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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | 区域创新系统的管治框架演化——来自深圳和东莞的对比实证显示文摘本文在电子企业问卷调查的基础上,对比分析深圳和东莞的区域创新机制,并进一步从管治角度构建区域创新机制差异的理论框架,在中国转型的体制背景下阐释管治的演化逻辑。结果显示,改革开放初期自上而下的管治模式相对于自下而上的管治,在各自向网络化管治模式演化的过程中,由于先发制度优势和组织能力禀赋,更能顺利的推动工业基础薄弱地区向区域创新系统的转变。最后指出,演化视角分析必须注重时间和地理的特殊性。 | 符文颖 Javier Revilla Diez Daniel Schiller | 2013 | 人文地理2013，28，4： | 8 |
| 4 | A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple显示文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. | Doreen Schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab | 2015 | Horticulture Research2015，2，1： | 6 |
| 5 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography显示文摘 | Lawrence G. Rudski Wyman W. Lai Jonathan Afilalo Lanqi Hua Mark D. Handschumacher Krishnaswamy Chandrasekaran Scott D. Solomon Eric K. Louie Nelson B. Schiller | 2010 | Journal of the American Society of Echocardiography2010，，7： | 6 |
| 6 | UNIFORM SUPERCONVERGENCE OF A FINITE ELEMENT METHOD WITH EDGE STABILIZATION FOR CONVECTION-DIFFUSION PROBLEMS显示文摘在现在的纸,边稳定技术在联合起来的平方上与指数的边界层被用于一个传送对流散开问题,用有在层区域的双线性的有限元素和网孔的粗糙的部分上的线性元素的一个 Shishkin 网孔。错误界限为 || u 被证明 - u [h ]||[E ] ,在 u 是答案 u 的某 interpolant 的地方并且哦分离答案。这 supercloseness 结果关于 L 暗示最佳的错误估计[2 ] 标准并且为改进分离答案打开门到 postprocessing 的申请。[从作者抽象] | Sebastian Franz Torsten Linβ Hans-Grg Roos Sebastian Schiller | 2010 | Journal of Computational Mathematics2010，28，1： | 5 |
| 7 | Differential effect of age on survival in advanced NSCLC in women versus men: Analysis of recent Eastern Cooperative Oncology Group (ECOG) studies, with and without bevacizumab显示文摘 | H.A. Wakelee S.E. Dahlberg J.R. Brahmer J.H. Schiller M.C. Perry C.J. Langer A.B. Sandler C.P. Belani D.H. Johnson | 2011 | Lung Cancer2011，，3： | 3 |
| 8 | 小型激光天文动力学空间计划概念显示文摘小型激光天文动力学空间计划是 :使用在太阳轨道上无拖曳航天器和地面站以激光干涉和脉冲测距的方法 ,精确地探讨天文动力学 ,检测相对论与时空基本定律 ,改进探测引力波的灵敏度以及更准确地测定太阳、行星和小行星的参数。 1 969年开始的月球激光 (反射 )测距 ,对地球物理、参考坐标的选定、相对论的检验均有重要的贡献。 3 0年来 ,激光技术的长足进步 ,使现在正是适合于开始进行研究空间有源 (主动 )测距和光波空间通讯的时候。激光天文动力学的兴起是必然的趋势 ,其精确度将比现在提高 3到 6个数量级 ,将是天文动力学革命性的发展。小型激光天文动力学空间计划可以起到带头作用。它的关键技术有三 ,即 :弱光锁相、极精确无拖曳航天和高衰减日冕仪。弱光锁相已有长足的进步。对高衰减日冕仪的研究 ,也有了初步的方案。LISA空间计划将于 2 0 0 6年 8月发射SMART -2 ,研究测试极精确无拖曳航天。小型激光天文动力学空间计划的关键技术已日趋成熟。在第一届国际激光天文动力学研讨会 ( 2 0 0 1 ,9.1 3 -2 3 )中介绍了各相关学科背景及前沿研究 ,讨论了激光天文动力学空间计划科学目标及相关技术 ,并召开了两次小型激光天文动力学空间计划预研究筹备会 ,建立了和欧洲的合作关系。会后着手进行此项对基础? | 倪维斗 朱进 武向平 褚桂柏 杨彬 高健 关敏 汤健仁 周翊 张中豪 黄天衣 曲钦岳 易照华 李广宇 陶金河 吴岸明 罗俊 叶贤基 周泽兵 熊耀恒 毕少兰 须重明 吴雪君 唐孟希 包芸 李芳昱 黄珹 杨福民 叶叔华 张书练 张元仲 聂玉昕 陈光 Joergen Christensen-Dalsgaard Hansjoerg Dittus Yasunori Fujii Claus Laemmerzahl Jean Francois Mangin Achim Peters Albrecht Ruediger Etienne Samain Stephan Schiller | 2002 | 云南天文台台刊2002，，3： | 3 |
| 9 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography显示文摘 | Lawrence G. Rudski Wyman W. Lai Jonathan Afilalo Lanqi Hua Mark D. Handschumacher Krishnaswamy Chandrasekaran Scott D. Solomon Eric K. Louie Nelson B. Schiller | 2010 | Journal of the American Society of Echocardiography2010，，7： | 2 |
| 10 | Exploring graphene as a corrosion protection barrier显示文摘 | N.T. Kirkland T. Schiller N. Medhekar N. Birbilis | 2011 | Corrosion Science2011，，： | 2 |
| 11 | Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation显示文摘 | Joseph Romagnuolo Dan Schiller Robert J Bailey | 2002 | The American Journal of Gastroenterology2002，，5： | 2 |
| 12 | Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properities and expression patterns显示文摘 | Moll R Schiller D L Franke W W | 1990 | J Cell Biol1990，111，2： | 2 |
| 13 | Comparison of four chemotherapy for advanced non-small-cell lung cancer显示文摘 | Schiller JH Harrington D Belani CP | 2002 | N Engl J Med2002，346，2： | 2 |
| 14 | ECOG 4599 phase Ⅲ trial of carboplatin and paclitaxel ± bevacizumab: Subset analysis of survival by gender显示文摘 | BRAHMER JR GRAY R SCHILLER JH | 2006 | Proc Am Soc Clin Oncol2006，24，： | 1 |
| 15 | Design for computer experiments显示文摘 | Sacks J Schiller S B Welch W J | 1989 | Technometrics1989，31，： | 1 |
| 16 | Comparison of Four Chemotherapy Regimens for Advanced Non Small Cell Lung Cancer显示文摘 | Harrington D Belanie CP | 2002 | New Eng J Med2002，346，2： | 1 |
| 17 | Entrepreneurial origins: a longitudinal inquiry显示文摘 | Schiller B R Crewson P E | 1997 | Economic Inquiry1997，35，3： | 1 |
| 18 | Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer:a phase Ⅲ trial-INTACT2显示文摘 | Herbst RS Giaccone G Schiller JH | 2004 | J Clin Oncol2004，22，5： | 1 |
| 19 | IR and NMR Studies on the Action of Hypochlorous Acid on Chondroitin Sulfate and Taurine显示文摘 | Servaty R Schiller J | 1998 | Biooraganic Chemistry1998，26，1： | 1 |
| 20 | A randomized phase Ⅲ trial of four chemotherapy regimens in advanced non-small cell lung cancer(NSCLC)显示文摘 | Schiller JH Harrington D Sandler A | 2002 | N Engl J Med2002，346，： | 1 |
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