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| 1 | Role of hepatitis B virus DNA integration in human hepatocarcinogenesis显示文摘Liver cancer ranks sixth in cancer incidence,and is the third leading cause of cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the most common type of liver cancer,which arises from hepatocytes and accounts for approximately 70%-85%of cases.Hepatitis B virus(HBV)frequently causes liver inflammation,hepatic damage and subsequent cirrhosis.Integrated viral DNA is found in 85%-90%of HBV-related HCCs.Its presence in tumors from non-cirrhotic livers of children or young adults further supports the role of viral DNA integration in hepatocarcinogenesis.Integration of subgenomic HBV DNA fragments into different locations within the host DNA is a significant feature of chronic HBV infection.Integration has two potential consequences:(1)the host genome becomes altered('cis'effect);and(2)the HBV genome becomes altered('trans'effect).The cis effect includes insertional mutagenesis,which can potentially disrupt host gene function or alter host gene regulation.Tumor progression is frequently associated with rearrangement and partial gain or loss of both viral and host sequences.However,the role of integrated HBV DNA in hepatocarcinogenesis remains controversial.Modern technology has provided a new paradigm to further our understanding ofdisease mechanisms.This review summarizes the role of HBV DNA integration in human carcinogenesis. | Hoang Hai Akihiro Tamori Norifumi Kawada | 2014 | World Journal of Gastroenterology2014，20，20： | 22 |
| 2 | Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B显示文摘Infection with hepatitis B virus is an important healthproblem worldwide:it affects more than 350 millionpeople and is a leading cause of liver-related morbidity,accounting for 1 million deaths annually.Hepatic fibrosis is a consequence of the accumulation of extracellular matrix components in the liver.An accurate diagnosis of liver fibrosis is essential for the management of chronic liver disease.Liver biopsy has been considered the gold standard for diagnosing disease,grading necroinflammatory activity,and staging fibrosis.However,liver biopsy is unsuitable for repeated evaluations because it is invasive and can cause major complications,including death.Several noninvasive evaluations have been introduced for the assessment of liver fibrosis:serum biomarkers,combined indices or scores,and imaging techniques including transient elastography,acoustic radiation force impulse,real-time tissue elastography,and magnetic resonance elastography.Here,we review the recent progress of noninvasive assessment of liver fibrosis in patients with chronic hepatitis B.Most noninvasive evaluations for liver fibrosis have been validated first in patients with chronic hepatitis C,and later in those with chronic hepatitis B.The establishment of a noninvasive assessment of liver fibrosis is urgently needed to aid in the management of this leading cause of chronic liver disease. | Masaru Enomoto Hiroyasu Morikawa Akihiro Tamori Norifumi Kawada | 2014 | World Journal of Gastroenterology2014，20，34： | 16 |
| 3 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 4 | Hepatitis B virus infection and alcohol consumption显示文摘Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer, and the second most common cause of cancer deaths worldwide. The top three causes of HCC are hepatitis B virus(HBV),hepatitis C virus(HCV), and alcoholic liver disease. Owing to recent advances in direct-acting antiviral agents, HCV can now be eradicated in almost all patients. HBV infection and alcoholic liver disease are expected, therefore, to become the leading causes of HCC in the future. However, the association between alcohol consumption and chronic hepatitis B in the progression of liver disease is less well understood than with chronic hepatitis C. The mechanisms underlying the complex interaction between HBV and alcohol are not fully understood, and enhanced viral replication, increased oxidative stress and a weakened immune response could each play an important role in the development of HCC. It remains controversial whether HBV and alcohol synergistically increase the incidence of HCC. Herein, we review the currently available literature regarding the interaction of HBV infection and alcohol consumption on disease progression. | ayako iida-ueno masaru enomoto akihiro tamori norifumi kawada | 2017 | World Journal of Gastroenterology2017，23，15： | 11 |
| 5 | Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients显示文摘AIM: To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS: Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis. RESULTS: The profile data showed several biological changes associated with progression of hepatic fibrosis. Clustered genes in functional categories showed sequential changes in expression. Several sets of clustered genes, including those related to the extracellular matrix (ECM), inflammation, lipid metabolism, steroid metabolism, and some transcription factors important for hepatic biology showed expression changes in the immediate early phase (F1/F2) of fibrosis. Genes associated with aromatic amino acid (AA) metabolism, sulfur-containing AA metabolism and insulin/ Wnt signaling showed expression changes in the middle phase (F2/F3), and some genes related to glucose metabolism showed altered expression in the late phase of fibrosis (F3/F4). Therefore, molecular networks showing serial changes in gene expression are present in liver fibrosis progression in hepatitis C patients. CONCLUSION: Analysis of gene expression profiles from a perspective of functional categories or molecular networks provides an understanding of disease and suggests new diagnostic methods. Selected marker genes have potential utility for biological identification of advanced fibrosis. | Yoshiyuki Takahara Mitsuo Takahashi Qing-Wei Zhang Hirotaka Wagatsuma Maiko Mori Akihiro Tamori Susumu Shiomi Shuhei Nishiguchi | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 6 | HLA class Ⅱ associated with outcomes of hepatitis B and C infections显示文摘Several factors influence the clinical course of hepatitis B virus(HBV)and hepatitis C virus(HCV)infection.The human leukocyte antigen(HLA)system,the major histocompatibility complex(MHC)in humans,has been considered one of the most important host factors with respect to outcomes.To date,conventional genotyping studies have shown that HLA classⅡloci are mainly associated with spontaneous clearance of HBV and HCV.However,the specific HLA locus associated with the outcomes of hepatitis virus infection remains unclear.A recent genome-wide association study(GWAS)using a comprehensive approach for human genotyping demonstrated single nucleotide polymorphisms(SNPs)associated with the outcomes of hepatitis virus infection.Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLADPB1 loci are associated with persistent HBV infection in Asian populations.To date,however,few studies have focused on HLA-DP because polymorphisms of HLA-DP haplotype do not vary greatly as compared with other loci of HLA.There are not enough studies to reveal the function of HLA-DP.GWAS additionally detected candidate SNPs within HLA loci associated with chronic HBV or HCV hepatitis,hepatic fibrosis,and the development of hepatocellular carcinoma.The results of one cohort were not always consistent with those of other cohorts.To solve several controversial issues,it is necessary to validate reported SNPs on HLA loci in global populations and to elucidate the HLA-allele-regulated molecular response to hepatitis virus infection. | Akihiro Tamori Norifumi Kawada | 2013 | World Journal of Gastroenterology2013，19，33： | 4 |
| 7 | Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case显示文摘We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved. | Hirotoshi Okazaki Kazuhide Higuchi Masatsugu Shiba Shirou Nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga Toshio Watanabe Yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 8 | RBP4, an unexpected adipo-kine显示文摘 | Tamori Y Sakaue H Kasuga M | 2006 | Nat Med2006，12，2： | 1 |
| 9 | Analysis of invasion-metastasis mechanism in pancreatic cancer:involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation显示文摘 | Tan X Tamori Y Egami H | 2004 | Oncol Rep2004，11，： | 1 |
| 10 | Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug resistant variants during larnivodine therapy:analyses of the polymerase gene and full-length sequences显示文摘 | Enomoto M Tamori A Kohmoto MT | 2007 | J Med Virol2007，79，11： | 1 |
| 11 | Effect of long term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma 显示文摘 | Nishiguchi S Tamori A Kubo S | 2005 | Intervirology2005，48，1： | 1 |
| 12 | Hepatitis B virus genotypes and response to antiviral therapy 显示文摘 | Enomoto M Tamori A Nishiguchi S | 2006 | Clin Lab2006，52，12： | 1 |
| 13 | p16 promoter hyperme-thylation in human hepatocellular carcinoma with or withouthepatitis virus infection显示文摘 | Narimatsu T Tamori A Koh N | 2004 | Intervirology2004，47，1： | 1 |
| 14 | Cimetidine reduces impairment of cellular immunity after transcatheter arterial em- bolization in patients with hepatocellular carcinoma显示文摘 | Nishiguchi S Tamori A Shiomi S | 2003 | Hepato- gastroenterology2003，50，50： | 1 |
| 15 | CASE REPORT: Asymptomatic Chronic Intestinal Ischemia Caused by Idiopathic Phlebosclerosis of Mesenteric Vein显示文摘 | Nobuhide Oshitani Yoshiki Matsumura Mizuki Kono Akihiro Tamori Kazuhide Higuchi Takayuki Matsumoto Shuichi Seki Tetsuo Arakawa | 2002 | Digestive Diseases and Sciences2002，，12： | 1 |
| 16 | An increase in the circulating concentration of monocyte chemoattractant pro- tein-1 elicits systemic insulin resistance irrespective of adi- pose tissue inflammation in mice 显示文摘 | Tateya S Tamori Y Kawaguchi TA | 2010 | Endocrinology2010，151，3： | 1 |
| 17 | MCP-1 con- tributes to macrophage infiltration into adipose tissue, insu- lin resistance, and hepatic steatosis in obesity 显示文摘 | KANDA H TATEYA S TAMORI Y | 2006 | J Clin Invest2006，116，6： | 1 |
| 18 | Effect of alcohol abuse on polyamine metabolism in hepatocellular carcinoma and noncancerous hepatic tissue显示文摘 | Kubo S Tamori A Nishiguchi S | 1998 | Surgery1998，123，2： | 1 |
| 19 | Role of peroxisome proliferatorsactivated receptor-γ in maintenance of the characteristics of mature 3T3-L1 adipocytes显示文摘 | Tamori Y Masugi J Nishino N | 2002 | Diabetes2002，51，7： | 1 |
| 20 | Catalysis- assisted plasmatechnology for carbon tetrachloride destruc- tion显示文摘 | YAMAMOTO T MIZUNO K TAMORI I | 1996 | IEEE Transactionson Industry Application1996，32，3： | 1 |
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