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| 1 | Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection显示文摘AIM:To evaluate the effects of fucoidan,a complex sulfated polysaccharide extract from marine seaweed,on hepatitis C virus(HCV) RNA load both in vitro and in vivo.METHODS:HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa,Japan,and quantified the level of HCV replication.In an open-label uncontrolled study,15 patients with chronic hepatitis C,and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan(0.83 g/d) for 12 mo.The clinical symptoms,biochemical tests,and HCV RNA levels were assessed before,during,and after treatment.RESULTS:Fucoidan dose-dependently inhibited the expression of HCV replicon.At 8-10 mo of treatment with fucoidan,HCV RNA levels were significantly lower relative to the baseline.The same treatment also tended to lower serum alanine aminotransferase levels,and the latter correlated with HCV RNA levels.However,the improved laboratory tests did not translate into significant clinical improvement.Fucoidan had no serious adverse effects.CONCLUSION:Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCVrelated chronic liver diseases.Further controlled clinical trials are needed to confirm the present findings. | Naoki Mori Kazunori Nakasone Koh Tomimori Chie Ishikawa | 2012 | World Journal of Gastroenterology2012，18，18： | 3 |
| 2 | Rheological behavior of reactive blending of epoxidized natural rubber with cassava starch and epoxidized natural rubber with natural rubber and cassava starch显示文摘 | C Nakason A Kaesaman W Sainamsai | 2004 | J Appl Polym Sci2004，91，3： | 1 |
| 3 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loop-mediated isothermal amplification method显示文摘 | SONG Tian-Yan Toma C Nakasone N | 2005 | FEMS Microbiology Letters2005，243，： | 1 |
| 4 | Shock index correlates with extravasation on angio- graphs of gastrointestinal hemorrhage A logistics re- gression analysis 显示文摘 | NAKASONE Y IKEDA O YAMASHITA Y | 2007 | Cardiovasc Intervent Radiol2007，30，： | 1 |
| 5 | The eternal tooth germ is formed at the apical end of continuously growing teeth显示文摘 | Ohshima H Nakasone N Hashimoto E | | 0，，02： | 1 |
| 6 | Dissemination of pan- ton-valentine leukocidin-positive methicillin-resistant Stal)hylo coccusaureus in Okinawa, Japan显示文摘 | Mine Y Nakasone I Yamamoto Y | 2013 | J Dermatol2013，40，1： | 1 |
| 7 | Nonoperative management of unruptured visceral artery aneurysms: Treatment by transcatheter coil embolization显示文摘 | Osamu Ikeda Yoshitaka Tamura Yutaka Nakasone Yasuhiko Iryou Yasuyuki Yamashita | 2008 | Journal of Vascular Surgery2008，，6： | 1 |
| 8 | Selective serotonin reuptake inhibitors and rhabdomyloysis after eccentric exercise 显示文摘 | LABOLZ M WOLFF T K NAKASONE K T | 2006 | Med Sci Sports Exerc2006，38，9： | 1 |
| 9 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loop-mediated isothermal amplification method显示文摘 | Song T Toma C Nakasone N | 2005 | FEMS MicroBiol Lett2005，243，： | 1 |
| 10 | Numerical equivalent inclusion method:a new computational method for analyzing stress fields in and around inclusions of various shapes显示文摘 | NAKASONE Y NISHIYAMA H NOJIRI T | | 0，，： | 1 |
| 11 | Study of aeration at weirs and cascades显示文摘 | Nakasone H | 1987 | Journal of environmental engineering1987，113，1： | 1 |
| 12 | Study of aeration at weirs and cascades显示文摘 | Nakasone H | 1987 | Journal of Environmental Engineering1987，113，1： | 1 |
| 13 | Host-derived MCP-1 and MIP-lct regulate protective anti-tumor immunity to localized and metastatic B16 melanoma 显示文摘 | Nakasone Y Fujimoto M Matsushita T | 2012 | Am J Pathol2012，180，1： | 1 |
| 14 | Shock index correlates with extravasation on angiographs of gastrointestinal hemorrhage : A logistics regression analysis 显示文摘 | Nakasone Y lkeda O Yamashita Y | 2007 | Cardiovasc Intervent Radiol2007，30，5： | 1 |
| 15 | Effect of Vulcaniza- tion System on Properties of Thermoplastic Vulcanizates Based on Epoxidized Natural Rubber/Polypropylene Blends 显示文摘 | Nakason C Wannavilai P Kaesaman A | 2006 | Polymer Testing2006，25，1： | 1 |
| 16 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loop-mediated isothermal amplification method显示文摘 | Song Tianyan Toma C Nakasone N | 2005 | FEMS Microbiology Letters2005，243，： | 1 |
| 17 | Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen显示文摘 | Kawahara M Matsuo K Nakasone T | 2003 | Vaccine2003，21，34： | 1 |
| 18 | Prediction of transplant- related complications by C-reactive protein levels before hema- topoietic SCT 显示文摘 | Sato M Nakasone H Oshima K | 2013 | Bone Marrow Transplant2013，48，5： | 1 |
| 19 | A case of afebrile miliary tuberculosis that progressed from tuberculous span- dylitis with iliopsoas abscess 显示文摘 | NAMISATO S NAKASONE C OKUDAIRA S | 2010 | Intern Med2010，49，19： | 1 |
| 20 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loopmediated isothermal amplification method显示文摘 | Toma C Nakasone N | 2005 | FEMS Microbiol Lett2005，243，1： | 1 |
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