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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | 饲喂果寡糖对奥尼罗非鱼Oreochromisaurea ♂×O.nilotica♀肠道菌群、成活率及生长性能的影响(英文)显示文摘本研究通过8周生长试验研究了饲喂果寡糖对奥尼罗非鱼Oreochromis aurea♂×O.nilotica♀肠道菌群、存活率及生产性能的影响。试验设计3组果寡糖水平(0、0.8及1.2 g/kg),按每天4次饱食投喂初始重为5.55 g的奥尼罗非鱼,试验系统为淡水养殖系统,试验期间平均水温为28℃,罗非鱼养殖密度40尾/箱,每组3个重复。饲喂试验结束后,试验动物整体称重并测定形态学参数。从每个养殖单元随机取出3尾试验鱼,无菌条件下取肠道通过选择性培养基分别分析副溶血性弧菌Vibrio parahaemolyticus、嗜水气单胞菌Aeromonas hydrophila、乳酸杆菌Lactobacillussp.及粪链球菌Streptococcus faecalis的数量。结果表明:随着饲喂果寡糖水平增加,奥尼罗非鱼末重(FBW,g)和特定生长率(SGR,%/d)均显著增加(P<0.10);日摄食率(FI,g/(d.只)也增加(P>0.10);饲料转化率和肝胰腺指数均降低(P>0.10);而存活率(SR,%)、屠宰率(DCY,%)及丰满度(CF,g/cm3)则不受影响。所检测的全部罗非鱼肠道菌群数量随着饲喂果寡糖水平的上升呈增加状态(P>0.10)。本研究说明,饲料中添加果寡糖对奥尼罗非鱼生产性能、饲料转化效率及肠道菌群有一定改善作用,本研究推荐奥尼罗非鱼饲料中适宜果寡糖水平为1.2 g/kg。[动物营养学报,2007,19(6):691-697] | 吕慧源 周志刚 Florence Rudeaux Frédérique Respondek | 2007 | 动物营养学报2007，19，6： | 16 |
| 3 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 4 | Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease显示文摘 | Vlad Ratziu Frédéric Charlotte Agnès Heurtier Sophie Gombert Philippe Giral Eric Bruckert André Grimaldi Frédérique Capron Thierry Poynard | 2005 | Gastroenterology2005，，7： | 4 |
| 5 | Inheritance patterns of secondary symbionts during sexual reproduction of pea aphid biotypes显示文摘食草的昆虫经常怀有影响他们的生态学和进化的细菌的共生者。蚜虫招待应尽的 endosymbiont Buchnera,它为复制被要求,和其频率越过蚜虫人口变化的容许的共生者。这些似母亲播送了第二等的共生者特别地在豌豆蚜虫被学习了, Acyrthosiphon pisum,哪个港口穿上环境地依赖的效果的至少 8 不同细菌的种类(不数的 Buchnera ) 主人健康。特别地,这些共生者种类与豌豆蚜虫人口在特定的植物上喂被联系。尽管他们是继承的似母亲,这些细菌偶尔越过昆虫系被转移。如此的 nonmaternal 转移的一机制在性复制期间是到子孙的父亲的传播。迄今为止,第二等的共生者的传播在仅仅蚜虫系和 3 共生者种类的一把在蚜虫的性复制期间被调查了。更好描绘这个过程,我们通过包含属于 9 专业化主人的遗传因子型,和 117 个十字的 49 克隆的一个交叉实验在豌豆蚜虫的性复制期间调查了 7 共生者种类的继承模式。在子孙的共生者种类在从鸡蛋并且在以后的单性生殖的代孵化的 fundatrix 阶段与诊断质的 PCR 被检测。我们没发现共生者的父亲的传播的证实的案例到子孙,并且我们观察到特别共生者种(Serratia symbiotica ) 的母亲的传播是相当低效的。我们在尊重讨论这些观察到豌豆蚜虫的生态学。 | Jean Peccoud Joêl Bonhomme Frédérique Mahéo Manon de la Huerta Olivier Cosson Jean-Christophe Simon | 2014 | Insect Science2014，21，3： | 4 |
| 6 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 7 | Relationship between texture and pectin composition of two apple cultivars during storage显示文摘 | Ludivine Billy Emira Mehinagic Ga?lle Royer Catherine M.G.C. Renard Ga?lle Arvisenet Carole Prost Frédérique Jourjon | 2007 | Postharvest Biology and Technology2007，，3： | 3 |
| 8 | 9种商业消毒剂对猪2型圆环病毒的杀灭效能测试显示文摘养猪业中常用的许多商业消毒剂,都获得了法国农业部批准。然而对其杀灭增殖初期猪2型圆环病毒(PCV2)的效能却不甚了解。用在法国分离到的PCV2悬液来测试9种商业消毒剂的效能,在20℃下病毒悬液与消毒剂作用30 min后,将该混合液过滤和稀释进行脱毒处理以去除对圆环病毒和猪肾细胞系有害的物质,再经一系列稀释后接种于人工培养的猪肾细胞进行免疫过氧化物酶单层细胞试验(IPMA)测定PCV2的感染性。结果表明,用碘类和苯酚类消毒剂并不能减少病毒滴度。在此着重介绍其他消毒剂效能(病毒滴度减少量≥1.61 log_(10)),其中5种消毒剂:一种含过一硫酸氢钾,另两种含一种季铵盐、一到三种醛、次氯酸钠和氢氧化钠,在标准浓度下或1.5~4倍低于标准浓度时可显著杀灭PCV2;其余两种,其中一种含过一硫酸氢钾,另一种含过氧乙酸和过氧化氢,在标准浓度下或2倍高于标准浓度时也可杀灭PCV2。 | Hélène Martin Marie-Frédérique Le Potier Pierre Maris 杨满军 | 2009 | 今日养猪业2009，，3： | 2 |
| 9 | Characteristics of patients with dual infection by hepatitis B and C viruses显示文摘 | Jean-Pierre Zarski Benoit Bohn Anne Bastie Jean-Michel Pawlotsky Maryline Baud Frédérique Bost-Bezeaux Jeanne Tran van Nhieu Jean-Marie Seigneurin Catherine Buffet Daniel Dhumeaux | 1998 | Journal of Hepatology1998，，1： | 2 |
| 10 | Upper digestive intolerance during enteral nutrition in critically ill patients: Frequency, risk factors, and complications显示文摘 | Hervé Mentec Hervé Dupont Maria Bocchetti Pascale Cani Frédérique Ponche Gérard Bleichner | 2001 | Critical Care Medicine2001，，10： | 2 |
| 11 | Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy显示文摘 | Philippe Lévy Vincent Jouannaud Dermot O’Toole Anne Couvelard Marie Pierre Vullierme Laurent Palazzo Alain Aubert Philippe Ponsot Alain Sauvanet Frédérique Maire Olivia Hentic Pascal Hammel Philippe Ruszniewski | 2006 | Clinical Gastroenterology and Hepatology2006，，4： | 2 |
| 12 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 13 | The Ratio of Metastatic to Examined Lymph Nodes Is a Powerful Independent Prognostic Factor in Rectal Cancer显示文摘 | Frédérique Peschaud Stéphane Benoist Catherine Julié Alain Beauchet Christophe Penna Philippe Rougier Bernard Nordlinger | 2008 | Annals of Surgery2008，，6： | 2 |
| 14 | A New Efficient Synthesis of the Immunosuppressive Agent FTY-720显示文摘 | Philippe Durand Philippe Peralba Frédérique Sierra Patrice Renaut | 2000 | Synthesis2000，，04： | 1 |
| 15 | Sc FOS a prebiotic for synbiotic associations:Recent studies in humans显示文摘 | Céline H Anne W Frédérique R | 2010 | Nutrafoods2010，9，1： | 1 |
| 16 | Does Spectral Entropy Reflect the Response to Intubation or Incision During Propofol-Remifentanil Anesthesia?显示文摘 | Grégoire Weil Sylvie Passot Frédérique Servin | 2008 | Anesth & Analg2008，106，1： | 1 |
| 17 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 18 | Study of the microbial ecology of cold-smoked salmon during storage at 8°C显示文摘 | Fran?oise Leroi Jean-Jacques Joffraud Frédérique Chevalier Mireille Cardinal | 1998 | International Journal of Food Microbiology1998，，1： | 1 |
| 19 | The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas显示文摘 | Wafaa Khannoussi Marie Pierre Vullierme Vinciane Rebours Frédérique Maire Olivia Hentic Alain Aubert Alain Sauvanet Safi Dokmak Anne Couvelard Pascal Hammel Philippe Ruszniewski Philippe Lévy | 2012 | Pancreatology2012，，3： | 1 |
| 20 | Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors for Which FISH Analysis Does Not Detect an Increase in EGFR Gene Copy Number显示文摘 | Antoine Italiano MD Philippe Follana MD Fran?ois-Xavier Caroli MD Jean-Luc Badetti MD Daniel Benchimol MD Georges Garnier MD Jean Gugenheim MD Juliette Haudebourg MD Frédérique Keslair MS Gérard Lesbats MD Gérard Lledo MD Jean-Francois Roussel MD Florence | 2008 | Annals of Surgical Oncology2008，，2： | 1 |
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