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| 1 | Microstructure and wear resistance of PTA clad Cr_7C_3/γ-Fe ceramal composite coating显示文摘A 穿抵抗 Cr 7 C 3/γ-Fe 合金陶瓷合成涂层在变硬和 tempering C 度钢 by6 PTA 的底层上被制作(转移的血浆是) cladding 与(wt%) Fe-25Cr-7C 元素的粉末相配。涂层的微观结构被 OM, SEM, XRD 和版本描绘穿涂层的抵抗在干燥滑动下面被测试在房间温度穿状况。结果显示合成涂层有的 PTA 穿着的合金陶瓷由 Cr 7 C 3 主要粒子一致地在 γ-Fe 矩阵散布了,冶金学的联盟者被结合到 C 度钢底层。PTA 穿着的 Cr 7 C 3/Fe ceremal 合成涂层有高坚硬并且优秀在干燥滑动下面穿抵抗穿测试条件。优秀穿 Cr 7 C 3/γ-Fe ceremal 合成涂层被归因于涂层的高坚硬。 | LIU Junbo WANG Limei HUANG Jihua | 2006 | Progress in Natural Science:Materials International2006，16，8： | 13 |
| 2 | Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales显示文摘The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions. | Liping Zhu Junbo Wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu Boping Han Linshan Liu Mingda Wang Qingfeng Ma | 2019 | Science Bulletin2019，64，7： | 13 |
| 3 | Anti-loosening performance of coatings on fasteners subjected to dynamic shear load显示文摘This paper investigates the self-loosening of threaded fasteners subjected to dynamic shear load. Three kinds of typical coatings, PTFE, MoS_2, and TiN applied to bolts and nuts, are tested in this investigation. The study experimentally examines the loosening mechanisms of fasteners and assesses the anti-loosening performance of the three tested coatings based on their tightening characteristics, loosening curves, and the damage of thread surface. Additionally, the anti-loosening performance of the three coatings is compared under different load forms. The results indicate that the PTFE and MoS_2 coatings have significant anti-loosening effect, whereas the anti-loosening performance of Ti N coating is not satisfactory. It is also found that an appropriate increase of the initial tightening torque can significantly improve the anti-loosening effect. In addition, the microscopic analyses of PTFE and MoS2 coating reveal that a reduced initial tightening torque leads to fretting wear on the thread contact surfaces of fasteners, thereby aggravating the damage. | Junbo ZHOU Jianhua LIU Huajiang OUYANG Zhenbing CAI Jinfang PENG Minhao ZHU | 2018 | Friction2018，6，1： | 10 |
| 4 | Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes显示文摘公牛,有条件地必要的氨基酸,在心血管的功能起一个关键作用。这里,我们检验了效果在在老鼠 cardiomyocytes 的线粒体和 endoplasmic 蜂窝胃上公牛在葡萄糖剥夺(GD ) 期间。数据证明房间生存能力,细胞内部的公牛的内容,和公牛的 transporter 表示在 GD 期间被减少。相反,反应的氧种类的增加和细胞内部的 Ca2+ 内容被观察。也引起的 GD 破坏了展开的蛋白质反应(UPR ) 的 mitochondrial 膜潜力, apoptotic 房间死亡,和分离在 cardiomyocytes 的相对蛋白质。信号 transduction 分析证明那 Bcl-2 家庭蛋白质平衡被扰乱, caspase-12 被激活, UPR 亲戚蛋白质层次是起来调整的。而且,有 80 公里的预告的处理在 cardiomyocytes 的外长的公牛的稀释 GD 效果。我们的结果建议那公牛在禁止线粒体依赖者房间 apoptosis 和联系 UPR 的房间 apoptosis 上有有益的效果并且可能在未来在尖锐心肌的梗塞上有临床的含意。 | Yujie Yang Yue Zhang Xiaoyu Liu Ji Zuo Keqiang Wang Junbo Ge | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 10 |
| 5 | PTA clad (Cr,Fe)_7C_3/γ-Fe in situ ceramal composite coating显示文摘A wear-resistant (Cr, Fe)7C3/γ-Fe in situ ceramal composite coating was fabricated on the substrate of 0.45wt%C carbon steel by a plasma-transferred arc cladding process using the Fe-Cr-C elemental powder blends. The microstructure, microhardness, and dry-sliding wear resistance of the coating were evaluated. The results indicate that the microstructure of the coating, which was composed of (Cr, Fe)7C3 primary phase uniformly distributed in the γ-Fe, and the (Cr, Fe)7C3 eutectic matrix was metallurgically bonded to the 0.45wt%C carbon steel substrate. From substrate to coating, the microstructure of the coating exhibited an evident epitaxial growth character. The coating, indehiscent and tack-free, had high hardness and appropriate gradient. It had excellent wear resistance under the dry sliding wear test condition. | Junbo Liu Limei Wang Jihua Huang | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 9 |
| 6 | New Evidence for Hydrothermal Sedimentary Genesis of the Ni-Mo Deposits in Black Rock Series of the Basal Cambrian, Guizhou Province: Discovery of Coarse-Grained Limestones and its Geochemical Characteristics显示文摘The molybdenum-nickel deposits in Shuidong District of Nayong County (Guizhou Province, Southwest China) are found mainly in black shale series of Lower Cambrian Niutitang Formation, which is another Mo-Ni-rich region besides Zunyi District (Guizhou province). Our systematic study on the Mo-Ni deposits in Tangjiaba of Nayong reveals that layered coarse-grained limestones, spherical beaded limestones concretions are hosted at the lower seam of the Mo-Ni deposits. Its strong negative carbon isotope anomaly (the carbon isotope value of the coarse-grained limestones varies from -2.148‰ to 8.223‰) is similar to that in the modern submarine black smoker chimney. The carbon in the coarse-grained limestones from black rock series of Nayong County might be deep source inorganic carbon. The seams, coarse-grained limestones, ore-bearing coarse-grained limestones and the roof and floor of the deposits are characterized by co-variation on the trace element spider diagram, showing good homology. The extraordinary enrichment of Ag, As and Sb resembles hydrothermal sedimentation. Pro-Earth's core elements Se is strongly enriched in Ni-Mo ore-bearing coarse-grained limestones. The ore-bearing rock series has an extremely low Th/U value (0.012-0.19); in the logU-logTh Cartesian Coordinates, the samples of the roof and floor of the deposits and ore-bearing coarse-grained limestones are found in the East Pacific tise; and the samples of coarse-grained limestones are found between the paleo-hydrothermal dedimentary area and the East Pacific tise. The chondrite-normalized rare earth element patterns of the Ni-Mo deposits show LREE enrichment, Ce negative anomaly, and Eu negative anomaly (which is supposed to be influenced by the deep magmatic processes in an extensional environment) resembles the rare earth element distribution patterns of the fluid and its sediments in modern submarine hydrothermal system. It proves that coarse-grained limestones is characterized by typical hydrothermal limestones, being closely related with the genesis of Mo-Ni deposits in Nayong County, which provides new evidence for hydrothermal sedimentary genesis of Mo-Ni deposit and negative carbon anomaly in the basal Cambrian on a global scale. | WEI Huairui YANG Ruidong GAO Junbo CHEN Jiyan LIU Kun CHENG Wei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 8 |
| 7 | Glycerol aerobic oxidation to glyceric acid over Pt/hydrotalcite catalysts at room temperature显示文摘Glycerol(GLY) aerobic oxidation in an aqueous solution is one of the most prospective pathways in biomass transformation, where the supported catalysts based on noble metals(mainly Au, Pd, Pt) are most commonly employed. Herein, Pt nanoparticles supported on rehydrated MgxAl1-hydrotalcite(denoted as re-MgxAl1-LDH-Pt) were prepared via impregnation-reduction method followed by an in situ rehydration process, which showed high activity and selectivity towards GLY oxidation to produce glyceric acid(GLYA) at room temperature. The metal-support interfacial structure and catalyst basicity were modulated by changing the Mg/Al molar ratio of the hydrotalcite precursor, and the optimal performance was achieved on re-Mg6Al1-LDH-Pt with a GLY conversion of 87.6% and a GLYA yield of 58.6%, which exceeded the traditional activated carbon and oxide supports. A combinative study on structural characterizations(XANES, CO-FTIR spectra, and benzoic acid titration) proves that a higher Mg/Al molar ratio promotes the formation of positively charged Ptd+species at metal-support interface, which accelerates bond cleavage of a-C–H and improves catalytic activity. Moreover, a higher Mg/Al molar ratio provides a stronger basicity of support that contributes to the oxidation of terminal-hydroxyl and thus enhances the selectivity of GLYA. This catalyst with tunable metal-support interaction shows prospective applications toward transformation of biomass-based polyols. | Junbo Zhang Xiaolin Li Ming Xu Yusen Yang Yinwen Li Ning Liu Xiaoyu Meng Lifang Chen Shuxian Shi Min Wei | 2019 | Science Bulletin2019，64，23： | 8 |
| 8 | Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input显示文摘Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly. | Qing Du Li Zhou Ping Chen Xiaoming Liu Chun Song Feng Yang Xiaochun Wang Weiguo Liu Xin Sun Junbo Du Jiang Liu Kai Shu Wenyu Yang Taiwen Yong | 2020 | The Crop Journal2020，8，1： | 7 |
| 9 | Optimization of construction scheme and supporting technology for HJS soft rock tunnel显示文摘For a soft rock tunnel under high stress in jointed and swell soft rock(HJS), two construction schemes pilot-tunneling enlarging excavation and step-by-step excavation were optimized using FLAC2 D, and the deformation effects of the two construction schemes were verified by field tests. Based on engineering geological investigation and mechanical analysis of large deformations, the complex deformation mechanisms of stress expansion and structural deformation of the soft rock tunnel were confirmed,and support countermeasures from the complex deformation mechanism converted to a single type were proposed, and the support parameters were optimized by field tests. These technologies were proved by engineering practice, which produced significant technical and economic benefits. | Wang Shuren Li Chunliu Liu Zhaowei Fang Junbo | 2014 | International Journal of Mining Science and Technology2014，24，6： | 7 |
| 10 | Influence of Zn on oxide films on Alloy 690 in borated and lithiated high temperature water显示文摘 | Junbo Huang Xiahe Liu En-Hou Han Xinqiang Wu | 2011 | Corrosion Science2011，，10： | 6 |
| 11 | TiC/Fe cermet coating by plasma cladding using asphalt as a carbonaceous precursor显示文摘A new Ti-Fe-C compound powder for plasma cladding was prepared by heating a mixture powder of ferrotitanium and asphalt pyro-lyzed as a carbonaceous precursor. The carbon by the pyrolysis of the asphalt acts as a reactive constituent as well as a binder in the compound powder. The TiC/Fe cermet coatings were prepared by plasma cladding with the compound powder. Results show that the Ti-Fe-C compound powder has a very tight structure, which can avoid the problem of the reactive constituent particles being sep- arated during cladding. The TiC/Fe cermet coating presents a typical morphology of plasma cladding coatings with two different lam- inated layers:one is the composite layer in which the round fine TiC particles (<500 nm) are dispersed within a Fe matrix, the other is the paragentic layer of TiC and Ti2O3. The coating shows high hardness and excellent wear resistance. The surface hardness of the coating is 68 ± 5(HR30N). In the same fretting conditions, the wear area of Ni60 coating is about 11 times as much as the TiC/Fe cermet coating. | Junbo Liu | 2008 | Progress in Natural Science:Materials International2008，18，4： | 6 |
| 12 | Research on carbon and oxygen isotopes in phosphorus-bearing rock series of the Late Neoproteroic-Early Cambrian Taozichong Formation in Qingzhen City, Guizhou Province, Southwest China显示文摘In the study of the phosphate-bearing stratum at the bottom of the Cambrian system, the authors found that there occurred carbon isotope negative anomalies in the Taozichong section phosphate-bearing stratum in Qingzhen, Guizhou Province; they can be correspondingly compared with other synsedimentary carbon isotope negative anomalies both at home and abroad. The results showed that there occurred three negative anomalies of carbon isotopes in the Neoproterozoic-Early Cambrian Taozichong Formation, indicating that the temporal palaeo-oceanographical environment changed significantly, in which there happened two times of intensive carbon isotope variation, corresponding to creature extinction. Meanwhile, it is believed that the carbon isotope negative anomalies in phosphorites were caused by the ascending water mass of ocean current with the negative carbon isotopic composition of deep-ocean hydrothermal deposits. | MAO Tie YANG Ruidong MAO Jiaren YE Chun LIU Kun GAO Junbo | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 6 |
| 13 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 14 | Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury显示文摘Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion(I/R)injury and can be alleviated via the mitochondrial transplantation.The efficiency of mitochondrial transplantation is determined by mitochondrial vitality.Because aldehyde dehydrogenase 2(ALDH2)has a key role in regulating mitochondrial homeostasis,we aimed to investigate its potential therapeutic effects on mitochondrial transplantation via the use of ALDH2 activator,Alda-1.Our present study demonstrated that time-dependent internalization of exogenous mitochondria by cardiomyocytes along with ATP production were significantly increased in response to mitochondrial transplantation.Furthermore,Alda-1 treatment remarkably promoted the oxygen consumption rate and baseline mechanical function of cardiomyocytes caused by mitochondrial transplantation.Mitochondrial transplantation inhibited cardiomyocyte apoptosis induced by the hypoxia-reoxygenation exposure,independent of Alda-1 treatment.However,promotion of the mechanical function of cardiomyocytes exposed to hypoxia-reoxygenation treatment was only observed after mitochondrial Alda-1 treatment and transplantation.By using a myocardial I/R mouse model,our results revealed that transplantation of Alda-1-treated mitochondria into mouse myocardial tissues limited the infarction size after I/R injury,which was at least in part due to increased mitochondrial potential-mediated fusion.In conclusion,ALDH2 activation in mitochondrial transplantation shows great potential for the treatment of myocardial I/R injury. | Xiaolei Sun Rifeng Gao Wenjia Li Yongchao Zhao Heng Yang Hang Chen Hao Jiang Zhen Dong Jingjing Hu Jin Liu Yunzeng Zou Aijun Sun Junbo Ge | 2021 | Bioactive Materials2021，6，7： | 5 |
| 15 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 16 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 17 | New insights into the transovarial transmission of the symbiont Rickettsia in whiteflies显示文摘Endosymbiont transmission via eggs to future host generations has been recognized as the main strategy for its persistence in insect hosts;however,the mechanisms for transmission have yet to be elucidated.Here,we describe the dynamic locations of Rickettsia in the ovarioles and eggs during oogenesis and embryogenesis in a globally significant pest whitefly Bemisia tabaci.Field populations of the whitefly have a high prevalence of Rickettsia,and in all Rickettsia-infected individuals,the bacterium distributes in the body cavity of the host,especially in the midgut,fat body,hemocytes,hemolymph,and near bacteriocytes.The distribution of Rickettsia was subjected to dynamic changes in the ovary during oogenesis,and our ultrastructural observations indicated that the bacteria infect host ovarioles during early developmental stages via two routes:(i)invasion of the tropharium by endocytosis and then transmission into vitellarium via nutritive cord and(ii)entry into vitellarium by hijacking bacteriocyte translocation.Most of the Rickettsia are degraded in the oocyte cytoplasm in late-stage oogenesis.However,a few reside beneath the vitelline envelope of mature eggs,spread into the embryo,and proliferate during embryogenesis to sustain high-fidelity transmission to the next generation.Our findings provide novel insights into the maternal transmission underpinning the persistence and spread of insect symbionts. | Hongwei Shan Yinquan Liu Junbo Luan Shusheng Liu | 2021 | Science China(Life Sciences)2021，64，7： | 3 |
| 18 | BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas显示文摘Objective:BYSL,which encodes the Bystin protein in humans,is upregulated in reactive astrocytes following brain damage and/or inflammation.We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.Methods:BYSL expression in glioma tissues was measured by quantitative real-time PCR,Western blot,and immunohistochemistry.In vitro assays were performed to assess the role of BYSL in cell proliferation and apoptosis.Protein interactions and co-localization were determined by co-immunoprecipitation and double immunofluorescence.The expression and activity of the AKT/m TOR signaling molecules were determined by Western blot analysis,and the role of BYSL in glioma growth was confirmed in an orthotopic xenograft model.Results:The BYSL m RNA and protein levels were elevated in glioma tissues.Silencing BYSL inhibited glioma cell proliferation,impeded cell cycle progression,and induced apoptosis,whereas overexpressing BYSL protein led to the opposite effects.We identified a complex consisting of BYSL,RIOK2,and m TOR,and observed co-localization and positive correlations between BYSL and RIOK2 in glioma cells and tissues.Overexpressing BYSL or RIOK2 increased the expression and activity of AKT/m TOR signaling molecules,whereas downregulation of BYSL or RIOK2 decreased the activity of AKT/m TOR signaling molecules.Silencing BYSL or RIOK2 decreased the growth of the tumors and prolonged the lifespan of the animals in an orthotopic xenograft model.Conclusions:High expression of BYSL in gliomas promoted tumor cell growth and survival both in vitro and in vivo.These effects could be attributed to the association of BYSL with RIOK2 and m TOR,and the subsequent activation of AKT signaling. | Shangfeng Gao Zhuang Sha Junbo Zhou Yihao Wu Yunnong Song Cheng Li Xuejiao Liu Tong Zhang Rutong Yu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 19 | Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration显示文摘The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration.However,no systemic investigations have been made on the change of this pharmacokinetic difference,resulted either from the physiological or from the pathological factors.In this paper,we used polymorphic nimodipine(Nim) as a model drug and investigated the effect of age difference(2- and 9-month old) on the pharmacokinetics after oral delivery in rats.As the results shown,for L-form of Nim(L-Nim),the AUC0–24 hin 2-month-old rats was 343.68747.15 ng h/m L,which is 23.36% higher than that in 9-month-old rats.For H-form of Nim(H-Nim),the AUC0–24 hin 2-monthold rats was 140.91719.47 ng h/m L,which is 54.64% higher than that in 9-month-old rats.The AUC0–24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats.Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs,the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs. | Wenli Liu Xiaona Wang Ruilian Chen Kaixuan Zhang Yao Li Yi Li Duanyun Si Junbo Gong Dianshu Yin Yongli Wang Zhenping Wei Mingshi Yang | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 20 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
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