|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An Update on Abscisic Acid Signaling in Plants and More显示文摘 | Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas Frei dit Frey Jeffrey Leung | 2008 | Molecular Plant2008，1，2： | 46 |
| 2 | Nutrition and physical activity in NAFLD:An overview of the epidemiological evidence显示文摘Nonalcoholic fatty liver disease(NAFLD)has been recognized as a major health burden.The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity,unhealthy dietary pattern,and sedentary lifestyle.The efficacy and safety profile of pharmacotherapy in the treatment of NAFLD remains uncertain and obesity is strongly associated with hepatic steatosis;therefore,the first line of treatment is lifestyle modification.The usual management of NAFLD includes gradual weight reduction and increased physical activity(PA)leading to an improvement in serum liver enzymes,reduced hepatic fatty infiltration,and,in some cases,a reduced degree of hepatic inflammation and fibrosis.Nutrition has been demonstrated to be associated with NAFLD and Non-alcoholic steatohepatitis(NASH)in both animals and humans,and thus serves as a major route of prevention and treatment.However,most human studies are observational and retrospective,allowing limited inference about causal associations.Large prospective studies and clinical trials are now needed to establish a causal relationship.Based on available data,patients should optimally achieve a 5%-10%weight reduction.Setting realistic goals is essential for long-term successful lifestyle modification and more effort must be devoted to informing NAFLD patients of the health benefits of even a modest weight reduction.Furthermore,all NAFLD patients,whether obese or of normal weight,should be informed that a healthy diet has benefits beyond weight reduction.They should be advised to reduce saturated/trans fat and increase polyunsaturated fat,with special emphasize on omega-3 fatty acids.They should reduce added sugar to its minimum,try to avoid soft drinks containing sugar,including fruit juices that contain a lot of fructose,and increase their fiber intake.For the heavy meat eaters,especially those of red and processed meats,less meat and increased fish intake should be recommended.Minimizing fast food intake will also help maintain a healthy diet.PA should be integrated into behavioral therapy in NAFLD,as even small gains in PA and fitness may have significant health benefits.Potentially therapeutic dietary supplements are vitamin E and vitamin D,but both warrant further research.Unbalanced nutrition is not only strongly associated with NAFLD,but is also a risk factor that a large portion of the population is exposed to.Therefore,it is important to identify dietary patterns that will serve as modifiable risk factors for the prevention of NAFLD and its complications. | Shira Zelber-Sagi Ran Oren Zelber-Sagi Vlad Ratziu | 2011 | World Journal of Gastroenterology2011，17，29： | 33 |
| 3 | 为弥漫的甲状腺腺病理的评估的 ARFI elastography : 初步的结果显示文摘 AIM:To assess whether acoustic radiation force impulse(ARFI)elastography can differentiate normal from pathological thyroid parenchyma.METHODS:We evaluated 136 subjects(mean age 45.8±15.6 years,106 women and 30 men):44(32.3%) without thyroid pathology,48(35.3%)with BasedowGraves’disease(GD),37(27.2%)with chronic autoimmune thyroiditis(CAT;diagnosed by specific tests),4(2.9%)with diffuse thyroid goiter and 3(2.2%)cases with thyroid pathology induced by amiodarone.In all patients,10 elastographic measurements were made in the right thyroid lobe and 10 in the left thyroid lobe,using a 1-4.5 MHZ convex probe and a 4-9 MHz linear probe,respectively.Median values were calculated for thyroid stiffness and expressed in meters/second(m/s).RESULTS:Thyroid stiffness(TS)assessed by means of ARFI in healthy subjects(2±0.40 m/s)was significantly lower than in GD(2.67±0.53 m/s)(P<0.0001) and CAT patients(2.43±0.58 m/s)(P=0.0002),but the differences were not significant between GDvs CAT patients(P=0.053).The optimal cut-off value for the prediction of diffuse thyroid pathology was 2.36 m/s.For this cut-off value,TS had 62.5%sensitivity,79.5% specificity,87.6%predictive positive value,55.5% negative predictive value and 72.7%accuracy for the presence of diffuse thyroid gland pathology(AUROC=0.804).There were no significant differences between the TS values obtained with linear vs convex probes and when 5 vs 10 measurements were taken in each lobe(median values).CONCLUSION:ARFI seems to be a useful method for the assessment of diffuse thyroid gland pathology. | Ioan Sporea Roxana Sirli Simona Bota Mihaela Vlad Alina Popescu Ioana Zosin | 2012 | World Journal of Radiology2012，4，4： | 25 |
| 4 | A position statement on NAFLD/NASH based on the EASL 2009 special conference显示文摘 | Vlad Ratziu Stefano Bellentani Helena Cortez-Pinto Chris Day Giulio Marchesini | 2010 | Journal of Hepatology2010，，2： | 9 |
| 5 | Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer显示文摘Epithelial-to-mesenchymal transition(EMT) is defined as the transformation of an epithelial cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of mesenchymal markers positivity. In the field of colorectal cancer(CRC), first data about EMT was published in 1995 and more than 400 papers had been written up to March 2016. Most of them are focused on the molecular pathways and experimentally-proved chemoresistance. In the present article, an update in the field of EMT in CRC based on the review of the literature and personal experience of the authors is presented. The information about the molecular and immunohistochemical(IHC) particularities of these processes and their possible role in the prognosis of CRC were also up-dated. This article focuses on the IHC quantification of the EMT, the immunoprofile of tumor buds and on the relation between EMT, angiogenesis, and stem cells activation. The EMT-induced chemoresistance vs chemotherapyor radiotherapy-induced EMT and cellular senescence was also synthesized for both conventional and targeted therapy. As a future perspective, the EMTangiogenesis-stemness link could be used as a possible valuable parameter for clinical follow-up and targeted therapeutic oncologic management of patients with CRC. Association of dexamethasone and angiotensin converting enzyme inhibitors combined with conventional chemotherapies could have clinical benefits in patients with CRC. The main conclusion is that, although many studies have been published, the EMT features are still incompletely elucidated and newly discovered EMT markers provide confusing data in understanding this complicated process, which might have significant clinical impact. | Simona Gurzu Camelia Silveanu Annamaria Fetyko Vlad Butiurca Zsolt Kovacs Ioan Jung | 2016 | World Journal of Gastroenterology2016，22，30： | 8 |
| 6 | Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification显示文摘AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. | Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 7 | Applicability and variability of liver stiffness measurements according to probe position显示文摘AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a signif icant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03).CONCLUSION: The anterior position of the probe should be the fi rst choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position. | Patrick Ingiliz Kim Pav Chhay Mona Munteanu Pascal Lebray Yen Ngo Dominique Roulot Yves Benhamou Dominique Thabut Vlad Ratziu Thierry Poynard | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 8 | Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease显示文摘 | Vlad Ratziu Frédéric Charlotte Agnès Heurtier Sophie Gombert Philippe Giral Eric Bruckert André Grimaldi Frédérique Capron Thierry Poynard | 2005 | Gastroenterology2005，，7： | 4 |
| 9 | Technical tailoring of pancreaticoduodenectomy in patients with hepatic artery anatomic variants显示文摘BACKGROUND:Pancreaticoduodenectomy is the treatment of choice for periampullary and pancreatic head tumors.In case of hepatic artery abnormalities,early pancreatic transection during pancreaticoduodenectomy may prove inappropriate Early retroportal lamina dissection improves exposure of the superior mesenteric vessels and anatomic variants of the hepatic artery,where safeguarding is mandatory.METHOD:We describe our early retroportal lamina approach in patients with anatomic variants of the hepatic artery before pancreatic transection.RESULTS:This approach was used during 42 pancreatico duodenectomies with a hepatic artery anatomic variant which was spared in 40 patients.Arterial reconstruction was performed in 2 patients.Five patients with a hepatic artery variant and adenocarcinoma involving the portomesenteric junction required venous resection and reconstruction.CONCLUSIONS:Early retroportal lamina dissection during pancreaticoduodenectomy in patients with hepatic artery anatomic variants enables easier exposure,avoiding injuries that might compromise the liver arterial supply.When the portomesenteric vein is involved,this approach facilitates en bloc 'no touch' venous resection and reconstruction. | Cristian Lupascu Dan Andronic Corina Ursulescu Ciprian Vasiluta Nutu Vlad | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 3 |
| 10 | Unstable mallet fractures: a comparison between three different techniques in a multicenter study显示文摘槌破裂的客观管理仍然是在整个文学的讨论的一件事。为一些作者,多于关节的表面的 1/3 和远侧的方阵的手掌的 subluxation 包含的槌破裂要求外科的处理。在这研究,我们回顾地为槌破裂比较了三种不同技术:远侧的 interphalangeal 关节,用作游戏杆(KWJ ) 的 Kirschner 电线和为开的减小的 interfragmentary 微型螺丝钉的有延期块卡住的 Kirschner 电线固定(EBP ) 和内部固定(ORIF ) 。58 槌在 58 个病人与手掌的 subluxation 折断的方法与上述的外科的技术被对待。在 20 个病人的二十槌破裂 18 ~ 70 岁(一般水准 42 年) 被操作在之上由 EBP, 16 个病人 22 ~ 56 岁(一般水准 56 年) 被操作在之上用 KWJ 和 22 个病人, 22 ~ 54 岁(一般水准 36 年) 收到了 ORIF。后续时间是 6 ~ 58 个月(一般水准 21 月) 。下列 intraoperative 参数被考虑:intraoperative 时间, Kirschner 电线 / 螺丝钉的数字和技术问题。手术后的参数包括了工作缺席和复杂并发症。放射学的评估外科手术前地基于 A-P 和侧面的看法并且在后续会见时间。骨头联合被在至少一个看法上穿过破裂地点的骨头 trabeculae 的放射学的证据定义。临床的评估包含了运动(ROM ) 的范围有角度计的测试。把大小基于这些,一个功能的 Crawford 分数被建立。所有折断的结果愈合了。在 KWJ 组, intraoperative 时间更短,全部的 ROM 更宽( 72 ??????????偍?′??偍?″??偍????偍????偍木″???????????偍木?€ ????€ 吗?? | Stefano Lucchina Alejandro Badia Vlad Dornean Cesare Fusetti | 2010 | Chinese Journal of Traumatology2010，13，4： | 3 |
| 11 | From NAFLD in clinical practice to answers from guidelines显示文摘 | Fabio Nascimbeni Raluca Pais Stefano Bellentani Christopher Paul Day Vlad Ratziu Paola Loria Amedeo Lonardo | 2013 | Journal of Hepatology2013，，： | 3 |
| 12 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 13 | Design of Flexible and Self-Standing Electrodes for Li-lon Batteries显示文摘灵活便携式的电子设备在最后十年期间吸引了增加的注意。如此的设备的精力消费曾经正在增加并且表现电源来源,是而且灵活,要发展无缝地集成到如此的体系结构的需要。当锂离子电池看起来是最好的答案满足电源和精力要求时,他们的结构、机械的考虑仍然需要被探讨。这里,我们认识到碳 nanotubes (CNT ) 的电气化学的表演上的影响基于并且学习,没有收集者、没有文件夹的电流, Li 离子电池电极。多围的碳 nanotubes 是行动一机械并且电子传导性的支架启用结构的灵活性和好电气化学的表演。与如此的电极做的灵活 Li 离子房间证明当通过简单生产被认识到时,答应表演来临。 | Jean-Pierre Bourgeois Alexandru Vlad Sorin Melinte Jean-Frangois Gohy | 2017 | Chinese Journal of Chemistry2017，35，1： | 2 |
| 14 | Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard显示文摘 | Thierry Poynard Mona Munteanu Elena Luckina Hugo Perazzo Yen Ngo Luca Royer Larysa Fedchuk Florence Sattonnet Raluca Pais Pascal Lebray Marika Rudler Dominique Thabut Vlad Ratziu | 2013 | Journal of Hepatology2013，，5： | 2 |
| 15 | Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study显示文摘 | Jorg Petersen Vlad Ratziu Maria Buti Harry L.A. Janssen Ashley Brown Pietro Lampertico Jan Schollmeyer Fabien Zoulim Heiner Wedemeyer Martina Sterneck Thomas Berg Christoph Sarrazin Marc Lutgehetmann Peter Buggisch | 2011 | Journal of Hepatology2011，，3： | 2 |
| 16 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver<!-- Doctopic: GMD -->显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 17 | Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest?) and transient elastography (FibroScan?)显示文摘 | Thierry Poynard Julien Vergniol Yen Ngo Juliette Foucher Mona Munteanu Wassil Merrouche Massimo Colombo Vincent Thibault Eugene Schiff Clifford A. Brass Janice K. Albrecht Marika Rudler Olivier Deckmyn Pascal Lebray Dominique Thabut Vlad Ratziu Victor de | 2013 | Journal of Hepatology2013，，： | 2 |
| 18 | Viral hepatitis B显示文摘 | Ching Lung Lai Vlad Ratziu Man-Fung Yuen Thierry Poynard | 2003 | The Lancet2003，，9401： | 2 |
| 19 | Ultrasound in rheu- matoid arthritis: volar versus dorsal synovitis evaluation and scoring显示文摘 | VLAD V BERGHEA F LIBIANU S | 2011 | BMC Musculoskelet Disord2011，3，12： | 1 |
| 20 | Drug targeting显示文摘 | TORCH IL IN J VLAD IM IR P | 2000 | Eur J Pharm Sci2000，11，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员