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| 1 | Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis显示文摘AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain diagnosis.METHODS A retrospective chart review was performed.Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included.Baseline characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were analyzed.Interventions based on CLE findings were also analyzed.We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens.RESULTS A total of 144 patients were included.Of these,51%(74/144) were female.The mean age was 51 years old.In all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,respectively.Cohen's Kappa was 69.20%,thus indicating good agreement.Changes in management were observed in 54% of the cases.CONCLUSION CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis. | Carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara Hannah Pitanga Lukashok | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 6 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | T cell responses and viral variability in blood donation candidates with occult hepatitis B infection显示文摘 | Marta Bes Victor Vargas Maria Piron Natalia Casamitjana Juan Ignacio Esteban Nuria Vilanova Asuncion Pinacho Josep Quer Lluis Puig Jaime Guardia Silvia Sauleda | 2011 | Journal of Hepatology2011，，4： | 2 |
| 5 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 6 | Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient显示文摘We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib,a tyrosine kinase inhibitor,is usually transient with mild elevation of transaminases,although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication. | Maria Salvado Victor Vargas Marta Vidal Macarena Simon-Talero Jessica Camacho Josep Gamez | 2015 | World Journal of Gastroenterology2015，21，36： | 1 |
| 7 | IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3显示文摘 | Merima Bublin Maria Kostadinova Christian Radauer Christine Hafner Zsolt Szépfalusi Eva-Maria Varga Soheila J. Maleki Karin Hoffmann-Sommergruber Heimo Breiteneder | 2013 | The Journal of Allergy and Clinical Immunology2013，，1： | 1 |
| 8 | Selling two environmental services:In-kind payments for bird habitat and watershed protection in Los Negros,Bolivia显示文摘 | Nigel M Maria A Varga T Wunder S | 2008 | Ecological Economic2008，，12： | 1 |
| 9 | Anaesthesia and orphan disease: laparoscopic cholecystectomy with paroxysmal nocturnal haemoglobinuria and human mAb therapy显示文摘 | Maria Vargas Clara Lallo Annachiara Marra Giuseppe Servillo | 2013 | European Journal of Anaesthesiology2013，，12： | 1 |
| 10 | Characterisation of volatile composition of white salsify ( Tragopogon porrifolius L.) by headspace solid-phase microextraction (HS-SPME) and simultaneous distillation–extraction (SDE) coupled to GC–MS显示文摘 | Montserrat Riu-Aumatell Liliana Vargas Stefania Vichi Josep Maria Guadayol Elvira López-Tamames Susana Buxaderas | 2011 | Food Chemistry2011，，2： | 1 |
| 11 | Clinical applications of diffusion tensor tractography of the spinal cord 显示文摘 | Maria isabel vargas Jacqueiine delavelle Helmi jlassi | 2008 | Neuroradiology2008，50，1： | 1 |
| 12 | Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications显示文摘 | Mélina L. Heuzé Pablo Vargas Mélanie Chabaud Ma?l Berre Yan‐Jun Liu Olivier Collin Paola Solanes Rapha?l Voituriez Matthieu Piel Ana‐Maria Lennon‐Duménil | 2013 | Immunol Rev2013，，1： | 1 |
| 13 | Oxidative Stress Damage in the Liver of Fish and Rats Receiving an Intraperitoneal Injection of Hexavalent Chromium as Evaluated by Chemiluminescence显示文摘 | Kelly Cristina Tagliari Vera Maria Ferrao Vargas | 2004 | Environmental Toxicology and Pharmacology2004，17，： | 1 |
| 14 | Use of essential oils in bioactive edible coatings显示文摘 | LAURA SANCHEZ-GONZALEZ MARIA VARGAS CHELO GONZALEZ-MARTINEZ | 2011 | Food Eng Rev2011，，3： | 1 |
| 15 | Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer显示文摘 | Edna Maria Vissoci Reiche Helena Kaminami Morimoto Sandra Morimoto Vargas Nunes | 2005 | International Review of Psychiatry2005，，6： | 1 |
| 16 | Evaluation of genetic diversity and plant growth promoting activities of nitrogen-fixing bacilli isolated from rice fields in South Brazil显示文摘 | Anelise Beneduzi Daiane Peres Luciano K. Vargas Maria Helena Bodanese-Zanettini Luciane Maria P. Passaglia | 2008 | Applied Soil Ecology2008，，3： | 1 |
| 17 | Chemoradiation with raltitrexed (TOMUDEX) in preoperative treatment of stage II-III resectable rectal cancer: A phase II study 1 1 Tomudex is a trademark of the AstraZeneca group of companies.显示文摘 | Maria Antonietta Gambacorta Vincenzo Valentini Alessio Giuseppe Morganti Giovanna Mantini Francesco Miccichè Carlo Ratto Dario Di Miceli Fabio Rotondi Sergio Alfieri Giovan Battista Doglietto Jose Garcia Vargas Antonino De Paoli Carlo Rossi Numa Cellini | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，1： | 1 |
| 18 | Cyclooxygenase -2 and kidney failure显示文摘 | Amelia Rios Hilda Vargas - Robles Ana Maria Gatmez - Mrndez | 2012 | Science Di- rect2012，，34： | 1 |
| 19 | High‐sensitivity C‐reactive protein for identification of disease phenotype, active disease, and clinical relapses in Crohn’s disease: A marker for patient classification?显示文摘 | Lajos Sandor Kiss Maria Papp Barbara Dorottya Lovasz Zsuzsanna Vegh Petra Anna Golovics Eszter Janka Eva Varga Miklos Szathmari Peter Laszlo Lakatos | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 20 | Characterisation of volatile composition of white salsify ( Tragopogon porrifolius L.) by headspace solid-phase microextraction (HS-SPME) and simultaneous distillation–extraction (SDE) coupled to GC–MS显示文摘 | Montserrat Riu-Aumatell Liliana Vargas Stefania Vichi Josep Maria Guadayol Elvira López-Tamames Susana Buxaderas | 2011 | Food Chemistry2011，，2： | 1 |
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