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| 1 | Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR. | Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa | 2005 | World Journal of Gastroenterology2005，11，46： | 25 |
| 2 | Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance显示文摘In this paper,we review the concept of quality of ulcer healing(QOUH) in the gastrointestinal tract and its role in the ulcer recurrence.In the past,peptic ulcer disease(PUD) has been a chronic disease with a cycle of repeated healing/remission and recurrence.The main etiological factor of PUD is Helicobacter pylori(H.pylori),which is also the cause of ulcer recurrence.However,H.pylori-negative ulcers are present in 12%-20% of patients;they also recur and are on occasion intractable.QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated.Within the scars of healed ulcers,regenerated tissue is immature and with distorted architecture,suggesting poor QOUH.The abnormalities in mucosal regeneration can be the basis for ulcer recurrence.Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence.Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macrophages,which in turn produce increased amounts of cytokines and chemokines,which attract neutrophils to the regenerated area.Neutrophils release proteolytic enzymes that destroy the tissue,resulting in ulcer recurrence.Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a deficiency and/or an imbalance of endogenous growth factors.Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar.In addition to PUD,the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn's disease and ulcerative colitis. | Tetsuo Arakawa Toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga Yasuhiro Fujiwara Kenichi Morimoto | 2012 | World Journal of Gastroenterology2012，18，35： | 16 |
| 3 | BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy显示文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed 'reduced volume method'(group A) with the 'conventional volume method'(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method. | Yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri | 2012 | World Journal of Gastroenterology2012，18，17： | 8 |
| 4 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 5 | A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding显示文摘 | Natsuhiko Kameda Kazuhide Higuchi Masatsugu Shiba Hirohisa Machida Hirotoshi Okazaki Hirokazu Yamagami Tetsuya Tanigawa Kenji Watanabe Toshio Watanabe Kazunari Tominaga Yasuhiro Fujiwara Nobuhide Oshitani Tetsuo Arakawa | 2008 | Journal of Gastroenterology2008，，6： | 2 |
| 6 | Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case显示文摘We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved. | Hirotoshi Okazaki Kazuhide Higuchi Masatsugu Shiba Shirou Nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga Toshio Watanabe Yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 7 | Small Bowel Injury by Low-Dose Enteric-Coated Aspirin and Treatment With Misoprostol: A Pilot Study显示文摘 | Toshio Watanabe Satoshi Sugimori Natsuhiko Kameda Hirohisa Machida Hirotoshi Okazaki Tetsuya Tanigawa Kenji Watanabe Kazunari Tominaga Yasuhiro Fujiwara Nobuhide Oshitani Kazuhide Higuchi Tetsuo Arakawa | 2008 | Clinical Gastroenterology and Hepatology2008，，11： | 2 |
| 8 | CASE REPORT: Asymptomatic Chronic Intestinal Ischemia Caused by Idiopathic Phlebosclerosis of Mesenteric Vein显示文摘 | Nobuhide Oshitani Yoshiki Matsumura Mizuki Kono Akihiro Tamori Kazuhide Higuchi Takayuki Matsumoto Shuichi Seki Tetsuo Arakawa | 2002 | Digestive Diseases and Sciences2002，，12： | 1 |
| 9 | Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan显示文摘 | Soji Ozawa Koichiro Kumai Kazuhide Higuchi Tetsuo Arakawa Mototsugu Kato Masahiro Asaka Natsuya Katada Hiroyuki Kuwano Masaki Kitajima | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 10 | Rebamipide, novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer comparison with cimetidine显示文摘 | Dr. Tetsuo Arakawa MD PhD Toshio Watanabe MD Takashi Fukuda MD PhD Katsuya Yamasaki PhD Kenzo Kobayashi MD PhD | 1995 | Digestive Diseases and Sciences1995，，11： | 1 |
| 11 | Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial显示文摘 | Akira Terano Tetsuo Arakawa Toshiro Sugiyama Hidekazu Suzuki Takashi Joh Toshikazu Yoshikawa Kazuhide Higuchi Ken Haruma Kazunari Murakami Kenzo Kobayashi | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 12 | Present status and strategy of NSAIDs-induced small bowel injury显示文摘 | Kazuhide Higuchi Eiji Umegaki Toshio Watanabe Yukiko Yoda Eijiro Morita Mitsuyuki Murano Satoshi Tokioka Tetsuo Arakawa | 2009 | Journal of Gastroenterology2009，，9： | 1 |
| 13 | Rebamipide, novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer comparison with cimetidine显示文摘 | Dr. Tetsuo Arakawa MD PhD Toshio Watanabe MD Takashi Fukuda MD PhD Katsuya Yamasaki PhD Kenzo Kobayashi MD PhD | 1995 | Digestive Diseases and Sciences1995，，11： | 1 |
| 14 | Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence显示文摘 | Dr. Tetsuo Arakawa MD PhD Toshio Watanabe MD PhD Takashi Fukuda MD PhD Kazuhide Higuchi MD PhD Osamu Takaishi MD Katsuya Yamasaki MD PhD Kenzo Kobayashi MD PhD Andrzej Tarnawski MD DSc | 1996 | Digestive Diseases and Sciences1996，，10： | 1 |
| 15 | Rebamipide, novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer comparison with cimetidine显示文摘 | Dr. Tetsuo Arakawa MD PhD Toshio Watanabe MD Takashi Fukuda MD PhD Katsuya Yamasaki PhD Kenzo Kobayashi MD PhD | 1995 | Digestive Diseases and Sciences1995，，11： | 1 |
| 16 | Quality of ulcer healing—A new concept to rank healed peptic ulcers显示文摘 | Tetsuo Arakawa Kenzo Kobayashi | 1993 | Gastroenterologia Japonica1993，，5： | 1 |
| 17 | Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients显示文摘 | Hirotoshi Okazaki Yasuhiro Fujiwara Satoshi Sugimori Yasuaki Nagami Natsuhiko Kameda Hirohisa Machida Hirokazu Yamagami Tetsuya Tanigawa Masatsugu Shiba Kenji Watanabe Kazunari Tominaga Toshio Watanabe Nobuhide Oshitani Tetsuo Arakawa | 2009 | Journal of Gastroenterology2009，，6： | 1 |
| 18 | Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers显示文摘 | Junko Arimoto Yoshihiro Ikura Takehisa Suekane Masashi Nakagawa Chizuko Kitabayashi Yoko Iwasa Kenichi Sugioka Takahiko Naruko Tetsuo Arakawa Makiko Ueda | 2010 | Journal of Gastroenterology2010，，3： | 1 |
| 19 | Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats显示文摘 | Fumio Tanaka Kazunari Tominaga Masahiro Ochi Tetsuya Tanigawa Toshio Watanabe Yasuhiro Fujiwara Kensuke Ohta Nobuhide Oshitani Kazuhide Higuchi Tetsuo Arakawa | 2008 | Life Sciences2008，，23： | 1 |
| 20 | Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells显示文摘 | Sawako Kobayashi Shuichi Seki Norifumi Kawada Hiroyasu Morikawa Kazuki Nakatani Naoki Uyama Kazuo Ikeda Yuji Nakajima Tetsuo Arakawa Kenji Kaneda | 2003 | Cell and Tissue Research2003，，3： | 1 |
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