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| 1 | Type 2 diabetes mellitus:From a metabolic disorder to an inflammatory condition显示文摘Diabetes mellitus is increasing at an alarming rate and has become a global challenge.Insulin resistance intarget tissues and a relative deficiency of insulin secretion from pancreatic β-cells are the major features of type 2 diabetes(T2D).Chronic low-grade inflammation in T2 D has given an impetus to the field of immuno-metabolism linking inflammation to insulin resistance and β-cell dysfunction.Many factors advocate a causal link between metabolic stress and inflammation.Numerous cellular factors trigger inflammatory signalling cascades,and as a result T2 D is at the moment considered an inflammatory disorder triggered by disordered metabolism.Cellular mechanisms like activation of Tolllike receptors,Endoplasmic Reticulum stress,and inflammasome activation are related to the nutrient excess linking pathogenesis and progression of T2 D with inflammation.This paper aims to systematically review the metabolic profile and role of various inflammatory pathways in T2 D by capturing relevant evidence from various sources.The perspectives include suggestions for the development of therapies involving the shift from metabolic stress to homeostasis that would favour insulin sensitivity and survival of pancreatic β-cells in T2 D. | Iqra Hameed Shariq R Masoodi Shahnaz A Mir Mudasar Nabi Khalid Ghazanfar Bashir A Ganai | 2015 | World Journal of Diabetes2015，6，4： | 36 |
| 2 | Binding interaction of phosphorus heterocycles with bovine serum albumin:A biochemical study显示文摘Interaction between bovine serum albumin(BSA) and phosphorus heterocycles(PHs) was studied using multispectroscopic techniques. The results indicated the high binding affinity of PHs to BSA as it quenches the intrinsic fluorescence of BSA. The experimental data suggested the fluorescence quenching mechanism between PHs and BSA as a dynamic quenching. From the UV–vis studies, the apparent association constant(K_(app)) was found to be 9.25×10~2, 1.27×10~4and 9.01×10~2L/mol for the interaction of BSA with PH-1, PH-2 and PH-3,respectively. According to the F?rster's non-radiation energy transfer(FRET) theory, the binding distances between BSA and PHs were calculated. The binding distances(r) of PH-1, PH-2 and PH-3 were found to be2.86, 3.03, and 5.12 nm, respectively, indicating energy transfer occurs between BSA and PHs. The binding constants of the PHs obtained from the fluorescence quenching data were found to be decreased with increase of temperature. The negative values of the thermodynamic parameters ΔH, ΔS and ΔG at different temperatures revealed that the binding process is spontaneous; hydrogen bonds and van der Waals interaction were the main force to stabilize the complex. The microenvironment of the protein-binding site was studied by synchronous fluorescence and circular dichroism(CD) techniques and data indicated that the conformation of BSA changed in the presence of PHs. Finally, we studied the BSA-PHs docking using Auto Dock and results suggest that PHs is located in the cleft between the domains of BSA. | Swarup Roy Raj Kumar Nandi Sintu Ganai K.C. Majumdar Tapan K. Das | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 4 |
| 3 | A comparative overview of general risk factors associated with the incidence of colorectal cancer显示文摘 | Sabha Rasool Showkat Ahmad Kadla Vamiq Rasool Bashir Ahmad Ganai | 2013 | Tumor Biology2013，，： | 2 |
| 4 | Screening mammography: bringing backinto focus the value of a lifesaving intervention显示文摘 | Ganai S Winchester D J | 2011 | Cancer2011，117，14： | 1 |
| 5 | Biochemical and physiological changes during thermal stress in bovines显示文摘 | Ganaie A H Shanker G Bumla N A | 2013 | Journal of Veterinary Science & Technology2013，3，3： | 1 |
| 6 | Ellagic acid, an NF-tB inhibitor, ameliorates renal function in experimental diabetic nephropathy 显示文摘 | Ahad A Ganai A A Mujeeb M | 2014 | Chem Biol Interact2014，219，： | 1 |
| 7 | Folate: Metabolism, genes, polymorphisms and the associated diseases显示文摘 | Fakhira Hassan Nazki Aga Syed Sameer Bashir Ahmad Ganaie | 2014 | Gene2014，，： | 1 |
| 8 | Genistein modulates the expression of NF-κB and MAPK(p-38 and ERK1/2),thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats显示文摘 | Ganai AA Khan AA Malik ZA | 2015 | Toxicol Appl Pharmacol2015，283，2： | 1 |
| 9 | Biochemical andphysiological changes during thermal stress in bovines : a review显示文摘 | GANAIE A H GHASURA K S MIR N A | 2013 | Iran J Appl Anim Sci2013，3，3： | 1 |
| 10 | NeutrophIL-to-lymphocyte ra- tio in chronic obstructive pulmonary disease: a retrospective study 显示文摘 | Ganay E Ulasli SS Akar O | 2014 | Inflammation2014，37，2： | 1 |
| 11 | In vitro corrosion behavior of 13prosthodontic alloys显示文摘 | Ganay S Oktemer M | 1992 | Quintessence Int1992，23，： | 1 |
| 12 | Synthesis and Antimicrobial Studies of Chalconyl Pregnenolones显示文摘 | Banday A H Zargar M I Ganaie B A | 2011 | Steroids2011，76，12： | 1 |
| 13 | Anti-oxidant activities of extracts of the inflorescences and aerial parts of the herb, Ar?temisia amygdalina Decne显示文摘 | Rasool R Ganai BA Akbar S | 2012 | J Hort Sci Biotechnol2012，87，5： | 1 |
| 14 | Synthesis and antimi- crobial studies of chalconyl pregnenolones 显示文摘 | Banday A H Zargar M I Ganaie B A | 2011 | Steroids2011，76，12： | 1 |
| 15 | Folate:metabolism,genes,polymorphisms and the associated diseases显示文摘 | Nazki F H Sameer A S Ganaie B A | | 0，，01： | 1 |
| 16 | Adverse outcomes ofgeriatric patients undergoing abdominal surgery who areat high risk for delirium显示文摘 | Ganai S Lee KF Merrill A | 2007 | Arch Surg2007，142，11： | 1 |
| 17 | Immobilization of fructosyltransfer-ase by chitosan and alginate for efficient production of fructooligosaccharides显示文摘 | Mohd Anis Ganaie Hemant Kumar Rawat Owais Ahmad Wani | 2014 | Process Biochemistry2014，49，5： | 1 |
| 18 | Recycling of cell culture and efficient release of intracellular fructosyltransferase by ultrasonication for the production of fructooligosaccharides显示文摘 | Mohd Anis Ganaie Uma Shanker Gupta | 2014 | Carbohydrate Polymers2014，110，： | 1 |
| 19 | Synthesis and antimicrobial studies of chalconyl pregnenolones显示文摘 | Banday A H Zargar M I Ganaie B A | | 0，，： | 1 |
| 20 | Local recurrence after transanal endoscopic microsurgery for rectal polyps and early cancers显示文摘 | Ganai S Kanumuri P Rao RS | 2006 | Ann Surg Oncol2006，13，4： | 1 |
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