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| 1 | 自发性脑出血管理指南 美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索,检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见,采用美国心脏协会/美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南,重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。 | J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung Joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆 徐欣 | 2015 | 国际脑血管病杂志2015，23，10： | 444 |
| 2 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 3 | Matching Electronic Distribution Channels to Product Characteristics: The Role of Congruence in Consideration Set Formation显示文摘 | Pamela D Morrison John H Roberts | 1998 | Journal of Business Research1998，，3： | 1 |
| 4 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
| 5 | Friends or Strangers? Firm-Specific Uncertainty,Market Uncertainty,and Network Partner Selection 显示文摘 | CHRISTINE M B PAMELA R H DAMON J P | 2004 | Organization Science2004，15，3： | 1 |
| 6 | Comparative Anatomy of Vol- canic - Hosted Epithermal Deposits : Acid - Sulfate and Adularia- Serieite Types 显示文摘 | Pamela H Nora K F Daniel O H | 1987 | Economic Geology1987，82，1： | 1 |
| 7 | A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21显示文摘 | Song W Y Wang G L Chen L L HanSuk K Pi L Y Tom H GardnerJ Wang B Zhai W X Zhu L H Claude F Pamela R | 1995 | Science1995，270，5243： | 1 |
| 8 | Relationships between cigarette smoking during pregnancy, gestational age, maternal weight gain, and infant birthweight 显示文摘 | ROGER H SECKER W PAMELA MV | 2003 | Addictive Behaviors2003，28，： | 1 |
| 9 | Roy's adaptation model显示文摘 | Pamela N Stacey H Debra H | 2011 | Nursing Science Quarterly2011，24，4： | 1 |
| 10 | Gender differ- ences in correlates of depressive symptoms in adolescents显示文摘 | Pamela K Schraedley MA Ian H | 1999 | Journal of Adolescent Health1999，，25： | 1 |
| 11 | Socio - economic patterns of sport demandand ggeing 显示文摘 | CHRISTOPH B KIRSTIN H PAMELA W etal | 2010 | Academic literature review2010，7，2： | 1 |
| 12 | Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure显示文摘AIM To investigate the changes of hemodynamic and laboratory parameters during the course of acute liver failure following acetaminophen overdose.METHODS Eight pigs underwent a midline laparotomy following jejunal catheter placement for further acetaminophen intoxication and positioning of a portal vein Doppler flow-probe. Acute liver failure was realized by intrajejunal acetaminophen administration in six animals, two animals were sham operated. All animals were invasively monitored and received standardized intensive care support throughout the study. Portal blood flow, hemodynamic and ventilation parameters were continuously recorded. Laboratory parameters were analysed every eight hours. Liver biopsies were sampled every 24 h following intoxication and upon autopsy.RESULTS Acute liver failure (ALF) occurred after 28 ± 5 h resulted in multiple organ failure and death despite maximal support after further 21 ± 1 h (study end). Portal blood flow (baseline 1100 ± 156 m L/min) increased to a maximum flow of 1873 ± 175 m L/min at manifestation of ALF, which was significantly elevated(P < 0.01). Immediately after peaking, portal flow declined rapidly to 283 ± 135 m L/min at study end. Thrombocyte values (baseline 307 × 103/μL± 34 × 103/μL) of intoxicated animals declined slowly to values of 145 × 103/μL± 46 × 103/μL when liver failure occurred. Subsequent appearance of severe thrombocytopenia in liver failure resulted in values of 11 × 103/μL± 3 × 103/μL preceding fatality within few hours which was significant(P > 0.01).CONCLUSION Declining portal blood flow and subsequent severe thrombocytopenia after acetaminophen intoxication precede fatality in a porcine acute liver failure model. | Karolin Thiel Wilfried Klingert Kathrin Klingert Matthias H Morgalla Martin U Schuhmann Pamela Leckie Yalda Sharifi Nathan A Davies Rajiv Jalan Andreas Peter Christian Grasshoff Alfred Konigsrainer Martin Schenk Christian Thiel | 2017 | World Journal of Gastroenterology2017，23，9： | 1 |
| 13 | Reasons for increasing trends in large for gestational age births显示文摘 | Pamela JS Chung-Cheng H Anna LVJ | 2004 | Obstetrics Gynecol2004，，4： | 1 |
| 14 | Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2dopamine receptors显示文摘 | Suzanne H Pamela C Marie-Pierre C | 2010 | Journal of Neuroscience2010，30，42： | 1 |
| 15 | Feasibility studies for the detection of volatile organic compounds in the gas phase using microelectrode sensors 显示文摘 | Pamela A Mosier-Boss Stephen H Lieberman | 1999 | Journal of Electroanalytical Chemistry1999，460，12： | 1 |
| 16 | Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients 显示文摘 | Solveig H Pamela K James K | 2003 | Stroke2003，34，9： | 1 |
| 17 | The development of a standard method for determining oxidation induction times of hydrocarbon liquids by PDSC 显示文摘 | Pamela L S Gerald H P Alan T R | 1994 | Thermochimica Acta1994，，243： | 1 |
| 18 | Effects of linalyl ole ate on soybean oil flavor and quality in a frying applica- tion 显示文摘 | Baran O U Pamela W Earl H | 2007 | Journal of the American Oil Chemists Socie- ty2007，84，2： | 1 |
| 19 | Gender differences in cor- relates of depressive symptoms in adolescents显示文摘 | Pamela K Schraedley MA Ian H | 1999 | Journal of Ado- lescent Health1999，25，： | 1 |
| 20 | Long - term outcome of head injuries: A 23 year follow up study of children with head injuries显示文摘 | Klonoff H Clark C Pamela | 1993 | Journal of Neurology Neurosurgery and Psychiatry1993，56，2： | 1 |
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