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    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2For the Pravastatin or Atorvastatin evaluation and intention versus moderate lipid lowering with statius after acute coronary syndrome显示文摘Braunwald E McCabe CH Rader DJ 2004N Eng J Med2004,350,15:1
3Lipoproteins,macrophage function,and atherosclerosis:beyond the foam cell?显示文摘Rader DJ Pure E 2005Cell Meta2005,1,4:1
4Role of N-linked glycosylation in the secretion and activity of endothelial lipase显示文摘Miller G C Long C J Bojilova E D Marchadier D Badellino K 0 Blanchard N Fuki I V Glick J M Rader D J 2004Journal of Lipid Research2004,45,11:1
5Intensive versus moderate lipid lowering with statins after acute coronary syndromes 显示文摘Cannon C Braunwald E MeCabe C Rader D Rouleau J Belder R 2004New Engl J Med2004,350,:1
6The role of reverse cholesterol transport in animals and humans and relationship to atheroselerosis显示文摘RADER D J ALEXANDER E T WEIBEL G L 2009J Lipid Res2009,50,:1
7Left ventricular hy- pertrophy in valvular aortic stenosis: mechanisms and clinical implications 显示文摘Rader F Sachdev E Arsanjani R 2015Am J Med2015,128,4:1
8Atrial and ventricular cardiac myosins contain different heavy chain species 显示文摘Flink I L Rader J H Banerjee S K Morkin E 1978FEBS Lett1978,94,:1
9Topotecan in platinum-and paclitaxel-resistant ovarian cancer显示文摘SWISHER E M MUTCH D G RADER J S 1997Gynecol Oncol1997,66,:1
10Fine-needle aspiration biopsy diagnosis of gastrointestinal stromal tumors using morphology,immunocytochemistry and mutational analysis of c-kit显示文摘RADER A E AVERY A WAIT C L 2001Cancer2001,2593,:1
11Unique cell surface expression of receptor tyrosine kinase Rorl in human B-cell chronic lymphocytic leukemia 显示文摘Baskar S Kwong KY Hofer T Levy JM Kennedy MG Lee E Staudt LM Wilson WH Wiestner A Rader C 2008Clin Cancer Res2008,14,2:1
12A digital frequency synthesizer显示文摘Tierney J Rader C M Gold E 1971IEEE Twins Audio Electroocouxt1971,19,:1
13The threat of victimization: A theoretical re- conceptualization of fear of crime 显示文摘Rader N E 2004Sociological Spec- trnm2004,24,:1
14Flexural stiffness propertier of asphalt concrete at low temperature显示文摘Busby E O Rader L F 1992Asphalt Paving Technologists1992,,5:1
15Further data on the pulse ratio test显示文摘PHILIPS M E RADER E 1943Res Quart1943,14,:1
16Beyond high-density lipoprotein cholesterol levels: evaluating high-density lipoprotein function as influenced by novel therapeutic approaches显示文摘de Goma E M de Goma R L Rader D J 2008J Am Coil Cardiol2008,51,23:1
17Targeting high density lipoproteins in the prevention of cardiovascular disease? 显示文摘LARACH D B DEGOMA E M RADER D J 2012Curt Cardiol Rep2012,14,6:1
18Topotecan in platinum-and paclitaxel-resistant ovarian cancer显示文摘 Mutch D G Rader J S 1997Gynecol Oncol1997,66,3:1
19High incidence of t(11;18)(q21;q21)in Helicobacter pylori-negative gastric MALT lymphoma显示文摘e H Liu H Raderer M 2003Blood2003,101,7:1
20Isolation and mapping of microsatellite markers specific for the D genome of bread wheat 显示文摘PESTSOVA E GANAI M W RADER M S 2000Genome2000,43,:1
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