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| 1 | LCSH,SKOS和关联数据显示文摘论述将美国国会图书馆MARCXML格式的主题标目转换为SKOS(RDF编码格式)的技术方法。着重阐述SKOS词表的优势、可能的扩展方向以及与其他语义网词表的整合,如都柏林核心集。还介绍一个利用关联数据(LinkedData)技术在网上发布词表的Web应用。 | Ed Summers Antoine Isaac Clay Redding Dan Krech 姚小乐 刘炜(译) 张春景(校) | 2009 | 现代图书情报技术2009，，3： | 41 |
| 2 | 嗓音的客观多参数分析与主观听觉分析相关性的研究显示文摘目的 探讨嗓音的客观多参数检测与主观听觉评估的相关性 ,建立嗓音客观多参数评估模式 ,实现嗓音评估的客观化、数据化。方法 声音样本采自 135例声音嘶哑患者和 2 9例嗓音正常者。客观检测采用法国开发的“EVA ”嗓音工作站 ,测试对象发长元音 /α :/时 ,检测下列参数 :基频 (F0 )、音强 (intensity)、基频微扰 (jitter)、信噪比 (signal-to -noiseratio ,SNR)、Lyapunov系数、口腔气流量 (oralairflow ,OAF)、音域 (range)及最大发声时间 (maxi mumphonatorytime,MPT) ;发 /pα/音时 ,检测声门下压 (estimatedsubglotticpressure ,ESGP)。主观听觉评估采用日本言语语音学会声音嘶哑评估GRBAS系统中的总嘶哑度 (grade,G) 4级评估标准。所有受试者以自然的音调及音强读一段统一的标准文字 ,听评委由 4名嗓音学家组成。结果 应用判别分析方法 ,建立了 7参数客观评估模式 (音域、Lyapunov系数、声门下压、最大发声时间、口腔气流量、信噪比和基频 )。客观评估结果与主观评估结果的一致性达到 84 %。结论 嗓音的客观检测是多参数的 。 | 于萍 Giovanni Antoine | 2003 | 听力学及言语疾病杂志2003，11，3： | 34 |
| 3 | IAP/LASG海洋环流模式对风应力的响应显示文摘为了检验第三代 IAP/LASG全球海洋环流模式在模拟 20世纪 80年代热带太平洋年际变化方面特别是圆 Nino和 La Nina事件的能力,作者使用了三种风应力资料强迫该模式。然后,将模拟的海温同NCEP海洋同化资料相比较。分析表明,在赤道附近,模式对风应力的响应在 SST分布。温跃层的描绘以及突出El Nino和 La Nina事件方面同 NCEP海洋同化资料有许多共同点。然而,在描绘10°N以北和10°S以南的SST异常以及描写季节循环方面,响应是不够精确的。另外。 | 俞永强 Antoine Izard 张学洪 郭裕福 | 2001 | 大气科学2001，25，6： | 24 |
| 4 | Eosinophilic gastroenteritis:Approach to diagnosis and management显示文摘Eosinophilic gastroenteritis(EGE) is a rare and benign inflammatory disorder that predominantly affects the stomach and the small intestine.The disease is divided into three subtypes(mucosal,muscular and serosal) according to klein's classification,and its manifestations are protean,depending on the involved intestinal seg-ments and layers.Hence,accurate diagnosis of EGE poses a significant challenge to clinicians,with evidence of the following three criteria required:Suspicious clinical symptoms,histologic evidence of eosinophilic infiltration in the bowel and exclusion of other pathologies with similar findings.In this review,we designed and applied an algorithm to clarify the steps to follow for diagnosis of EGE in clinical practice.The management of EGE represents another area of debate.Prednisone remains the mainstay of treatment;however the disease is recognized as a chronic disorder and one that most frequently follows a relapsing course that requires maintenance therapy.Since prolonged steroid treatment carries of risk of serious adverse effects,other options with better safety profiles have been proposed;these include budesonide,dietary restrictions and steroid-sparing agents,such as leukotriene inhibitors,azathioprine,anti-histamines and mast-cell stabilizers.Single cases or small case series have been reported in the literature for all of these options,and we provide in this review a summary of these various therapeutic modalities,placing them within the context of our novel algorithm for EGE management according to disease severity upon presentation. | Antoine Abou Rached Weam El Hajj | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 24 |
| 5 | Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis显示文摘瞄准:为了决定嗜中性的弄空和 Kupffer 房间抑制是否可能联合,他们的 protective 完成尖锐胰腺炎的严厉到减少。方法:老鼠有 cerulein 管理导致尖锐胰腺炎并且是有任何一个反老鼠 neutrophil 浆液或金轧氯化物(GdCl3 ) 的 pretreated 阻止 Kupffer 房间激活,或两个处理。损害在胰和肺被估计。Myeloperoxidases (军邮局) 估计了嗜中性的渗入。Interleukin-6 (IL-6 ) 和 IL-10 在浆液,胰,肺和肝被测量。结果:在有尖锐胰腺炎的老鼠,嗜中性的弄空减少了胰腺炎和联系胰腺炎的肺损害的严厉。在由 GdCl3 的激活的 Kupffer 房间有更少的保护的效果,尽管 IL-6 和 IL-10 集中显著地被减少。嗜中性的弄空带的普雷茨氏疗法没被 Kupffer 房间在激活提高,两个处理没联合他们的保护的效果。结论:当 Kupffer 房间激活的角色是不太明显的时,我们的结果在在尖锐胰腺炎加重机关损害证实激活的 neutrophils 的角色。 | Catherine M Pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe Morel Jean-Louis Frossard | 2006 | World Journal of Gastroenterology2006，12，8： | 22 |
| 6 | 活体共聚焦显微镜在感染性角膜炎诊治中的应用显示文摘感染性角膜炎是一种严重的致盲性眼病,早期病原学诊断直接影响着患者的治疗效果.如何快速、准确地鉴别致病病原体目前还是一个挑战.活体共聚焦显微镜检查(IVCM)作为一种非侵入性图像诊断技术,可在细胞水平提供高分辨率图像以显示眼表组织的结构特征.IVCM对感染性角膜炎中棘阿米巴性角膜炎及丝状真菌性角膜炎的诊断具有重要应用价值,已在临床开始推广使用,逐渐成为感染角膜炎随诊的客观依据.本文对近年来IVCM在感染性角膜炎诊治中的应用及进展进行综述. | 梁庆丰 孙旭光 LABBE Antoine | 2013 | 中华眼科杂志2013，49，10： | 20 |
| 7 | Insights on the solubilization products after combined alkaline and ultrasonic pre-treatment of sewage sludge显示文摘This work provides insights on the solubilization products after a simultaneous combination of alkaline and ultrasonic(ALK + ULS) pre-treatment of sewage sludge.Soluble chemical oxygen demand(SCOD) increased from 1200 to 11,000 mg/L after such treatment. Organics with molecular weight around 5.6 k Da were solubilized because of the synergistic effect of ultrasound and alkali. Organics with molecular weight larger than300 k Da increased from 7.8% to 60%, 16% and 42.3% after ULS, ALK and ALK + ULS treatment, respectively. Excitation emission matrix fluorescence spectroscopy analysis identified soluble microbial product-like and humic acid-like matters as the main solubilization products. Sludge anaerobic biodegradability was significantly enhanced with the simultaneous application of ALK + ULS pre-treatment. ALK + ULS pre-treatment resulted in 37.8% biodegradability increase compared to the untreated sludge. This value was higher compared to the biodegradability increase induced by individual ALK pre-treatment(5.7%) or individual ULS pre-treatment(20.7%) under the same conditions applied. | Xinbo Tian Chong Wang Antoine Prandota Trzcinski Leonard Lin Wun Jern Ng | 2015 | Journal of Environmental Sciences2015，27，3： | 19 |
| 8 | Changes in reproductive investment with altitude in an alpine plant显示文摘Aims In perennial species,the allocation of resources to reproduction results in a reduction of allocation to vegetative growth and,therefore,impacts future reproductive success.As a consequence,variation in this trade-off is among the most important driving forces in the life-history evolution of perennial plants and can lead to locally adapted genotypes.In addition to genetic variation,phenotypic plasticity might also contribute to local adaptation of plants to local conditions by mediating changes in reproductive allocation.Knowledge on the importance of genetic and environmental effects on the tradeoff between reproduction and vegetative growth is therefore essential to understand how plants may respond to environmental changes.Methods We conducted a transplant experiment along an altitudinal gradient from 425to1921 min the frontrange of the Western Alps of Switzerland to assess the influence of both altitudinal origin of populations and altitude of growing site on growth,reproductive investment and local adaptation in Poa alpina.Important findings In our study,the investment in reproduction increased with plant size.Plant growth and the relative importance of reproductive investment decreased in populations originating from higher altitudes compared to populations originating from lower altitudes.The changes in reproductive investment were mainly explained by differences in plant size.In contrast to genetic effects,phenotypic plasticity of all traits measured was low and not related to altitude.As a result,the population from the lowest altitude of origin performed best at all sites.Our results indicate that in P.alpina genetic differences in growth and reproductive investment are related to local conditions affecting growth,i.e.interspecific competition and soil moisture content. | Yann Hautier Christophe F.Randin Jurg Stocklin Antoine Guisan | 2009 | Journal of Plant Ecology2009，2，3： | 17 |
| 9 | 睑板腺热脉动系统治疗睑板腺功能障碍的临床观察显示文摘目的评价睑板腺热脉动系统治疗睑板腺功能障碍(MGD)的临床效果及安全性。方法回顾性系列病例研究。本研究对48例(96只眼)MGD患者进行12rain的睑板腺热脉动系统治疗,在治疗前、治疗后4周及12周进行包括主观症状、泪膜稳定性、脂质层厚度(LLT)、睑板腺缺失情况等方面的临床评估,不同时间点有效性评估参数的变化采用独立样本t检验进行分析。结果48例MGD患者进行睑板腺热脉动系统治疗后随访12周,患者主观症状明显缓解,眼表疾病评分指数(OSDI)由治疗前(45.36±19.34)分降至4周后的(23.82±11.94)分及12周的(25.66±14.12)分,差异有统计学意义(t=-2.009,1.976;P=0.035,0.038)。睑板腺开口数量由治疗前(2.91±1.13)个增加至治疗后4周的(6.27±2.37)个(f=3.505,P〈0.001)及12周的(5.15±2.08)个(t=2.004,P=0.027);睑板腺分泌物性状由治疗前(6.18±2.48)分增至4周后的(13.55±3.46)分0=2.689,P=0.005)及12周后的(12.67±3.41)分(f=2.403,P=0.009)。患者LLT较治疗前(42.13±9.67)nm明显增加,分别为治疗后4周的(59.02±16.39)nm(t=2.971,P=0.002)及12周的(54.65±12.52)nm(t=2.021,P=0.021),差异有统计学意义。不完全瞬目比率也由治疗前的0.37±0.30降至4周后的0.15±0.140=3.428,P=0.035)及12周后的0.12±0.13(t=1.986,P=0.026)。BUT在经过睑板腺热脉动系统的治疗后得到明显缓解,由治疗前的(4.73±2.34)S增至4周后的(9.32±2.18)s(t=3.385,P〈0.001)及12周后的9.91±3.01S(t=3.253,P〈0.001),差异有统计学意义。治疗1d后进行安全性评估,与基线相比:最佳矫正视力、角膜染色及眼压无明显变化(P=0.141,O.376,0.421)。结论12周的临床观察表明,睑板腺热脉动系统是一种有效且安全的MGD治疗方法. | 梁庆丰 刘含若 郭燕 崔蕊 李彬 王宁利 LABBE Antoine | 2015 | 中华眼科杂志2015，51，12： | 16 |
| 10 | 应用BioMod集成多种模型研究物种的空间分布——以铁杉在中国的潜在分布为例显示文摘新型统计方法和多源、多尺度空间信息数据的产生促进了物种空间分布模型的快速发展。不同的物种空间分布模型在生态学理论的运用以及前提假设上存在差异。选用不同的模型方法和输入数据会带来预测结果的不确定性。对比并集成多个物种空间分布模型,同时利用多组输入数据可降低预测的不确定性,提高物种分布模拟的精度。本文以中国特有种铁杉(Tsuga chinensis)为例,运用基于R语言开发的BioMod软件包对比9个物种空间分布模型对铁杉的模拟效果。最后以曲线下面积(ROC)为权重集成9个模型的模拟结果,产生和筛选最佳的铁杉潜在空间分布图。研究发现随机森林模型(RF)的模拟效果最好,其次是多元适应回归样条函数模型(MARS)和广义相加模型(GAM),模拟效果最差的是表面分布区分室模型(SRE)。模型集成结果显示,最适宜铁杉分布的区域集中在中国的西南及四川盆地周围,其次零星分散于华南和台湾部分地区。这一结果与前人对铁杉自然分布的描述和研究结果较为吻合。研究进一步表明,通过模型的集成能有效地降低由于单个模型所带来的模拟结果不确定性,从而提高模拟的精度和效果。 | 毕迎凤 许建初 李巧宏 Antoine Guisan Wilfried Thuiller Niklaus E.Zimmermann 杨永平 杨雪飞 | 2013 | 植物分类与资源学报2013，35，5： | 16 |
| 11 | 泪膜客观散射指数对干眼诊断价值的研究显示文摘目的探讨泪膜客观散射指数在干眼诊断中的意义。方法前瞻性病例对照研究。选取2016年7至10月在北京同仁眼科中心就诊的干眼患者53例(53只眼)作为干眼组,其中男性18例,女性35例;平均年龄(37.3±7.2)岁。选取健康志愿者32名(32只眼)作为对照,其中男性10名,女性22名;平均年龄(38.1±13.8)岁。所有被检查者均按如下顺序进行检查:(1)眼表疾病评分指数(OSDI)问卷调查;(2)视觉质量检测;(3)泪膜脂质层厚度测量;(4)泪膜破裂时间测定;(5)SchirmerⅠ检测。视觉质量使用双通道视觉质量分析系统Ⅱ(OQASⅡ)检测,获取调制传递函数(MTF)截止频率、基础客观散射指数及总客观散射指数值,通过计算得出泪膜客观散射指数(TF—OSI),并对比两组受试者TF-OSI之间的差异,明确TF—OSI与其他干眼客观指标间的相关性,并通过受试者工作特征曲线(ROC曲线)研究该参数对于干眼诊断的敏感性和特异性。两组数据比较采用独立样本t检验,性别差异使用卡方检验;干眼组中各项参数间相关性分析使用Spearman相关分析法。结果干眼组MTF截止频率(32.07±11.95)明显低于对照组(39.38±9.44)(t=-3.096,P=0.003);TF—OSI平均值(0.50±0.43)明显高于对照组(0.21±0.16)(t=4.300,P=0.000),干眼患者TF—OSI离散度(0.52±0.81)明显高于对照组(0.12±0.06)(t=3.546,P=0.001)。TF—OSI平均值与泪膜脂质层厚度呈正相关(r=0.365,P=0.007),与MTF截止频率呈负相关(r=0.368,P=0.007),与TF—OSI离散度呈正相关(r=0.581,P=0.000)。TF—OSI对干眼诊断价值:TF-OSI平均值诊断干眼的敏感性为0.736,特异性为0.762,曲线下面积为0.764;TF—OSI标准差诊断干眼的敏感性为0.811,特异性为0.810,曲线下面积为0.900。结论干眼患者泪膜客观散射指数平均值和离散度均增加,该参数凭其特有的优势可成为辅助诊断干眼的新方法。 | 苏远东 梁庆丰 王宁利 Antoine Labbe | 2017 | 中华眼科杂志2017，53，9： | 15 |
| 12 | 妻子参与旅游决策的研究显示文摘本文将旅游决策划分为 17个小任务。要求接受问卷调查的妻子就每一项任务的参与程度评分。调查发现 ,理财活动的参与程度低 ,而某些任务的参与程度却较高 ,如“购物” ,“选择餐厅” ,“收集资料”和“准备行李”。本文还验证了两个假设 :①妻子的社会经济特征和旅行的性质对其在决策过程中的参与程度有正面的影响 ;②妻子的参与程度具有稳定性。本文最后讨论了此项对市场营销的启示和未来研究的方向。 | Antoine Zalatan 苗学玲 | 2003 | 人文地理2003，18，2： | 15 |
| 13 | Hydraulic characteristics of an anaerobic baffled reactor as onsite wastewater treatment system显示文摘The feasibility of using anaerobic baffled reactor(ABR) as onsite wastewater treatment system was discussed.The ABR consisted of one sedimentation chamber and three up-flow chambers in series was experimented under different peak flow factors(PFF of 1 to 6), superficial gas velocities(between 0.6 and 3.1 cm/hr) and hydraulic retention times(HRT)(24, 36 and 48 hr).Residence time distribution(RTD) analyses were carried out to investigate the hydraulic characteristics of the ABR.It was found that the PFF resulted in hydraulic dead space.The dead space did not exceed 13% at PFF of 1, 2 and 4 while there was 2-fold increase(26%) at PFF of 6.Superficial gas velocities did not result in more(biological) dead space.The mixing pattern of ABR tended to be a completely-mixed reactor when PFF increased.Superficial gas velocities did not affect mixing pattern.The effects of PFF on mixing pattern could be minimized by higher HRT(48 hr).The tank-in-series(TIS) model(N = 4) was suitable to describe the hydraulic behaviour of the studied system.The HRT of 48 hr was able to maintain the mixing pattern under different flow patterns, introducing satisfactory hydraulic efficiency.Chemical oxygen demand(COD) and total suspended solids(TSS) removals under all flow patterns were achieved more than 85% and 90%, respectively.The standard deviation of effluent COD and TSS concentration did not exceed 15 mg/L. | Yuttachai Sarathai Thammarat Koottatep Antoine Morel | 2010 | Journal of Environmental Sciences2010，22，9： | 14 |
| 14 | Gastric leaks post sleeve gastrectomy:Review of its prevention and management显示文摘Gastric sleeve gastrectomy has become a frequent bariatric procedure. Its apparent simplicity hides a number of serious,sometimes fatal,complications. This is more important in the absence of an internationally adopted algorithm for the management of the leaks complicating this operation. The debates exist even regarding the definition of a leak,with several classification systems that can be used to predict the cause of the leak,and also to determine the treatment plan. Causes of leak are classified as mechanical,technical and ischemic causes. After defining the possible causes,authors went into suggesting a number of preventive measures to decrease the leak rate,including gentle handling of tissues,staple line reinforcement,larger bougie size and routine use of methylene blue test per operatively. In our review,we noticed that the most important clinical sign or symptom in patients with gastric leaks are fever and tachycardia,which mandate the use of an abdominal computed tomography,associated with an upper gastrointrstinal series and/or gastroscopy if no leak was detected. After diagnosis,the management of leak depends mainly on the clinical condition of the patient and the onset time of leak. It varies between prompt surgical intervention in unstable patients and conservative management in stable ones in whom leaks present lately. The management options include also endoscopic interventions with closure techniques or more commonly exclusion techniques with an endoprosthesis. The aim of this review was to highlight the causes and thus the prevention modalities and find a standardized algorithm to deal with gastric leaks post sleeve gastrectomy. | Antoine Abou Rached Melkart Basile Hicham El Masri | 2014 | World Journal of Gastroenterology2014，20，38： | 14 |
| 15 | 眼睑阴虱感染一例显示文摘患者 女性,41岁。左眼睑阵发性瘙痒、异物感1个月,以夜间为甚。 | 梁庆丰 Antoine Labbe 孙旭光 潘志强 | 2012 | 眼科2012，21，6： | 11 |
| 16 | Epidemiology and Natural History of Inflammatory Bowel Diseases显示文摘 | Jacques Cosnes Corinne Gower–Rousseau Philippe Seksik Antoine Cortot | 2011 | Gastroenterology2011，，6： | 11 |
| 17 | Kinetic study of phytotoxicity induced by foliar lead uptake for vegetables exposed to fine particles and implications for sustainable urban agriculture显示文摘At the global scale, foliar metal transfer occurs for consumed vegetables cultivated in numerous urban or industrial areas with a polluted atmosphere. However, the kinetics of metal uptake, translocation and involved phytotoxicity was never jointly studied with vegetables exposed to micronic and sub-micronic particles(PM). Different leafy vegetables(lettuces and cabbages) cultivated in RHIZOtest? devices were, therefore, exposed in a greenhouse for 5, 10 and 15 days to various Pb O PM doses. The kinetics of transfer and phytotoxicity was assessed in relation to lead concentration and exposure duration. A significant Pb accumulation in leaves(up to 7392 mg/kg dry weight(DW) in lettuce) with translocation to roots was observed. Lead foliar exposure resulted in significant phytotoxicity, lipid composition change, a decrease of plant shoot growth(up to 68.2% in lettuce) and net photosynthesis(up to 58% in lettuce). The phytotoxicity results indicated plant adaptation to Pb and a higher sensitivity of lettuce in comparison with cabbage. Air quality needs, therefore, to be considered for the health and quality of vegetables grown in polluted areas, such as certain megacities(in China, Pakistan, Europe, etc.) and furthermore, to assess the health risks associated with their consumption. | TianTian Xiong Annabelle Austruy Antoine Pierart Muhammad Shahid Eva Schreck Stéphane Mombo Camille Dumat | 2016 | Journal of Environmental Sciences2016，28，8： | 10 |
| 18 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 19 | 活体共聚焦显微镜检查对翼状胬肉活动性评价的应用研究显示文摘目的 探讨活体共聚焦显微镜(IVCM)检查对翼状胬肉活动性评价的应用价值.方法 前瞻性病例对照研究.2015年8月至2016年2月对北京同仁医院眼科中心28例(36只眼)原发性翼状胬肉患者纳入研究.所有受试者均通过如下检查:眼表症状评分、裂隙灯显微镜下翼状胬肉充血程度、翼状胬肉荧光素染色评分及有无Fuchs小岛,进行翼状胬肉活动性评分(PAS),其中低活动性翼状胬肉(PAS评分≤3分)12只眼,高活动性翼状胬肉(PAS评分≥4分)24只眼.翼状胬肉IVCM检查的主要评价指标包括:翼状胬肉头部与周边角膜边界是否整齐;有无Fuchs小岛;翼状胬肉头部及邻近角膜的树突状细胞密度;翼状胬肉体部新生血管数量及杯状细胞密度.对比分析不同活动性翼状胬肉患者IVCM表现差异并采用Spearman相关分析法对翼状胬肉裂隙灯显微镜PAS评分及IVCM评分进行相关性分析.结果 在IVCM下,翼状胬肉由表层的上皮细胞和其下的纤维组织、新生血管组成.病变组织中可见少许树突状细胞浸润及卵圆形杯状细胞散在分布.活动性较高的翼状胬肉(PAS评分≥4分)头部与周围角膜的边界不规则,其评分为(0.84±0.51)分,与低活动性翼状胬肉组[(0.23±0.12)分]相比,差异有统计学意义(t=2.68,P=0.009);活动性较高的翼状胬肉头部附近可见明显的Fuchs小岛,数量不等、形状差异性大,评分为(0.75±0.25)分,与低活动性胬肉组[(0.23±0.12)分]相比,差异有统计学意义(t=3.79,P=0.001);活动性较高的翼状胬肉及附近角膜上皮层均可见大量树突状细胞浸润,评分为(2.75±0.76)分,角膜基质层可见数量较多的活化角膜细胞[(1.92±0.68)分],与低活动性胬肉组相比,树突状细胞浸润及活化角膜细胞差异均有统计学意义(t=2.01,P=0.001;t=2.22,P=0.030);活动性较高的翼状胬肉的体部杯状细胞密度为(2.08±0.42)分,明显高于活动性翼状胬肉,差异有统计学意义(t=3.25,P<0.001).IVCM对翼状胬肉的活动性评价与传统裂隙灯显微镜PAS评价之间存在明显的正相关(r=0.95,P<0.05).结论 IVCM可定量分析翼状胬肉的炎症细胞密度、血管增生程度及基质细胞活化情况,是临床较可靠的评价翼状胬肉活动性的方法. | 梁庆丰 高超 梁红 李彬 杜向红 Labbe Antoine | 2016 | 中华眼科杂志2016，52，10： | 10 |
| 20 | 不同类型干眼患者泪膜脂质层厚度及其与临床特征的关系显示文摘目的研究不同类型干眼患者泪膜脂质层厚度(LLT)及其与干眼临床特征的关系。方法采用系列病例观察研究方法,连续纳入2016年4—8月在北京同仁医院就诊的干眼患者306例306眼行眼表疾病指数(OSDI)问卷调查、睑缘及眼表裂隙灯显微镜检查、泪膜LLT测量、泪膜破裂时间(TBUT)测定、Schirmer试验Ⅰ(SⅠt)检测和红外线睑板腺照相,其中OSDI〉12分、睑缘评分≥2分者157例为睑板腺功能障碍(MGD)组,OSDI〉12分、SⅠt〈5 mm/5 min者53例作为水液缺乏性干眼(ADDE)组,OSDI〉12分、SⅠt〈5 mm/5 min且睑缘评分≥2分者96例作为混合型干眼组。采用LipiView?眼表面干涉仪测量干眼患者泪膜LLT的分布,分析其与患者症状、体征间的相关性。结果干眼患者泪膜LLT值平均为(60.41±18.57)nm,呈正态分布。MGD组、ADDE组和混合型干眼组患者泪膜LLT分别为(57.04±18.26)、(63.52±18.44)和(60.26±18.71)nm,总体比较差异有统计学意义(F=2.347,P=0.035),其中MGD组患者泪膜LLT明显薄于ADDE组,差异有统计学意义(t=2.077,P=0.039)。患者LLT与OSDI问卷评分呈低度负相关(r=-0.201,P=0.003),与SⅠt及睑板腺缺失率均呈负相关(r=-0.146,P=0.005;r=-0.156,P=0.046)。亚组分析显示,MGD组患者LLT与OSDI评分呈负相关(r=-0.285,P=0.000),ADDE组和混合型干眼组患者LLT与OSDI评分无明显相关性(均P〉0.05);3个组患者LLT与SⅠt间均无明显相关性(均P〉0.05);混合型干眼组及MGD组患者LLT与睑板腺缺失率的相关性均明显大于总体相关性(r=-0.335、-0.248、-0.156)。患者异物感、眼酸痛、看电视后眼部不适和看计算机后眼部不适与LLT均呈负相关(r=-0.243、-0.205、-0.223、-0.258,均P〈0.05)。结论不同类型的干眼患者LLT不同,MGD患者LLT偏薄,而ADDE患者LLT偏厚,泪膜呈现油-水互补趋势;异物感、眼酸痛、看电视或计算机引起眼部不适等症状与LLT相关。 | 梁庆丰 杜向红 苏远东 李彬 Antoine Labbe | 2018 | 中华实验眼科杂志2018，36，2： | 10 |
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