CagA using in vitro cultured gastric epithelial cells has indicated that the nonphysiological scaffolding actions of CagA cell-autonomously promote the malignant transformation of the cells by endowing the cells with multiple phenotypic cancer hallmarks:sustained proliferation,evasion of growth suppressors,invasiveness,resistance to cell death,and genomic instability.Transgenic expression of CagA in mice leads to in vivo oncogenic action of CagA without any overt inflammation.The in vivo oncogenic activity of CagA is further potentiated in the presence of chronic inflammation.Since Helicobacter pylori infection triggers a proinflammatory response in host cells,a feedforward stimulation loop that augments the oncogenic actions of CagA and inflammation is created in CagA-injected gastric mucosa.Given that Helicobacter pylori is no longer colonized in established gastric cancer lesions,the multistep nature of gastric cancer development should include a“hit-and-run”process of CagA action.Thus,acquisition of genetic and epigenetic alterations that compensate for CagA-directed cancer hallmarks may be required for completion of the“hit-and-run”process of gastric carcinogenesis. | Atsushi Takahashi-Kanemitsu Christopher T.Knight Masanori Hatakeyama | 2020 | Cellular & Molecular Immunology2020，17，1： | 25 |
| 2 | Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases显示文摘Reactive oxygen species (ROS) have been known to play an important role in the pathogenesis of atherosclerosis and several other cardiovascular diseases. It is now apparent that ROS induce endothelial cell damage and vascular smooth muscle cell (VSMC) growth and cardiac remodeling, which are associated with hypertension, atherosclerosis, heart failure, and restenosis. Several lines of evidence have indicated that ROS and mitogen-activated protein (MAP) kinases were involved in vascular remodeling under various pathological conditions. Recently, it was also reported that MAP kinases were sensitive to oxidative stress. MAP kinases play an important role in cell differentiation, growth, apoptosis, and the regulation of a variety of transcription factors and gene expressions. Bioflavonoids and polyphenolic compounds are believed to be beneficial for the prevention and treatment of athero-sclerosis and cardiovascular diseases. One of the most widely distributed bioflavonoids, 3,3',4',5,7-penta-hydroxyflavone (quercetin) and its metabolite quercetin 3-O-β-D-glucuronide (Q3GA) inhibited Angiotensin Ⅱ-stimulated JNK activation and resultant hypertrophy of VSMC. Several studies have suggested that various antioxi-dants including probucol, N-acetyl-L-cysteine, diphenylene iodonium, Trolox C (vitamin E analogue), and vitamin C inhibit VSMC growth, which is associated with pathogenesis of cardiovascular diseases. Therefore, inhibition of MAP kinases by antioxidant treatment may prove to be a therapeutic strategy for cardiovascular diseases. In contrast, some clinical studies have reported that antioxidant vitamins did not show beneficial effects in coron aryartery disease or in a number of high-risk people. Thus, further studies are needed to clarify why antioxidants showed beneficial effects in vitro, whereas less satisfactory results were obtained in some clinical conditions. | Moe KYAW Masanori YOSHIZUMI Koichiro TSUCHIYA Yuki IZAWA Yasuhisa KANEMATSU Toshiaki TAMAKI | 2004 | Acta Pharmacologica Sinica2004，25，8： | 24 |
| 3 | Molecular Cloning and Functional Characterization of Porcine MyD88 Essential for TLR Signaling显示文摘We isolated cDNA encoding porcine MyD88 (poMyD88) from Peyer's patches (Pps) of GALT. The complete open reading frame (ORF) of poMyD88 contains 879 bp encoding a deduced 293 aa residues. The amino acid sequence of poMyD88 was characterized by N-terminal death,intermediate and C-terminal Toll/IL-1 receptor (TIR) domains. The putative poMyD88 protein shares a higher level of homology with its human (87.2% amino acid identity) than with its mouse (77.4% amino acid identity) counterpart. Overexpression of poMyD88 participated in the further enhanced activation of NF-κB in human embryonic kidney (HEK) 293 cells expressing porcine TLR2 and porcine TLR4/MD-2,but not porcine RP105/MD-1 after stimulation with the corresponding ligands. The expression levels of MyD88 were highest in the spleen and mesenteric lymph nodes (MLNs),and lower in digestive tissues of newborn swine. In adult swine,the expression levels in the digestive tissues were lower than those in MLNs and the spleen. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals. | Masanori Tohno Tomoyuki Shimazu Hisashi Aso Yasushi Kawai Tadao Saito Haruki Kitazawa | 2007 | Cellular & Molecular Immunology2007，4，5： | 20 |
| 4 | High-density circulating fluidized bed gasifier for advanced IGCC/IGFC-Advantages and challenges显示文摘Coal-fired Integrated Gasification Combined Cycle(IGCC)and Integrated coal Gasification Fuel-cell Combined cycle(IGFC)are being developed as high-efficiency electric power generation technology.However,the highest theoretical gross thermal efficiency of the conventional IGCC/IGFC is still below 52%.In order to obtain higher power generation efficiency,an advanced IGCC(A-IGCC)or advanced IGFC(A-IGFC)system making use of the exergy recuperation concept by recycling waste heat from gas turbine or fuel cells for steam gasification of coal and biomass was proposed in our laboratory.Corresponding to this system,a novel high-density triple-bed combined circulating fluidized bed(TBCFB)gasifier,composed of a downer pyrolyzer,a bubbling fluidized bed char gasifier,and a riser combustor,was proposed to replace traditional gasifiers such as the entrained flow bed gasifier.The new system is expected to more effectively utilize the waste heat from gas turbines or fuel cells and the heat produced by the combustion of the unreacted char in the riser combustor for pyrolysis and gasification of coal and biomass.In this short review,the advantages and future challenges in the development of high-density TBCFB gasifier are presented and discussed. | Guoqing Guan Chihiro Fushimi Atsushi Tsutsumi Masanori Ishizuka Satoru Matsuda Hiroyuki Hatano Yoshizo Suzuki | 2010 | Particuology2010，8，6： | 17 |
| 5 | 流动加速腐蚀引起的管壁减薄分析及验证显示文摘针对危害电站安全运行的流动加速腐蚀(FAC)现象,结合专用分析程序包DRAWTHREE的模型和结构.阐明了FAC的发生机理及其决定性因素,提出了用于评估FAC和管壁减薄速率的方法和步骤,并将上述程序分析结果与实验及电厂实际测量数据进行了比较,结果吻合较好.最后给出了用于缓解FAC的一些措施. | Masanori Naitoh 陈耀东 Shunsuke Uchida Hidetoshi Okada | 2011 | 金属学报2011，47，7： | 16 |
| 6 | Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion显示文摘AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center. | Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi Hiroki Masumoto Hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 16 |
| 7 | Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers显示文摘AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or rebamipide.METHODS:We examined 90 patients with early gastric cancer who had undergone ESD.All patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were compared.RESULTS:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 groups.At both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 wk.The medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for rebamipide.No ulcer bleeding or complications due to the drugs were observed in either treatment group.CONCLUSION:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing. | Masaki Takayama Shigenaga Matsui Masanori Kawasaki Yutaka Asakuma Toshiharu Sakurai Hiroshi Kashida Masatoshi Kudo | 2013 | World Journal of Gastroenterology2013，19，34： | 15 |
| 8 | Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis显示文摘AIM To provide a simple surrogate marker predictive of liver cirrhosis(LC).METHODS Specimens from 302 patients who underwent resection for hepatocellular carcinoma between January 2006 and December 2012 were retrospectively analyzed. Based on pathologic findings, patients were divided into groups based on whether or not they had LC. Parameters associated with hepatic functional reserve were compared in these two groups using MannWhitney U-test for univariate analysis. Factors differing significantly in univariate analyses were entered into multivariate logistic regression analysis.RESULTS There were significant differences between the LC group(n = 100) and non-LC group(n = 202) in prothrombin activity, concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin, cholinesterase, type Ⅳ collagen, hyaluronic acid, indocyanine green retention rate at 15 min, maximal removal rate of technitium-99 m diethylene triamine pentaacetic acid-galactosyl human serum albumin and ratio of mean platelet volume to platelet count(MPV/PLT). Multivariate analysis showed that prothrombin activity, concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin and hyaluronic acid, and MPV/PLT ratio were factors independently predictive of LC. The area under the curve value for MPV/PLT was 0.78,with a 0.8 cutoff value having a sensitivity of 65% and a specificity of 78%.CONCLUSION The MPV/PLT ratio, which can be determined simply from the complete blood count, may be a simple surrogate marker predicting LC. | Hiroya Iida Masaki Kaibori Kosuke Matsui Morihiko Ishizaki Masanori Kon | 2018 | World Journal of Hepatology2018，10，1： | 14 |
| 9 | Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity显示文摘AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene sequencing.RESULTS Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were lowered.CONCLUSION Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis. | Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，47： | 14 |
| 10 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012，18，1： | 11 |
| 11 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 12 | Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations显示文摘瞄准:在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法:我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型,在 APC 和 p53 的变化的存在,和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检验人的表示决定胃粘蛋白(HGM ) , MUC6, MUC2 和 CD10。肿瘤然后被分类进胃 --(G-) ,胃、肠混合 --( 官方补给 --) ,或肠 --( 我 --) 显型,根据上述标记的免疫确实。在 APC 和 p53 和 MSI 地位的变化的存在也在所有肿瘤被调查。结果:胃的腺瘤显著地与 CD10 表示,我显型肿瘤和 APC 变化的存在被联系,与癌相比(66.7% 对 25.1% , P <
0.0001;56.3% 对 14.6% , P <
0.0001;39.6% 对 14.0% , P <
0.0001,分别地) 并且相反地与 HGM 和 MUC6 和 p53 变化的存在的表情联系了(10.4% 对 62.6% , P <
0.0001;39.6% 对 64.3% , P = 0.003;2.0% 对 26.3% , P = 0.001,分别地) 。APC 变化的频率在比在 HGM 积极的肿瘤, MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤的 HGM 否定的肿瘤, MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤是显著地更高的(32.7% 对 7.1% , P <
0.0001;27.8% 对 14.0% , P = 0.0182;37.3% 对 10.4% , P <
0.0001;并且 38.5% 对 9.5% , P = 0.0017,分别地) 。MSI 的频率在比在 MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤的 MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤是显著地更高的(24.8% 对 6.7% , P = 0.0009;22.2% 对 8.0% , P = 0.0143;并且 28.6% 对 9.6% , P = 0.0353,分别地) 。结论:肿瘤区别显型是仔细与在胃的区分类型的肿瘤的肿瘤侵略和基因改变有关。 | Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato Masaaki Sakamoto Koji Morohara Tsutomu Kaetsu Mitsuo Kusano | 2006 | World Journal of Gastroenterology2006，12，24： | 9 |
| 13 | Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment显示文摘BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal damage.Although surgical removal of the damaged portion is effective,some patients can recover with conservative treatments.AIM To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical cases.METHODS Thirty-four cases of HPVG(patients aged 34-99 years)were included.Necessity for surgery had been determined mainly by CT findings(i.e.free-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical cases.RESULTS Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)died.In each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was removed.Non-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general conditions.Surprisingly,however,three(25%)of the twelve inoperable patients survived.The remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)died.Comparative analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal cases.The mortality was 90%if two or all of these three clinical findings were detected.CONCLUSION HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical indication.In non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated with poor prognoses,and are applicable as predictors of patients’prognoses. | Masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori Hasegawa Kentaro Kawasaki Takatoshi Nakashima | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 14 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 15 | Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection显示文摘Endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer specifically.We report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed tomography.On diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric cancer.Six months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer regimen.She is still alive at 33 mo after the lobectomy.Generally,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term survival.Precise diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis. | Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa Kazuhito Yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 7 |
| 16 | Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis显示文摘许多流行病学的报告显示感染玩的那 Helicobacter pylori (H pylori ) 在胃的致癌作用的一个重要角色。几基因、渐成说的改变以一种多步方式贡献癌症房间的开始,提升,和前进。H pylori 被知道在胃粘膜导致慢性炎。包括超级氧化物,它的产品参予开始跟随的 DNA 损坏,并且导出发炎的 cytokines 和生长因素贡献胃的致癌作用的提升。由根除 H pylori,胃的发炎能被治好;治疗减少不仅煽动性的房间渗入,而且 atrophy/intestinal 组织变形的层次部分地。使随机化的控制试用表明根除治疗减少了在没有癌症前期的条件的情况中的胃的癌症流行。另外,从日本组的最近的流行病学的研究证明特别肠的类型,胃的癌症的发展被成功的根除治疗减少,尽管这些以一种非使随机化的方式被设计。然而,内视镜的察觉是评估胃的致癌作用的度的唯一的方法,这应该被提及。我们报导了内视镜、组织学的形态学能被根除治疗修改,它可能贡献胃的癌症开发的流行。就癌症房间增长的生物性质而言,足够地长期的后续将是必要的讨论根除治疗的反癌症效果,这被考虑。 | Masanori Ito Shinji Tanaka Tomoari Kamada Ken Haruma Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 17 | Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B显示文摘AIM To evaluate the diagnostic performance of angiotensinconverting enzyme(ACE)on significant liver fibrosis in patients with chronic hepatitis B(CHB). METHODS In total,100 patients with CHB who underwent liver biopsy in our hospital were enrolled,and 70 patients except for 30 patients with hypertension,fatty liver or habitual alcoholic consumption were analyzed.We compared histological liver fibrosis and serum ACE levels and evaluated the predictive potential to diagnose significant liver fibrosis by comparison with several biochemical marker-based indexes such as the aspartate aminotransferase(AST)-to-platelet ratio index(APRI),the fibrosis index based on four factors(FIB-4),the Mac-2 binding protein glycosylation isomer(M2BPGi)level and the number of platelets(Plt). RESULTS Serum ACE levels showed moderately positive correlation with liver fibrotic stages(R2=0.181).Patients with significant,advanced fibrosis and cirrhosis(F2-4)had significantly higher serum ACE levels than those with early-stage fibrosis and cirrhosis(F0-1).For significant fibrosis(≥F2),the 12.8 U/L cut-off value of ACE showed 91.7%sensitivity and 75.0%specificity.The receiver-operating characteristic(ROC)curves analysis revealed that the area under the curve(AUC)value of ACE was 0.871,which was higher than that of APRI,FIB-4,M2BPGi and Plt. CONCLUSION The serum ACE level could be a novel noninvasive,easy,accurate,and inexpensive marker of significant fibrosis stage in patients with CHB. | Ryuichi Noguchi Kosuke Kaji Tadashi Namisaki Kei Moriya Mitsuteru Kitade Kosuke Takeda Hideto Kawaratani Yasushi Okura Yosuke Aihara Masanori Furukawa Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 18 | 铁矿石烧结过程二恶英排放的影响因素研究显示文摘通过采用2水平7因素正交试验设计(L8(2^7))的烧结锅试验,研究了影响烧结机二恶英排放的相关因素。EP灰、BF灰和外购氧化铁皮是二恶英排放的主要"促进剂",而生石灰是二恶英排放的"抑制剂"。对各影响因素而言,二恶英的排放模型并不是加和模型而是乘积模型,对应于添加5%EP灰、5%BF灰、5%外购氧化铁皮和2%生石灰时,它们的系数分别为28、4、4和0.7。至于操作条件,包括料层高度、焦粉含量、气体流速和废气补燃器的开/关对二恶英排放没有显著影响。这些事实支持了烧结过程二恶英的合成为化学反应控制。 | Nakano Masanori Kawachi Shinji Morii Kazuyuki Sato Takehiko 齐伟(译) 俞勇梅(校) | 2012 | 世界钢铁2012，12，2： | 6 |
| 19 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 20 | Effects of Heterogeneous Condensation on the Transonic Flow Fields on a Bump Model显示文摘In the present study, effect of the heterogeneous condensation on the characteristics of shock wave generated on the bump model in the transonic flow field was investigated numerically. As a result, it was found that, for the flow field with steady adiabatic shock wave on the bump model, the condensation with heterogeneous nucleation has a strong effect on the whole flow field, and it reduced the strength of the shock. Furthermore, the total pressure loss was dependent on the concentration of the solid particles per unit volume. | Masanori TANAKA Shigeru MATSUO Toshiaki SETOGUCHI Heuy-Dong KIM | 2005 | Journal of Thermal Science2005，14，1： | 5 |
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