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| 1 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 2 | Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein显示文摘The reverse cholesterol transport mediated by highdensity lipoprotein(HDL)is an important mechanism for maintaining body cholesterol,and hence,the crucial anti-atherogenic action of the lipoprotein.Recent studies,however,have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism.The present review provides an overview of the roles of sphingosine 1-phosphate(S1P)/S1P receptor and apolipoprotein A-I/ scavenger receptor class B typeⅠsystems in the antiatherogenic HDL actions.In addition,the physiological significance of the existence of S1P in the HDL particles is discussed. | Koichi Sato Fumikazu Okajima | 2010 | World Journal of Biological Chemistry2010，1，11： | 4 |
| 3 | Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef显示文摘 | Rumiko Nakashita Yaeko Suzuki Fumikazu Akamatsu Yoshiko Iizumi Takashi Korenaga Yoshito Chikaraishi | 2008 | Analytica Chimica Acta2008，，1： | 2 |
| 4 | Increase in sphingolipid catabolic enzyme activity during aging显示文摘 | Santosh J SACKET Hae-young CHUNG Fumikazu OKAJIMA Dong-soon IM | 2009 | Acta Pharmacologica Sinica2009，30，10： | 2 |
| 5 | Local recurrence after rectal endoscopic submucosal dissection: a case of tumor cell implantation显示文摘 | Takashi Inoue Hisao Fujii Fumikazu Koyama Tadashi Nakagawa Kazuaki Uchimoto Shinji Nakamura Takeshi Ueda Naoto Nishigori Keijiro Kawasaki Shinsaku Obara Takayuki Nakamoto Yoshiyuki Nakajima | 2014 | Clinical Journal of Gastroenterology2014，，1： | 1 |
| 6 | Plexin-A4 mediates 5Axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance显示文摘 | Fumikazu Suto Keisuke Ito | 2005 | J Neurosci2005，25，14： | 1 |
| 7 | The yield stress equation for the electrorheological fluids显示文摘 | Tian Hao Akiko Kawai Fumikazu Ikazak | 2000 | Langmuir2000，16，7： | 1 |
| 8 | Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits显示文摘Increased expression of matrix metalloproteinase-1(MMP-1)has been observed in the lesions of atherosclerosis and aneurysms;however,it is not fully understood whether macrophage-derived MMP-1 affects these diseases.To investigate whether macrophage-derived MMP-1 participates in the development of vascular diseases,we generated transgenic(Tg)rabbits expressing human MMP-1 in the monocyte/macrophage lineage under the control of the human scavenger receptor enhancer/promoter.Tg rabbits exhibited no visible abnormalities throughout their bodies.Western blotting analysis revealed that the amount of MMP-1 proteins in the conditioned media secreted from peritoneal macrophages of Tg rabbits was up to 3-fold higher than that in non-Tg rabbits.For the first experiment,Tg and non-Tg rabbits were fed a cholesterol diet for 16 weeks,and aortic and coronary atherosclerosis were evaluated.The gross lesion area of aortic atherosclerosis in Tg rabbits was not significantly different from that in non-Tg rabbits,but Tg rabbits had marked destruction of the medial elastic lamina of the aortic lesions on microscopic examination.For the second experiment,we generated aortic aneurysms by incubating with elastase.Compared with non-Tg rabbits,Tg rabbits exhibited a significantly greater aortic dilation.Increased macrophage-derived MMP-1 led to increased medial destruction in both aortic atherosclerosis and aneurysms.These results demonstrate that MMP-1 plays a different role in the pathogenesis of atherosclerosis and aneurysms. | Manabu Niimi Kazutoshi Nishijima Shuji Kitajima Fumikazu Matsuhisa Kaneo Satoh Hirokazu Yamazaki Jifeng Zhang Y. Eugene Chen Jianglin Fan | 2019 | The Journal of Biomedical Research2019，33，4： | 1 |
| 9 | The Effect of Mixing Particles of Different Size on the Electrorheological Response Under Steady Shear Flow显示文摘 | Akiko Kawai Fumikazu Ikazaki | 2002 | Rheology Acta2002，41，12： | 1 |
| 10 | Dielectric Criteria for the Electrorheological Effect显示文摘 | Tian Hao Akiko Kawai Fumikazu Ikazaki | 1999 | Langmuir1999，15，： | 1 |
| 11 | The Yield Stress Equation for the Electrorheological Fluids 显示文摘 | Tian Hao Akiko Kawai Fumikazu Ikazaki | 2000 | Langmuir2000，16，： | 1 |
| 12 | Underwater Stud Welding 显示文摘 | Masanobu Harnaaki and Fumikazu Tateiwa | 1979 | Transation of the Japan Welding Society1979，10，1： | 1 |
| 13 | Imaging Diagnosis of Interstitial Pneumonia with Emphysema (Combined Pulmonary Fibrosis and Emphysema)显示文摘 | Fumikazu Sakai Junya Tominaga Akiko Kaga Yutaka Usui Minoru Kanazawa Takashi Ogura Noriyo Yanagawa Tamiko Takemura Masahito Ebina | 2012 | Pulmonary Medicine2012，，： | 1 |
| 14 | Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors显示文摘 | Hideaki Tomura Chihiro Mogi Koichi Sato Fumikazu Okajima | 2005 | Cellular Signalling2005，，12： | 1 |
| 15 | Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5显示文摘 | Tetsuya Tanigawa Toshio Watanabe Koji Otani Yuji Nadatani Fumikazu Ohkawa Mitsue Sogawa Hirokazu Yamagami Masatsugu Shiba Kenji Watanabe Kazunari Tominaga Yasuhiro Fujiwara Koji Takeuchi Tetsuo Arakawa | 2013 | 2013 (1-3)2013，，1： | 1 |
| 16 | Discovery of new phase and analysis of phase relationships in BaBiO3 with thermal analyses 显示文摘 | Makoto Y Fumikazu T Takuya H | 2005 | Thermochim Acta2005，431，： | 1 |
| 17 | Analysis on the sintering process ofX7R MLCC materials 显示文摘 | Fujikawa Yoshinori Umeda Yuji Yamane Fumikazu | 2004 | J Jpn Soc Powder and Powder Metallurgy2004，42，51： | 1 |
| 18 | Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells显示文摘 | Toshihiko Toyofuku Junko Yoshida Tamiko Sugimoto Midori Yamamoto Nobuhiko Makino Hyota Takamatsu Noriko Takegahara Fumikazu Suto Masatsugu Hori Hajime Fujisawa Atsushi Kumanogoh Hitoshi Kikutani | 2008 | Developmental Biology2008，，： | 1 |
| 19 | Forest sustainability and the free trade of forest products : cases from Southeast Asia 显示文摘 | Mihoko Shimamoto Fumikazu Ubukata Yoshiki Seki | 2004 | Ecological Economics2004，50，12： | 1 |
| 20 | Food source of riparian spiders analyzed by using stable isotope ratios显示文摘 | Fumikazu AKAMATSU Hideshige TODA and Tokio OKINO | 2004 | Ecological Research2004，19，6： | 1 |
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