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| 1 | 条背萤的形态和生物学研究显示文摘首次在中国大陆发现水栖萤火虫条背萤Luciolasubstriata。形态观察发现 ,条背萤成虫橙黄色 ,鞘翅末端灰黑色 ;发光器均为白色 ,雄虫发光器位于第 5、6腹节 ,位于第 5腹节的发光器呈带状 ,第 6腹节的发光器呈“V”字形 ;雌虫的发光器呈带状 ,位于第 5腹节 ;卵椭圆形 ,橙黄色。幼虫有两种形态 ,1~ 2龄具有 7对呼吸鳃 ,3~ 6龄幼虫无呼吸鳃。幼虫具有一对发光器 ,位于第 7腹节腹面 ;初蛹期仍保留幼虫形态的发光器 ,后呈现成虫的发光器 ,两种形态的发光器并存直至羽化。对条背萤生活史及习性调查发现 ,条背萤生活在水草较多的池塘、湖泊和流速缓慢的河流中。该虫 1年发生 1代 ,以幼虫在水中越冬 ,5月初老熟幼虫开始上岸化蛹。在 2 5℃下 ,条背萤预蛹期平均为 6 17天 ,蛹期平均为 4 4 3天。成虫 5月上旬至 9月中旬发生。日落后的 1h内是条背萤成虫闪光求偶的最盛期。卵期平均 12 5天。幼虫的猎物为静水椎实螺Lymnaeastagnalis,凸旋螺Gyraulusconwexiusculus等 ,天敌为克氏原螯虾Procambarusclarkii、中华绒毛蟹Eriocheirsinensis、草鱼Ctenopharyngodonidellus等。利用光谱仪对条背萤的发光光谱进行测定发现 ,条背萤的萤光光谱为 4 2 5~ 6 0 3nm ,峰值为 5 0 4nm 。 | 付新华 Ohba Nobuyoshi 雷朝亮 | 2004 | 昆虫学报2004，47，3： | 17 |
| 2 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 3 | 条背萤的闪光求偶行为显示文摘水栖萤火虫条背萤Luciola substriata(Gorh.)发出单脉冲周期性特异闪光信号进行求偶.室外观测发现,在23 ℃、86%RH时,雄萤飞行求偶闪光信号脉冲闪光持续时间为0.52 s,间隔时间为0.28 s,闪光信号的最大亮度为0.6 lx;雌萤求偶信号周期为0.67 s,最大亮度为0.4 lx.雄萤发出求偶信号0.22 s后,雌萤发出两个连续的回应信号.第一个回应信号为0.49 s,第二个为0.41 s,两个回应信号的间隔时间为0.11 s.雄萤发现雌萤回应信号后,降落至离雌萤5~10 cm处,继续发出闪光信号,但闪光脉冲频率减小,闪光脉冲时间为1.23 s,间隔时间为0.50 s.条背萤交配时呈'V'或'一'字形交配姿势. | 付新华 OHBA Nobuyoshi 王余勇 雷朝亮 | 2005 | 昆虫学报2005，48，2： | 10 |
| 4 | 萤火虫(鞘翅目:萤科)两性交流中的闪光信号显示文摘对国内外萤火虫两性交流闪光信号的研究进行了综述,萤火虫发光器因种而异,多数发出黄绿色萤光,闪光信号的频率、光谱、强度及其时空分布的闪光模式包含着两性交流信息。萤火虫闪光交流系统有两种分类方法,其一是萤火虫具两个类型的闪光信号交流系统,及系统和系统,前者多在旧大陆,后者多在新大陆;其二是萤火虫具6个类型闪光信号交流系统,即HP,LL,LC,PR,CR和LB型,其中PR型与系统相对应,HP型与系统对应。萤火虫两性交流闪光信号常因时间和空间上的差异及外界物体的干扰使两性闪光交流的效率受到影响。萤火虫两性交流的闪光信号起源于鞘翅目的幼虫阶段,并起警戒天敌的作用,经过两性选择成为成虫两性交流的一种途径,进而成为新大陆的一些萤火虫间捕食猎物和逃避天敌的生存策略。 | 付新华 王俊刚 Ohba Nobuyoshi 雷朝亮 | 2005 | 生态学报2005，25，6： | 7 |
| 5 | Chronic hepatitis C virus infection and lipoprotein metabolism显示文摘Hepatitis C virus(HCV) is a hepatotrophic virus and a major cause of chronic liver disease,including hepatocellular carcinoma,worldwide. The life cycle of HCV is closely associated with the metabolism of lipids and lipoproteins. The main function of lipoproteins is transporting lipids throughout the body. Triglycerides,free cholesterol,cholesteryl esters,and phospholipids are the major components of the transported lipids. The pathway of HCV assembly and secretion is closely linked to lipoprotein production and secretion,and the infectivity of HCV particles largely depends on the interaction of lipoproteins. Moreover,HCV entry into hepatocytes is strongly influenced by lipoproteins. The key lipoprotein molecules mediating these interactions are apolipoproteins. Apolipoproteins are amphipathic proteins on the surface of a lipoprotein particle,which help stabilize lipoprotein structure. They perform a key role in lipoprotein metabolism by serving as receptor ligands,enzyme co-factors,and lipid transport carriers. Understanding the association between the life cycle of HCV and lipoprotein metabolism is important because each step of the life cycle of HCV that is associated with lipoprotein metabolism is a potential target for anti-HCV therapy. In this article,we first concisely review the nature of lipoprotein and its metabolism to better understand the complicated interaction of HCV with lipoprotein. Then,we review the outline of the processes of HCV assembly,secretion,and entry into hepatocytes,focusing on the association with lipoproteins. Finally,we discuss the clinical aspects of disturbed lipid/lipoprotein metabolism and the significance of dyslipoproteinemia in chronic HCV infection with regard to abnormal apolipoproteins. | Yoshio Aizawa Nobuyoshi Seki Tomohisa Nagano Hiroshi Abe | 2015 | World Journal of Gastroenterology2015，21，36： | 6 |
| 6 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 7 | Development of massively parallel electron beam direct write lithography using active-matrix nanocrystalline-silicon electron emitter arrays显示文摘Nanoscale lithographic technologies have been intensively studied for the development of the next generation of semiconductor manufacturing practices.While mask-less/direct-write electron beam(EB)lithography methods serve as a candidate for the upcoming 10-nm node approaches and beyond,it remains difficult to achieve an appropriate level of throughput.Several innovative features of the multiple EB system that involve the use of a thermionic source have been proposed.However,a blanking array mechanism is required for the individual control of multiple beamlets whereby each beamlet is deflected onto a blanking object or passed through an array.This paper reviews the recent developments of our application studies on the development of a high-speed massively parallel electron beam direct write(MPEBDW)lithography.The emitter array used in our study includes nanocrystalline-Si(nc-Si)ballistic electron emitters.Electrons are drifted via multiple tunnelling cascade transport and are emitted as hot electrons.The transport mechanism allows one to quickly turn electron beamlets on or off.The emitter array is a micro-electro-mechanical system(MEMS)that is hetero-integrated with a separately fabricated active-matrix-driving complementary metal-oxide semiconductor(CMOS)large-scale integration(LSI)system that controls each emitter individually.The basic function of the LSI was confirmed to receive external writing bitmap data and generate driving signals for turning beamlets on or off.Each emitted beamlet(10×10μm^(2))is converged to 10×10 nm^(2) on a target via the reduction electron optic system under development.This paper presents an overview of the system and characteristic evaluations of the nc-Si emitter array.We examine beamlets and their electron emission characteristics via a 1:1 exposure test. | Masayoshi Esashi Akira Kojima Naokatsu Ikegami Hiroshi Miyaguchi Nobuyoshi Koshida | 2015 | Microsystems & Nanoengineering2015，1，1： | 4 |
| 8 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 9 | MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes显示文摘 | Keiko Tano Rie Mizuno Tomoko Okada Randeep Rakwal Junko Shibato Yoshinori Masuo Kenichi Ijiri Nobuyoshi Akimitsu | 2010 | FEBS Letters2010，，22： | 4 |
| 10 | Improvement of registration accuracy of a handheld augmented reality system for urban landscape simulation显示文摘 | Tomohiro Fukuda Tian Zhang Nobuyoshi Yabuki | 2014 | Frontiers of Architectural Research2014，3，4： | 4 |
| 11 | Stewart平台的运动奇异性与力奇异性研究显示文摘Stewart平台运动时 ,平台可能发生运动奇异性和力奇异性 .通过对平台运动方程Jacobian矩阵和力平衡方程Jacobian矩阵的分析 ,给出了两Jacobian矩阵的元素、行列式和条件数之间的联系 ,并对比了两种奇异面方程 .数学分析与实例说明 。 | 仇原鹰 段宝岩 盛英 Nobuyoshi MORITA | 2001 | 西安电子科技大学学报2001，28，2： | 3 |
| 12 | Microvascular Invasion in Patients with Hepatocellular Carcinoma and Its Predictable Clinicopathological Factors显示文摘 | Shuji Sumie MD Ryoko Kuromatsu MD Koji Okuda MD Eiji Ando MD Akio Takata MD Nobuyoshi Fukushima MD Yasutomo Watanabe MD Masamichi Kojiro MD Michio Sata MD | 2008 | Annals of Surgical Oncology2008，，5： | 2 |
| 13 | Molecular cloning and characterization of DMRT genes from the medaka Oryzias latipes and the platyfish Xiphophorus maculatus显示文摘 | Mariko Kondo Alexander Froschauer Akiko Kitano Indrajit Nanda Ute Hornung Jean-Nicolas Volff Shuichi Asakawa Hiroshi Mitani Kiyoshi Naruse Minoru Tanaka Michael Schmid Nobuyoshi Shimizu Manfred Schartl Akihiro Shima | 2002 | Gene2002，，2： | 2 |
| 14 | A MEMS Electromagnetic Optical Scanner for a Comercial Confocal Laser Scanning Microscope显示文摘 | Hiroshi Miyajima Nobuyoshi Asaoka Toshihiko Isokawa | 2003 | Journal of Microelectromechanical Systems2003，12，3： | 2 |
| 15 | A regression model-based method for indoor positioning with compound location fingerprints显示文摘This paper proposed and evaluated an estimation method for indoor positioning.The method combines location fingerprinting and dead reckoning differently from the conventional combinations.It uses compound location fingerprints,which are composed of radio fingerprints at multiple points of time,that is,at multiple positions,and displacements between them estimated by dead reckoning.To avoid errors accumulated from dead reckoning,the method uses short-range dead reckoning.The method was evaluated using 16 Bluetooth beacons installed in a student room with the dimensions of 11×5 m with furniture inside.The Received Signal Strength Indicator(RSSI)values of the beacons were collected at 30 measuring points,which were points at the intersections on a 1×1 m grid with no obstacles.A compound location fingerprint is composed of RSSI vectors at two points and a displacement vector between them.Random Forests(RF)was used to build regression models to estimate positions from location fingerprints.The root mean square error of position estimation was 0.87 m using 16 Bluetooth beacons.This error is lower than that received with a single-point baseline model,where a feature vector is composed of only RSSI values at one location.The results suggest that the proposed method is effective for indoor positioning. | Tomofumi Takayama Takeshi Umezawa Nobuyoshi Komuro Noritaka Osawa | 2019 | Geo-Spatial Information Science2019，22，2： | 2 |
| 16 | Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer显示文摘A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer(T3N2M0 Stage Ⅲ) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation,including redness,erosion,edema,bleeding,friability,and exudate with white plaques; and multiple depressions in the residual esophagus. Radiographical examination revealed numerous fine,gastrografinfilled projections and an anastomotic stricture. Biopsy specimens from the area of the anastomotic stricture revealed inflammatory changes without signs of malignancy. Candida glabrata was detected with a culture test of the biopsy specimens. The stricture was diagnosed as a benign stricture that was caused by esophageal intramural pseudodiverticulosis. Accordingly,endoscopic balloon dilatation was performed and antifungal therapy was started in the hospital. Seven weeks later,endoscopic examination revealed improvement in the mucosal inflammation; only the pseudodiverticulosis remained. Consequently,the patient was discharged. At the latest follow-up,the patient was symptomfree and the pseudodiverticulosis remained in the residual esophagus without any signs of stricture or inflammation. | Nobuyoshi Takeshita Naoki Kanda Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Masaya Uesato Tetsutaro Sazuka Tetsuro Maruyama Naohiro Aida Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 17 | Performance of a Direct Methanol Fuel Cell Operated at Atmospheric Pressure显示文摘 | Nobuyoshi N Yikun X | 2003 | Journal of Power Sources2003，118，2： | 1 |
| 18 | Active role of SDC interlayer in multi-layer anode of SOFCs 显示文摘 | Wang Xiaoge Nakagaw Nobuyoshi Kato Kunio | 2002 | Electrochemistry2002，70，4： | 1 |
| 19 | Identification of antigenic proteins encoded by human herpesvirus 8 and seroprevalence in the general population and among patients with and without Kaposi's sarcoma显示文摘 | Harutaka K Takuya I Nobuyoshi B | 2000 | Virology2000，74，8： | 1 |
| 20 | Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians显示文摘 | Satoki Homma Nobuyoshi Hirose Hiroyuki Ishida | 2001 | Stroke2001，32，4： | 1 |
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