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| 1 | Simultaneous removal of COD and nitrogen using a novel carbon-membrane aerated biofilm reactor显示文摘膜给简历电影反应堆充气了是为废水处理的一种有希望的技术。在这研究,碳膜给简历电影反应堆(CMABR ) 充气了被开发了,到同时把碳 organics 和氮从一个反应堆移开。当它与 20 h 的一水力的保留时间(HRT ) 被操作,结果证明 CMABR 有一个高化学的氧要求(货到付款) 和氮移动效率,并且它也显示出完美的表演,就算 HRT 被弄短到 12 h。在这个时期,货到付款,氨氮(NH4+-N ) ,和总氮(TN ) 的移动效率分别地到达了 86% , 94% ,和 84% 。然而,当 HRT 被弄短到 8 h, NH4+-N 和 TN 的移动效率很快衰退了。这因为非编织的纤维和很高器官的装载率上的生物资源的过多的生长。荧光原位杂交(鱼) 分析显示氧化的氨细菌(AOB ) 主要在简历电影的内部层被散布。在一部简历电影的 AOB 和 eubacteria 的共存能提高货到付款和氮的同时的移动。 | HU Shaowei YANG Fenglin SUN Cui ZHANG Jianye WANG Tonghua | 2008 | Journal of Environmental Sciences2008，20，2： | 12 |
| 2 | Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance显示文摘OBJECTIVE: To investigate the protective effects of Jiayan Kangtai(JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis(AIT), and the possible underlying mechanism.METHODS: Female Lewis rats(6-8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin(IL)-6,IL23 p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper(Th)17 cells and regulatory T cells(Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.RESULTS: Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.CONCLUSION: JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg imbalance in AIT. | Hou Yi Wang Tieshan Guo Xiangyu Sun Wen Guo Xuan Wu Lili Qin Lingling Zhang Chengfei Liu Tonghua | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 9 |
| 3 | Ultraselective carbon molecular sieve membrane for hydrogen purification显示文摘Hydrogen is a green clean fuel and chemical feedstock. Its separation and purification from hydrogencontaining mixtures is the key step in the production of hydrogen with high purity(>99.99%). In this work, carbon molecular sieve(CMS) membranes with ultrahigh permselectivity for hydrogen purification were fabricated by high-temperature(700–900 ℃) pyrolysis of polymeric precursor of phenolphthaleinbased cardo poly(arylene ether ketone)(PEK-C). The evolution of the microstructural texture and ultramicroporous structure and gas separation performance of the CMS membrane were characterized via TG-MS, FT-IR, XRD, TEM, CO2 sorption analysis and gas permeation measurements. CMS membranes prepared at 700 ℃ exhibited amorphous turbostratic carbon structures and high H2 permeability of 5260 Barrer with H2/CH4, H2/N2 and H2/CO selectivities of 311, 142, 75, respectively. When carbonized at900 ℃, the CMS membrane with ultrahigh H2/CH4 selectivity of 1859 was derived owing to the formation of the dense and ordered carbon structure. CMS membranes with ultrahigh permselectivity exhibit an attractive application prospect in hydrogen purification. | Ruisong Xu Liu He Lin Li Mengjie Hou Yongzhao Wang Bingsen Zhang Changhai Liang Tonghua Wang | 2020 | Journal of Energy Chemistry2020，29，11： | 8 |
| 4 | DNA barcoding provides distinction between Radix Astragali and its adulterants显示文摘Based on variable nuclear and/or organellar DNA sequences among vastly divergent species as well as morphologically indistinguishable species, DNA barcoding is widely applicable in species identification, biodiversity studies, forensic analyses, and authentication of medicinal plants. The roots of Astragalus membranaceus and A. membranaceus var. mongholica are commonly used as Radix Astragali in several Asian countries, including China, Japan, and Korea. However, in addition to the two species recorded in the Chinese Pharmacopoeia, there are twenty-three species from different genera including Astragalus, Oxytropis, Hedysarum, and Glycyrrhiza, which have been used as adulterants not only in trading markets but also by the herbal medicine industry. Therefore, a simple, reliable, and accurate classification method is important for distinguishing authentic Radix Astragali from its adulterants. In this study, we acquired data for 37 samples from four related genera within the family Fabaceae. Then we compared four candidate DNA barcoding markers using ITS, matK, rbcL, and coxI sequences from nuclear, chloroplast, and mitochondrial genomes, all commonly used for plants to identify genetic variations among genera, intraspecies, and interspecies. We observed higher divergences among genera and interspecies for ITS, which have the average Kimura 2-parameter distances of 4.5% and 14.1%, respectively, whereas matK was found to have sufficient divergence at the intraspecific level. Moreover, two indels detected in the matK sequence are useful for PCR studies in distinguishing Radix Astragali from its adulterants. This study suggests that the combined barcoding regions of ITS and matK are superior barcodes for Radix Astragali and further studies should focus on evaluating the applicability and accuracy of such combined markers for a wide range of traditional Chinese herbs. | GUO HaiYan1,2, WANG WeiWei2, YANG Ning2, GUO BaoLin3, ZHANG Sun2, YANG RuiJing2, YUAN Ye2, YU JunLin4, HU SongNian2, SUN QiShi1 & YU Jun2 1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 2Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China 3Chinese Academy of Medical Sciences, Peking Union Medical College Institute of Medicinal Plant Development, Beijing 100094, China 4Department of Chemistry, Tonghua Normal College, Tonghua 134002, China | 2010 | Science China(Life Sciences)2010，53，8： | 7 |
| 5 | Effect of lit-moxa stimulation of Guanyuan(CV 4) acupoint on levels of lactic acid and super-oxide dismutase in skeletal muscle of rats显示文摘OBJECTIVE:To observe the effect of lit-moxa stimulating acupoint Guanyuan(CV 4) on lactic acid and super-oxide dismutase(SOD) in skeletal muscle after exercise exhaustion.METHODS:Twenty-eight adult male Sprague-Dawley rats were randomly divided into normal control group,exhausted control group,exercise group and moxibustion group using exercise training and mild heating with lit-moxa stick as treatment methods.The exhausted control group,moxibustion group and exercise group received an exhaustive swimming after 20 days of intervention.Swimming exhausted times were recorded.Lactic acid and SOD concentration in soleus muscle were detected and compared between every two groups.RESULTS:The swimming exhausted times of the moxibustion group and the exercise group were significantly increased compare to the exhausted control group(P < 0.05).The lactic acid of the exhausted control group was significantly increased comparing with the normal control group(P <0.05),and the lactic acid of the moxibustion group and the exercise group were significantly lower than that of the exhausted control group(P < 0.05).The SOD level of the exhausted control group was significantly decreased comparing with the normal control group(P < 0.05),and the SOD level of the moxibustion group and the exercise group were significantly higher than that of the exhausted control group(both,P < 0.05).There was no statistical difference between the moxibustion group and the exercise group.CONCLUSION:With lit moxa stick,heat stimulating acupoint of Guanyuan(CV 4) decreased the levels of lactic acid and SOD in rat's skeletal muscle. | Mo Jie Wu Lili Sun Zhifang Wang Hongbin Ding Na He Long Zhang Lufen Liu Tonghua Li Xiaohong | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 6 |
| 6 | Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice显示文摘OBJECTIVE:To investigate the effects of cinnamaldehyde(CA),an active and major compound in cinnamon,on glucose metabolism and insulin resistance in C57BLKS/J db/db mice.METHODS:Sixteen male C57BLKS db/db mice were randomly divided into control and CA treatment groups.CA was given(20 mg.kg-1.day-1,p.o.) for 4 weeks.Pure water was given to control and db/+ mice.Subsequently,the levels of fasting blood glucose(FBG),fasting serum insulin,triglyeride,cholesterol,low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),and free fatty acids(FFA),as well as the mRNA content of adiponectin and tumor necrosis factor(TNF)-α in adipose tissue,glucose transporter type 4(GLUT-4) in skeletal muscle,and protein expressions of Akt,phospho-Akt(Thr308),AMPKα,phospho-AMPKα(Thr172) in skeletal muscle were measured.RESULTS:1) CA decreased serum levels of FBG and insulin as well as body weight in db/db mice;2) CA increased serum HDL-C levels;3) CA significantly decreased the mRNA expression of TNF-α in adipose tissue and upregulated mRNA expression of GLUT-4 in skeletal muscle;4) protein expression of p-Akt was increased in CA-treated mice,but Akt,AMPKα and p-AMPKα showed no change.CONCLUSION:CA has antihyperglycemic and antihyperlipidemic actions in db/db mice and could be useful in the treatment of type-2 diabetes. | Juane Li Tonghua Liu Lei Wang Xiangyu Guo Tunhai Xu Lili Wu Lingling Qin Wen Sun | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 4 |
| 7 | De-colorization of Reactive Brilliant Orange X-GN by a novel rotating electrochemical disc process显示文摘A novel electrochemical setup for wastewater treatment-rotating electrochemical disc process(RECDP)was developed in this article. The anode and cathode are distributed alternatively and evenly on a flat round disc,which was designed to improve mass transfer of organics from bulk solution to electrode surface,while at the same time increasing oxygen transfer from air to the liquid to benefit the organics oxidization.The color removal of dye Reactive Brilliant Orange X-GN(RBO)was experimentally investigate... | Zhong Dengjie Yang Ji Xu Yunlan Jia Jinping Wang Yalin Sun Tonghua | 2008 | Journal of Environmental Sciences2008，20，8： | 3 |
| 8 | Tangnaikang improves insulin resistance and β-cell apoptosis by ameliorating metabolic inflammation in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE: To investigate the effects of Tangnaikang(TNK), a mixture of five herbal plant extracts,on inflammation-mediated insulin resistance andβ-cell apoptosis in SHR.Cg-Leprcp/NDmcr(SHR-cp)rats.METHODS: Seven-week-old SHR-cp rats were randomly divided into a control(CON) group and a TNK(3.24 g/kg) group. Wistar-Kyoto rats at the same age were used as the normal control group.After 7 weeks of continuous intragastric administration of TNK, the glucose metabolic status and insulin sensitivity of the rats were evaluated by assessing fasting serum glucose(FBG), the oral glucose tolerance test(OGTT), fasting serum insulin(FINS),and the insulin sensitivity index(ISI). Serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP) and adiponectin were measured via enzyme-linked immunosorbent assays.Macrophage infiltration and apoptosis in adipose tissues were detected through F4/80 immunohistochemistry and the terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay. Islet morphology and β-cell apoptosis were investigated using double immunofluorescence staining and the TUNEL assay. The expression of cytokine genes in adipose tissue, the liver, and the pancreas was detected in real-time polymerase chain reaction assays. The expression and phosphorylation levels of insulin signaling-, inflammation-, and β-cell survival-related proteins in the liver and pancreas of SHR-cp rats were detected by western blotting.RESULTS: TNK(3.24 g/kg) treatment significantly decreased body weight, FBG and FINS; improved impaired glucose tolerance; increased the ISI; reduced serum levels of TNF-α, CRP and IL-6; and increased serum adiponectin. The m RNA expression of inflammatory markers was markedly reduced in the liver, pancreas, and adipose tissue. F4/80-and TUNEL-positive cells in adipose tissues were decreased, as was the number of TUNEL-positiveβ-cells. The phosphorylation of c-Jun N-terminal kinase and that of insulin receptor substrate-1 at serines 307 and 1101 was significantly decreased.In the pancreas, the expression of nuclear factor kappa-light chain-enhancer of activated B cells-p65 was significantly decreased, and phosphoinositide3-kinase and IRS-2 were significantly increased.CONCLUSION: TNK was able to improve insulin resistance and β-cell apoptosis in SHR-cp rats, which might be associated with its ability to relieve the overall and local metabolic inflammatory responses observed in SHR-cp rats. | Li Linyi Hisae Yoshitomi Qin Lingling Wu Xinli Zhou Tian Wang Haiyan Jiang Yueying Wei Ying Xu Tunhai Liu Tonghua Gao Ming | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 3 |
| 9 | Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract显示文摘To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF SD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSF SD. The DSF SD was added to borate buffer solution(BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSF SD combined with in-situ gel(DSF SD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSF SD/in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSF SD/in-situ gel as a drug delivery system can improve DSF ocular permeability. | Chunjuan Zhang Tonghua Xu Donglei Zhang Wei He Siling Wang Tongying Jiang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 3 |
| 10 | LabVIEW-based auto-timing counts virtual instrument system with ORTEC 974 Counter/Timer显示文摘In order to achieve the auto-timing counts measurement of nuclear radiation using ORTEC 974 Counter/Timer, an auto-timing counts virtual instrument system based on the LabVIEW virtual instrument development platform and GPIB instrument control and transmission bus protocol is designed in this paper. By introducing software timing technique, the minimum time base of factory setting improves from 0.1 s to 0.03 s. The timing counts performance and longtime stability are also discussed in detail. The automatic data recording and saving facilitates data analysis and processing. Its real-time display and statistic function is very convenient for monitoring the nuclear radiation. | YAN Jie LIU Rong LI Cheng JIANG Li LU Xinxin ZHU Tonghua WANG Mei WEN Zhongwei LIN Jufang | 2009 | Nuclear Science and Techniques2009，20，5： | 2 |
| 11 | Reaction rates in blanket assemblies of a fusion-fission hybrid reactor显示文摘To validate neutronics calculation for the blanket design of fusion-fission hybrid reactor,experiments for measuring reaction rates inside two simulating assemblies are performed.Two benchmark assemblies were developed for the neutronics experiments.A D-T fusion neutron source is placed at the center of the setup.One of them consists of three layers of depleted uranium shells and two layers of polyethylene shells,and these shells are arranged alternatively.The ^(238)U capture reaction rates are measured using depleted uranium foils and an HPGe gamma spectrometer.The fission reaction rates are measured using a fission chamber coated with depleted uranium.The other assembly consists of depleted uranium and LiH shells.The tritium production rates are measured using the lithium glass scintillation detector which is placed in the LiH region of the assembly.The measured reaction rates are compared with the calculated ones predicted using MCNP code,and C/E values are obtained. | LIU Rong ZHU Tonghua YAN Xiaosong WANG Xinhua LU Xinxin JIANG Li WANG Mei WEN Zhongwei HAN Zijie LIN Jufan YANGYiwei | 2012 | Nuclear Science and Techniques2012，23，4： | 2 |
| 12 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hkf55vcfwfbok6cpp.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | Changes in the global cryosphere and their impacts:A review and new perspective显示文摘As one of the five components of Earth's climatic system,the cryosphere has been undergoing rapid shrinking due to global warming.Studies on the formation,evolution,distribution and dynamics of cryospheric components and their interactions with the human system are of increasing importance to society.In recent decades,the mass loss of glaciers,including the Greenland and Antarctic ice sheets,has accelerated.The extent of sea ice and snow cover has been shrinking,and permafrost has been degrading.The main sustainable development goals in cryospheric regions have been impacted.The shrinking of the cryosphere results in sea-level rise,which is currently affecting,or is soon expected to affect,17 coastal megacities and some small island countries.In East Asia,South Asia and North America,climate anomalies are closely related to the extent of Arctic sea ice and snow cover in the Northern Hemisphere.Increasing freshwater melting from the ice sheets and sea ice may be one reason for the slowdown in Atlantic meridional overturning circulation in the Arctic and Southern Oceans.The foundations of ports and infrastructure in the circum-Arctic permafrost regions suffer from the consequences of permafrost degradation.In high plateaus and mountainous regions,the cryosphere's shrinking has led to fluctuations in river runoff,caused water shortages and increased flooding risks in certain areas.These changes in cryospheric components have shown significant heterogeneity at different temporal and spatial scales.Our results suggest that the quantitative evaluation of future changes in the cryosphere still needs to be improved by enhancing existing observations and model simulations.Theoretical and methodological innovations are required to strengthen social economies'resilience to the impact of cryospheric change. | ShiYin Liu TongHua Wu Xin Wang XiaoDong Wu XiaoJun Yao Qiao Liu Yong Zhang JunFeng Wei XiaoFan Zhu | 2020 | Research in Cold and Arid Regions2020，12，6： | 2 |
| 14 | Prepara- tion of Composite Carbon-Zeolite Membranes Using A SimpleMethod显示文摘 | Zhang Xiongfu Wang Tonghua Liu Haiou | 2004 | JMaterSci2004，39，1617： | 1 |
| 15 | Preparation and characterization of activated carbon from wood via microwave induced ZnC12 activation显示文摘 | Tonghua Wang Suxia Tan Changhai Liang | 2009 | CARBON2009，47，7： | 1 |
| 16 | Preparation and characterization of carbon membranes made from poly(phthalazinone ether sulfone ketone)显示文摘 | Bing Zhang Tonghua Wang Shouhai Zhang Jieshan Qiu Xigao Jian | 2006 | Carbon2006，，13： | 1 |
| 17 | Towards the Preparation of Ordered Mesoporous Carbon/Carbon Composite Membranes for Gas Separation显示文摘 | Bing Zhang Yi Shi Yonghong Wu Tonghua Wang Jieshan Qiu | 2014 | Separation Science and Technology2014，，2： | 1 |
| 18 | A novel carbon/ZSM-5 nanocomposite membrane with high performance for oxygen/nitrogen separation显示文摘 | Qingling Liu Tonghua Wang Jieshan Qiu | 2006 | Chem Commun2006，11，： | 1 |
| 19 | Pore structure prediction of coal-based microfiltration carbon membranes显示文摘This paper presents a method that is capable of predicting pore structure of coal-based microfiltration carbon membranes. The tubular carbon membranes are prepared from coal samples with different particle size and distribution by using the extrusion method. According to the relationship between properties of coal samples (particle size and distribution) and pore structure parameters of coal-based carbon membranes, the experiential equations of average pore size and porosity are concluded, and the change law of pore size distribution curve is also summarized. The results show pore structure properties of coal-based carbon membranes can be exactly predicted for different separation requirements by adjusting coal particle size and distribution, which allows us to minimize cost and time consuming experiments in the development of coal-based microfiltration membranes. | SONG ChengWen WANG TongHua QIU JieShan | 2010 | Chinese Science Bulletin2010，55，13： | 1 |
| 20 | Preparation and gas separation properties of Poly(furfuryl alcohol) - based C/CMS compasite membrane 显示文摘 | Song Chengwen Wang Tonghua Wang Xiuyue | 2008 | Sep Purif Technol2008，58，： | 1 |
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