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| 1 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 2 | Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input显示文摘Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly. | Qing Du Li Zhou Ping Chen Xiaoming Liu Chun Song Feng Yang Xiaochun Wang Weiguo Liu Xin Sun Junbo Du Jiang Liu Kai Shu Wenyu Yang Taiwen Yong | 2020 | The Crop Journal2020，8，1： | 7 |
| 3 | Progress of Pharmaceutical Continuous Crystallization显示文摘 | Dejiang Zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong | 2017 | Engineering2017，3，3： | 5 |
| 4 | Distributed Real-time State Estimation for Combined Heat and Power Systems显示文摘This paper proposes a distributed real-time state estimation(RTSE)method for the combined heat and power systems(CHPSs).First,a difference-based model for the heat system is established considering the dynamics of heat systems.This heat system model is further used along with the power system steady-state model for holistic CHPS state estimation.A cubature Kalman filter(CKF)-based RTSE is developed to deal with the system nonlinearity while integrating both the historical and present measurement information.Finally,a multi-timescale asynchronous distributed computation scheme is designed to enhance the scalability of the proposed method for largescale systems.This distributed implementation requires only a small amount of information exchange and thus protects the privacy of different energy systems.Simulations carried out on two CHPSs show that the proposed method can significantly improve the estimation efficiency of CHPS without loss of accuracy compared with other existing models and methods. | Tingting Zhang Wen Zhang Qi Zhao Yaxin Du Jian Chen Junbo Zhao | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 5 |
| 5 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 6 | Mineralogy,sulfur isotopes and infrared microthermometric study of the Leishan-Rongjiang antimony ore field,SW China显示文摘The Leishan-Rongjiang antimony ore field(LAOF) is in a unique geotectonic location in the uplift between the Youjiang and Xiangzhong basins.This paper focuses on two representative deposits in the LAOF:the Bameng and Peize antimony(Sb) deposits.We analyzed fluid inclusions(FIs) in stibnite and coexisting quartz,as well as the sulfur isotopic composition of stibnite,to better understand the nature of the ore-forming fluid and the metallogenic process.The FIs data from samples of the stibnite and coexisting quartz indicate that the ore-forming fluids were characterized by low-temperature(150-210 ℃),low-salinity(1.5 wt%-6.0 wt%NaCl equiv.),and low-density(0.872-0.961 g/cm^3).The δ^(34)S values of stibnite(-8.21‰ to 3.76‰,average =-6.30‰)fall in between the sulfur isotopic compositions of the mantle and of biogenic sulfur in sedimentary rocks.However,the δ^(34)S_(∑s) values(-4.41 ‰ to +0.04‰,average =-2.49‰) of the ore-forming fluids are generally closer to the sulfur isotopic composition of the mantle source,indicating that the sulfur in the LAOF was mainly sourced from the mantle,but with possible involvement of biogenic sulfur.In addition,FIs petrography and ore deposit geology show that fluid boiling resulted from an abrupt decrease in pressure,which may have triggered the precipitation of stibnite.We conclude that low-temperature,dilute hydrothermal fluids with mixed origins migrated along the regional fault and interacted with the wall rock,extracting the ore-forming materials.Then,the oreforming fluids were injected into the fault fracture zones. | Jun Chen Ruidong Yang Junbo Gao Lulin Zheng Lijuan Du Minggang Yuan Huairui Wei | 2017 | Acta Geochimica2017，36，2： | 2 |
| 7 | Inhibition of TRPC6degradation suppresses ischemic brain damage in rats显示文摘 | Wanlu Du Junbo Huang Kechun Zhou et al | 2010 | Journal of Clinical Investigation2010，120，10： | 1 |
| 8 | Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network显示文摘Covalent ligands have attracted increasing attention due to their unique advantages,such as long residence time,high selectivity,and strong binding affinity.They also show promise for targets where previous efforts to identify noncovalent small molecule inhibitors have failed.However,our limited knowledge of covalent binding sites has hindered the discovery of novel ligands.Therefore,developing in silico methods to identify covalent binding sites is highly desirable.Here,we propose DeepCoSI,the first structure-based deep graph learning model to identify ligandable covalent sites in the protein.By integrating the characterization of the binding pocket and the interactions between each cysteine and the surrounding environment,DeepCoSI achieves state-of-the-art predictive performances.The validation on two external test sets which mimic the real application scenarios shows that DeepCosI has strong ability to distinguish ligandable sites from the others.Finally,we profiled the entire set of protein structures in the RCSB Protein Data Bank(PDB)with DeepCoSI to evaluate the ligandability of each cysteine for covalent ligand design,and made the predicted data publicly available on website. | Hongyan Du Dejun Jiang Junbo Gao Xujun Zhang Lingxiao Jiang Yundian Zeng Zhenxing Wu Chao Shen Lei Xu Dongsheng Cao Tingjun Hou Peichen Pan | 2022 | Research2022，，4： | 1 |
| 9 | Self-Supervised Entity Alignment Based on Multi-Modal Contrastive Learning显示文摘Dear Editor,This letter proposes an unsupervised entity alignment method,which realizes integration of multiple multi-modal knowledge graphs adaptively.In recent years,Large-scale multi-modal knowledge graphs(LMKGs),containing text and image,have been widely applied in numerous knowledge-driven topics,such as question answering,entity linking,information extraction,reasoning and recommendation. | Bo Liu Ruoyi Song Yuejia Xiang Junbo Du Weijian Ruan Jinhui Hu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，11： | 0 |
| 10 | Massive and parallel 10 Tbit/s physical random bit generation with chaotic microcomb显示文摘Ultrafast physical random bit(PRB)generators and integrated schemes have proven to be valuable in a broad range of scientifc and technological applications.In this study,we experimentally demonstrated a PRB scheme with a chaotic microcomb using a chip-scale integrated resonator.A microcomb contained hundreds of chaotic channels,and each comb tooth functioned as an entropy source for the PRB.First,a 12 Gbits/s PRB signal was obtained for each tooth channel with proper post-processing and passed the NIST Special Publication 800-22 statistical tests.The chaotic microcomb covered a wavelength range from 1430 to 1675 nm with a free spectral range(FSR)of 100 GHz.Consequently,the combined random bit sequence could achieve an ultra-high rate of about 4 Tbits/s(12 Gbits/s×294=3.528 Tbits/s),with 294 teeth in the experimental microcomb.Additionally,denser microcombs were experimentally realized using an integrated resonator with 33.6 GHz FSR.A total of 805 chaotic comb teeth were observed and covered the wavelength range from 1430 to 1670 nm.In each tooth channel,12 Gbits/s random sequences was generated,which passed the NIST test.Consequently,the total rate of the PRB was approximately 10 Tbits/s(12 Gbits/s×805=9.66 Tbits/s).These results could ofer potential chip solutions of Pbits/s PRB with the features of low cost and a high degree of parallelism. | Yuqi Hu Qingsong Bai Xi Tang Wei Xiong Yilu Wu Xin Zhang Yanlan Xiao Runchang Du Leiji Liu Guangqiong Xia Zhengmao Wu Junbo Yang Heng Zhou Jiagui Wu | 2023 | Frontiers of Optoelectronics2023，16，3： | 0 |
| 11 | TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage显示文摘Clinical application of doxorubicin(DOX)is heavily hindered by DOX cardiotoxicity.Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)involved remains to be elucidated.This study evaluated the potential role of TBC domain family member 15(TBC1D15)in DOX cardiotoxicity.Tamoxifen-induced cardiac-specific Tbcldi5 knockout(Tbcldi5^(CKO))or Tbcldi5 knockin(Tbcldi5^(CKI))male mice were challenged with a single dose of DOx prior to cardiac assessment 1 week or 4 weeks following DOX challenge.Adenoviruses encoding TBC1D15 or containing shRNA targeting Tbcld15 were used for Tbcld15 overexpression or knockdown in isolated primary mouse cardiomyocytes.Our results re-vealed that DOX evoked upregulation of TBC1D15 with compromised myocardial function and overt mortality,the effects of which were ameliorated and accentuated by Tbcldi5 deletion and Tbcld15 overexpression,respectively.DOX overtly evoked apoptotic cell death,the effect of which was alleviated and exacerbated by Tbcld15 knockout and overexpression,respectively.Meanwhile,DOX provoked mitochondrial membrane potential collapse,oxidative stress and DNA damage,the effects of which were mitigated and exacerbated by Tbcld15 knockdown and overexpression,respectively.Further scrutiny revealed that TBC1D15 fostered cytosolic accumulation of the cardinal DDR element DNA-dependent protein kinase catalytic subunit(DNA-PKcs).Liquid chromatography-tandem mass spectrometry and coimmunoprecipitation denoted an interaction between TBCID15 and DNA-PKcs at the segment 594-624 of TBC1D15.Moreover,overexpression of TBC1D15 mutant(A594-624,deletion of segment 594-624)failed to elicit accentuation of DOX-induced cytosolic retention of DNA-PKcs,DNA damage and cardiomyocyte apoptosis by TBC1D15 wild type.However,Tbcld15 deletion ameliorated DOXinduced cardiomyocyte contractile anomalies,apoptosis,mitochondrial anomalies,DNA damage and cytosolic DNA-PKcs accumulation,which were canceled off by DNA-PKcs inhibition or ATM activation.Taken together,our findings denoted a pivotal role for TBCID15 in DOX-induced DNA damage,mitochondrial injury,and apoptosis possibly through binding with DNA-PKcs and thus gate-keeping its cytosolic retention,a route to accentuation of cardiac contractile dysfunction in DOX-induced cardiotoxicity. | Wenjun Yu Haixia Xu Zhe Sun Yuxin Du Shiqun Sun Miyesaier Abudureyimu Mengjiao Zhang Jun Tao Junbo Ge Jun Ren Yingmei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 12 | Topological multipolar corner state in a supercell metasurface and its interplay with two-dimensional materials显示文摘Second-order topological insulators(SOTIs) have recently attracted much attention due to their capability to support lower-dimensional topological states, namely, the corner states. Here, we demonstrate that properly designed supercell metasurfaces can support photonic corner states, meanwhile further serving as an ideal platform for the implementations of topological polaritons and dynamically reconfigurable corner states by assembling two-dimensional materials. Such metasurfaces consist of an array of finite-sized SOTIs mimicking the twodimensional Su–Schrieffer–Heeger model. We reveal that the topological transition happens in unit cells without the bandgap, and nondegenerate multipolar corner states emerge in the supercell metasurface due to the inter-and intrasupercell coupling effects. Especially since these corner states are above the light line of the metasurface, we realize the collective stimulation of the two dipolar corner states and their superposition state via far-field excitation. By stacking monolayer hexagonal boron nitride film onto the metasurface, we further achieve the topological phonon polaritons through the strong coupling between the corner state and the phonon, which is confirmed by the Rabi splitting as well as anticrossing behavior emerging in the transmission spectra.Furthermore, we reveal the robustness of the corner state and strong coupling by introducing defects into the metasurface. Finally, tunable corner state and strong coupling with on-demand control are realized by assembling monolayer graphene onto the metasurface. Our theoretical study proposes a unique hybrid-material platform for topological polaritonics and reconfigurable topological photonics, which can promote large-area topological applications in practice. | Zhaojian Zhang Junbo Yang Te Du Xinpeng Jiang | 2022 | Photonics Research2022，10，4： | 0 |
| 13 | 荫蔽和微生物可在分子水平上调控植物激素以增强植物的耐旱性显示文摘植物在其生命周期内会受到一系列不利环境的影响。其中,干旱胁迫是限制农业生产力的重要因素之一。为了在逆境的环境中得以生存,植物进化出了识别环境胁迫严重性的机制。植物可通过多种方式调节激素活性,以减轻干旱带来的不良影响。受荫蔽和微生物调控,植株的抗旱性提高,产量损失减少。脱落酸、生长素和乙烯等植物激素,可调控多种代谢途径,在荫蔽和微生物介导的植株抗旱性增强过程中起着重要作用。如我们的调控模型所示,CLAVATA3/EMBRYOSURROUNDING REGION-RELATED 25多肽因其可影响ABA合成而在此过程中具有重要作用。 | Muhammad Ahsan Asghar Bushra Ahmad Ali Raza Bilal Adil Hafz Hassan Javed Muhammad Umer Farooq Abuzar Ghafoor Muhammad Iftikhar Hussain Iram Shafq Hassan Karim Xin Sun Wenyu Yang Gábor Kocsy Junbo Du | 2022 | Journal of Plant Ecology2022，15，6： | 0 |
| 14 | Clinical Diagnosis and Treatment Recommendations for Immune Checkpoint Inhibitor-Associated Myocarditis显示文摘Immune checkpoint inhibitors(ICIs)are often beneficial in the treatment of multiple types of malignant tumors.However,ICI-associated myocarditis has introduced new clinical challenges.This report highlights the key clinical issues of ICI-associated myocarditis,such as risk factors,diagnosis and differential diagnosis,clinical classification and treatment,monitoring of outcomes,and restart of treatment.Additionally,practical guidance and suggestions for the diagnosis and treatment of ICI-associated myocarditis are proposed with reference to the relevant consensuses or guidelines and newly published evidence-based studies in China and other countries in combination with clinical experience of physicians from Shanghai,China. | Yan WANG Huiyong CHEN Jinyi LIN Jiahui CHEN Yuhong ZHOU Yingmei ZHANG Hongwei ZHANG Wei ZHU Jie HU Gang ZHAO Xiangdong YANG Shisuo DU Xiaoyu LI Guoming SHI Jie CUI Wei WU Jing LI Chi ZHANG Cong WANG Rongle LIU Zheng LI Chunhui WANG Leilei CHENG Junbo GE | 2022 | Clinical Cancer Bulletin2022，1，3： | 0 |
| 15 | Improving the device performances of two-dimensional semiconducting transition metal dichalcogenides: Three strategies显示文摘Two-dimensional(2D)semiconductors are emerging as promising candidates for the next-generation nanoelectronics.As a type of unique channel materials,2D semiconducting transition metal dichalcogenides(TMDCs),such as MoS2 and WS2,exhibit great potential for the state-of-the-art fieldeffect transistors owing to their atomically thin thicknesses,dangling-band free surfaces,and abundant band structures.Even so,the device performances of 2D semiconducting TMDCs are still failing to reach the theoretical values so far,which is attributed to the intrinsic defects,excessive doping,and daunting contacts between electrodes and channels.In this article,we review the up-to-date three strategies for improving the device performances of 2D semiconducting TMDCs:(i)the controllable synthesis of wafer-scale 2D semiconducting TMDCs single crystals to reduce the evolution of grain boundaries,(ii)the ingenious doping of 2D semiconducting TMDCs to modulate the band structures and suppress the impurity scatterings,and(iii)the optimization design of interfacial contacts between electrodes and channels to reduce the Schottky barrier heights and contact resistances.In the end,the challenges regarding the improvement of device performances of 2D semiconducting TMDCs are highlighted,and the further research directions are also proposed.We believe that this review is comprehensive and insightful for downscaling the electronic devices and extending the Moore’s law. | Mo Cheng Junbo Yang Xiaohui Li Hui Li Ruofan Du Jianping Shi Jun He | 2022 | Frontiers of physics2022，17，6： | 0 |
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