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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016,54,6: | 44 |
| 2 | 通络清脑注射液对脑缺血再灌注损伤大鼠脑微透析液中两种氨基酸水平的影响显示文摘目的:观察清热解毒活血中药有效组分配伍通络清脑注射液对脑缺血再灌注损伤大鼠脑微透析液中2种氨基酸类神经递质谷氨酸(Glu)和γ-氨基丁酸(gamma-aminobutyric acid,GABA)水平的影响。方法:24只SD大鼠随机分为大脑中动脉阻塞/再灌注(MCAO/RP)模型组,尼莫地平组(0.4 mg·kg-1),通络清脑注射液低剂量组(48 mg·kg-1)及高剂量组(95mg·kg-1),每组6只。采用微透析技术对大鼠纹状体脑组织进行连续取样,流速1μL·min-1,每30 min采集1个样品。收集至第3个样品时,采用线栓法制备MCAO/RP模型,90 min后拔出线栓,实现再灌注,同时经大鼠尾静脉给予各组药物,继续收集微透析液至再灌注后180 min。微透析液样品经柱前衍生化后,经高效液相色谱-电化学(HPLC-ECD)检测Glu和GABA的水平。分别以造模时间点Glu及GABA含量为基础值计算释放率百分比。结果:建立MCAO模型后,各组Glu,GABA释放量均急剧上升,造模后120 min,通络清脑注射液高剂量组Glu释放量(327.29±127.31)%与模型组(1 041.08±190.57)%相比明显下降(P<0.05),造模后120,150 min,通络清脑注射液高剂量组GABA释放量(11 843.99±3 952.45)%,(4 785.80±3 051.98)%与模型组(35 204.61±6 919.45)%,(27 694.76±18 393.61)%相比明显下降(P<0.05)。随后各组Glu,GABA释放量均呈逐渐下降趋势。结论:抑制氨基酸的过量释放是通络清脑注射液抗脑缺血/再灌注损伤的可能机制之一。 | 姚明江 张鹏 宋文婷 徐立 Alan Bensoussan Dennis Chang 刘建勋 | 2014 | 中国实验方剂学杂志2014,20,12: | 8 |
| 3 | In vitro Stent Graft Fenestration to Preserve All Supra-aortic Branches in the Treatment of a Stanford Type A Aortic Arch Dissection显示文摘 | Tun Wang Chang Shu Ming Li Alan Dardik Quan-Ming Li | 2017 | Chinese Medical Journal2017,,15: | 8 |
| 4 | Hedgehog信号通路及其抑制剂在癌症中的研究进展显示文摘Hedgehog(HH)信号通路在胚胎发育和器官形成中发挥重要作用。当该通路中成员发生异常如patched(PTCH)发生缺失或突变,smoothened(SMO)发生突变,Gli异常扩增或者蛋白质稳定性增加等,都会导致该通路异常激活,并诱导如基底细胞癌、成神经管细胞瘤等癌症发生。因此阻断HH信号通路是应用于癌症治疗的一个有效手段。目前以HH信号通路不同成员为靶点已开发出多种HH信号通路小分子抑制剂,其中以HH信号通路上游成员为靶点的抑制剂最多。在今后的研究中,应该更加注重于以HH信号通路下游为靶点,开发更加有效的抗癌药物。 | 王岛 Alan K Chang 伍会健 | 2014 | 生命的化学2014,34,1: | 3 |
| 5 | 生命科学国际化人才培养模式研究与分子生物学课程教学改革实践显示文摘生命科学理论和技术的发展日新月异,这对生命科学学生的培养目标提出了新的要求。我们认为这一目标应当是培养具备国际竞争能力的以及一定自主创新能力的高素质的创新型人才。当前为实现这一目标进行有益的尝试变得异常重要。本文以中英双语教学授课的分子生物学课程为例,从教学改革的内容和具体实施方案方面进行了介绍,以期对生命科学国际化人才培养模式的实践提供参考。 | 芦秀丽 金莉莉 Alan Chang 曹向宇 陈冬松 霍亚鹏 | 2015 | 教育教学论坛2015,,37: | 3 |
| 6 | Neo- and Paleopolyploidy contribute to the species diversity of Asplenium the most species-rich genus of ferns显示文摘Polyploidy 广泛地在植物的进化被看作一个主要过程,但是多倍体种类差异的累积仍然是争论的。一些最近的研究与他们的双祖先相比在 neopolyploids 建议了增加的扑灭风险。多倍体蕨纲植物的高比例被期望主要被 neopolyploids 形成,而 paleopolyploid 种类被预言在整个染色体复制成立的 clades 被聚类。这里,我们由在导出的蕨纲植物家庭 Aspleniaceae 探索 polyploidy 的进化测试这预言。家庭有全球分布并且在所有蕨纲植物之中显示出多倍体 taxa 的最高的频率。测试假设,我们用代表 292 种类的 883 个标本的叶绿体 DNA 序列获得了全面发展史。所有出版染色体计数被印射到这个种系发生的框架上以便探索多倍体的进化。我们 Aspleniaceae 的历史上为几整个染色体复制恢复了证据。超过 tetraploid 水平的多倍体的种系发生的关系建议那 tetraploid Asplenium 种可能在这个家庭的某 clades 作为主要进化播放器代替了他们的双祖先。 | Harald Schneider Hong-Mei Liu Yan-Fen Chang Daniel Ohlsen Leon R. Perrie Lara Shepherd Michael Kessler Dirk N. Karger Sabine Hennequin Jeannine Marquardt Stephen Russell Stephen Ansell Ngan Thi Lu Peris Kamau Josmaily Loriga Ledis Regalado Jochen Heinrichs Atsushi Ebihara Alan R. Smith Mary Gibby | 2017 | Journal of Systematics and Evolution2017,55,4: | 2 |
| 7 | Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity显示文摘在这简短评论,我们相对小肽 ligand 的发现总结当前的 fndings, phoenixin (PNX ) 。用一条生物信息的途径,分别地,包含 14 和 20 氨基酸的二新奇的肽 PNX-14 和 PNX-20 包括大脑,心,肺和胃从多样的纸巾被孤立。集体 spectrometry 分析识别了相应于 PNX-14 和 PNX-20 的一座主要、次要的山峰,在针的绳索提取的老鼠或老鼠。与兔子 polyclonal 抗血清的使用, phoenixin immunoreactivity (irPNX ) 包括几 hypothalamic subnuclei 和迷走神经的背面的马达原子核在啮齿类动物大脑的分离区域被检测。另外, irPNX 包括背面的根中心,有节的中心和三叉的中心在感觉中心房间的一张人口,并且在浓密地散布到背面的角,独居的道的原子核和针的三叉的道的表面的层的房间过程被检测。irPNX 房间过程也在皮肤和 myenteric 丛被检测,建议一个大脑勇气或大脑皮连接。PNX-14 皮下地注射了到老鼠的颈的项的药理学研究表演挑起了重复的抓一回与 hindpaws 指导了到颈的背的剂量依赖者。我们的结果建议肽 PNX-14 或 PNX-20,可以用作内长的信号分子 transducing 痒感觉之一。另外,从另外的实验室的结果证明外长的 PNX 可以影响象记忆形成,消沉,复制,食物吸入和象 anxiolytic 一样行为那样的很多多样的行为。 | Rong-Ming LYU Alan COWAN Ying ZHANG Yi-Hung CHEN Siok L DUN Jaw-Kang CHANG Nae J DUN Jin Jun LUO | 2018 | Acta Pharmacologica Sinica2018,39,5: | 2 |
| 8 | A New Risk Scheme to Predict Warfarin-Associated Hemorrhage显示文摘 | Margaret C. Fang Alan S. Go Yuchiao Chang Leila H. Borowsky Niela K. Pomernacki Natalia Udaltsova Daniel E. Singer | 2011 | Journal of the American College of Cardiology2011,,4: | 2 |
| 9 | Global road traffic injury statistics:Challenges,mechanisms and solutions显示文摘High-quality data are the foundation to monitor the progress and evaluate the effects of road traffic injury prevention measures.Unfortunately,official road traffic injury statistics delivered by governments worldwide,are often believed somewhat unreliable and invalid.We summarized the reported problems concerning the road traffic injury statistics through systematically searching and reviewing the literature.The problems include absence of regular data,under-reporting,low specificity,distorted cause spectrum of road traffic injury,inconsistency,inaccessibility,and delay of data release.We also explored the mechanisms behind the problematic data and proposed the solutions to the addressed challenges for road traffic statistics. | Fang-Rong Chang He-Lai Huang David CSchwebel Alan HSChan Guo-Qing Hu | 2020 | Chinese Journal of Traumatology2020,23,4: | 2 |
| 10 | CYBERKNIFE RADIOSURGERY FOR TRIGEMINAL NEURALGIA TREATMENT: A PRELIMINARY MULTICENTER EXPERIENCE显示文摘 | Alan T. Villavicencio Michael Lim Sigita Burneikiene Pantaleo Romanelli John R. Adler Lee McNeely Steven D. Chang Laura Fariselli Melinda McIntyre Regina Bower Giovanni Broggi Jeffrey J. Thramann | 2008 | Neurosurgery2008,,3: | 1 |
| 11 | Risk factor for unsatisfactory outcome after lumbar foraminal and far lateral microdecom- pression显示文摘 | Chang SB Lee SH Alan Y | 2006 | Spine2006,31,10: | 1 |
| 12 | Automatic inspection of turbine blades using a 3-axis CMM together with a 2-axis dividing head显示文摘 | Hui-Chin Chang Alan C. Lin | 2005 | The International Journal of Advanced Manufacturing Technology2005,,7: | 1 |
| 13 | Interleukin1 activatesphospholipase A2 in rabbit chondroctes: A possible signal for IL-1 action显示文摘 | Joseph Chang Steven C Gilman Alan J | 1986 | Journal ofImmuology1986,136,: | 1 |
| 14 | Five-axis automated measurement by coordinate measuring machine 显示文摘 | Chang Huichin Lin Alan C | 2011 | The International Journal of Advanced Manufacturing Technology2011,55,5: | 1 |
| 15 | IBS中药复方不同方法制备样品的比格犬灌胃给药吸收入血成分定性差异及其意义显示文摘目的:通过对同一种复方中药采用水煎和乙醇提取两种不同方法制备样品进行血中吸收成分的比较,为目前中药药代动力学研究所面临的技术难点提供解决方案。方法:采用液-液萃取净化、996-二极管阵列检测高效液相色谱法测定血浆样品。结果:以多种剂量灌胃给予比格犬IBS复方水煎剂,血浆样品中均未检测到任何吸收入血的成分,但是用同样的方法给予比格犬IBS复方乙醇提取样品,在剂量较水提样品低约27倍时,却至少可以检测到20种化学成分。结论:比格犬灌胃给予IBS中药复方乙醇提取样品和给予水提取样品相比,两者吸收入血成分具有重大差异,这一差异对揭示目前中药复方药代动力学研究难点以及提高中药的临床疗效可能潜在重要意义。 | 王建农 刘建勋 Dennis Chang Alan Bensoussan | 2008 | 世界科学技术-中医药现代化2008,10,6: | 1 |
| 16 | A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma显示文摘 | Andrew H. Ko Noelle LoConte Margaret A. Tempero Evan J. Walker R. Kate Kelley Stephanie Lewis Wei-Chou Chang Emily Kantoff Michael W. Vannier Daniel V. Catenacci Alan P. Venook Hedy L. Kindler | 2016 | Pancreas2016,,3: | 1 |
| 17 | Magnesium research and applications: Past, present and future显示文摘As the lightest structural metal and one of the most abundant metallic elements on earth, magnesium(Mg) has been used as an 'industrial metal' for lightweighting in the transportation and electronics industries, in addition to other traditional applications in aluminum alloying,steel desulfurization and protective anodes. In recent years, research has shown significant potential for Mg to become a 'technology metal'in a variety of new applications from energy storage/battery to biomedical products. However, global Mg production has shown steady but moderate growth in the last three decades. Mg applications as an industry metal are still limited due to some sustainability concerns of primary Mg production, as well as a number of technical issues related to the structural and corrosion performance of commercial Mg alloys.New Mg applications as an industrial or technology metal face tremendous technical challenges, which have been reflected in the intensified global research efforts in the last twenty years. This paper will review some past and present applications, and discuss future opportunities and challenges for Mg research and applications for the global Mg community. | Jianyue Zhang Jiashi Miao Nagasivamuni Balasubramani Dae Hyun Cho Thomas Avey Chia-Yu Chang Alan A.Luo | 2023 | Journal of Magnesium and Alloys2023,11,11: | 1 |
| 18 | Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo显示文摘 | Hui-Chun Wang Alan Yueh-Luen Lee Wen-Cheng Chou Chin-Chung Wu Chao-Neng Tseng Kevin Yen-Ting Liu Wen-Lien Lin Fang-Rong Chang Da-Wei Chuang Attila Hunyadi Yang-Chang Wu | 2012 | Molecular Cancer Therapeutics2012,,7: | 1 |
| 19 | Interleukin-1activates phospholipase A2 in rabbit chondrocytes: A possible signal for IL-1 action显示文摘 | Joseph Chang Steven C Gilman and Alan J Lewis | 1986 | Journal of Immuology1986,136,: | 1 |
| 20 | Analysis of conjugate gradient algorithms for adaptive filtering 显示文摘 | CHANG Pi sheng WILLSON Alan N | 2000 | IEEE Transactions on signal processing2000,48,2: | 1 |