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| 1 | Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure显示文摘AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure. | Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 2 | Selective Mimics of Strigolactone Actions and Their Potential Use for Controlling Damage Caused by Root Parasitic Weeds显示文摘Strigolactones (SL ) 是植物荷尔蒙和根围通讯信号的一个新奇的类,尽管位于他们的活动下面的分子的机制还没是充分坚定的。他们的应用程序也不在很好开发的农业。植物荷尔蒙收缩筋的重要性在基本、适用的研究被表明了,并且模仿 strigolactone 功能的化学药品应该极大地便于 strigolactone 研究。这里,我们报导我们新 phenoxyfuranone 混合物的发现, 4-Br debranone (4BD ) ,那显示出类似的活动到主要 strigolactone (SL ) 的在植物上的生物试金的许多方面的模拟 GR24。4BD 强烈在象 GR24 的一样的集中在 SL 缺乏的米饭异种 d10 禁止了 tiller 芽长出,没有不利效果,甚至在延长耕作期间。这结果也在 Arabidopsis thaliana 被观察 SL 缺乏的异种 max1, max3,和 max4。然而,到 Arabidopsis SL 感觉迟钝的变异的 max2 的 4BD 的应用程序没在它导致词法变化。SL biosynthetic 基因的表示被 4BD 处理也减少,可能经由否定反馈规定。然而在 Striga hermonthica 上的种子萌芽试金,一条根寄生植物, 4BD 远比 GR24 显示出更少的活动。这些结果建议 4BD 是第一植物特定的 strigolactone 模仿。 | Kosuke Fukui Shinsaku Ito Tadao Asami | 2013 | Molecular Plant2013，6，1： | 9 |
| 3 | 越南山茶×金花茶杂交种的子叶培养显示文摘开黄花的金花茶C,Chrysantha(二倍体)与其他物种的种间杂交,在用种子培育杂交种植株上的尝试己被证明是不成功的在我们的杂交试验中,将越南山茶(六倍体)和金花茶进行五次人工控制授粉处理,成功地获得了含有三粒可育的种子的两个成熟蒴果。将这些可育的种子的成熟子叶置于BA3mg/L+NAA1.0mg/L的MS培养基上进行离体培养,经过六个月时间的缓慢增殖,把它转移到椰乳10%+GA_3 1mg/L的MS培养基上,子叶表面形成大量的浅黄色或浅绿色的芽点。这些发生出来的芽只有4.3%(6/138)形成5厘米以上的带叶小植株发育成苗。由根的分生细胞的核形态特征可以看出,这此新生植株是越南山茶和金花茶的杂交种。 | SHINSAKU NADAMITSU YOSHIAKI ANDOH KATSUHIKO KONDO NICHIHARU SEGAWA 薛原 | 1991 | 广西林业科技1991，20，4： | 5 |
| 4 | Hemophagocytic lymphohistiocytosis: Recent progress in the pathogenesis, diagnosis and treatment显示文摘Hemophagocytic lymphohistiocytosis(HLH) is a hyperinflammatory syndrome that develops as a primary(familial/hereditary) or secondary(non-familial/hereditary) disease characterized in the majority of the cases by hereditary or acquired impaired cytotoxic T-cell(CTL) and natural killer responses. The molecular mechanisms underlying impaired immune homeostasis have been clarified, particularly for primary diseases. Familial HLH(familial hemophagocytic lymphohistiocytosis type 2-5, Chediak-Higashi syndrome, Griscelli syndrome type 2, Hermansky-Pudlak syndrome type 2) develops due to a defect in lytic granule exocytosis, impairment of(signaling lymphocytic activation molecule)-associated protein, which plays a key role in CTL activity [e.g., X-linked lymphoproliferative syndrome(XLP) 1], or impairment of X-linked inhibitor of apoptosis, a potent regulator of lymphocyte homeostasis(e.g., XLP2). The development of primary HLH is often triggered by infections, but not in all. Secondary HLH develops in association with infection, autoimmune diseases/rheumatological conditions and malignancy. The molecular mechanisms involved in secondary HLH cases remain unknown and the pathophysiology is not the same as primary HLH. For either primary or secondary HLH cases, immunosuppressive therapy should be given to control the hypercytokinemia with steroids, cyclosporine A, or intravenous immune globulin, and if primary HLH is diagnosed, immunochemotherapy with a regimen containing etoposide or anti-thymocyte globulin should be started. Thereafter, allogeneic hematopoietic stem-cell transplantation is recommended for primary HLH or secondary refractory disease(especially EBVHLH). | Shinsaku Imashuku | 2014 | World Journal of Hematology2014，3，3： | 5 |
| 5 | Clinical features and treatment strategies of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis显示文摘 | Shinsaku Imashuku | 2002 | Critical Reviews in Oncology and Hematology2002，，3： | 2 |
| 6 | Non-ablative skin rejuvenation utilizing a combination of Q-switched and long pulse Nd:YAG laser,assisted with carbon suspended lotion显示文摘 | Takahiro Fujimoto Youichi Terashima Shinsaku Tsuji | 2004 | Laser Surg Med2004，16，： | 1 |
| 7 | Local recurrence after rectal endoscopic submucosal dissection: a case of tumor cell implantation显示文摘 | Takashi Inoue Hisao Fujii Fumikazu Koyama Tadashi Nakagawa Kazuaki Uchimoto Shinji Nakamura Takeshi Ueda Naoto Nishigori Keijiro Kawasaki Shinsaku Obara Takayuki Nakamoto Yoshiyuki Nakajima | 2014 | Clinical Journal of Gastroenterology2014，，1： | 1 |
| 8 | Multi-h phasecoded modulation显示文摘 | IWAO sasase SHINSAKU mori | 1991 | IEEE Communications Magazine1991，29，6： | 1 |
| 9 | Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria显示文摘 | Shinsaku Fukuda Tadashi Shimoyama Noriko Umegaki Tatsuya Mikami Hajime Nakano Akihiro Munakata | 2004 | Journal of Gastroenterology2004，，9： | 1 |
| 10 | INFECTION- AND MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROMES显示文摘 | Gritta Janka Shinsaku Imashuku G?ran Elinder Marion Schneider Jan-Inge Henter | 1998 | Hematology/Oncology Clinics of North America1998，，2： | 1 |
| 11 | Development of Fracture Splitting Connecting Rod 显示文摘 | Shinsaku Fukuda Hirohito Eto | 2002 | JSAE Review2002，23，1： | 1 |
| 12 | Ocular Involvement and Visual Sequelae in Hemophagocytic Lymphohistiocytosis in Association with Congenital Dyfsfibrinogenemia显示文摘 | Kousaku Matsubara Hiroyuki Nigami Hidekazu Harigaya Kunizou Baba Mika Iwami Makoto Hojo Shinsaku Imashuku | 1998 | Pediatric Hematology-Oncology1998，，4： | 1 |
| 13 | A secret key cryptosystem using a chaotic map显示文摘 | TOSHIKI N Y H IWAO S SHINSAKU M | 1990 | Trans of the IEICE1990，73，7： | 1 |
| 14 | Clinicopathological analysis for recurrence of stage Ib gastric cancer (according to the second English edition of the Japanese classification of gastric carcinoma)显示文摘 | Takashi Yokoyama Kiyoshi Kamada Yoshikazu Tsurui Hisanori Kashizuka Eiji Okano Sanehito Ogawa Shinsaku Obara Mitsutoshi Tatsumi | 2011 | Gastric Cancer2011，，4： | 1 |
| 15 | Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8显示文摘 | Tadashi Shimoyama Shinsaku Fukuda Qiang Liu Shigeyuki Nakaji Akihiro Munakata Kazuo Sugawara | 2001 | Journal of Gastroenterology2001，，3： | 1 |
| 16 | Development of fracture splitting connecting rod 显示文摘 | Shinsaku Fukuda Hirohito Eto | 2002 | JSAE Review2002，23，： | 1 |
| 17 | Tissue-specific mRNA expression profiles of human toll-like receptors and related genes显示文摘 | Masuhiro N Shinsaku N | 2005 | Biol Pharm Bull2005，28，5： | 1 |
| 18 | A new metllod 0f indu-cing selective brain hypothermia with saline perfusion into the subdural space:efects on transient cerebral ischemia in cats显示文摘 | Yasuhiro N Shinsaku N MasamLtsu K | | 0，，： | 1 |
| 19 | Long-Term (>10 Years) Clinical Outcomes of First-in-Human Biodegradable Poly-l-Lactic Acid Coronary Stents: Igaki-Tamai Stents显示文摘 | Soji Nishio Kunihiko Kosuga Keiji Igaki Masaharu Okada Eisho Kyo Takafumi Tsuji Eiji Takeuchi Yasutaka Inuzuka Shinsaku Takeda Tatsuhiko Hata Yuzo Takeuchi Yoshitaka Kawada Takeshi Harita Junya Seki Shunji Akamatsu Shinichi Hasegawa Nico Bruining Salvator | 2012 | Circulation2012，，19： | 1 |
| 20 | Design of an Efficient Security Protocol Analyzer显示文摘 | Shinsaku KIYOMOTO Haruki OTA Toshiaki TANAKA | 2007 | Computer Science and Network Security2007，7，6： | 1 |
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