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| 1 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Study on patterns and chemical features of NO effect on marine phytoplankton growth显示文摘This article discusses the patterns of NO effect on marine phytoplankton growth from chemical perspective.The experimental results of four algae,which are Platymonas hal-golandica var.tsingtaoensis,Platymonas subcordiformis,Skeletonema costatum and Nitzschia closterium farma minutissima,are as follows:(i) In f/2 medium or f/50 medium,the growth of these four algae was obviously promoted or inhibited when nitric oxide of different concentrations was added once or twice each day during the cultivation;(ii) The NO effects on the growth of marine phytoplankton are in normal distribution.Different phytoplankton has different optimum NO concentration,which is consistent with the influence of NO on the growth of high plants;(iii) The effect of NO on Platymonas halgolandica var.tsingtaoensi,which is a food alga,is different from that on the red tide algae Skeletonema costatum and Nitzschia closterium farma minutis-sima.The authors put forward a new opinion that every alga has its own NO threshold concen-tration.All the above results may provide new clues to understand the formation of red tide. | ZHANG Zhengbin LIN Cai LIU Chunying XING Lei WU Zhenzhen SUN Feng | 2005 | Science China Chemistry2005，48，4： | 9 |
| 4 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 5 | Heavy Oil and Oil Sands:Global Distribution and Resource Assessment显示文摘Global recoverable resources of heavy oil and oil sands have been assessed by CNPC using a geology-based assessment method combined with the traditional volumetric method, spatial interpolation method, parametric-probability method etc. The most favourable areas for exploration have been selected in accordance with a comprehensive scoring system. The results show:(1) For geological resources, CNPC estimate 991.18 billion tonnes of heavy oil and 501.26 billion tonnes of oil sands globally, of which technically recoverable resources of heavy oil and oil sands comprise 126.74 billion tonnes and 64.13 billion tonnes respectively. More than 80% of the resources occur within Tertiary and Cretaceous reservoirs distributed across 69 heavy oil basins and 32 oil sands basins. 99% of recoverable resources of heavy oil and oil sands occur within foreland basins, passive continental-margin basins and cratonic basins.(2) Since residual hydrocarbon resources remain following large-scale hydrocarbon migration and destruction, heavy oil and oil sands are characterized most commonly by late hydrocarbon accumulation, the same basin types and source-reservoir conditions as for conventional hydrocarbon resources, shallow burial depth and stratabound reservoirs.(3) Three accumulation models are recognised, depending on basin type: degradation along slope; destruction by uplift; and migration along faults.(4) In addition to mature exploration regions such as Canada and Venezuela, the Volga-Ural Basin and the Pre-Caspian Basin are less well-explored and have good potential for oil-sand discoveries, and it is predicted that the Middle East will be an important region for heavy oil development. | LIU Zuodong WANG Hongjun Graham BLACKBOURN MA Feng HE Zhengjun WEN Zhixing WANG Zhaoming YANG Zi LUAN Tiansi WU Zhenzhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 9 |
| 6 | Geochemical Characteristics of Selenium and Its Correlation to Other Elements and Minerals in Selenium-Enriched Rocks in Ziyang County,Shaanxi Province,China显示文摘Ziyang County, Shaanxi Province, China is a world known selenium(Se)-enriched area, and a severe selenosis incident was reported in Naore Village during the 1990 s. This study investigated the geochemical characteristics of Se and its fractions in Se-enriched rocks from Ziyang. Se distribution is uneven, ranging from 0.23 to 57.00 μg/g(17.29±15.52 μg/g). Se content is higher in slate than chert, and even lower in carbonate rocks. Cd, As and V are enriched but Pb is depleted in Se-enriched strata. Se has different correlations both with TS(total sulfur)(R^2=0.59 for chert) and TC(total carbon)(R^2=0.77 for slate, R^2=0.87 for carbonate). Se has significant positive correlations with V(r=0.65), As(r=0.485), Cd(r=0.459) and Pb(r=0.405). The Se level correlates with mineral content, positively with pyrite, chlorite and illite, negatively with albite. Se associated with sulfide/selenide and elemental Se are the predominant fractions of total recovered Se, suggesting that a reducing environment and the formation of sulfides were significant to Se deposition during its geochemical cycle. Although low concentration of bio-available Se(average 5.62%±3.69%) may reduce the risk of Se poisoning in the target area, utilization of Se-rich rock as natural fertilizer should be restricted. | Huan Tian Zhenzhen Ma Xiaolei Chen Hongyu Zhang Zhengyu Bao Changhua Wei Shuyun Xie Shitou Wu | 2016 | Journal of Earth Science2016，27，5： | 7 |
| 7 | Discovery of nitric oxide in marine ecological system and the chemical characteristics of nitric oxide显示文摘Nitric oxide was discovered in both the lab and the alga culture pond of Daya Bay (1―300 m3) before the growth of alga reached the maximum. The results included: (1) NO was detected before the growth of alga reached the maximum in the case of red tide alga and food alga, and the concentration of NO decreased rapidly after the growth maximum; (2) the curve between NO con-centration and time indicated that the concentration of NO in the daytime was more than that at night, and the maximal concentration of NO appeared in the midday (1―3 pm); (3) the growth of alga reached the maximum in the alga culture pond of Daya Bay in about 8―10 d, and NO was discovered in 5―7 d; (4) the measured NO concentration was 10-9 mol/L, 10-9―10-8 mol/L, and 10-8 mol/L for Haeterosigma akashiwo, mixed alga in Daya Bay and Chaetoceros Curvisetus individually; (5) the relation of illumination with NO production was discussed. | ZHANG Zhengbin XING Lei WU Zhenzhen LIU Chunying LIN Cai LIU Liansheng | 2006 | Science China Chemistry2006，49，5： | 7 |
| 8 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 9 | Transcriptome Profiling Reveals Auxin and Cytokinin Regulating Somatic Embryogenesis in Different Sister Lines of Cotton Cultivar CCRI24显示文摘在在棉花(Gossypium hirsutum L.) 位于体的 embryogenesis (SE ) 下面的分子的机制上得到一个更宽广的看法,棉花 transcriptome 动力学的全球分析用 RNA-Seq 在在不同姐妹线的 SE 期间被执行。204349 unigenes 的一个总数被 214977462 Illumina 的汇编读的 de novo 检测。量的反向的 transcriptionpolymerase 链反应(qRT-PCR ) 大小断然与几乎所有测试基因的 RNA-Seq 结果被相关(R2=0.841,关联在 0.01 水平是重要的) 。不同植物激素(植物生长素和细胞激动素) 在媒介和在在不同姐妹线的二个阶段的这二植物激素的内长的内容变化的集中比率在棉花 SE 期间建议了植物生长素和细胞激动素的角色。根据植物激素相关的基因的全球基因规定,从所有差别的众多的基因表示了抄本涉及植物生长素和细胞激动素生合成和信号 transduction 小径。差别的分析表示了涉及揭示的这些小径的基因在在二根姐妹线之间的基因类型和丰富的实质的变化。隔离,克隆并且在棉花 SE 期间揭示了显著起来表示或下面表示的基因是的 silencing/overexpressing 重要。而且,植物生长素和细胞激动素与对方或另外的因素遗体一起在 SE,而是潜在的串音起一个主要作用不清楚。 | Zhenzhen Xu Chaojun Zhang Xueyan Zhang Chuanliang Liu Zhixia Wu Zuoren Yang Kehai Zhou Xiaojie Yang Fuguang Li | 2013 | Journal of Integrative Plant Biology2013，55，7： | 5 |
| 10 | Effect of transcutaneous electrical nerve stimulation at acupoints on patients with type 2 diabetes mellitus:a randomized controlled trial显示文摘OBJECTIVE:To examine whether transcutaneous electric nerve stimulation at acupoints(Acu-TENS)improved the biochemical and physical indices of patients with type 2 diabetes mellitus(T2DM).METHODS:Ninety subjects with T2DM were divided randomly into a control group(n = 30),aerobic exercise group(n- 30),or Acu-TENS group(n = 30).In addition to conventional diabetes drug treatment,patients in the Acu-TENS group received acupoint stimulation,the aerobic exercise group engaged in walking exercises,and the control group was given sham electrical stimulation.All groups were treated for 30 min for each session and five times a week for 2 months.The indices of glycosylated hemoglobin,2 h postprandial glucose,fasting serum insulin,triglyceride,total cholesterol,and body mass index were assessed at pre-treatment,post-treatment,and follow-up,which was 2 months after treatment.RESULTS:The indices of the control group were not changed(P > 0.05) at the three time points.At the pre-treatment measurement,there were significant differences(P > 0.05) in indices among the three groups.At post-treatment,each index of the two groups was lower than that of the control group(P < 0.05),and improved in comparison with the pre-treatment measurement(P < 0.05).In follow-up,each index of the aerobic exercise group and Acu-TENS group increased,but was still decreased compared with the pre-treatment value(P < 0.05),excluding body mass index.CONCLUSION:Acu-TENS could improve the state of patients with T2 DM and be used as a therapy in clinical application. | Wu Zhiyuan Yang Ming Jia Jie Wu Yi Huang Tiansheng Li Mingfen He Zhijie Guo Zhenzhen Leung Mason Chin Pang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 5 |
| 11 | A hydrophilic poly(methyl vinyl ether-alt-maleic acid) polymer as a green, universal, and dual-functional binder for high-performance silicon anode and sulfur cathode显示文摘Binders could play crucial or even decisive roles in the fabrication of low-cost, stable and high-capacity electrodes. This is especially the case for the silicon (Si) anodes and sulfur (S) cathodes that undergo large volume change and active material loss in lithium-ion batteries during prolonged cycles. Herein, a hydrophilic polymer poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was explored as a dual-functional aqueous binder for the preparation of high-performance silicon anode and sulfur cathode. Benefiting from the dual functions of PMVEMA, i.e., the excellent dispersion ability and strong binding forces, the as-prepared electrodes exhibit improved capacity, rate capability and long-term cycling performance. In particular, the as-prepared Si electrode delivers a high initial discharge capacity of 1346.5 mAh g^(−1) at a high rate of 8.4 A/g and maintains 834.5 mAh g^(−1) after 300 cycles at 4.2 A/g, while the as-prepared S cathode exhibits enhanced cycling performance with high remaining discharge capacities of 663.4 mAh g^(−1) after 100 cycles at 0.2 C and 487.07 mAh g^(−1) after 300 cycles at 1 C, respectively. These encouraging results suggest that PMVEMA could be a universal binder to facilitate the green manufacture of both anode and cathode for high-capacity energy storage systems. | Hao Chen Zhenzhen Wu Zhong Su Luke Hencz Su Chen Cheng Yan Shanqing Zhang | 2021 | Journal of Energy Chemistry2021，30，11： | 5 |
| 12 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 13 | Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose- polymerase-mediated apoptosis under high-glucose stimulation显示文摘Proliferative 糖尿病的 retinopathy,在成年人的视觉损失的主要原因,严肃的 microvascular 复杂并发症之一被糖尿病引起。poly-ADP-ribose-polymerase (PARP ) 和原子因素(NF ) 发信号的 -B 涉及损害过程。损害激活 PARP,它接着加强 NF-B 激活和原因房间 apoptosis。象 NF-B 小径一样,发信号的 Notch1 在房间增长,区别,和 apoptosis 的规定起一个关键作用。然而,在这些发信号的小径之间的连接很好没被理解。在这研究,我们使用了导致的两 streptozotocin (STZ ) 糖尿病的老鼠和人的网膜的脉管的 endothelial 房间(HRVEC ) 在高葡萄糖到有教养检测这些关系。我们发现 apoptosis 在导致 STZ 的糖尿病的老鼠和 high-glucose-treated HRVEC 被增加,它由于 Notch1 和 p-Akt 的 PARP,劈开的 caspase3,和减少的表示的增加的激活。Notch1 overexpression 的结果并且击倒显示发信号的 Notch1 参予了 PARP 和 p50 的相互作用,并且直接禁止了调停 PARP 、调停 p50 的 apoptosis。这些现象能被预告的处理经由减少 p-Akt 层次与 PI3K 禁止者 wortmannin 堵住。因此,我们的学习证明发信号的 Notch1 通过 Akt 的激活在高葡萄糖下面保护房间免受 PARP-B-induced 和 NF-B-induced apoptosis 的伤害。 | Xiuhong Qin Zhenzhen Zhang Haitao XLI Yazhen Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 4 |
| 14 | CD146:a potential therapeutic target For systemic sclerosis显示文摘Dear Editor, Systemic sclerosis (scleroderma,SSc)is a chronic disease of connective tissues,and is clinically characterized by persistent fibrosis in the skin as well as in a variety of organs (Katsumoto et al.,2011).The pathogenesis of SSc is com- plex and involves vasculopathy,autoimmunity and fibrosis. The hallmarks of late-stage SSc are the excessive secretion and accumulation of extracellular matrix (ECM)by aberrantly activated fibroblasts (myofibroblasts)in the skin and internal organs (Bhattacharyya et al.,2012). | Lingling Zhang Yongting Luo Xiao Teng Zhenzhen Wu Mengtao Li Dong Xu Qian Wang Fei Wang Jing Feng Xiaofeng Zeng Xiyun Yan | 2018 | Protein & Cell2018，9，12： | 4 |
| 15 | Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor显示文摘Dear Editor,Infertility poses a major challenge to human reproductive health,affecting approximately 48 million women worldwide.1 Assisted reproductive techniques(ART),including in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI),enable infertile women to have their biological embryos in vitro and further give birth to babies after embryo transfer.However,about 10%of all human embryos produced by ART are blocked in the early embryonic stage2 and approximately 2%fertilized oocytes derived from ART could not accomplish the first cell division.3 About one half of human infertility cases involve an underlying genetic factor,although the majority of genetic causes have remained elusive.4 In this study,we report that dominant mutations in CHK1 are responsible for pronuclear fusion failure and zygote arrest(PFF-ZA)in 7 out of 29 cases,likely through increasing the CHK1 activity.Importantly,PFF-ZA caused by these mutations could be effectively rescued by using the CHK1 inhibitor,PF477736. | Honghui Zhang Tailai Chen Keliang Wu Zhenzhen Hou Shigang Zhao Chuanxin Zhang Yuan Gao Ming Gao Zi-Jiang Chen Han Zhao | 2021 | Cell Research2021，31，7： | 4 |
| 16 | Functional additives for solid polymer electrolytes in flexible and high-energy-density solid-state lithium-ion batteries显示文摘Solid polymer electrolytes(SPEs)have become increasingly attractive in solid-state lithium-ion batteries(SSLIBs)in recent years because of their inherent properties of flexibility,processability,and interfacial compatibility.However,the commercialization of SPEs remains challenging for flexible and high-energy-density LIBs.The incorporation of functional additives into SPEs could significantly improve the electrochemical and mechanical properties of SPEs and has created some historical milestones in boosting the development of SPEs.In this study,we review the roles of additives in SPEs,highlighting the working mechanisms and functionalities of the additives.The additives could afford significant advantages in boosting ionic conductivity,increasing ion transference number,improving high-voltage stability,enhancing mechanical strength,inhibiting lithium dendrite,and reducing flammability.Moreover,the application of functional additives in high-voltage cathodes,lithium-sulfur batteries,and flexible lithiumion batteries is summarized.Finally,future research perspectives are proposed to overcome the unresolved technical hurdles and critical issues in additives of SPEs,such as facile fabrication process,interfacial compatibility,investigation of the working mechanism,and special functionalities. | Hao Chen Mengting Zheng Shangshu Qian Han Yeu Ling Zhenzhen Wu Xianhu Liu Cheng Yan Shanqing Zhang | 2021 | Carbon Energy2021，3，6： | 3 |
| 17 | Efficacy of moxibustion by stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) on hyperplasia of mammary gland in rats显示文摘OBJECTIVE: To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) in rats with hyperplasia of mammary gland(HMG) which induced by estrogen and progestogen.METHODS: Thirty female Sprague-Dawley rats were randomly divided into saline control group,HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progesto-gen with moxibustion at the same time. The Changes of nipple diameter and height were measured.The rats' skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.RESULTS: The diameter and height of the nipples in model group were prominently bigger and higher than that in control group(P < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group(P < 0.01), and there was no significant difference between moxibustion group and control group.Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong(CV 17) and Ganshu(BL 18) decreased prominently in model group(P < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently(P <0.05).CONCLUSION: Treatment with moxibustion can effectively decrease the HMG rats' nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia. | Yang Jiamin Wu Jihui Shen Xiaoyu Zhang Mei Liu Zhenzhen Qi Dandan Zhou Jin Cui Xiao Zhang Lufen Li Yuhang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 18 | A distributed spatial computing prototype system in grid environment显示文摘Digital Earth has been a hot topic and research trend since it was proposed,and Digital China has drawn much attention in China.As a key technique to implement Digital China,grid is an excellent and promising concept to construct a dynamic,inter-domain and distributed computing environment.It is appropriate to process geographic information across dispersed computing resources in networks effectively and cooperatively.A distributed spatial computing prototype system is designed and implemented with the Globus Toolkit.Several important aspects are discussed in detail.The architecture is proposed according to the characteristics of grid firstly,and then the spatial resource query and access interfaces are designed for heterogeneous data sources.An open-up hierarchical architecture for resource discovery and management is represented to detect spatial and computing resources in grid.A standard spatial job management mechanism is implemented by grid service for convenient use.In addition,the control mechanism of spatial datasets access is developed based on GSI.The prototype system utilizes the Globus Toolkit to implement a common distributed spatial computing framework,and it reveals the spatial computing ability of grid to support Digital China. | WU Lun,YAN MengLong,GAO Yong,YANG ZhenZhen,ZHAO Yong & CHEN Bin Institute of Remote Sensing and Geographic Information System,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 19 | In vitro expansion of human sperm through nuclear transfer显示文摘Dear Editor,Mammalian haploid embryonic stem cells(haESCs)represent an ideal tool for genetic analysis due to the presence of only one set of genetic materials.HaESCs fall into two readily distinguishable groups based on their genome origins:parthenogenetic haESCs(PG-haESCs)that are derived from oocyte-originated parthenogenetic embryos and androgenetic haESCs(AG-haESCs)that are produced through sperm nuclear transfer.Both PG-and AGhaESCs are feasible for delineating genome function at cellular level in vitro.Importantly,AG-haESCs can be used as a sperm replacement and applied to deciphering gene function at organismal level when combined with CRISPR-Cas9 technology.1 However,while PG-haESCs have been generated from both rodent and primates,2-5 AG-haESCs can only be obtained in rodent to date. | Xiaoyu Merlin Zhang Keliang Wu Yuxuan Zheng Han Zhao Junpeng Gao Zhenzhen Hou Meiling Zhang Jiaoyang Liao Jingye Zhang Yuan Gao Yuanyuan Li Lin Li Fuchou Tang Zi-Jiang Chen Jinsong Li | 2020 | Cell Research2020，30，4： | 3 |
| 20 | Rational design of a biosensor circuit with semi-log dose-response function in Escherichia coli显示文摘 | Haoqian Zhang Ying Sheng Qianzhu Wu Ao Liu Yuheng Lu Zhenzhen Yin Yuansheng Cao Weiqian Zeng Qi Ouyang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，3： | 2 |
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