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| 1 | Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations显示文摘瞄准:在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法:我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型,在 APC 和 p53 的变化的存在,和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检验人的表示决定胃粘蛋白(HGM ) , MUC6, MUC2 和 CD10。肿瘤然后被分类进胃 --(G-) ,胃、肠混合 --( 官方补给 --) ,或肠 --( 我 --) 显型,根据上述标记的免疫确实。在 APC 和 p53 和 MSI 地位的变化的存在也在所有肿瘤被调查。结果:胃的腺瘤显著地与 CD10 表示,我显型肿瘤和 APC 变化的存在被联系,与癌相比(66.7% 对 25.1% , P <
0.0001;56.3% 对 14.6% , P <
0.0001;39.6% 对 14.0% , P <
0.0001,分别地) 并且相反地与 HGM 和 MUC6 和 p53 变化的存在的表情联系了(10.4% 对 62.6% , P <
0.0001;39.6% 对 64.3% , P = 0.003;2.0% 对 26.3% , P = 0.001,分别地) 。APC 变化的频率在比在 HGM 积极的肿瘤, MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤的 HGM 否定的肿瘤, MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤是显著地更高的(32.7% 对 7.1% , P <
0.0001;27.8% 对 14.0% , P = 0.0182;37.3% 对 10.4% , P <
0.0001;并且 38.5% 对 9.5% , P = 0.0017,分别地) 。MSI 的频率在比在 MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤的 MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤是显著地更高的(24.8% 对 6.7% , P = 0.0009;22.2% 对 8.0% , P = 0.0143;并且 28.6% 对 9.6% , P = 0.0353,分别地) 。结论:肿瘤区别显型是仔细与在胃的区分类型的肿瘤的肿瘤侵略和基因改变有关。 | Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato Masaaki Sakamoto Koji Morohara Tsutomu Kaetsu Mitsuo Kusano | 2006 | World Journal of Gastroenterology2006，12，24： | 9 |
| 2 | Predicting herbicides concentrations in paddy water and runoff to the river basin显示文摘This study was conducted to investigate the dissipation pattern and runoff of herbicides to the river basin from the paddy fields. Pesticide paddy field model(PADDY) was applied to predict herbicide concentration in paddy fields. A field study was conducted in a paddy farm of Higashi Hiroshima City, Hiroshima Prefecture, Japan in the year of 2003 paddy season. The herbicides were mefenacet, thiobencarb, and bensulfuron methyl. The sample water was analyzed by using gas chromatography and HPLC after solid phase extraction. Predicted dissipation rate of thiobencarb in paddy water was higher(DT_ 50 = 4 36) than that measured, with a lower k value(-0 069). Two weeks after application no thiobencarb was detected in the drainage channel and down stream. In the down stream, thiobencarb was detected until 3 d after application, with a range of 0 02% to 0 08% of applied herbicide. The predicted dissipation rate(k) and half-life(DT_ 50 ) of mefenacet was not significantly different from that of measured. In the drainage channel, upstream and downstream mefenacet was found during the whole study period. In downstream, the maximum concentration of mefenacet was present 0 61% of applied in the paddy field on 3DAH. The dissipation rate(k) of BSM varied from -0 0860 to -0 1059 to with half-life(DT_ 50 ) 3 5 and 2 84 d. In upstream water, no BSM was detected except trace amounts(0 01 μg/L) at 3 d after application. However, in the drainage channel 8%, 6% and 1 58% of applied BSM was present at 0, 1 and 3 d after application respectively. In the down stream, the highest concentration was 1 06%, shortly after application. | PARVEEN Sultana KOHGUCHI Testuyuki BISWAS Moloy NAKAGOSHI Nobukazu | 2005 | Journal of Environmental Sciences2005，17，4： | 6 |
| 3 | SPATIAL GRADIENT ANALYSIS OF URBAN GREEN SPACES COMBINED WITH LANDSCAPE METRICS IN JINAN CITY OF CHINA显示文摘Urban green spaces have been arisen growing concern responded to the social and environmental costs of urban sprawl. A wide range of planning and policies has been and/or will be designed to protect urban green spaces and optimize their spatial pattern. A better design or planning of urban green space can make a major contribution to quality of environment and urban life, and furthermore can decide whether we can have a sustainable development in the urban area. Information about the status quo of urban green spaces can help planners design more effectively. However, how to quantify and capture such information will be the essential question we face. In this paper, to quantify the urban green space, a new method comprising gradient analysis, landscape metrics and GIS was developed through a case of Jinan City. The results demonstrate: 1) the gradient analysis is a valid and reliable instrument to quantify the urban green space spatial pattern precisely; 2) using moving window, explicit landscape metrics were spatially realized. Compared with quantifying metrics in the entire landscape, it would be better to link pattern with process and establish an important basis for analyzing the ecological and socioeconomic functions of green spaces. | KONG Fan-hua Nobukazu NAKAGOSHI YIN Hai-wei Akira KIKUCHI | 2005 | Chinese Geographical Science2005，15，3： | 6 |
| 4 | Impact of Land Use Change on Groundwater Recharge in Guishui River Basin,China显示文摘It is important to understand how land use change impacts groundwater recharge,especially for regions that are undergoing rapid urbanization and there is limited surface water.In this study,the hydrological processes and re-charge ability of various land use types in Guishui River Basin,China(in Beijing Municipality) were analyzed.The impact of land use change was investigated based on water balance modeling,WetSpass and GIS.The results indicate that groundwater recharge accounts for only 21.16% of the precipitation,while 72.54% is lost in the form of evapotranspiration.The annual-lumped groundwater recharge rate decreases in the order of cropland,grassland,urban land,and forest.Land use change has resulted in a decrease of 4 × 106 m3 of yearly groundwater recharge in the study area,with a spatially averaged rate of 100.48 mm/yr and 98.41 mm/yr in 1980 and 2005,respectively.This variation has primarily come from an increase of urban area and rural settlements,as well as a decrease of cropland. | PAN Yun GONG Huili ZHOU Demin LI Xiaojuan NAKAGOSHI Nobukazu | 2011 | Chinese Geographical Science2011，21，6： | 5 |
| 5 | Spatial-temporal gradient analysis of urban green spaces in Jinan, China显示文摘 | Fanhua Kong Nobukazu Nakagoshi | 2005 | Landscape and Urban Planning2005，，3： | 4 |
| 6 | The impact of urban planning on land use and land cover in Pudong of Shanghai, China显示文摘Functional zones in cities constitute the most conspicuous components of newly developed urban areas, and have been a hot spot for domestic and foreign investors in China, which not only show the expanse of urban space accompanied by the shifts both in landscape (from rural to urban) and land use(from less extensive to extensive), but also display the transformation of regional ecological functions. By using the theories and methods of landscape ecology, the structure of landscapes and landscape ecological planning can be analyzed and evaluated for studying the urban functional zones’ layout. In 1990, the Central Government of China declared to develop and open up Pudong New Area so as to promote economic development in Shanghai. Benefited from the advantages of Shanghai’s location and economy, the government of Pudong New Area has successively built up 7 different functional zones over the past decade according to their functions and strategic goals. Based on the multi-spectral satellite imageries taken in 1990, 1997 and 2000, a landscape ecology analysis was carried out for Pudong New Area of Shanghai, supported by GIS technology. Green space (including croplands) and built-up areas are the major factors considered in developing urban landscape. This paper was mainly concerned with the different spatial patterns and dynamics of green space, built-up areas and new buildings in different functional zones, as influenced by different functional layouts and development strategies. The rapid urbanization in Pudong New Area resulted in a more homogeneous landscape. Agricultural landscape and suburban landscape were gradually replaced by urban landscape as the degree of urbanization increased. As a consequence of urbanization in Pudong, not only built-up patches, but also newly-built patches and green patches merged into one large patch, which should be attributed to the construction policy of extensive green space as the urban development process in Pudong New Area. The shape of green area of 7 functional zones became more and more regular because of the horticultural needs in Shanghai urban planning. Some suggestions were finally made for the study of future urban planning and layout. | Nobukazu Nakagoshi CHEN Jia-kuan KONG Ling-yi | 2003 | Journal of Environmental Sciences2003，15，2： | 3 |
| 7 | Landscape ecological characteristics in temporal changes of riverside open space in urbanized area显示文摘1IntroductionRecentlyinJapan,theriverspaceinurbanareasischangingintoriverparks,riveropenspaceandnatureorientedbank.Consequen... | Shigeru TANIMOTO *, Nobukazu NAKAGOSHI Graduate School for International Development and Cooperation, Hiroshima University, Kagamiyama, Higashi Hiroshima 739 8529, Japan. E mail: shigeru.tanimoto@aratani.co.jp | 1999 | Journal of Environmental Sciences1999，11，2： | 3 |
| 8 | Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas显示文摘Hepatic epithelioid hemangioendothelioma(HEH)is a rare neoplasm of vascular origin with variable malignant potential.Because most patients with this condition have multiple bilobar lesions,liver transplantation is the standard treatment,and hepatectomy is much less frequently indicated.We describe a case of a 35-yearold woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy.This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors. | Shohei Komatsu Takeshi Iwasaki Yusuke Demizu Kazuki Terashima Osamu Fujii Atsushi Takebe Akihiro Toyokawa Kazuhiro Teramura Takumi Fukumoto Yonson Ku Nobukazu Fuwa | 2014 | World Journal of Gastroenterology2014，20，26： | 2 |
| 9 | Toxicity studies for indigenous Bacillus thuringiensis isolates from Malang city,East Java on Aedes aegypti larvae显示文摘Objective:To investigate the toxicity of indigenous Bacillus thuringiensis(B.thuringiensis)isolates from Malang City for controlling Aedes aegypti(Ae.aegypti)larvae.Methods:Soil samples were taken from Purwantoro and Sawojajar sub-districts.Bacterial isolation was performed using B.thuringiensis selective media.Phenotypic characteristics of the isolates were obtained with the simple matching method.The growth and prevalence of spores were determined by the Total Plate Count method,and toxicity tests were also performed on the third instar larval stage of Ae.aegypti.The percentage of larval mortality was analysed using probit regression.The LC50was analysed by ANOVA,and the Tukey HSD interval was 95%.Results:Among the 33 selected bacterial isolates,six were obtained(PWR4-31,PWR4-32,SWJ4-2b,SWJ4-4b,SWJ-4k and SWJ5-1)that had a similar phenotype to reference B.thuringiensis.Based on the dendrogram,all of the bacterial isolates were 71%similar.Three isolates that had a higher prevalence of reference B.thuringiensis were PWR4-32,SWJ4-4b and SW5-1,of which the spore prevalence was 52.44%,23.59%,34.46%,respectively.These three indigenous isolates from Malang City successfully killed Ae.aegypti larvae.The PWR4-32 isolates were the most effective at killing the larvae.Conclusions:Six indigenous B.thuringiensis isolates among the 33 bacterial isolates found in the Sawojajar and Purwantoro sub-districts were toxic to the third instar larvae of Ae.aegypti.The PWR4-32 isolates were identical to tbe reference B.thuringiensis and had 88%phenotype similarity.The PWR4-32 isolates had the highest spore prevalence(52.44%),and the early stationary phase occurred at 36 h.The PWR4-32 isolates were the most effective at killing Ae.aegypti larvae(LC50-72 h=2.3×108 cells/mL). | Zulfaidah Penata Gama Nobukazu Nakagoshi Suharjono Faridah Setyowati | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 2 |
| 10 | 改进的离子色谱系统监测重庆嘉陵江水质(英文)显示文摘The w ater quality monitoring operation to evaluate the w ater quality of polluted river is an extremely im po rtant task fo r the river-w atershed m anagem ent/co ntro l based o n the enviro nm ental po licy.In this study,the no vel,sim ple and co nvenient w ater quality m o nito ring o f Jialing-River in Cho ngqing,China w as carried o ut using an advanced io n chro m ato graphy(IC) co nsisting o f io n-ex clusio n/catio n-ex change chro m ato graphy(IEC/CEC) with conductivity detection for determining simultaneously the common anions such as SO 2 4,Cl,and NO 3 and the catio ns such as Na +,NH + 4,K +,Mg 2 +,and Ca 2 +,the ion-exclusion chromatography(IEC) w ith visible detectio n fo r determ ining sim ultaneo usly the nutrient co m po nents such as pho sphate and silicate io ns,and the IEC w ith the enhanced co nductivity detectio n using a po st co lum n o f K +-fo rm catio n-ex change resin fo r determ ining HCO 3-alkalinity as an ino rganic-carbo n so urce fo r bio m ass synthesis in bio lo gical reactio n pro cess under the aero bic co nditio ns.Acco rding to the io nic balance theo ry betw een the to tal equivalent co ncentratio ns o f anio ns and catio ns,the w ater quality evaluatio n o f the Jialing-River w aters taking at different sam pling sites in Cho ngqing m etro po litan area w as carried o ut using the advanced IC system.As a result,the effectiveness o f this no vel w ater quality m o nito ring m etho do lo gy using the IC system w as dem o nstrated o n the several practical applicatio ns to a typical bio lo gical sew age treatm ent plant o n Jialing-River o f Cho ngqing. | Kazuhiko TANAKA Chao-Hong SHI Nobukazu NAKAGOSHI | 2012 | 色谱2012，30，4： | 2 |
| 11 | 离子排斥色谱结合光度检测的水质监测系统用于测定离子型营养物(英文)显示文摘A unified ion-exclusion chromatography(IEC) system for monitoring anionic and cationic nutrients like NH + 4,NO 2,NO 3,phosphate ion,silicate ion and HCO 3 was developed and applied to several environmental waters.The IEC system consisted of four IEC methodologies,including the IEC with ultraviolet(UV) detection at 210 nm for determining NH + 4 on anion-exchange separation column in OH form connected with anion-exchange UV-conversion column in I form in tandem,the IEC with UV-detection at 210 nm for determining simultaneously NO 2 and NO 3 on cation-exchange separation column in H + form,the IEC with UV-detection at 210 nm for determining HCO 3 on cation-exchange separation column in H + form connected with anion-exchange UV-conversion column in I form in tandem,and the IEC with visible-detection based on molybdenum-blue reaction for determining simultaneously silicate and phosphate ions on cation-exchange separation column in H + form.These IEC systems were combined through three manually-driven 6-port column selection valves to select each separation column to determine selectively the ionic nutrients.Using this sequential water quality monitoring system,the analytical performances such as calibration linearity,reproducibility,detection limit and recovery were also tested under the optimized chromatographic conditions.This novel water quality monitoring system has been applied successfully for the determination of the ionic eutrophication components in sub-urban river waters. | Daisuke KOZAKI Nobutake NAKATANI Masanobu MORI Nobukazu NAKAGOSHI Kazuhiko TANAKA | 2012 | 色谱2012，30，7： | 2 |
| 12 | Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer显示文摘 | Kento Takatori Kazuki Terashima Rihito Yoshida Aya Horai Shinya Satake Takayuki Ose Naoto Kitajima Yoshikazu Kinoshita Yusuke Demizu Nobukazu Fuwa | 2014 | Journal of Gastroenterology2014，，6： | 2 |
| 13 | The effects of drainage basin geomorphometry on minimum low flow discharge: the study of small watershed in Kelang River Valley in Peninsular Malaysia显示文摘This study investigate the relationships between geomorphometric properties and the minimum low flow discharge of undisturbed drainage basins in the Taman Bukit Cahaya Seri Alam Forest Reserve, Peninsular Malaysia. The drainage basins selected were third-order basins so as to facilitate a common base for sampling and performing an unbiased statistical analyses. Three levels of relationships were observed in the study. Significant relationships existed between the geomorphometric properties as shown by the correlation network analysis; secondly, individual geomorphometric properties were observed to influence minimum flow discharge; and finally, the multiple regression model set up showed that minimum flow discharge(Q min) was dependent of basin area(AU), stream length(LS), maximum relief(Hmax), average relief(HAV) and stream frequency(SF). These findings further enforced other studies of this nature that drainage basins were dynamic and functional entities whose operations were governed by complex interrelationships occurring within the basins. Changes to any of the geomorphometric properties would influence their role as basin regulators thus influencing a change in basin response. In the case of the basin’s minimum low flow, a change in any of the properties considered in the regression model influenced the “time to peak' of flow. A shorter time period would mean higher discharge, which is generally considered the prerequisite to flooding. This research also conclude that the role of geomorphometric properties to control the water supply within the stream through out the year even though during the drought and less precipitations months. Drainage basins are sensitive entities and any deteriorations involve will generate reciprocals and response to the water supply as well as the habitat within the areas. | Ahmad Jailani Muhamed Yunus Nobukazu Nakagoshi Khairulmaini Osman Salleh | 2003 | Journal of Environmental Sciences2003，15，2： | 2 |
| 14 | Removal of competitive native species combined with tree planting can accelerate the initial afforestation process: an experiment in an old field in Japan invaded by dwarf bamboo and kudzu显示文摘Restoring natural forests after field abandonment is a land management objective that fosters the recovery of forest biodiversity. We performed seeding and transplanting of native tree species 40 years after the abandonment of an arable field that became dominated by a dwarf bamboo(Pleioblastus chino(Franch. et Sav.)Makino) and by kudzu(Pueraria lobata(Willd.) Ohwi).By permutation tests, the removal of competing vegetation(gap creation) significantly increased the survival of three seeded species of Fagaceae and of eight transplanted species. In contrast, intact vegetation prevented most individuals of all species from surviving for 1 year after planting. The lack of natural recruitment of Fagaceae in the nonseeded subplots indicated that seed limitation was a cause of the slow afforestation. Although litter accumulation in gaps at the time of seeding slightly increased survival for late-germinating Quercus myrsinifolia Blume and Castanopsis sieboldii(Makino) Hatus. ex T. Yamaz. et Mashiba, the effect was not consistent among plots and was not statistically significant. Our results suggest that for successful afforestation using native trees in abandoned fields, it will be necessary to remove competitive native species to avoid severe limitations on microsite availability and that simultaneous tree establishment by seeding or transplanting should be implemented to accelerate the establishment of native tree species. | Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi Takahiro Ara Nobukazu Nakagoshi | 2015 | Journal of Forestry Research2015，26，3： | 2 |
| 15 | Higher serum uric acid is associ- ated with increased arterial stiffness in Japanese individuals 显示文摘 | Nobukazu I Yuko I Ei-Ichi T | 2007 | Atherosclerosis2007，192，： | 1 |
| 16 | Enzymeproduction of theanine, an 'umami' component of tea, from glutamine and ethylamine with bacterial γ-glutamyltranspeptidase 显示文摘 | Hideyuki Suzuki Shunsuke Izuka Nobukazu Miyakawa | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 17 | In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage显示文摘 | Haruo Mitani Nobukazu Ishizaka Toru Aizawa Minoru Ohno Shin-ichi Usui Toru Suzuki Toshihiro Amaki Ichiro Mori Yasushi Nakamura Misako Sato Masaomi Nangaku Yasunobu Hirata Ryozo Nagai | 2002 | Hypertension: Journal of the American Heart Association2002，，4： | 1 |
| 18 | Enzymatic production of γ-L-glutamyltaurine through the transpeptidation reaction of γ-glutamyltranspeptidase from Escherichia coli K - 12显示文摘 | Hideyuki Suzuki Nobukazu Miyakawa Hidehiko Kumagai | 2002 | Enzyme and Microbial Technology2002，30，： | 1 |
| 19 | Copper-Catalyzed 1,2-Hydroxysulfenylation of Alkene Using Disulfide via Cleavage of the SS Bond显示文摘 | Taniguchi Nobukazu | | 0，，： | 1 |
| 20 | Effects of resistance exercise training on mass, strength, and turnover of bone in growing rats显示文摘 | Takuya Notomi Sang Jig Lee Nobukazu Okimoto Yuichi Okazaki Takaichi Takamoto Toshitaka Nakamura Masashige Suzuki | 2000 | European Journal of Applied Physiology2000，，4： | 1 |
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