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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease显示文摘 | Achuthan Sourianarayanane Gaurav Garg Thomas H. Smith Mujtaba I. Butt Arthur J. McCullough Bo Shen | 2013 | Journal of Crohn’s and Colitis2013，，8： | 2 |
| 3 | Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR显示文摘 | Justin O’Grady Margaret Ruttledge Sara Sedano-Balbás Terry J. Smith Thomas Barry Majella Maher | 2008 | Food Microbiology2008，，1： | 2 |
| 4 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 5 | Prediction of cochlear implant performance by genetic mutation: The spiral ganglion hypothesis显示文摘 | Robert W. Eppsteiner A. Eliot Shearer Michael S. Hildebrand Adam P. DeLuca Haihong Ji Camille C. Dunn Elizabeth A. Black-Ziegelbein Thomas L. Casavant Terry A. Braun Todd E. Scheetz Steven E. Scherer Marlan R. Hansen Bruce J. Gantz Richard J.H. Smith | 2012 | Hearing Research (-)2012，，1： | 1 |
| 6 | The Association Between Personal Measurements of Environmental Exposure to Particulates and Heart Rate Variability显示文摘 | Shannon R. Magari Joel Schwartz Paige L. Williams Russ Hauser Thomas J. Smith David C. Christiani | 2002 | Epidemiology2002，，3： | 1 |
| 7 | Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma显示文摘 | Gabriela Richard Thomas W. White Lisa E. Smith Regina A. Bailey John G. Compton David L. Paul S. J. Bale | 1998 | Human Genetics1998，，4： | 1 |
| 8 | Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators显示文摘 | George P. Lahm Thomas P. Selby John H. Freudenberger Thomas M. Stevenson Brian J. Myers Gilles Seburyamo Ben K. Smith Lindsey Flexner Christopher E. Clark Daniel Cordova | 2005 | Bioorganic & Medicinal Chemistry Letters2005，，22： | 1 |
| 9 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 10 | Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C显示文摘 | K.Rajender Reddy Teresa L. Wright Paul J. Pockros Mitchell Shiffman Gregory Everson Robert Reindollar Michael W. Fried Preston P. Purdum Donald Jensen Coleman Smith William M. Lee Thomas D. Boyer Amy Lin Simon Pedder Jean DePamphilis | 2001 | Hepatology2001，，2： | 1 |
| 11 | ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Committee Members Thomas J. Ryan Jeffrey L. Anderson Elliott M. Antman Blaine A. Braniff Neil H. Brooks Robert M. Califf L. David Hillis Loren F. Hiratzka Elliott Rapaport Barbara J. Riegel Richard O. Russell Earl E. Smith W. Douglas Weaver | 1996 | Journal of the American College of Cardiology1996，，5： | 1 |
| 12 | Secondary Transporters for Nickel and Cobalt Ions: Theme and Variations显示文摘 | Thomas Eitinger Jennifer Suhr Lucy Moore J. Andrew C. Smith | 2005 | BioMetals2005，，4： | 1 |
| 13 | A Rural Cancer Outreach Program Lowers Patient Care Costs and Benefits Both the Rural Hospitals and Sponsoring Academic Medical Center显示文摘 | Christopher E. Desch Michael A. Grasso Michael J. McCue Debra Buonaiuto Kay Grasso Mary K. Johantgen James E. Shaw Thomas J. Smith | 1999 | The Journal of Rural Health1999，，2： | 1 |
| 14 | Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots显示文摘 | Dennis M. Jensen Thomas O.G. Kovacs Rome Jutabha Gustavo A. Machicado Ian M. Gralnek Thomas J. Savides James Smith Mary Ellen Jensen Gwen Alofaituli Jeff Gornbein | 2002 | Gastroenterology2002，，2： | 1 |
| 15 | ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial显示文摘 | Thomas J. Ryan Jeffrey L. Anderson Elliott M. Antman Blaine A. Braniff Neil H. Brooks Robert M. Califf L. David Hillis Loren F. Hiratzka Elliot Rapaport Barbara J. Riegel Richard O. Russell Earl E. Smith W. Douglas Weaver | 1996 | Circulation1996，，9： | 1 |
| 16 | High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue显示文摘 | Wenjuan Jobgen Wenjiang J. Fu Haijun Gao Peng Li Cynthia J. Meininger Stephen B. Smith Thomas E. Spencer Guoyao Wu | 2009 | Amino Acids2009，，1： | 1 |
| 17 | Reported use of intravesical therapy for non‐muscle‐invasive bladder cancer (NMIBC): results from the Bladder Cancer Advocacy Network (BCAN) survey显示文摘 | Matthew E. Nielsen Angela B. Smith Raj S. Pruthi Thomas J. Guzzo Gilad Amiel Neal Shore Yair Lotan | 2012 | BJU International2012，，7： | 1 |
| 18 | Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods显示文摘 | R. J. MacIsaac C. Tsalamandris M. C. Thomas E. Premaratne S. Panagiotopoulos T. J. Smith A. Poon M. A. Jenkins S. I. Ratnaike D. A. Power G. Jerums | 2006 | Diabetologia2006，，7： | 1 |
| 19 | Development of allometric relations for three mangrove species in South Florida for use in the Greater Everglades Ecosystem restoration显示文摘 | Thomas J. Smith Kevin R. T. Whelan | 2006 | Wetlands Ecology and Management2006，，5： | 1 |
| 20 | Arginine metabolism and nutrition in growth, health and disease显示文摘 | Guoyao Wu Fuller W. Bazer Teresa A. Davis Sung Woo Kim Peng Li J. Marc Rhoads M. Carey Satterfield Stephen B. Smith Thomas E. Spencer Yulong Yin | 2009 | Amino Acids2009，，1： | 1 |
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