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您的检索式：作者名="ZHENG FanFan"
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| 1 | Detection of free surface composition and molecular-level structural development of styrene(S)/butadiene(B) block copolymer films during a solution-to-film process显示文摘The surface chemical structure development in solution-cast styrene(S)/butadiene(B) block copolymer films as a function of solvent evaporation time was investigated using sum frequency generation vibrational spectroscopy(SFG).The surface structure formation of the styrene(S)/butadien(B) block copolymer(30 wt% PS) films during the solution-to-film process was found to be controlled mainly by dynamic factors,such as the mobility of the PB block in solution.For SB diblock copolymers,a pure PB surface layer was formed only when the film was cast by dilute toluene solution.With increasing concentration of casting solution,PB and PS components were found to coexist on the film surface,and the morphology of the PB component on the film surface changed from cylindrical rods to spheres.For SBS triblock copolymers,a small amount of PS component existed on the surface even if the film was cast by 1.0 wt% toluene solution.In addition,PS components at the outermost layer of the film increased and the length of PB cylindrical rods on the surface decreased with increasing concentration of casting solution. | YAN ZhuoHua ZHANG RongPing ZHAO YuRong ZUO Biao ZHENG FanFan CHEN TianYu WANG XinPing SHEN ZhiQuan | 2012 | Science China Chemistry2012，55，7： | 1 |
| 2 | Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters显示文摘AIM: To evaluate the inhibitory effects of apigenin and kaempferol on the uptake of several important solute carrier(SLC) transporters.METHODS: Various SLC transporters including the essential human organic anion transporter 1(OAT1), OAT2, OAT3 and OAT4 as well as the important organic cation transporter 1(OCTN1) and OCTN2, were overexpressed in human embryonic kidney(HEK)-293 cells, a well-established cell model of transporter studies. Transport uptake assay was performed 24 h after the transfection. The transport activity was assessed with the uptake of previously determined transporter model substrates and the inhibitory effect of apigenin and kaempferol was evaluated with the substrate uptake in the presence of 10 μmol/L of each compound. Uptakemeasurements with varying concentrations of inhibitors(ranged from 0.0001 to 50 μmol/L) were performed to further characterize the inhibitory potency of apigenin and kaempferol. The IC50 value(the concentration that inhibits 50% of the transporter function) of each compound was then calculated by the nonlinear regression model of Graphpad Prism 6.0 software.RESULTS: Our data indicated that apigenin could potently inhibit the uptake of estrone-3-sulfate(ES) mediated by the HEK-293 cells expressing OAT2, OAT3 and OAT4 as well as the L-ergothioneine uptake via OCTN1-expressing HEK-293 cells. Among these transporters, the most prominent inhibition of apigenin was observed in the case of OAT3. Kaempferol showed significant inhibitory effects on the uptake of ES mediated through OAT2 and OAT3. Impaired L-ergothioneine uptake due to the presence of kaempferol was also observed in OCTN1-expressing HEK-293 cells. Similar to apigenin, kaempferol showed the most potent inhibitory effect on OAT3 as well. To further assess the inhibitory potencies of these two compounds on the uptake of ES mediated by OAT3-expressing HEK-293 cells, their IC50 values were then determined. Both chemicals showed pronounced inhibitory potencies on OAT3 with the IC50 values of 1.7 ± 0.1 and 1.0 ± 0.1 μmol/L(P < 0.01) for apigenin and kaempferol, respectively. CONCLUSION: Both apigenin and kaempferol are potent inhibitors of OAT3; precautions will be necessary when co-administrating them with drugs that are substrates of OAT3. | Ting Chan Zhen Li Jian Zheng Florence Shin Gee Cheung Ling Zhu Fanfan Zhou | 2013 | World Journal of Pharmacology2013，2，4： | 0 |
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