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| 1 | Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes显示文摘The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental implants.Ti surface modification was accomplished in two steps.First,TiO2 nanotubes(NT)array was fabricated via anodization.Diameters and depths of NTs were controlled by applied voltage and duration.Subsequently,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular fashion.Surface wettability was assessed by contact angle measurement.The bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen extension.Early attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF surfaces.Platelet-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was observed.Furthermore,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular fashion.Within the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal. | Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi Nagai Toshiki Nojiri Masazumi Nagai | 2020 | International Journal of Oral Science2020，12，4： | 3 |
| 2 | Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface显示文摘Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease. | Hidemichi Kihara David M.Kim Masazumi Nagai Toshiki Nojiri Shigemi Nagai Chia-Yu Chen Cliff Lee Wataru Hatakeyama Hisatomo Kondo John Da Silva | 2018 | International Journal of Oral Science2018，10，3： | 2 |
| 3 | Repeated Resection of Colorectal Cancer Pulmonary Oligometastases: Pooled Analysis and Prognostic Assessment显示文摘 | Samer Salah Kazuhiro Watanabe Joon Suk Park Alaa Addasi Ji Won Park Jon Zabaleta Francesco Ardissone Jhingook Kim Marc Riquet Kazunori Nojiri Mara Gisabella Sun Young Kim Kuniya Tanaka | 2013 | Annals of Surgical Oncology2013，，6： | 2 |
| 4 | Determination of Sucralose in foods by HPLC using pre - column derivatization 显示文摘 | Nojiri S Nakazato M Kasuya Y | 2002 | Shokuhin Eiseigaku Zasshi2002，43，5： | 1 |
| 5 | Immunolocalization of nitric oxide synthase and VEGF receptors in cultured lymphatic endothelial cells显示文摘 | Nojiri H Ohhashi T | 1999 | Microcireulation1999，6，1： | 1 |
| 6 | Fluorescence detection of biotin using post-column derivatization with OPA in high performance liquid chromatography显示文摘 | NOJIRI S KAMATA K NISHLJIMA M | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，16，8： | 1 |
| 7 | Extraforaminalentrapment of the fifth lumbar spinal nerve by osteophytes of thelumbosacral spine : anatomic study and a report of four cases 显示文摘 | MATSUMOTO M CHIBA K NOJIRI K | 2002 | Spine (Phila Pa 1976)2002，27，6： | 1 |
| 8 | Numerical equivalent inclusion method:a new computational method for analyzing stress fields in and around inclusions of various shapes显示文摘 | NAKASONE Y NISHIYAMA H NOJIRI T | | 0，，： | 1 |
| 9 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 10 | Utility of delayed gadolinium-enhanced MRI (dGEMRIC) for qualitative evaluation of articular cartilage of patellofemoral joint 显示文摘 | Nojiri T Watanabe N Namura T | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，8： | 1 |
| 11 | Continuous bladder irrigation following transurethral resection of the prostate(TURP)显示文摘 | Nojiri Y Okamura K Kinukawa T | 2007 | Nippon Hinyokika Gakkai Zasshi2007，98，6： | 1 |
| 12 | Unified cosmic history in modified gravity:From F(R) theory to Lorentz non-invariant models显示文摘 | NOJIRI S ODINTSOV S D | 2011 | Phys Rept2011，505，： | 1 |
| 13 | Comparative assessment of pedicle morphology of the lumbar spine in various degenerative disease显示文摘 | Nojiri K Matsumoto M Chiba K | 2005 | Surg Radiol Anat2005，27，4： | 1 |
| 14 | Continuous bJadder irrigation following tnunsurethral resection of the prostate (TURP) 显示文摘 | Nojiri Y Okamura K Kinukawa T | 2007 | Nippon Hinyokika Gakkai Zasshi2007，98，6： | 1 |
| 15 | Bialaphos treatment of transgenic rice plants expressing a bar gene prevents infection by the sheath blight pathogen (Rhizoctonia solani)显示文摘 | Uchimiya H Iwata M Nojiri C | 1993 | Bio/Technology1993，11，： | 1 |
| 16 | Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarction in Japanese显示文摘 | Nojiri T Morita H Imai Y | 2003 | Int J Cardiol2003，92，23： | 1 |
| 17 | Utility of delayed gadolinium-enhanced MRI (dGEMRIC) for qualitative evaluation of articular cartilage of patellofemoral joint显示文摘 | Takehiro Nojiri Nobuyoshi Watanabe Takehiko Namura Wataru Narita Kazuya Ikoma Takehiko Suginoshita Hisatake Takamiya Hiroto Komiyama Hirotoshi Ito Tsunehiko Nishimura Toshikazu Kubo | 2006 | Knee Surgery Sports Traumatology Arthroscopy2006，，8： | 1 |
| 18 | Comparative assessment of pedicle morphology of the lumbar spine in various degenerative diseases显示文摘 | Kenya Nojiri Morio Matsumoto Kazuhiro Chiba Yoshiaki Toyama Suketaka Momoshima | 2005 | Surgical and Radiologic Anatomy2005，，4： | 1 |
| 19 | Global sea–air CO 2 flux based on climatological surface ocean p CO 2 , and seasonal biological and temperature effects显示文摘 | Taro Takahashi Stewart C. Sutherland Colm Sweeney Alain Poisson Nicolas Metzl Bronte Tilbrook Nicolas Bates Rik Wanninkhof Richard A. Feely Christopher Sabine Jon Olafsson Yukihiro Nojiri | 2002 | Deep-Sea Research Part II2002，，9： | 1 |
| 20 | 查看详情显示文摘 | Ritchie C Ferguson A Nojiri H Miras H.N. Song Y.F. Long D.L. Burkholder E. Murrie M. K(o)erler R Brechin E.K. Cronin L | | 0，，： | 1 |
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