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| 1 | Deficiency of Mouse CD4^+CD25^+Foxp3^+ Regulatory T Cells in Xenogeneic Pig Thymus-Grafted Nude Mice Suffering from Autoimmune Diseases显示文摘Xenogeneic thymus transplantation can efficiently induce specific immune tolerance to donor antigens in athymic recipients. However, many nude mice suffer from autoimmune diseases (AID) for over 10 weeks after xenogeneic thymus transplantation. CD4+CD25+Foxp3+ regulatory T (Treg) cells were recently determined to play a pivotal role in keeping immune tolerance in humans and mice. Thus, we investigated this subpopulation of Treg cells in the periphery of pig thymus-grafted nude mice suffering from AID. Our results showed that the expression of Foxp3, CTLA-4 and GITR on mouse CD4+CD25+ T cells and the ratio of CD4+CD25+Foxp3+ Treg cells to CD4+ T cells were significantly decreased in the periphery of pig thymus-grafted nude mice suffering from AID, compared with healthy pig or mouse thymus-grafted nude mice. Furthermore, mouse CD4+CD25+ T cells in pig thymus-grafted nude mice suffering from AID showed more severe deficiency in immunosuppressive function compared with the counterpart in xenogeneic pig or syngeneic thymus-grafted nude mice without AID. Thus, the decreased frequency, altered phenotype and functional deficiency of mouse CD4+CD25+ Treg cells in pig thymus-grafted nude mice may contribute to the development of AID in this model. | Baojun Zhang Chenming Sun Yanyan Qu Aijun Zhang Jun Liu Lianjun Zhang Zeqing Niu Yong Zhao | 2008 | Cellular & Molecular Immunology2008，5，5： | 6 |
| 2 | Analysis of the ore-controlling structure of the Shihu gold deposit, Hebei Province and deep-seated ore-prospecting prediction显示文摘Under the guidance of the theory of mantle-branch structure-associated metallogenesis and on the basis of the geological characteristics, analysis of the ore-forming and ore-controlling structures, the geochemical characteristics of metallogenesis, the source of ore-forming materials, changes in the physical and chemical conditions of metallogenesis, changes in the vertical width of ore veins, and changes in gold grade of the Shihu gold deposit, the mechanism of its metallogenesis was discussed and the rules of vertical variation of ore veins were summarized in this study. It is pointed out that the orebodies under exploitation at present time should be in the middle and upper portions of gold veins in the Shihu gold mining district. Particularly on the basis of the characteristics of mantle-branch structure-associated metallogenesis, it is indicated that metallogenesis is controlled mainly by such ore-forming conditions as temperature and pressure. Deep-seated ore-forming fluids are characterized mainly by injection and precipitation. So the vein bodies in the adjacent metallogenic structures are of obvious comparability, and there would be great prospects for ore search both at depth and in the periphery of the Shihu gold deposit. Therefore, ore prospecting should be strengthened both at depth and in the peripheries. | NIU Shuyin WANG Baode SUN Aiqun CHEN Chao WANG Zili MA Baojun WANG Wenxue JIANG Xiaoping ZHAO Yongli GAO Yincang LIU Huabin QIU Jianping | 2009 | Chinese Journal Of Geochemistry2009，28，4： | 6 |
| 3 | Study on the Metallogenetism of Sub-mantle Plume and Mantle Branches in the Gold Mineralization Concentration Area of Northwest Jiaodong Peninsula显示文摘The northwest of Jiaodong peninsula is characterized by its greatest gold concentration area, enormous gold reserves and limited time interval(115±5Ma) of gold mineralization in China. Studies show that the east area of north China began its mantle plume evolution since the Yanshanian movement, and the Laiyang sub-mantle plume and its surrounding mantle branches such as those in Guojiadian, Aishan and Panshidian were formed in the mineralization concentration area of northwestern Jiaodong peninsula. With the development of mantle plume → sub-mantle plume → mantle branch → favorable expending structures, the deep-derived hydrothermal fluid moved up to the favorable places, such as brittle-ductile or ductile-brittle shearing zones, the internal and external contact zones of intrusions, dense fracturing zones and the contact zones between dikes and countryrocks, and concentrated into deposits. Then the gold mineralization concentration zones that are centralized on mantle branches were formed. This study takes Guojiadian mantle branch as an example to discuss their metallogenetism and conclude the metallogenetic mode. | NIU Shuyin CHENG Guangsuo ZHANG Jianzhen SUN Aiqun MA Baojun ZHANG Fuxiang WANG Baode XU Meng WU Jichun ZHAO Rongxin WANG Shanfei | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 4 |
| 4 | The Seasonal Acclimatisation of Locomotion in a Terrestrial Reptile, Plestiodon chinensis(Scincidae)显示文摘Studies of the seasonal acclimatisation of behavioural and physiological processes usually focus on aquatic or semi-aquatic ectotherms and focus less effort on terrestrial ectotherms that experience more thermally heterogeneous environments. We conducted comparative studies and thermal acclimation experiments on the locomotion of the Chinese skink(Plestiodon chinensis) to test whether seasonal acclimatisation in locomotion exists in these terrestrial ectothermic vertebrates, and whether seasonal acclimatisation is predominantly induced by thermal environments. In natural populations, skinks ran faster during the summer season than during the spring season at high-test temperatures ranging from 27°C to 36°C but not at low-test temperatures ranging from 18°C to 24°C. In contrast, the thermal acclimation experiments showed that the cold-acclimated skinks ran faster than the warm-acclimated skinks at the lowtest temperatures but not at high-test temperatures. Therefore, the seasonal acclimatisation occurs to P. chinensis, and may be induced by temperature as well as other factors like food availability, as indicated by the seasonal variation in the thermal dependence of locomotion, and the discrepancy between seasonal acclimatisation and thermal acclimation on locomotion. | Baojun Sun Wenqi Tang Zhigao Zeng Weiguo Du | 2014 | Asian Herpetological Research2014，5，3： | 4 |
| 5 | Timing of mineralization at the Shihu gold deposit in the middle segment of the Taihang Mountain, China显示文摘The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma. | Chao Chen Shuyin Niu Fang Wang Fuxiang Zhang Qinglian Zhang Baojun Ma Aiqun Sun Jianzhen Zhang Yaqi Cao Xiaoqing Zhang | 2018 | Acta Geochimica2018，37，1： | 3 |
| 6 | Study on the ore-forming and ore-controlling structure of the Mujicun Cu (Mo) ore deposit, Hebei Province, China显示文摘The Mujicun Cu (Mo) ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu (Mo) deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He'ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series. | NIU Shuyin MA Guoxi CHEN Zhikuan WANG Baode CHEN Lijing SUN Aiqun MA Xiaofeng ZHANG Jianzhen MA Baojun CHEN Chao LU Hongpeng | 2012 | Chinese Journal Of Geochemistry2012，31，1： | 2 |
| 7 | Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China显示文摘Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep processes.The region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic time.At that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its periphery.The core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch structure.This study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment belt.Furthermore,on this basis,this study also pointed out the orientation for further ore prospecting in this region. | NIU Shuyin Sun Aiqun ZHANG Jianzhen MA Baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 2 |
| 8 | Laser-driven plasma collider for nuclear studies显示文摘A novel method of initiating nuclear fusion reactions in a full plasma environment was suggested, and a proof-of-concept experiment was carried out with the D t D ! n t3 He reaction. In this new approach, two plasma jets generated by high-intensity lasers collide headon-head. The center-of-mass energy of the nuclei increases accordingly, and therefore, reaction products can be significantly enhanced, especially in the sub-Coulomb barrier ranges. As a result of the fusion reaction, up to 7:6 105 neutrons had been observed. This new type of ‘‘plasma collider'' could provide an innovative tool to study nuclear reactions under astrophysical conditions. | Changbo Fu Jie Bao Liming Chen Jianjun He Long Hou Liang Li Yanfei Li Yutong Li Guoqian Liao Yongjoo Rhee Yang Sun Shiwei Xu Dawei Yuan Xiaopeng Zhang Gang Zhao Jiarui Zhao Baojun Zhu Jianqiang Zhu Jie Zhang | 2015 | Science Bulletin2015，60，13： | 2 |
| 9 | A Comparison Research on Industry-University-Research Strategic Alliances in Countries显示文摘 | Chunhua Feng Mengehun Ding Baojun Sun | 2011 | Asian Social Science2011，7，1： | 1 |
| 10 | On-chip ultrasensitive and rapid hydrogen sensing based on plasmon-induced hot electron-molecule interaction显示文摘Hydrogen energy is a zero-carbon replacement for fossil fuels.However,hydrogen is highly flammable and explosive hence timely sensitive leak detection is crucial.Existing optical sensing techniques rely on complex instruments,while electrical sensing techniques usually operate at high temperatures and biasing condition.In this paper an on-chip plasmonic-catalytic hydrogen sensing concept with a concentration detection limit down to 1 ppm is presented that is based on a metal-insulator-semiconductor(MIS)nanojunction operating at room temperature and zero bias.The sensing signal of the device was enhanced by three orders of magnitude at a one-order of magnitude higher response speed compared to alternative non-plasmonic devices.The excellent performance is attributed to the hydrogen induced interfacial dipole charge layer and the associated plasmonic hot electron modulated photoelectric response.Excellent agreements were achieved between experiment and theoretical calculations based on a quantum tunneling model.Such an on-chip combination of plasmonic optics,photoelectric detection and photocatalysis offers promising strategies for next-generation optical gas sensors that require high sensitivity,low time delay,low cost,high portability and flexibility. | Long Wen Zhiwei Sun Qilin Zheng Xianghong Nan Zaizhu Lou Zhong Liu David R.S.Cumming Baojun Li Qin Chen | 2023 | Light(Science & Applications)2023，12，4： | 1 |
| 11 | Thermal-physiological Strategies Underlying the Sympatric Occurrence of Three Desert Lizard Species显示文摘Sympatric reptiles are the ideal system for investigating temperature-driven coexistence. Understanding thermally physiological responses of sympatric lizards is necessary to reveal the physiological mechanisms that underpin the sympatric occurrence of reptiles. In this study, we used three lizard species, Eremias argus, E. multiocellata, and Phrynocephalus przewalskii, which are sympatric in the Inner Mongolia desert steppe, as a study system. By comparing their resting metabolic rates(RMR) and locomotion at different body temperatures, we aimed to better understand their physiological responses to thermal environments, which may explain the sympatric occurrence of these lizards. Our results showed that E. argus had significantly higher RMR and sprint speed than E. multiocellata, and higher RMR than P. przewalskii. In addition, the optimal temperature that maximized metabolic rates and locomotion for E. argus and E. multiocellata was 36°C, whereas for P. przewalskii it was 39°C. Our study revealed the physiological responses to temperatures that justify the sympatric occurrence of these lizards with different thermal and microhabitat preferences and active body temperatures. Eremias argus and E. multiocellata, which have lower body temperatures than P. przewalskii, depend on higher RMR and locomotion to compensate for their lower body temperatures in field conditions. Our study also highlights the importance of using an integrative approach, combining behavior and physiology, to explore the basis of sympatric occurrence in ectothermic species. | Xueqing WANG Shuran LI Li LI Fushun ZHANG Xingzhi HAN Junhuai BI Baojun SUN | 2019 | Asian Herpetological Research2019，10，3： | 1 |
| 12 | Oligomerization and Polymerization of Ethylene Initiated by a Novel Ni(Ⅱ)-Based Acetyliminopyridine Complexes as Single-Site Catalysts显示文摘新奇的镍( II )基于 acetyliminopyridine 建筑群 1b , 2b , 3b ( 1 ¨C 3b )从 ligands 1a 被综合, 2a , 3a ( 1-3a )并且[ NiCl2 ( DME )],是为为乙烯 oligomerization 和聚合反应是必要的催化剂的合适的先锋,由 methylaluminoxane (毛)激活。对待 MAO 1 ¨ C 3b 介绍一个活跃催化中心,它可以分别地生产线性 | á - 石蜡和聚乙烯的 oligomerize 和聚合乙烯。被获得的 oligomers 的分子量分布在对 oligomers 的 Schulz-Flory 规则的好同意 > C4。3b-MAO 建筑群的活动是 6.3 ? á 10 (7 ) 在 50 点的 g/(molNi-h )??6 号元素碳的化学符号。oligomers 的活动和分子量分布在催化剂先锋的结构上显示出重要信赖。给词调音:oligomerization;聚合;乙烯;镍(II ) 基于催化剂;| á - | Baojun Zhang Yanji Wang Gang Wang Jun Cao Shukun Sun Lihua Xing Yongcheng Sun Yunguang Han | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 1 |
| 13 | Metallogenic characteristics of the region of Northwest Hebei and analysis of ore prospecting potential in its peripheries显示文摘The region of Northwest Hebei is an area where Au-Ag polymetallic ore depsits are concentrated in Hebei Province. There were divided the Au ore-concentrated region with the magmatic-metamorphic diamictite zone as the center and the perpheral cover-strata zone and Ag-polymetallic metallogenic zone along the line of Xuanhua-Songli-Chicheng. Research on mantle branch structure indicates that Au-Ag polymetallic ore-forming materials come mainly from the deep interior of the Earth. The ore-forming materials tend to migrate upwards through the multi-stage evolution of mantle plume, and are concentrated as ores in the favourable tectonic expansion zone of a mantle branch structure. As viewed in plane, from the center to the periphery and as viewed in space, from the lower part to the upper part there exists Au-Ag-Pb-Zn zonation, as evidenced by drilling data from a number of mines. So, there is still great potential for ore prospecting in the region of Northwest Hebei. | SUN Aiqun NIU Shuyin WANG Baode HAN Yuchou WEI Minhui MA Baojun ZHAO Zhiyuan XIA Dong | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 1 |
| 14 | Solid modeling and motion characteristics analysis of oval gear pair based on the tooth profile conversion method 显示文摘 | Shiping Yang Baojun Zou Quanmin Sun | 2012 | Advanced Materials Research2012，，429： | 1 |
| 15 | Correlation between aortic/carotid atherosclerotic plaques and cerebralinfarction显示文摘 | Baojun Wang Shaoli Sun Guorong Liu Yuechun Li Jiangxia Pang Jingfen Zhang Lijuan Yang Ruiming Li Hui Zhang Changchun Jiang Xiue Li | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
| 16 | Combination of BIBW2992 and ARQ 197 is effective against erlotinib-resistanthuman lung cancer cells with the EGFR T790M mutation显示文摘 | Geping Qu Changting Liu Baojun Sun Changxi Zhou Zhijian Zhang Peng Wang | 2014 | Oncology Reports2014，，1： | 1 |
| 17 | High Levels of Inflammation and Insulin Resistance in Obstructive Sleep Apnea Patients with Hypertension显示文摘 | Xiaoshun Qian Tong Yin Tianzhi Li Chunyan Kang Ruibiao Guo Baojun Sun Changting Liu | 2012 | Inflammation2012，，4： | 1 |
| 18 | Phenotypic consequences of maternally selected nests:a cross-fostering experiment in a desert lizard显示文摘Despite the importance of maternally selected nests in shaping offspring phenotypes,our understanding of how the nest environment affects embryonic development and offspring traits of most non-avian reptiles is rather limited largely due to the logistical difficulty in locating their nests.To identify the relative contributions of environmental(temporal[seasonal]and spatial[nest-site])and intrinsic(clutch)factors on embryonic development and offspring traits,we conducted a cross-fostering experiment by swapping eggs between maternally-selected nests of the toad-headed agama(Phrynocephalus przewalskii)in the field.We found that nest environment explained a large proportion of variation in incubation duration,hatching success,and offspring size and growth.In contrast,clutch only explained a small proportion of variation in these embryonic and offspring traits.More significantly,compared with spatial effects,seasonal effects explained more phenotypic variation in both embryonic development and offspring traits.Eggs laid early in the nesting season had longer incubation durations and produced smaller hatchlings with higher post-hatching growth rates than did later-laid eggs.Consequently,hatchlings from early-laid eggs reached larger body sizes prior to winter.In addition,we found that female toad-headed agama did not select nests specific to reaction norms of their own offspring because hatchlings from original or translocated nests had similar phenotypic traits.Overall,our study demonstrates the importance of seasonal variation in nest environments in determining embryonic development and offspring phenotypes,which has not been widely appreciated at least in non-avian reptiles. | Shuran LI Xin HAO Baojun SUN Junhuai BI Yongpu ZHANG Weiguo DU | 2021 | Integrative Zoology2021，16，5： | 1 |
| 19 | T cells in health and disease显示文摘T cells are crucial for immune functions to maintain health and prevent disease.T cell development occurs in a stepwise process in the thymus and mainly generates CD4^(+)and CD8^(+)T cell subsets.Upon antigen stimulation,naïve T cells differentiate into CD4^(+)helper and CD8^(+)cytotoxic effector and memory cells,mediating direct killing. | Lina Sun Yanhong Su Anjun Jiao Xin Wang Baojun Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 20 | Optimizing protected areas to boost the conservation of key protected wildlife in China显示文摘To meet the challenge of biodiversity loss and reach the targets of the proposed Post-2020 Global Biodiversity Framework,the Chinese government updated the list of national key protected wildlife in 2021 and has been continually expanding the protected areas(PAs).However,the status of protected wildlife in PAs remains unclear.In this study,we conducted a national assessment of the status of protected wildlife and suggested an optimization plan to overcome these shortcomings.From 1988 to 2021,the number of protected species almost doubled,and the area of PAs increased by 2.4 times,covering over 92.8%of the protected species.Nonetheless,some protected species have less than 10%of their habitat included in PAs.Despite the significant addition of amphibians and reptiles to the latest protection list,they are the fewest species and are the least covered by PAs compared with birds and mammals.To fix these gaps,we systematically optimized the current PAs network by adding another 10.0%of China’s land area as PAs,which resulted in 37.6%coverage of protected species’habitats in PAs.In addition,26 priority areas were identified.Our research aimed to identify gaps in current conservation policies and suggest optimization solutions to facilitate wildlife conservation planning in China.In general,updating the list of key protected wildlife species and systematically optimizing PA networks are essential and applicable to other countries facing biodiversity loss. | Chunrong Mi Kai Song Liang Ma Jiliang Xu Baojun Sun Yuehua Sun Jianguo Liu Weiguo Du | 2023 | The Innovation2023，4，3： | 1 |
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