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| 1 | Pancreatic cancer stroma:understanding biology leads to new therapeutic strategies显示文摘Pancreatic ductal adenocarcinoma(PDA)is among the deadliest cancers in the United States and in the world.Late diagnosis,early metastasis and lack of effective therapy are among the reasons why only 6%of patients diagnosed with PDA survive past 5 years.Despite development of targeted therapy against other cancers,little progression has been made in the treatment of PDA.Therefore,there is an urgent need for the development of new treatments.However,in order to proceed with treatments,the complicated biology of PDA needs to be understood first.Interestingly,majority of the tumor volume is not made of malignant epithelial cells but of stroma.In recent years,it has become evident that there is an important interaction between the stromal compartment and the less prevalent malignant cells,leading to cancer progression.The stroma not only serves as a growth promoting source of signals but it is also a physical barrier to drug delivery.Understanding the tumor-stroma signaling leading to development of desmoplastic reaction and tumor progression can lead to the development of therapies to decrease stromal activity and improve drug delivery.In this review,we focus on how the current understanding of biology of the pancreatic tumor microenvironment can be translated into the development of targeted therapy. | Agnieszka Anna Rucki Lei Zheng | 2014 | World Journal of Gastroenterology2014，20，9： | 13 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Comparative transcriptome analyses shed light on carotenoid production and plastid development in melon fruit显示文摘Carotenoids,such asβ-carotene,accumulate in chromoplasts of various fleshy fruits,awarding them with colors,aromas,and nutrients.The Orange(CmOr)gene controlsβ-carotene accumulation in melon fruit by posttranslationally enhancing carotenogenesis and repressingβ-carotene turnover in chromoplasts.Carotenoid isomerase(CRTISO)isomerizes yellow prolycopene into red lycopene,a prerequisite for further metabolism intoβ-carotene.We comparatively analyzed the developing fruit transcriptomes of orange-colored melon and its two isogenic EMS-induced mutants,low-β(Cmor)and yofi(Cmcrtiso).The Cmor mutation in low-βcaused a major transcriptomic change in the mature fruit.In contrast,the Cmcrtiso mutation in yofi significantly changed the transcriptome only in early fruit developmental stages.These findings indicate that melon fruit transcriptome is primarily altered by changes in carotenoid metabolic flux and plastid conversion,but minimally by carotenoid composition in the ripe fruit.Clustering of the differentially expressed genes into functional groups revealed an association between fruit carotenoid metabolic flux with the maintenance of the photosynthetic apparatus in fruit chloroplasts.Moreover,large numbers of thylakoid localized photosynthetic genes were differentially expressed in low-β.CmOR family proteins were found to physically interact with light-harvesting chlorophyll a–b binding proteins,suggesting a new role of CmOR for chloroplast maintenance in melon fruit.This study brings more insights into the cellular and metabolic processes associated with fruit carotenoid accumulation in melon fruit and reveals a new maintenance mechanism of the photosynthetic apparatus for plastid development. | Noam Chayut Hui Yuan Yuval Saar Yi Zheng Tianhu Sun Xuesong Zhou Anna Hermanns Elad Oren Adi Faigenboim Maixia Hui Zhangjun Fei Michael Mazourek Joseph Burger Yaakov Tadmor Li Li | 2021 | Horticulture Research2021，8，1： | 3 |
| 4 | A New View of the Initiation and Propagation in Anionic Polymerization显示文摘这个工作证实开始和 anionic 聚合的繁殖机制的新看法以前求婚了,基于在自我的帮助下的苯乙烯和甲基苯乙烯的 anionic 体积聚合的调查设计了 microflow 设备并且由 GPC 并且在 situ 7Li NMR 描绘了。趋于形成聚集 hexameric 的结构并且弄平基于前者形成巨大的聚集的结构,被发现那 n-BuLi。开始者的这些聚集能直接开始 anionic 聚合并且形成 supramolecule 聚集。supramolecule 聚集不可避免地堵住了单体的散开到离子对并且导致了一个静止变换的平台。然后,集成者完全被分裂进相等的聚集二进制代码的种类,并且聚合在结束前很快再继续。Tetrahydrofuran (THF ) 充当了电子捐赠者,它能把电子云推到李阳离子并且做相当松开并且便于单体插入在里面的活跃种类的聚集的戒指。因此,小 THF 能极大地支持 anionic 聚合。然而, THF 的进一步的增加可能堵住在离子对和减少之间的隧道繁殖率。活跃种类的聚集的结构仅仅在 anionic 聚合期间取决于在聚合前被形成的开始者聚集,这也被发现。 | Anna Zheng Bo Chen Dihang Hu Yong Guan Dafu Wei Shuzhao Li Dandan Ji | 2013 | Chinese Journal of Chemistry2013，31，3： | 2 |
| 5 | Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration显示文摘 | Seh–Hoon Oh Rafal P. Witek Si–Hyun Bae Donghang Zheng Youngmi Jung Anna C. Piscaglia Bryon E. Petersen | 2007 | Gastroenterology2007，，： | 1 |
| 6 | Does Foreign Direct Investment Affect S0_(2) Emissions in the Yangtze River Delta?A Spatial Econometric Analysis显示文摘As the major source of air pollution,sulfur dioxide(S0_(2))emissions have become the focus of global attention.However,existing studies rarely consider spatial effects when discussing the relationship between foreign direct investment(FDI)and S0_(2) emissions.This study took the Yangtze River Delta as the research area and used the spatial panel data of 26 cities in this region for 2004-2017.The study investigated the spatial agglomeration effects and dynamics at work in FDI and S0_(2) emissions by using global and local measures of spatial autocorrelation.Then,based on regression analysis using a results of traditional ordinary least squares(OLS)model and a spatial econometric model,the spatial Durbin model(SDM)with spatial-time effects was adopted to quantify the impact of FDI on S0_(2) emissions,so as to avoid the regression results bias caused by ignoring the spatial effects.The results revealed a significant spatial autocorrelation between FDI and S0_(2) emissions,both of which displayed obvious path dependence characteristics in their geographical distribution.A series of agglomeration regions were observed on the spatial scale.The estimation results of the SDM showed that FDI inflow promoted S0_(2) emissions,which supports the pollution haven hypothesis.The findings of this study are significant in the prevention and control of air pollution in the Yangtze River Delta. | GUO Zheng Sophia Shuang CHEN YAO Shimou Anna Charles MKUMBO | 2021 | Chinese Geographical Science2021，31，3： | 1 |
| 7 | Poly(ethylene oxide) macromonomer-grafted polymer nanoparticles synthesised by emulsifier-free emulsion polymerisation显示文摘 | Zuifang Liu Huining Xiao Nicholas Wiseman Anna Zheng | 2003 | Colloid and Polymer Science2003，，9： | 1 |
| 8 | Improving Foamability of Polypropylene by Grafting Modification显示文摘 | LIU Chunsheng WEI Dafu ZHENG Anna | 2006 | Journal of Applied Polymer Science2006，101，6： | 1 |
| 9 | Studies on interface of glass fiber-reinforced polypropylene composite显示文摘 | Anna Zheng Honggan Wang Xinsheng Zhu Seizo Masuda | 2002 | Composite Interfaces2002，9，4： | 1 |
| 10 | 显示文摘 | Zheng Anna Yah Xue Wei Dafu | 2013 | Materials Science and Engineering2013，33，1： | 1 |
| 11 | Polychlorinated dibenzo- p -dioxins and dibenzofurans pollution in China: Sources, environmental levels and potential human health impacts显示文摘 | Gene J. Zheng Anna O.W. Leung Li Ping Jiao Ming H. Wong | 2008 | Environment International2008，，7： | 1 |
| 12 | Crystallization behaviors of polypropylene and functional polypropylene显示文摘 | Guan Yong Wang Shuzhong Zheng Anna | 2003 | Journal of Applied Polymer Science2003，88，4： | 1 |
| 13 | Study of pitting corrosion on mild steel during wet–dry cycles by electrochemical noise analysis based on chaos theory显示文摘 | Anna Chen Fahe Cao Xiaoning Liao Wenjuan Liu Liyun Zheng Jianqing Zhang Chunan Cao | 2013 | Corrosion Science2013，，： | 1 |
| 14 | A study on new polymerization technology of styrene 显示文摘 | Si Linxu Zheng Anna Yang Haibo | 2002 | Journal of Applied Polymer Science2002，85，10： | 1 |
| 15 | Polystyrene prepared by reactive extrusion: Kinetics and effect of processing parameters 显示文摘 | Gao Shishuang Zhang Ying Zheng Anna | 2004 | Polymers for Advanced Technologies2004，15，4： | 1 |
| 16 | Corrosion behaviour of copper under chloride-containing thin electrolyte layer显示文摘 | Xiaoning Liao Fahe Cao Liyun Zheng Wenjuan Liu Anna Chen Jianqing Zhang Chunan Cao | 2011 | Corrosion Science2011，，： | 1 |
| 17 | Antistatic modification of polypropylene by incorporating Tween/modified Tween显示文摘 | Zheng Anna Xu Xiang Xiao Huining | 2012 | Applied Surface Science2012，258，3： | 1 |
| 18 | Crystallization behaviors of polypropylene and functional polypropylene显示文摘 | Guan Yong Wang Shuzhong Zheng Anna | 2003 | J Appl Polym Sci2003，88，： | 1 |
| 19 | Vicinal hydroxyl group-inspired selective oxidation of glycerol to glyceric acid on hydroxyapatite supported Pd catalyst显示文摘Selective oxidation of glycerol provides a feasible route towards the sustainable synthesis of high value-added chemicals.Herein,the hydroxyapatite(HAP)supported palladium(Pd)species were fabricated by impregnation and subsequent calcination.The as-obtained heterogeneous Pd catalyst afforded not only excellent selectivity to glyceric acid(GLA)up to 90%with 59%conversion of glycerol but also good recyclability by using molecular oxygen as an oxidant under mild conditions.The characterization of catalysts indicated that both the surface basicity and Pd sites on the catalyst played a crucial role in promoting glycerol oxidation.Notably,it demonstrated that the presence of the vicinal hydroxyl group of glycerol molecule can assist the oxidation reaction via forming a coordination between the vicinal hydroxyl group and Ca^(2+) sites on HAP-derived catalysts.In this catalytic process,the secondary hydroxyl of glycerol kept untouched and the primary hydroxyl of glycerol was converted into carboxyl group,while the Pd species acted as active centers for cooperatively promoting the subsequent oxidation to generate GLA.Additionally,this catalytic system can be extended widely for the oxidative conversion of other vicinal diols into the corresponding a-hydroxycarboxylic acids selectively.Isotope labeling experiment using H_(2)^(18)O confirmed that H_(2)O not only acted as solvent but also was involved in the catalytic cycles.On the basis of the results,a possible reaction mechanism has been proposed.The HAP-supported Pd catalytic system has been shown to serve as an effective approach for the upgrading of bio-derived vicinal diols to high value-added chemicals. | Difan Li Xiuge Zhao Qingqing Zhou Bingjie Ding Anna Zheng Qingpo Peng Zhenshan Hou | 2022 | Green Energy & Environment2022，7，4： | 1 |
| 20 | Structural characterization and antibacterial activity of oligoguanidine (polyhexamethylene guanidine hydrochloride)显示文摘 | Dafu Wei Qiangxiang Ma Yong Guan Fuzeng Hu Anna Zheng Xi Zhang Zheng Teng Hua Jiang | 2009 | Materials Science & Engineering C2009，，6： | 1 |
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