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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Synthesis and Luminescence of SrZnO_2∶Eu^(3+), Li^+ Phosphor by Long Wavelength UV Excitation显示文摘SrZnO2∶Eu 3+, Li+ phosphor powder by long wavelength UV excitation was synthesized by conventional solid-state reaction method. XRD and PL were employed to characterize their properties. The results show that Eu 3+ ions preferentially occupy Sr 2+ asymmetry cationic sites, thus emitting 612 nm red light originated from 5D0 to 7F2 transition. The luminescent intensity can be greatly enhanced with incorporation of Li+ ions. The excitation efficiency in range of 350~400 nm also increases greatly due to incorporating Li+ ions. SrZnO2∶Eu 3+, Li+ is a promising red-emitting phosphor by long wavelength UV excitation. | Yu Xibin Yang Liangzhun Yang Shiping Zhou Chunlei Xu Xiaolin Tang Jingfen Peng Xiudong | 2005 | Journal of Rare Earths2005，23，5： | 7 |
| 3 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 4 | Comparison of different cooling methods for extending shelf life of postharvest broccoli显示文摘This study aimed to investigate and compare the effects of vacuum cooling,cooling water and cold room methods on the shelf life of broccoli.The experiments were divided into four groups:vacuum cooling(A),ice-water cooling(B),cold room cooling(C)and control.The cooling rate and changes of weight loss,respiratory rate,chlorophyll,vitamin C,reducing sugar content and sensory properties were measured at intervals of five days.The results indicated that vacuum cooling was the most effective method for extending the shelf life of postharvest broccoli in terms of cooling rate,respiration rate,chlorophyll,vitamin C,reducing sugar and sensory properties.Moreover,spraying the broccoli with water during the vacuum cooling process resulted in a significant reduction in weight compared with the other two cooling methods and did not reduce the quality of the broccoli.Consequently,vacuum cooling treatment can be applied to broccoli after harvest in the field to maintain quality during transportation and storage.Additionally,the application of water spraying during vacuum cooling can considerably reduce the negative influence caused by vacuum cooling. | Ding Tian Liu Fen Ling Jiangang Kang Mengli Yu Jingfen Ye Xingqian Liu DongHong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 5 |
| 5 | Nitrogen and phosphorus balance analysis of cultivated land in Jiangsu plain,China显示文摘Jiangsu plain is located along the downstream of the Yangtze River, the north part of which is also the coast area of the Yellow Sea. The specific location makes the local environmental issues regionally important. This paper studied arable land area, plantation structure, livestock sector data, which shows that livestock sector contributes a big amount of nitrogen and phosphorus, in terms of the demand from the agriculture use in Jiangsu plain. But actually, there is still much mineral fertiliser used in agriculture, which causes the N and P produced from livestock sector being an important source of pollution to the environment. The paper suggests to tighten up manure management, in order to lead to a big reduction in the pollution to both soil and surface water. | ZOU Xinqing Pierre Gerber LI Haiyu LIU Qingsong WANG Qian SHEN Jingfen SHI Binwen | 2001 | Chinese Science Bulletin2001，46，S1： | 5 |
| 6 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 7 | Three-dimensional path following control system for net cage inspection using bionic robotic fish显示文摘With the increasing impacts of overfishing and environmental pollution,the deep-sea cage culture of marine fishes has become an important direction of mariculture.In this paper,a tuna-like robotic fish with a three-dimensional helix path-following control system is designed for deep-sea net cage inspection.To mimic the flexibility of the fish’s movement,the kinematic model of the robotic fish adopts a tuna-like double-joint design with an addi-tional thruster device at the tail.Since the descending interval control plays a critical role in deep-sea net cage inspection,the control system utilizes the proportion integration differ-entiation(PID)based fuzzy logic control method to control the descending interval and yaw angle during the helix path movement.A polar coordinate path definition method is also proposed to simplify the reference path definition during net cage inspection.The experi-mental results demonstrates that the proposed three-dimensional path-following model can conduct net inspection task in an interferential environment and move along prede-fined reference path. | Yuanrong Chen Jingfen Qiao Jincun Liu Ran Zhao Dong An Yaoguang Wei | 2022 | Information Processing in Agriculture2022，9，1： | 2 |
| 8 | The Distribution of Sandstorms in Tallimakan Desert显示文摘 | Heqing Zhang Jingfen Nagashima Hedeki | 1996 | J Arid Land Studies1996，5，： | 1 |
| 9 | Repositioning techniques of malpositioned peripherally inserted central catheters显示文摘 | Jingfen Jin Chunfang Chen Ruiyi Zhao | | 0，，13： | 1 |
| 10 | 3D-QSAR study on phenoxy-alkylamine compounds of α_1-adrenoceptor antagonist显示文摘The study of three-dimensional quantitative structure-activity relationship (3D-QSAR) of DDPH and its derivatives that have been known with their activity parameters has been developed using the comparative molecular field analysis (CoMFA) method. Here, (+)-DDPH crystal structure was selected as the active conformation model and comparisons between the influences of different charge calculation methods and grid setup were conducted. The coefficients of cross-validation (q2) and regression (r2) are 0.481 and 0.997, respectively. The standard error (SE) is 0.102. The research result suggests that the steric field makes more contributions to the activity than the electrostatic field. This model can help us not only in improving our understanding of the receptor-ligand interactions, but also in predicting the activity of derivatives and designing new compounds with better potency. | FANG Hao, LU Jingfen, XIA Lin & ZHANG LineDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China State Key Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China | 2001 | Chinese Science Bulletin2001，46，4： | 1 |
| 11 | Synthesis erinicester显示文摘 | Jingfen Han Gerehu Borjihan Ruke Bai l | 2008 | Carbohydrate Polymers2008，71，： | 1 |
| 12 | Synthesis, characterization, and anti-inflammatory activities of rare earth metal complexes of luteolin显示文摘 | LI JINGFEN WANG LISHENG | 2011 | Medicinal Chemistry Research2011，，20： | 1 |
| 13 | FFP:Predicting molecular formulas of fragment ions with isotope patterns in tandem mass spectra显示文摘 | Zhang Jingfen Gao Wen Cai Jinjin | 2005 | IEEE/ACM Transactions on Computational Biology and Bioinformatics2005，2，3： | 1 |
| 14 | Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane 显示文摘 | Xiaogai Yang Kui Wang Jingfen Lu | 2003 | Coordination Chemistry Reviews2003，237，： | 1 |
| 15 | PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer显示文摘PIWI-interacting RNA(piRNAs),once thought to be mainly functioning in germlines,are now known to play an essential role in somatic and cancerous tissues.Ping-pong cycle initi-ation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals,including humans.By being involved in DNA methylation,histone marker deposition,mRNA degradation,and protein modification,piRNAs also contribute to carcinogenesis partly due to oncogenic stress-induced piRNA dysre-gulation.Also,piRNAs play important roles in cancer stemness,drug resistance,and tumor immunology.Results from liquid biopsy analysis of piRNA can be used in both cancer diagnoses and cancer prognoses.A combination of targeting piRNA with other therapeutic strategies could be groundbreaking cancer treatment. | Jingfen Su Anthony Concilla Dianzheng Zhang Fang Zhao Fangfang Shen Hao Zhang Fuyou Zhou | 2021 | Genes & Diseases2021，8，5： | 1 |
| 16 | Hydrolysis of oligodeoxynucleotide phosphodiester linkages显示文摘 | Hebai Shen Jingfen Xia Haifeng Yang Yumei Luo | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 17 | Infant diarrhea with rotavirus infection detection and analysis of maternal and child health care of China显示文摘 | Wei Jingfen ye Fufa | 2009 | 2009，，12： | 1 |
| 18 | Correlation between aortic/carotid atherosclerotic plaques and cerebralinfarction显示文摘 | Baojun Wang Shaoli Sun Guorong Liu Yuechun Li Jiangxia Pang Jingfen Zhang Lijuan Yang Ruiming Li Hui Zhang Changchun Jiang Xiue Li | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
| 19 | Blood oxygenation-level dependent functional MRI in evaluating the selective activation of motor cortexes associated with recovery of motor function in hemiplegic patients with ischemic stroke显示文摘BACKGROUND: Previous studies about blood oxygenation-level dependent (BOLD) functional MRI (fMRI) have indicated that the poststroke recovery of motor function is accompanied by the selective activation of motor cortexes with high correlation. OBJECTIVE: To evaluate the short-term outcomes after rehabilitative interventions with BOLD fMRI in hemiplegic patients with acute stroke, and analyze the correlation of the excitement of brain function in the passive and active movements of the affected limb with the recovery of motor function. DESIGN: A case observation. SETTING: Department of Neurology, Baotou Central Hospital. PARTICIPANTS: Thirty hemiplegic inpatients with ischemic stroke were selected from the Department of Neurology, Baotou Central Hospital from January to December in 2005, including 16 males and 14 females, aging 44-71 years with an average age of (56±5) years, and the disease course ranged from 12 to 72 hours. Inclusive criteria: In accordance with the diagnostic standard of ischemic stroke revised by the Fourth National Academic Meeting for Cerebrovascular Disease; Confirmed by cranial CT or MRI. They were all informed agreed with the detected items. METHODS: ① The Bobath technique was adopted in the rehabilitative interventions of the 30 patients, 30 minutes for each time, twice a day for three weeks continuously. ② The hand motor recovery of the stroke patients was graded by the Brunnstrom stages (Ⅰ-Ⅵ), and be able to grasp various objects and extend for the whole range was taken as grade Ⅵ. ③ The patients were examined with fMRI BOLD before rehabilitation and 3 weeks after rehabilitation. All the patients were trained with finger movements, the distracting thoughts should be eliminated as much as possible especially during the movement phase, the patients should highly concentrate on the hand movements. The range for the finger movements should be as large as possible with moderate frequency. The hand movements should be 10 s with an interval of 30 s. Te AVANTO 1.5T MRI machine (Siemens Company, Germany) was used for scanning, the 30 s before fMRI BOLD scanning was the adaptation phase for the patients, and the finger movements were alternated for 6-10 times till the end of the scanning. MAIN OUTCOME MEASURES: Differences after rehabilitation evaluated by the activations of different sensorimotor cortex in the hemiplegic patients with acute stroke. RESULTS: ① In passive and active movements of the affected hand, 5 cases of Brunnstrom grade Ⅰ orⅡ were manifested by the activation of unilateral sensorimotor cortex (SMC) of the hemiplegic side, and they were Brunnstrom grade Ⅱ after 3-week rehabilitation, and 1 case with activations of bilateral SMC recovered to Brunnstrom grade Ⅲ. ② Among the patients of Brunnstrom gradeⅢ or Ⅳ, 5 cases were unilaterally activated, and had no changes after 3-week rehabilitation; Whereas of the 9 cases of bilateral activations, 3 recovered to grade Ⅵ and 6 recovered to grade Ⅴ after 3-week rehabilitation. ③ In the passive and active movements of the affected hand, all the cases of Brunnstrom grades Ⅴ and Ⅵ were manifested by the activations of bilateral SMC. After 3-week rehabilitation, 2 of the 4 cases of grade Ⅴ recovered to grade Ⅵ, and the other 2 recovered to normal; Whereas 5 of the 6 cases of grade Ⅵ recovered to normal, and the other 1 was still grade Ⅵ. CONCLUSION: BOLD fMRI showed that the outcomes of short-term rehabilitation in the patients with bilateral activations were obvious, whereas the outcomes were bad in the patients whose ipsilateral cortexes were activated. The activated signal in ipsilateral or bilateral SMC and the activation of supplementary motor area in active movements were greater than those in the passive ones. | Yuechun Li Guorong Liu Ying He Baojun Wang Furu Liang Li Wang Hui Zhang Jingfen Zhang Ruiming Li Xiaoyan Liu | 2006 | Neural Regeneration Research2006，1，5： | 1 |
| 20 | Studies of antioxidant activity of natural products with EPR methods显示文摘 | Lu Jingfen Muteliefu Gulinuer Li Tingfeng | 2007 | Chinese Journal of Magnetic Resonance2007，，27： | 1 |
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